RSV나 인플루엔자 A형 바이러스에 감염된 비천식 소아에게 비인두 흡인액의 Interleukin - 11 , Interferon - γ치와 eosinophil cationic protein 치의 비교

오재원(Jae Won Oh),이하백(Ha Baik Lee),박일규(Il Kyu Park),강정옥(Jung Oak Kang) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1

N/A Background: Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. The objective of this study was to determine whether respiratory virus infections such as RSV, and influenza A virus are related to the productions of IL-11, IFN-γ, and ECP levels in nasopharyngeal secretions. Method: We compared IL-11, IFN-γ, and ECP levels in nasopharyngeal secretions from 38 non-asthmatic wheezing children with viral infections (RSV in 21 children, influenza A virus in 17 children), and 16 non-asthmatic healthy children who were included as the controls. IL-11, and IFN-y levels were analysed by ELISA. ECP concentrations were measured by monoclonal antibody-based fluorometric assay. Result. RSV infection in children induced a greater release of IL-11 in nasopharyngeal secretions than in influenza A virus infection, and in the controls. The release of IFN-γ levels in nasopharyngeal secretions from children with influenza A virus infection was significantly higher than in nasopharyngeal secretions from children with RSV. ECP levels of subjects with viral infection were significantly higher than in control children. Conclusion. This study demonstrated that RSV is a potent inducer of IL-11 elaboration in nasal epithelium and that IL-11 is an important mediator in the pathogenesis of RSV infection. Increased IFN-γ production in response to the influenza A virus infection may be related to effective Th1 responses.

Polytetrafluoroethylene 분말 현탁액을 통한 다공성 박막 제조 및 에너지 발생소자 응용

박일규,Park, Il-Kyu 한국분말야금학회 2017 한국분말재료학회지 (KPMI) Vol.24 No.2

Porous polytetrafluoroethylene (PTFE) thin films are fabricated by spin-coating using a dispersion solution containing PTFE powders, and their crystalline properties are investigated after thermal annealing at various temperatures ranging from 300 to $500^{\circ}C$. Before thermal annealing, the film is densely packed and consists of many granular particles 200-300 nm in diameter. However, after thermal annealing, the film contains many voids and fibrous grains on the surface. In addition, the film thickness decreases after thermal annealing owing to evaporation of the surfactant, binder, and solvent composing the PTFE dispersion solution. The film thickness is systematically controlled from 2 to $6.5{\mu}m$ by decreasing the spin speed from 1,500 to 500 rpm. A triboelectric nanogenerator is fabricated by spin-coating PTFE thin films onto polished Cu foils, where they act as an active layer to convert mechanical energy to electrical energy. A triboelectric nanogenerator consisting of a PTFE layer and Al metal foil pair shows typical output characteristics, exhibiting positive and negative peaks during applied strain and relief cycles due to charging and discharging of electrical charge carriers. Further, the voltage and current outputs increase with increasing strain cycle owing to accumulation of electrical charge carriers during charge-discharge.

수열합성중 계면활성제를 이용한 ZnO 나노구조 형상 제어

박일규,Park, Il-Kyu 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.4

We report on an all-solution-processed hydrothermal method to control the morphology of ZnO nanostructures on Si substrates from three-dimensional hemispherical structures to two-dimensional thin film layers, by controlling the seed layer and the molar contents of surfactants during their primary growth. The size and the density of the seed layer, which is composed of ZnO nanodots, change with variation in the solute concentration. The ZnO nanodots act as heterogeneous nucleation sites for the main ZnO nanostructures. When the seed layer concentration is increased, the ZnO nanostructures change from a hemispherical shape to a thin film structure, formed by densely packed ZnO hemispheres. In addition, the morphology of the ZnO layer is systematically controlled by using trisodium citrate, which acts as a surfactant to enhance the lateral growth of ZnO crystals rather than a preferential one-dimensional growth along the c-direction. X-ray diffraction and energy dispersive X-ray spectroscopy results reveal that the ZnO structure is wurtzite and did not incorporate any impurities from the surfactants used in this study.

