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박실무(Sil Moo Park),유병철(Byung Chul Yoo),장은하(Eun Ha Chang),이병직(Byung Jik Lee),송정길(Chung Gil song) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
Wilsons disease is a rare inborn error of metabolism inherited as a autosomal recessive trait. The disease has varied mode of manifestations. It is characterized by different neurologic disorder, hepatic disease from asymptomatic cirrhosis to fulminent hepatic failure, hemolytic anemia associated hepatic failure, renal osteodystrophy and psychiatric disease. We experience a case of uilsons disease. The patient was 21 years old male, He was suffered from liver cirrhosis, splenomegaly, ascites, classical neurologic symptoms such as dysarthria, tremer, mask-1ike face, rigidity. And he has Kayser-Fleischer ring. Serum ceruloplasmin was very low and urine copper, tissue copper were very high. Liver needle biopsy revealed cirrhotic change.
체외충격파를 이용한 담낭결석 쇄석술 - 실험적 및 임상적 연구 -
김건상,박실무,이정효,김영구,송군식,이관세,이종범,김상준,장선택,Kim, Kun-Sang,Park, Sil-Moo,Lee, Jung-Hyo,Kim, Young-Goo,Song, Kounn-Sik,Lee, Kwan-Seh,Lee, Jong-Beum,Kim, Sang-Joon,Chang, Sun-Taik 대한영상의학회 1988 대한영상의학회지 Vol.24 No.4
Although manyalternative treatment technics have been proposed recently for gallstone to substitute cholecystectomy the extracorporeal shock wave lithotripsy (ESWL) for gallbladder stones has rarely been tried. We have carried out a series of experiments to evaluate how effective the ESWL for gallbladder stones in and how safe this procedure is. At first in vitro shock wave application was carried out to 10 gallbladder stones which were obtained from human gallbladder. Secondly gallbladder stones were implanted to canine gallbladder and treated with shock wave Lastly a total of 41 volunteers with confirmed gallbladder stones were treated with shock wave and combined oral administration of ursodeoxycholic acid. In the in vitro experiment aoo of the 10 gallstones were fragmented with variable firing rates and duration. In animal experiment the implanted stones were successfully fragmented and the organs included in the pathway of shock wave were proved to be intact histologically. in juman study complete disappearance of gallstones was noted in 78.6% of patients with single radiolucent gallbladder stones smaller than 2.5cm in the longest diameter. two patients underwent cholecystectomy after ESWL due to sudden colic attack, Onee patient had experienced and episode of mild transient obstructive jaundice. It may be concluded that the ESWL for gallbladder stones is an effective and safe method of treatment of gallbladder stones in the selected cases for example small radiolucent stones and the further study is needed to establish improved technology og the ESWL for gallbladder stones.
궤양성 대장염에서 점소 당항원 sTn 과 Tn 의 발현에 관한 연구
장무선(Moo Sun Chang),도재혁(Jae Hyuk Do),김형준(Hyung Jun Kim),유경금(Kyung Kum Yoo),박수정(Soo Jeong Park),문철(Cheol Moon),허철행(Cheol Heang Heo),김재규(Jae Gyu Kim),장세경(Sae Kyung Chang),박실무(Sil Moo Park),김미경(Mi Kyung K 대한내과학회 1997 대한내과학회지 Vol.52 No.1
N/A Objectives: Long standing observation, which may relate either to the causes or the effects of UC, reveals that there is a pronounced alteration of mucin such as quantitative and qualitative abnormalities of mucin glycoprotein. But recently in situ hybridization technique showed no specific difference in the expression of apomucin mRNA in UC. Therefore we investigated whether abnormality of mucin was originated from defect in glycosylation. And we also tried to find differences in the expression of Tn and sTn antigens between Korean and Jewish patients with UC. Methods: We performed the immunohistochemical staining using the monoclonal antibody of mucin carbohydrate antigens Tn and sTn in 19 patients with UC. Results: Tn and sTn antigens were not expressed throughout the crypt and surface epithelium in normal colon but both of mucin carbohydrates antigens were well expressed in mild UC, Tn antigen was seen in the surface epithelium with perinuclear pattern and sTn antigen was shown not only in surface but also in crypt epithelium. In severe UC, Tn antigen was well expressed, but sTn antigen was not expressed. Tn antigen seemed to be ex-pressed more frequently than sTn antigen with severity of inflammation. These results were similar in Korean and Jewish patients with UC. Conclusion: These results suggest that inflammatory bowel disease has some deterioration in the step of glycosylation in the cytoplasm and there was no racial difference in the expression of Tn and sTn antigen in Korean and Jewish patients with UC.
소화성 궤양환자의 혈청 Pepsinogen I 치에 관한 연구
김종숙(Chong Sook Kim),박실무(Sil Moo Park),송인성(In Sung Song),이인덕(In Deog Lee),장세경(Sae Kyung Chang),김정룡(Jung Lyong Kim) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
This study was undertaken to evaluate the serum PG I levels in 30 normal control subjects, 36 gastric ulcers, and 60 duodenal ulcer patients. The results were as follows: 1) Serum PG I levels in gastric ulcer showed no statistical difference but in antral gastric ulcer was significantly higher than that of control subjects. 2) Serum PG I in duodenal ulcer patients reveals significantly higher levels than that of control subjects. 3) The high level of PG I in control subjects, gastric ulcer, duodenal ulcer patients was 6.7%, 37.1%, 58.2%, respectively. These results were suggested that serum PG I may be valuable in the diagnosis of peptic ulcer and could help understanding the relationship between serum PG I and acid secretion.
