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박용균,Park, Yong Kyun 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
In recent year, problems caused by the abuse of drugs hove been analyzed in many cases, especially women's pregnancy. The purchasing of drugs without prescription, the misunderstanding of symptoms of pregnancy(such os vomiting, headache) os other ilnnesses, taking medicine during the pregnancy because of a chronic disease has caused many unfortunate cases Apart from these cases, pregnant women may take several medicines such as anodyne, tranquilizers, hypnotics, and diuretics which also cause critical situations. According to Piper and his colleagues 1987 study, in overage, pregnant women in the United Slates intake 3.1 kinds of additional dregs other than prenatal vitamins and mineral supplements. In those cases, both pregnant women and physicians anticipate inborn deformity. Most drugs which have whole body effects get to the unborn child via the placenta, however, many of these drugs do not have adverse effects(Shepard 1986, 1989). In general, drugs present a stronger effect to unborn children than they do to pregnant women due to the baby's excretion and to the drug metabolism that occurs in the mother's body through the placenta. The effects of dregs on unborn children show different results. depending upon the type of drug, dosage, characteristics. gestational weeks, genetic characteristics of the mother an baby, and many other environmental factors.
최대 산소소모량 평가에 있어서 자전거 에르고미터를 이용한 최대하부하검사방법의 타당도
강동묵 ( Dong Mug Kang ),박용균 ( Yong Kyun Park ),이용환 ( Yong Hwan Lee ),설진곤 ( Jin Gon Sul ) 한국산업위생학회 2006 한국산업보건학회지 Vol.16 No.2
Because of the limitations of maximal load tests for VO2max, submaximal tests using cycle ergometer are used for field study in general. This study was conducted to evaluate validity of various submaximal tests using cycle ergometer. This study had been conducted during May to June 2005, which subjects were 15 males and 15 females in twenties. Experiment was performed with restrictive conditions which regulated ambient temperature, noise, and entrance restriction. Submaximal load test protocols including YMCA Protocol (YP), Astrand-Rhyming Protocol (ARP), Relative heart ratio Protocol (RP), and Ramp test Protocol (RP) were compared with maximal load test which used gas mask analyser using Bruce Protocol. All submaximal load tests were highly related with maximal load test (Spearman`s correlation coefficient>0.60) with statistical significancy. The highest correlation coefficient with maximal test was found in RP. Three submaximal test results except RP were significantly different with maximal test results (Wilcoxon rank test). All submaximal tests had high validity. The reason why RP had highest validity might be that it represents Korean physical strength and individual differences better than the others. RP using cycle ergometer would make easy to study for physical capacity evaluation and field workload estimation.
남성에서 Mycoplasma 감염이 정액검사소견에 미치는 영향에 관한 연구
김선행,김영호,김탁,허준용,박용균,구병삼,Kim, Sun-Haeng,Kim, Young-Ho,Kim, Tak,Hur, Jun-Yong,Park, Yong-Kyun,Ku, Pyung-Sham 대한생식의학회 1996 Clinical and Experimental Reproductive Medicine Vol.23 No.3
Mycoplasmas have long been suspected of contributing to involuntary infertility in couples. However considerable disagreement exits concerning the role of genital mycoplasma infection in human infertility. Several investigators have noted abnormalities in the semen analysis of men with positive mycoplasma cultures, and early epidemiologic studies indicated that Ureaplasma urealyticum was linked to human reproductive failure on the basis of higher frequencies of isolation from infertile versus fertile couples and successful pregnancies in infertile couples after doxycycline therapy. However, subsequent investigators have questioned these findings because there are many studies in which treatment for mycoplasma in the male or female did not demonstrate an improved pregnancy rate, and semen samples from unexplained infertile men containing ureaplasmas have not revealed poorer motility, fewer spermatozoa and more aberrant forms. The objective of this study were to investigate the incidence rate of mycoplasma in semen and to investigate whether the presence of mycoplasma in semen makes significant difference to the semen volume, sperm motility and sperm counts. The results were that the rate of isolation of mycoplasma species was 70.3%. Semen volume is $2.84{\pm}1.01ml$ for culture negative and $3.15{\pm}1.42ml$ for culture positive group. Sperm motility is $46.23{\pm}15.80%$ for culture negative and $50.09{\pm}15.69%$ for culture positive group, and sperm count is $95.47{\pm}47.14({\times}(P)10^6/ml)$ for culture negative and $86.73{\pm}47.59({\times}10^6/ml)$ for culture positive group. In conclusion, we suggest that the presence of mycoplasma in semen makes no significant differences to the sperm parameters.