원심분리법을 이용한 다공 크기 구배를 가지는 알지네이트 지지체의 제조 및 분석

박일규 ( Il Kyu Park ),오세행 ( Se Heang Oh ),이진호 ( Jin Ho Lee ) 한국조직공학과 재생의학회 2004 조직공학과 재생의학 Vol.1 No.2

It is well recognized that the pore size of scaffolds plays an important role for tissue ingrowth and regeneration: different kinds of cells were shown to have different optimal pore size ranges in the scaffolds for effective cell growth. So, if the tissue scaffold with pore size gradient (i. e., the scaffold with gradually increasing pore sizes along one direction) can be prepared, it will be of particular interest for basic studies of the interaction between tissue cells and scaffolds since the effect of pore size can be examined in a single experiment using one scaffold (pore size gradient scaffold). In recent years, several techniques have been used to fabricate porous polymer scaffolds having 3-dimensional pore structure. However, it is not possible to fabricate scaffolds with pore size gradient from those techniques. In this study, we developed a new method to fabricate pore size gradient scaffolds by a simple centrifugation. We fabricated alginate cylindrical scaffolds with gradually increasing pore size (80~310 μm) along the longitudinal direction by the centrifugation method. In this method, the pore size ranges of the scaffold could be easily controlled by adjusting centrifugal force. The prepared alginate scaffolds were impregnated into 1 wt% chitosan solution to improve cell adhesiveness as well as mechanical strengths. This study demonstrate that the centrifugation method is a simple and effective method to prepare tissue scaffolds with controllable pore size ranges.

반추동물에서 과립구의 기능에 대한 연구: 1. 소의 순환혈액에서 다형핵백혈구의 신속한 분리

박일규 ( Il Kyu Park ),윤창용 ( Chang Yong Yoon ),이정원 ( Jeoung Won Lee ),송희종 ( Hee Jong Song ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.22 No.4

Polymorphonuclear (PMN) leucocytes are fundamental importance to the body`s defense mechanism and play a major role in the local and systemic reactions to infectious disease. Investigation of the physiological and pathological role of the various leucocyte subtypes in host defence mechanisms is dependent upon the isolation of adequate numbers of viable, pure leucocyte fractions. This report describes the separate frequency of PMN leucocytes both from buffy coat layer and from packed RBC layer when bovine peripheral blood was treated with various anticoagulants such as acid-citrate-dextrose(ACD), ethyldiaminetetraacetic acid (EDTA), sodium citrate and heparin. The separate frequencies of PMN leucocytes from buffy coat layer was 60.4±9.6%(heparin), 56.8±11.8%(sodium citrate), 30.6±14.1%(ACD) and 6.2±3.7%(EDTA), in order. Those from packed RBC layer monitored with EDTA, ACD, sodium citrate and heparin was 85.0±4.7%, 84.3±5.5%, 83.8±6.5% and 76.3±7.7%, respectively. The Ficoll-hypaque(FH) density gradient method was used to remove a small part of lymphocytes and/or monocytes from leucocytes in packed RBC layer. With the result that it increased separate frequency of PMN leucocytes from EDTA(89.9±2.4%), ACD(89.5±3.6%), and sodium citrate(83.6±10.3%) than heparin(68.4±13.9%). These results indicate that the use of EDTA and ACD as anticoagulant is suitable for the separation of PMN leucocytes from bovine peripheral blood, and that the FH density gradient method is able to increase the separate frequency of PMN leucocytes from packed RBC layer.

모바일 기기 환경에서의 고품질 입체 영상 콘텐츠 제작 플랫폼 및 콘텐츠 제작 앱

박일규(Il Kyu Park),박성진(Seongjin Park),김도형(Do Hyung Kim),최진성(Jin Sung Choi),구본기(Bonki Koo) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.2