원발성 및 전이성 간암환자에서 혈청 Adenosine Deaminase 활성도
김종숙(Chong Sook Kim),박실무(Sil Moo Park),송정길(Jung Guil song),이상재(Sang Jae lee),박일진(Ill Gin Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A This study was carried out of assess the serum activities of adenosine deaminase(ADA) which was a key enzyme in normal catabolic pathway for adenosine nucleotides, in patients with primary and metastatic liver cancer. Sera of 70 normal adults, metastatic liver cancer were 50 patients with primary liver cancer and 34 patients with analyzed with colorimetric method of Giusti for ADA activities. The results were obtained as follows; 1) In normal adults the activity of ADA was 15.40+-4.69 U/L 2) The mean value of ADA activity was 40.52+-12.15 U/L in patients with primary liver cancer and 36.73+-10.09 U/L in patients with metastatic liver cancer, there was no significant difference between two(p)0.05). But there was significant difference between normal and cancer patients(p<0.0l).3) In patients with primary liver cancer, correlation between ADA activity and liver function test was not significant(p70.05). 4) In patients with metastatic liver cancer, correlation between ADA activity and liver function test was not significant except SGPT(r=0.37, p<0.05)
만성 B형 간염환자에서 재조합형 알파 인터페론 저용량 단기 치료법의 효과
박중원(Joong won Park),유병철(Byung Chul Yoo),박실무(Sil Moo Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1
N/A Background/Aims: We planed the study to cvaluate the effect of low dose, short term therapy of recombinant alpha-interferon(IFN) in patients with chronic hepatitis B. Methods: Seventy two patients treated with IFN and 32 controls were included in the study. All l04 patients had serum HBsAg, HBeAg and biopsy proven chronic hepatitis B. The treated group received alpha IFN 2a 300 million units daily for four weeks, total 8400 million units. Effects of therapy on aminotransferase activities and HBsAg, HBeAg, anti-Hbe status in serum was monitored. The criterion of complete response was loss of serum HBeAg and normalization of serum aspartate aminotransferase(AST)/alanin aminotransferase(ALT), that of partial response was loss of serum HBeAg or normalization of serum AST/ALT within 8 weeks after IFN trial. The mean follow-up period was 20.6 months(treated group)and 45.8 months(control). Results: The complete responders were 18 patients(25%), the partial responders 24 patients(33.3%) and the non- responders 30 patients(41.7/o). The only difference between tbe responders and the non-responders in clincal features was AST activity. Loss of serum HBeAg within 8 weeks after IFN trial occurred in 23(3l.9%) patients and 13(l8.1%) patients had anti-Hbe seroconversion within 3 months after IFN trial. Eleven patients(l5.3%) of complete responders had normal AST/ALT for mean J9.2 months. Two of Eleven percents patients had scrum anti-HBs. Within mean 20.6 month follow-up period, 34(47.2%) patients had serum anti-Hbe and l9(26.4%) patients had that for more than 12 months. Thirty four of 72(47.2%) patients receiving interferon responded by anti-Hbe seroconversion within mean 20.6 months, compared to 13 of 32(40%) controls within 45.8 months(p<0.01). Conclusions: These findings indicate that a short course(4 weeks) of low dose recombinant alpha-interferon can induce an anti-Hbe seroconversion and an improvement of serum aminotransferase activities for significant duration in approximately one-fourth or fifth of treated patients with chronic hepatitis B and that low dose, short term recombinant IFN therapy is useful and alternative method in treatment of chronic hepatitis B. (Korean J Gastroenterol 1995;27:55-63)
16 , 16 - Dimethyl prostaglandin E2 및 Urogastrone 투여가 흰쥐 위에 미치는 영향
김종숙(Chong Sook Kim),박실무(Sil Moo Park),한상희(Sang Hee Han) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A The effect of 16, 16-dimethyl prostaglandin E, and urogastrone on acute gastric mucosal lesions and DNA contents in the pylorus ligated rats with topical aspirin plus HCl were studied. 16, 16-dimethyl prostaglandin E, and urogastrone significantly reduced the lesion scores in stomach. Also, 16, 16-dimethyl prostaglandin E, and urogastrone significantly increased the DNA contents of oxyntic gland area of stomach, but decreased the DNA contents of antrum of stomach. We concluded that 16, 16-dimethyl prostaglandin E, and urogastrone have the cytoprotective effect on the gastric mucosa injured by topical aspirin plus HCl administration, and this was closely related with increase of DNA contents in stomach.
Superoxide Dismutase 가 Aspirin 에 의한 흰쥐 위점막 병변에 미치는 영향
김종숙(Chong Sook Kim),박실무(Sil Moo Park),송정길(Jung Guil song),전성훈(Sung Hoon Joun) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2
N/A The effect of superoxide dismutase(S.O.D.) on gastric mucosal lesions produced by aspirin (200 mg/kg) plus HC1(150 mM) in the pylorus ligated rats were studied. S.O.D. group was given 15,000 u/kg of superoxide dismutase and control group was given identical amount of saline. In the superoxide dismutase group, the ulcer score was reduced and the amount of total protein in the gastric mucosa was increased, but pH, acid output, and DNA content were not significantly changed as compared to aspirin and control group. We concluded that superoxide dismutase may has protective effect of aspirin plus HCl induccd gastric mucosal lesions due to increased total protein amount.