복부 종괴를 주소로 발견된 전이성 맥락막 흑색종

박원서(Won Seo Park),허승철(Seung Chul Heo),김지은(Ji Eun Kim),정중기(Jung Kee Chung),정인목(In Mok Jung),안영준(Young Joon Ahn),황기태(Ki-Tae Hwang) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.2

Primary omental tumors are rare, with most being metastatic, especially those from intra-abdominal organs. Breast and lung malignancies, as well as melanomas, are frequent causes of extra-abdominal cancers metastasizing to the omentum, peritoneum and mesentery. The case of a metastatic omental melanoma from the choroid of the eye was experienced, which formed a solitary mass in the omentum similar to that of a primary omental tumor. The patient was unaware of the nature of her eye disease following enucleation seven years previously. Concomitant liver metastases were also not identified on a CT scan, due to their relatively small sizes. Therefore, the metastatic melanoma was misconceived as a primary omental tumor until laparotomy and pathologic confirmation. This case shows that a metastatic melanoma can be presented as an abdominal mass, and should be considered in the differential diagnosis of an intra-abdominal mass.

레일연마에 따른 고속철도 레일 피로수명 평가

박원서(Won-Seo Park),임형준(Hyung-Jun Lim),박용걸(Yong-Gul Park),성덕룡(Deok-Yong Sung),강윤석(Yoon-Suk Kang) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.10

The control of rail surface irregularity is very important for the high speed train service in the high speed rail. In order to manage it initial preventative and maintainable rail grinding have been performed and among them preventative rail grinding conducts in every each year. This study carried out the field test for dynamic track response according to rail surface irregularity comparing before and after rail grinding. In addition the change of dynamic track responses according to rail grinding was analyzed and the fatigue life was estimated though Rainflow Counting Method and RMC Equivalence Stress. Therefore it suggested that rail fatigue life should be increased by rail grinding because amount of impact occurred on track is decreased by getting rid of rail surface irregularity

로봇을 이용한 내시경적 갑상선절제술

박원서 ( Won Seo Park ),민선영 ( Sun Young Min ),고석환 ( Suck Hwan Koh ) 경희대학교 경희의료원 2010 慶熙醫學 Vol.26 No.1

Thyroid cancer incidence is increasing rapidly especially in young female patients and differentiated thyroid cancer has a good prognosis. For these reasons, cosmetic results of thyroid surgery are important. There were many efforts to minimize or hide the scars on the neck using endoscopic surgical technique via various methods such as cervical approach, anterior chest approach, breast approach, gasless axillary approach, axillo bilateral breast approach and bilateral axillo-breast approach (BABA). The BABA is ideal approach because of excellent cosmetic results, optimal view for both lobes of thyroid and distant port location to avoid interference of instruments. Most of all, the BABA is suitable for total thyroidectomy. But the endoscopic thyroidectomy via BABA has some limitations such as long learning curve and difficulty dissecting central and lateral lymph nodes due to rigidity of instruments. Robotic surgical system provides surgeons three dimensional image with 15 times magnification, articulated instruments increasing degree of freedom and ergonomically comfortable position. Grafting robotics on the endoscopic technique can overcome limitations of endoscopic thyroidectomy via BABA without losing the advantage of that. The authors introduce the methods and experiences of robot-assisted endoscopic thyroidectomy.

치과에서의 이물흡인 -증례분석-

박원서,김성태,박무석,서지선,김기덕,Park, Won-Seo,Kim, Seong-Tae,Park, Mu-Seok,Seo, Ji-Seon,Kim, Gi-Deok 대한치과마취과학회 2011 Journal of Dental Anesthesia and Pain Medicine Vol.11 No.1

Despite all preventive efforts, aspiration of foreign body during clinical dental procedures occurs occasionally. Careful clinical physical examination, proper assessment of radiography and prompt emergency treatment can prevent any potentially serious consequences. In this report, we will report serial cases of foreign body in different situation from mild cases to severe cases and suggest some clinical guidelines to dental health care providers.

