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대간간학회지 제6차 춘계학술대회 초록집 : 구연 ; 비알코올성 및 알코올성 지방간염 환자들 간조직에서 쿠퍼세포와 내독소관련 염증매개체 발현의 유사성
정규 ( Jeong Gyu ),박중원 ( Park Jung Won ),김미경 ( Kim Mi Gyeong ),김상진 ( Kim Sang Jin ),김진희 ( Kim Jin Hui ),김재규 ( Kim Jae Gyu ),유병철 ( Yu Byeong Cheol ),박실무 ( Park Sil Mu ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
Rabeprazole을 포함한 3제요법의 헬리코박터 파이로리 제균 효과와 CYP2C19 유전자형의 영향
이상배 ( Lee Sang Bae ),박상종 ( Park Sang Jong ),류지곤 ( Lyu Ji Gon ),이진광 ( Lee Jin Gwang ),김회진 ( Kim Hoe Jin ),배진수 ( Bae Jin Su ),정현승 ( Jeong Hyeon Seung ),박실무 ( Park Sil Mu ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Background/Aims: Genetic polymorphism of cytochrome P450 CYP2C19 influences the efficacy of proton pump inhibitor (PPI) in Helicobacter pylori (H. pylori) eradication therapy. We investigated the difference in the cure rates of H. pylori infection by triple (rabeprazole plus amoxacillin and clarithromycin) therapy in relation to CYP2C19 genotype status. Methods: One hundred and sixteen H. pylori infected patients with gastric ulcer and duodenal ulcer completed the triple therapy with 10 mg of rabeprazole b.i.d., 1,000 mg amoxacillin b.i.d. and 500 mg of clarithromycin b.i.d. for one week. The genotype of CYP2C19 was determined by a PCR-restriction fragment length polymorphism method. Results: According to the univariate analysis, heterozygous extensive metabolizers (hetero EMs) and poor metabolizers (PMs) showed the highest (87.0%) and the lowest (80.0%) eradication rates, respectively. The difference in the therapeutic efficacy of rabeprazole among the different CYP2C19 genotypes was insignificant. With regard to gender, age and smoking history in relation to eradication rate, a statistical significance was noted only with age with odds ratio of 1.063 and p-value of 0.0202. Conclusions: In the eradication therapy of H. pylori, no statistically significant difference in therapeutic efficacy of rabeprazole was found among different CYP2C19 genotypes. (Korean J Gastroenterol 2003;42:468-475)
대한간학회지 제6차 춘계학술대회 초록집 : 구연 ; 비알코올성 지방간 환자에서 지방간염의 병리학적 심화도를 예측할 수 있는 임상적 지표들
김상진 ( Kim Sang Jin ),박중원 ( Park Jung Won ),김미경 ( Kim Mi Gyeong ),홍요한 ( Hong Yo Han ),한성혁 ( Han Seong Hyeog ),김재규 ( Kim Jae Gyu ),유병철 ( Yu Byeong Cheol ),박실무 ( Park Sil Mu ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
Sucralfate 가 흰쥐의 위 당단백 및 Somatostatin 에 미치는 영향
김종숙(Chong Suk Kim),김영수(Young Soo Kim),이인덕(In Deog Lee),안장훈(Jang Hoon Ahn),장세경(Sae Kyuong Chang),유병철(Byeong Chul Yoo),박실무(Sil Mu Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
To clarify the effect of sucralfate on glycoprotein and somatostatin, this study was performed with the use of Wistar rat and measuring the concentration of glycoprotein and somatostatin, using radioimmunoassay kits. The result were as follows; 1) In determination of ulcer index, there could be showed the increase in the sucralfate group as compared with the ulcer group (2.20+-1.94, p<0.01). In gastric pH, there could be demonstrated the ulcer group as compared with the control group. 2) In determination of Alcian blue-binding protein of soluble mucus, there could be demonstrated the increase in the sucralfate group as compared with the ulcer group (0.23+-0.07 mg/5 ml, 0.67+-0.03 mg/5 ml, p < 0.05). 3) The concentration of plasma somatostatin revealed the increase in the sucralfate group as compared with the ulcer group and control group (p<0.001). 4) The concentration of somatostatin of gastric juice revealed the increase in the sucralfate group and the ulcer group as compared with the control group respectively (p<0.001). 5) The concentration of somatostatin of gastric mucosa revealed the increase in the sucralfate group as compared with the control group and the ulcer group respectively (p<0.001, p<0.01).