카메라를 탑재한 휴대형 디지털 단말기가 광범위하게 보급되기 시작한 후 사용자들은 소비자의 위치에서 벗어나 스스로 콘텐츠를 제작, 공유하는 프로슈머 형태로 진화하고 있다. 최근 3 차원 출력센서가 보급되면서 콘텐츠 제작 및 공유를 위한 영상처리기술이 기존의 2D 디지털영상처리에서 입체영상처리로 확대되어야 한다. 본 논문은 모바일기기 환경에서 입체영상 콘텐츠를 제작할 수 있는 플랫폼과 이를 이용한 모바일 앱 디자인 방법을 제안한다. 입체영상제작 엔진에는 객체 인식 및 분리, 가림현상 인식 및 복원, 객체제거 및 제거된 영역 채우기 등의 기능을 제공한다. 입체영상기반의 제작엔진 플랫폼을 일반사용자와 전문가용 모바일 앱을 개발하여 테스트하였다. 앞으로 스테레오 카메라나 라이트필드 카메라 등 입체영상을 지원하는 디바이스가 많이 출시될 것이고, 본 논문에서 설계산 플랫폼이 이들 디바이스를 지원할 수 있도록 할 예정이다. After introducing mobile digital devices with camera broadly, users break the consumers and evolve the prosumers that produce and share contents themselves. As the 3D image output devices are provided lately, the image processing technology should extend from 2D to 3D image. In this paper, we propose the design method for 3D image authoring platform and mobile apps using the platform. The 3D image authoring platform provides three functions: object recognition and segmentation, hole filling in occlusion area, and object removal and hole filling in the removed area. We tested the 3D image authoring platform through developing mobile apps for general users and professional users. In the future, 3D image output devices like stereo cameras and light field cameras will be introduced, and we plan to support the new introducing devices using our 3D image authoring platform.

SCM 시스템 성과 평가모형 개발 및 평가항목별 AHP 분석

박일규(Il-Kyu Park),김상훈(Sang-Hoon Kim) 한국SCM학회 2011 한국SCM학회지 Vol.11 No.1

The objective of this research is to develop performance evaluation model for SCM(Supply Chain Management) systems aiming at optimizing internal and external logistics systems, production, flow of resources and finances, and to establish weight values for performance evaluation items. Through reviewing and interrelating a vast range of related theoretical studies the integrative evaluation model for SCM systems performance was derived, and then the weight value as relative importance to SCM systems performance was determined for each evaluation area and item by means of AHP(Analytic Hierarchy Process) analysis. The data for AHP analysis were collected by surveying 15 SCM systems experts from academic and corporate sectors. The performance evaluation model for SCM systems could be reasoned to consist of three evaluation areas(technological quality, task efficiency and organizational outcome) and nine evaluation items(system quality, information quality, service quality, contributiveness to task efficiency, users’ satisfaction and four BSC items). The results of AHP analysis shows that each evaluation area and item have significantly different weight value. By applying the integrative evaluation model suggested in this study and the weight values of evaluation areas and items identified via AHP analysis, the performance evaluation of SCM systems will be able to be done more correctly and meaningfully. Also, the development and application of this rational performance evaluation methodology will lead to effective management of SCM systems.

유아 및 아동의 체능 프로그램 참여가 기초운동기능 발달에 미치는 영향

박일규(Il Kyu Park),최민동(Min Dong Choi),이진훈(Jin Hun Lee),손기수(Ki Su Son) 한국발육발달학회 2001 한국발육발달학회지 Vol.9 No.1

