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위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성
이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)
체외 수정으로 임신된 쌍태아 중 발육 부전을 가진 태아에서 발견된 제대 막양 부착
박원일(Won Il Park),남종윤(Jong Yun Nam),김주오(Joo Oh Kim),주종은(Jong Eun Joo) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
To date, velamentous insertion of umbilical cord has not been a topic of interest. It has regarded as a phenomenon without clinical significance rather than a disease. Furthermore, antenatal diagnosis of velamentous insertion has been thought as an impossible task. Recently, some investigators raised the clinical importance of velamentous insertion of umbilical cord, especially in multiple gestation. Below we report on a case of velamentous insertion of umbilical cord in discordant twins conceived by in vitro fertilization. The aim of this report is to emphasis the clinical significance of velamentous insertion of umbilical cord in twin gestation. The velamentous insertion of umbilical cord can cause twin-twin transfusion syndrome (TTTS) and pseudo TTTS. Besides, the possible correlation between the high incidence of velamentous insertion of umbilical cord and discordancy in twin pregnancy obtained by in vitro fertilization is also discussed in this report in conjunction with the case.
박원일(Won Il Park),이종협(Jong Hyup Lee),조심현(Shim Hyun Jo),백봉력(Bong Luck Paik),최충경(Chung Keung Choi),이성근(Seung Geun Lee),문한규(Han Kyu Moon),최영미(Young Mee Choi),정윤석(Yoon Sok Jung),이관우(Kwan Woo Lee),김현만(Hyeon 대한내과학회 2002 대한내과학회지 Vol.62 No.3
N/A Background: There is increasing interest in the use of a very low calorie diet (VLCD) as a treatment regimen for weight loss in obese subjects. This study was designed to investigate the effect s and safety of a traditional Korean very-low-calory diet Methods: Twelve hospitalized obese patients at Dong Eui hospital in Busan city from May 1998 to December 1998 were selected. Height, body weight, blood lipids, blood insulin level, body fat, lean body mass, subcutaneous fat and visceral fat were measured. A traditional Korean VLCD was supplied for 14 days. Results: Patient's body weight was significantly decreased from 83.8 kg to 78.6 kg, body fat from 32.2 kg to 28.6 kg, lean body mass from 32.2 kg to 28.6 kg, and BMI from 31.4 to 29.5, respectively (p <0.05). Total fat was significantly decreased from 807 cc to 659 cc, subcutaneous fat from 567 cc to 473 cc, visceral fat from 273 cc to 185 cc, respectively. However there were no significant changes in minerals. After VLCD intervention, total cholesterol was significantly decreased from 199 mg/dL to 166mg/dL, HDL-cholesterol from 42 mg/dL, to 35mg/dL, triglyceride from 158mg/dL, to 75mg/dL (p<0.05). The insulin area under the curve was also significantly decreased from 205μIU/mL·2hr to 168 μIU/mL·2hr(p <0.05). Conclusion: Above findings suggested that a traditional Korean VLCD is effective and safe for short term use in terms of reducing body fat and improving insulin resistance in obese patients. (Korean J Med 62:250-257, 2002)
류마티스 다발근육통증 환자의 전형적 18-FDG-PET/CT 소견 1예
박진수 ( Jin Su Park ),표정윤 ( Jung Yoon Pyo ),박희진 ( Hee Jin Park ),이향선 ( Hyang Sun Lee ),강윤 ( Yoon Kang ),강미일 ( Mi Il Kang ),송정식 ( Jung Sik Song ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ),이상원 ( Sang Won 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.2
PMR의 병태생리는 명확히 밝혀져 있지 않지만, 염증을 시사하는 병리학적 소견이나 ESR의 상승은 염증이 주된 병인기전임을 시사한다. 최근 PMR 환자에서 시행한 18-FDG-PET에서 윤활막염과 윤활낭염 및 혈관염 등의 특징적인 소견이 관찰되고 있다. 이 증례는 PMR 환자에서 18-FDG-PET/CT를 시행하였고, 전형적인 윤활막염, 윤활낭염, 무증상의 큰 혈관염 등이 관찰된 첫 번째 증례이다. 향후 한국인 PMR 환자의 진단시, 18-FDG-PET의 유용성에 대한 정확한 자료를 얻기 위해서 표준화된 방법을 통한 여러 환자에서의 시행이 필요할 것이다. Polymyalgia rheumatica (PMR) is an inflammatory rheumatic condition characterized by generalized pain and morning stiffness in the shoulders, hip girdle, and neck. Since the pathogenesis of PMR is still uncertain, the diagnosis of PMR depends on clinical features. There have been several studies regarding radiological tools for the diagnosis of PMR. Recent studies using 18-FDG-PET showed bursitis, synovitis, uptake in the spinous process and asymptomatic large-vessel vasculitis in PMR patients. However, there was no report on the efficacy of 18-FDG-PET for diagnosis of PMR in Korea. Here, we are first reporting a case of a Korean patient with PMR, who had radiological findings including bursitis, synovitis, uptake in the spinous process and asymptomatic large-vessel vasculitis on 18-FDG-PET/CT.
녹차추출물과 테아닌 복합물의 신경전달물질 조절을 통한 항스트레스 효과
박상기(Sang-Ki Park),박형국(Hyoung Kook Park),김태일(Tae Il Kim),홍진태(Jin Tae Hong),이원경(Won Kyung Lee) 대한약학회 2009 약학회지 Vol.53 No.5
Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the combination relieving effect of green tea extract(GTE) and L-theanine on the stress induced by electric foot shock. Four week oral administration of GTE (24 mg/kg), L-theanine (4 mg/kg) or their combination reduced the levels of dopamine, noradrenaline and corticosterone in blood, brain cortex, hippocampus, and striatum, wherease increased serotonin level. The combination of GTE and L-theanine showed much greater effects than single treatment of each component, and the effects are comparable to diazepam (2 mg/kg). Therefore, this study suggests that the combination of GTE and L-theanine may act effective and be useful for stress relieving treatment.