갑상선 미세침흡인세포검사 슬라이드에서 BRAF Mutation 검출을 통한 갑상선 유두암의 진단

박원서<SUP>1<,SUP>,이규언<SUP>2<,SUP>,송정윤<SUP>1<,SUP>,정유승<SUP>3<,SUP>,김훈엽<SUP>4<,SUP>,고석환<SUP>1<,SUP>,윤여규<SUP>2,5<,SUP>,Won Seo Park,<SUP>1<,SUP>,Kyu Eun Lee,<SUP>2<,SUP>,Jeong Yoon Song,Ph,D,<SUP>1<,SUP>,Y 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.1

Purpose: The prevalence rate of the BRAF mutation in papillary thyroid cancer (PTC) is as high as about 52 to 83% in Korea. Preoperative detection of BRAF mutation on fine needle aspiration cytology (FNAC) slides may help the surgeon make better therapeutic decisions. The present study aims to assess the feasibility of the mutant allele specific amplification (MASA) and restriction fragment length polymorphism (RFLP) method with using conventional FNAC slides and we also wanted to evaluate the clinical role of preoperatively detecting BRAF mutation. Methods: We extracted the genomic DNA from 59 FNAC slides and performed direct sequencing (DS) for detecting BRAF mutation. We could use only 17 slides for the MASA method and 6 slides for the RFLP method due to the shortage of extracted DNA. Additionally, we retrospectively analyzed the cases for which a histological diagnosis could be made. Results: Genomic DNA was extracted from 23 out of the 59 FNAC slides. The BRAF mutation status could be assessed via DS in 33 out of the 59 FNAC slides. The concordance between the MASA method and DS and the RFLP method and DS was 36.3% and 66.7% respectively. The positive and negative predictive value of the 13 indeterminate nodules was 87.5% and 20%, respectively. We could not find any association between the BRAF mutations and the alleged risk factors of PTC. Conclusion: We believe that the purity and the amount of the DNA template must be increased to detect BRAF mutation with using a FNAC slide. Preoperative detection of the BRAF mutation on a FNAC slide may refine the cytological diagnosis, but the application of assessing BRAF mutation as a prognostic marker is debatable. (Korean J Endocrine Surg 2010;10:12-18)

불황타개를 위한 사육량 감축방안

박원서,Park, Won-Seo 한국오리협회 1999 오리마을 Vol.14 No.-

AF궤도회로의 전기적 구분 장치 설치이전에 따른 커패시터 보상으로 LC공진 주파수 대역의 전압특성 분석

원서연(Seo-Yeon Won),최재식(Jae-Sik Choi),박주훈(Hun-Jue Park),김희식(Hie-Sik Kim) 대한전기학회 2016 전기학회논문지 Vol.65 No.8

This paper analyzes the electrical characteristic such as the impedance(Z), inductance(L), and cable resistance(Rp) according to the change of cable length in order to move the electrical sorting device for distinguishing between AF non-insulated track circuits from the center of railway to outside railway. The simulation is performed to check the voltage difference between the voltage of sender and the voltage of receiver and determine the possibility of the voltage restoration availability in the frequency filter band through the capacitor compensation. It was applied to the results of the simulation to the sorting devices installed in the actual field. It is proved the availability by checking the measured voltage characteristic according to the capacitor compensating change of 10 ㎌ and 16 ㎌ before, and after the length of cable is increased with 6 meters. Through this, the prevention of breakdown and damage to facilities and the prevention the safety-related accidents of line workers from the train are expected according to moving the sorting devices of AR non-insulated track circuits to outside railway.

기능성 III급 부정교합자에서 편도 절제술 전 후의 pharyngeal airway, hyoid bone, head posture에 관한 연구

박원서,이진우,차경석,Park, Won-seo,Lee, Jin-Woo,Cha, Kyung-Suk 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.2