본 연구는 일반유치원에서 주당 1일 운동프로그램에 참여하는 아동과, 스포츠 센터에서 개인적으로 주당 5일 규칙적으로 운동프로그램에 참여하는 아동중 1년 이상 된 아동을 대상으로 체격(신장, 체중)과 운동능력을 연령별, 성별로 각 집단 간의 차이를 비교하여 스포츠센터 체능단의 운동프로그램의 실용성과 보완해야 할 사항 등을 규명하고자 하는데 그 목적이 있다. 측정은 신장, 체중, 25m 달리기, 윗몸일으키기, 제자리멀리뛰기, 체전굴, 왕복달리기, 철봉오래매달리기를 실시하였으며, 여기서 얻어진 자료는 각 요인별로 평균치를 얻어 집단간 비교를 실시하였다. 그 결과 체격에 있어서, 신장에서는 집단간 차이를 나타내지 않았지만, 체중에서는 체능단 집단이 유치원 집단보다 낮은 것으로 나타났다. 이는 현재 체능단에 운영되고 있는 일상적인 프로그램이 과잉된 영양을 소모하여 보기 좋은 체형을 만드는 데 도움이 되는 것으로 생각된다. 운동능력의 비교에서는 순발력과 평형성 부분에서는 체능단 아동이 우수하였으나, 유연성 부분에서는 각 집단간 차이가 없는 것으로 나타났다. 또한 근지구력과 민첩성 부분에서는 남자 아동은 집단 간 차이가 나타났지만, 여자 아동에 있어서는 차이가 없는 것으로 나타났다. 이러한 결과는 현재 진행되고 있는 운동 프로그램이 순발력을 기르는데 집중되고 있으며, 전체 프로그램에서 유연성 증가 프로그램을 보강할 필요성을 말하는 것이고, 또한 근지구력과 민첩성 부분은 현재 운동프로그램이 여자 아동에게는 적절하지 못하다고 할 수도 있을 것이고, 이 부분에 대해 여자 아동의 흥미를 유발시키는 기법을 개발하는 것이 시급하다고 할 수도 있을 것이다. This research is comparing orphaned children`s physique and movement capacity between two groups, one has physical education in a week, the other has it five times in a week in a certain city called P. After lots of comparison of reasons of child`s physique and movement capacity, so we have come to the following conclusion: The measured items are height, weight, 25m run, suttle run, trunk flexion, flexed arm hang, and sit ups, In comparing of each groups for child`s physique, there is no difference between groups in the height, but in weight, the sports center group is heavier than the opposition group In a comparison of each group for movement capacity, a group of the personal sport center is better than a kindergarten in 25m run, but there is no difference on trunk flexion, and shuttle run. In flexed arm hang, and sit ups, only boys had difference between two groups except girls. So sports center instructors have to be concerned about increasing flexion, with girls they need to be concerned about increasing interest of agility, endurance.

SCM 시스템 성과 평가모형 및 평가지표 개발 : SCOR 모델에 근거하여

박일규(Park Il Kyu),김상훈(Kim Sang Hoon) 한국IT서비스학회 2010 한국IT서비스학회 학술대회 논문집 Vol.2010 No.9

본 연구에서는 기업 내·외부를 연결하는 공급사슬을 통합적으로 관리하는 시스템으로서 내·외부의 물류체계, 생산, 자원과 자금의 흐름 등을 최적화하는데 그 목적을 두고 있는 SCM(Supply Chain Management) 시스템에 대한 성과평가 모형 및 평가지표를 개발하여 현재 SCM 시스템을 사용 중인 기업에 적용하여 타당성을 검증하였다. 실증분석을 위하여 SCM 시스템 사용자를 대상으로 인터넷 기반의 웹 설문을 실시하였으며, 부분최소자승법 (PLS: Partial Least Squares)을 이용하여 평가모형에 대한 경로분석을 실시한 결과, 15개의 연구가설 중 기각된 2개의 가설을 제외한 13개의 가설을 채택하였다. 본 연구의 의의로는 이론적 측면에서 SCOR 모델에 근거하여 방대하고, 복잡한 SCM 업무프로세스를 분석함으로써 모형의 이론적 견고성 및 차별성을 확보케 하였다는 점과 기업의 궁극적인 균형성과 목표를 이루는 성과창출경로를 규명하였다는 점을 들 수 있으며, 실천적 측면에서 SCM 시스템 운영과 관련한 기업의 의사결정자에게 성공적인 SCM 시스템 도입 및 확장을 위한 실무지침 및 전략적 안목을 제공하였다는 점이다.

온라인 게임서버에서의 k - 최근접 관심영역 관리기법

박일규(Park Il Kyu),심광현(Kwang-Hyun Shim),김종성(Jong-Sung Kim) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅲ

대규모 온라인 게임과 같이 수많은 사용자를 수용하는 클라이언트/서버 방식 응용에서는 네트워크의 대역폭을 효율적으로 사용하는 것이 중요하다. 각 클라이언트의 관심영역에 해당하는 데이터만을 보내어 트래픽을 줄이는 방법을 관심영역 관리라 하며, 클래스기반, 영역 기반, 격자기반 등 여러 가지의 방법이 제안되어 있다. 본 논문에서는 작은 영역에서 거리 기반으로 관심영역을 정하는 관심영역 관리 기법을 제안하고, 이를 이용하여 참가자의 편중된 영역에서 생기는 트래픽 집중 현상을 해소하는 방법을 제안한다.