김지연,조숙행,곽동일,박용균,Kim, Ji-Yun,Joe, Sook-Haeng,Kwak, Dong-Il,Park, Yong-Kyun 한국정신신체의학회 1997 정신신체의학 Vol.5 No.1
This study was designed to determine the frequency of premenstrual dysphoric disorder in gynecological outpatients, and also attempted to compare premenstrual change characteristics, functional impairment due to premenstrual changes and frequency of risk factors reported by women with confirmed premenstrual changes$(PMC^+)$(n=17) and those without confirmed premenstrual changes$(PMC^-)$(n=23). Forty gynecological outpatients who complained of premenstrual discomforts were asked to complete questionnaires on menstrual history, obstetric-gynecological history, and premenstrual change and functional impairment. The women were also asked to complete a daily rating form based on DSM-IV diagnostic criteria for one menstrual cycle. Absolute severity method, effect size method and percent change method were used to assess changes between follicular phase and luteal phase. The results of the study were as follows: 1) The frequency of premenstrual dysphoric disorder according to each of the three methods was 5% for the absolute severity method, 15% for the effect size method, and 27.5% for the percent change method. 2) The frequently reported symptoms were as follow: physical symptoms(64.7%) : lethargy, easy fatigability, or marked lack of energy(41.2%) : decreased interest in usual activities(29.4%) ; and marked affective lability(23.5%). 3) There were no significant differences in onset ages of premenstrual changes, regularities of premenstrual changes and changes of severity and duration of premenstrual symptoms over time between women with and without confirmed premenstrual changes. However, women with confirmed premenstrual changes reported both physical and emotional symptoms as earliest symptoms most frequently, while women without confirmed premenstrual changes reported only physical symptoms most frequently. 4) functional impairment was significantly higher in women with confirmed premenstrual changes than those without confirmed premenstrual changes, but impairment was not severe. 5) No differences were found between women with and without confirmed premenstrual changes in risk factors including demographic data, menstrual and obstetric and gynecological history. These results suggest that the prevalence of premenstrual dysphoric disorder varies with scoring methods. The women with confirmed premenstrual changes reported physical symptoms most frequently(64.7%). functional impairment was significantly higher in women with confirmed premenstrual changes, but impairment was not severe.
고도로 상승된 혈중 CA - 125 를 보이는 비파열 자궁내막종 1 예
오희숙(Hee Suk Oh),조수용(Soo Yong Chough),박용균(Yong Kyun Park),서호석(Ho Suk Saw),김철환(Chul Hwan Kim),허준용(Jun Young Hur) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
CA-125 is an antigenic determinant expressed by more than 80% epithelial ovarian cancer. Although developed for use in the diagnosis and monitoring of epithelial ovarian cancer, elevations of CA-125 concentrations can also be associated with some normal physiologic conditions, various other malignancies and benign conditions. Adnexal cysts are frequently encountered during the reproductive years. 10 to 35% of benign cystic adnexal masses may be an endometrioma. Because endometriomas are not likely to resolve spontaneously, and may enlarge or rupture during period of observation, a test to detect an endometrioma would assist in the evaluation and management of adnexal cysts. Serum CA-125 concentration is seldom >100 U/ml in endometriosis. We reported a patient with endometrioma presenting with a very high CA-125 concentration, which may confuse diagnosis with ovarian cancer.
도플러 초음파를 이용한 제대동맥 및 하강흉부 대동맥 혈류속도 파형에 따른 주산기 합병율 고찰
이재관(Jae Kwan Lee),허준용(Jun Young Hur),서호석(Ho Suk Saw),박용균(Yong Kyun Park),조수용(Soo Yong Chough) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
목적: 산과영역에서의 도플러 초음파는 산전 태아건강 평가방법으로서 많은 연구가 진행되어 현재 비침윤성 태아 안녕 평가 검사(noninvasive fetal well-being test)로 많은 연구가 이루어 지고 있다. 임신성 고혈압 산모의 예후판정과 주산기 예후를 예측하는데 있어 제대동맥, 태아 흉부 대동맥 도플러 파형분석의 유용성을 알아보고자 본연구를 시행하였다. 연구방법: 1995년 5월부터 96년 3월까지 고려대학교 의과대학 부속 구로병원 산부인과에 산전진찰을 위해 내원한 산모 35명과 임신성 고혈압 환자 18명을 대상으로 태아 제대동맥, 하강 흉부 대동맥의 수축/이완비와 주산기 예후를 비교 분석하였다. 결과: 연구 결과 정상임신군의 제대동맥의 수축/이완비는 평균 2.97 ± 0.52로 나타났으며, 임신성 고혈압 군에서는 3.8 ± 0.81로 정상임신군에 비해 높게 나타났다. 불량한 주산기 예후를 예측하는데 있어 제대동맥의 민감도, 특이도, 양성 예측도, 음성예측도는 57%, 87%, 75%, 75%로 하강 흉부 대동맥과 비교할 경우 제대동맥이 민감도, 양성 예측도, 음성 예측도가 높게 나타났으며 특이도는 비슷하였다. 결론: 불량한 주산기 예측에 제대동맥 도플러 파형분석이 유용하게 사용될 수 있음을 보여주었으며 낮은 민감도를 개선할 필요성이 대두되었다. Objectives: Early diagnosis of intrauterine growth retardation is important to ensure optimal monitoring and delivery with the introduction of real-time and Doppler ultrasound systems, a noninvasive method of measuring human fetal blood flow has become available. The aim of this study is to compare blood flow velocity waveforms at the fetal descending aorta and umbilical artery in normal and in patients with pregnancy induced hypertension. Methods: Using a combination of linear array real-time and pulsed Doppler ultrasound, blood flow velocity measurements were carried out at the fetal descending aorta and umbilical artery in 35 normal pregnancies and 18 cases of pregnancy induced hypertensive patients. Results: The mean systolic/diastolic ratio of umbilical artery and aorta was significantly higher in PIH patients than in normal pregnancies(3.8 ± 0.81 versus 2.97 ± 0.52, p<0.05) and to predict perinatal morbidity, umbilical velocimetry is more sensitive than that of descending thoracic aorta. Conclusion: This study suggests that umbilical artery velocimetry could be used as a marker to predict adverse perinatal outcome.