본 연구는 거대 편도를 가진 기능성 III급 부정 교합자의 구대 편도 절제술 전후의 인두강, 설골, 두부 위치의 변화 양상에 대해 알아보기 위해 단국 대학교 부속 치과 병원 교정과에 내원한 남녀 환자 42명을 대상으로 연구하여 다음과 같은 결론을 얻었다. 1. Enlarged tonsil을 보이는 기능성 3급 부정교합자는 1급 부정교합자보다 혀는 전방에 위치하고 설골은 하방에 위치한다. 2. Tonsillectomy 후에 편도 절제술전과 비교하여 혀는 후방에 위치하고, nasopharynx은 증가 양상을 보이며, 설골은상, 후방에 위치하며 counterclockwise rotation 양상을 보인다. 3. Tonsillectomy 후에 nasopharynx depth변화와 하악 전치 경사도, 혀의 수직적 변화와 cranial base에 대한 hyoid axis, hyoid의 수직적, 수평적 변화와 두경부 경사도, 두경부 경사도와 하악 전치간에 95% 유의수준으로 상관성을 보인다. 4. Tonsillectomy 후에 설골 장축의 counterclockwise rotation시 hya-NL의 감소와 nasopharyx의 증가를 보이고, 혀의 거상시 hya-NL의 감소를 보이며, 혀의 후방위치시 h-h1의 증가와 hya-ba-n의 감소를 보인다. This study was carried out in order to find out the changes of the pharyngeal airway, hyoid bone and head posture before and after tonsillectomy in functional class III malocclusion patients. For this study, 21 Angle's class I patients and 21 Angle's class III patients, totally 42 subjects were chosen. The results were as follows; 1. In comparison to Class I group, tongue was more anteriorly and hyoid bone was more inferiorly positioned in functional Class III group 2. In comparison to pre-tonsillectomy, tongue was more posteriorly positioned and larger nasopharynx depth was shown in post-tonsillectomy. In post tonsillectomy, the hyoid bone was displaced posteriorly and superiorly and counterclockwise rotation was shown. 3. The level of significance for the correlation shown was 5 percent (p<0.05) indicating that: The change of nasopharyx depth was correlated to the inclination of lower incisors. Vertical change of tongue posture was correlated to the hyoid axis change. Vertical change of hyoid bone was correlated to the horizontal change of hyoid bone, craruocervical inclination. The change of craniocervical inclination was correlated to the inclination of lower incisors. 4. After the tonsillectomy, counterclockwise rotation of hyoid axis was associated with decease of hya-NL and large nasopharyngeal airway. High posture of the tongue was associated with decrease of hya-NL. Posterior posture of the tongue was associated with increase of h-hl,and decrease of hya-ba-n.

Fine Needle Aspiration Cytology of Metastatic Prostatic Adenocarcinoma, Pseudohyperplastic Variant

권영미,박원서,이건국,홍은경,Kwon, Young-Mee,Park, Won-Seo,Lee, Geon-Kook,Hong, Eun-Kyung The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.2

Pseudohyperplastic prostatic adenocarcinoma is a rare histologic variant of prostatic adenocarcinoma that resembles benign nodular hyperplasia. Immunohistochemistry can verify the absence of basal cells, but it is frequently admixed with conventional adenocarcinoma. Because fine needle aspiration cytology is rarely performed in primary prostatic adenocarcinoma, the cytology of the pseudohyperplastic variant has not been described. We experienced a case of metastatic pseudohyperplastic adenocarcinoma in a pulmonary nodule of 75-year-old man. The cytologic smear was mostly composed of large, flat sheets with elongated branching papillae in a clean background. The sheets showed a well-defined honeycomb appearance of tall columnar, regularly arranged monotonous cells with little cytologic atypia. In subsequent prostatic biopsy, pseudohyperplastic variants were identified together with conventional adenocarcinoma of Gleason's grade 3 and 4. The cytologic features of pulmonary nodules were identical to those of pseudohyperplastic components of prostatic adenocarcinoma.

비피도박테리아의 생존성 증진을 위한 캡슐화 기술

송민유,박원서,유자연,함준상,Song, Minyu,Park, Won Seo,Yoo, Jayeon,Ham, Jun-Sang 한국낙농식품응용생물학회 2017 Journal of Dairy Science and Biotechnology (JMSB) Vol.35 No.3

The intestinal microbiota has been shown to have a vital role in various aspects of human health, and accumulating evidence has shown the beneficial effects of supplementation with bifidobacteria for the improvement of human health, ranging from protection against infection to various positive effects. However, maintaining bacterial cell viability during storage and gastrointestinal transit remains a challenge. Microencapsulation of probiotic bacterial cells provides protection against adverse conditions during processing, storage, and gastrointestinal passage. In this paper, we review the current knowledge, future prospects, and challenges of microencapsulation of probiotic Bifidobacterium spp.