Oncologic Safety of Immediate Breast Reconstruction for Invasive Breast Cancer Patients: A Matched Case Control Study

박신후,한원식,YOO TAE KYUNG R,이한별,진웅식,장학,민경원,노동영 한국유방암학회 2016 Journal of breast cancer Vol.19 No.1

Purpose: The purpose of this study was to compare locoregional recurrence-free survival (LRFS) and disease-free survival (DFS) between patients undergoing mastectomy and immediate breast reconstruction (IBR) and those undergoing mastectomy alone. Methods: A retrospective review of patients who underwent mastectomy and immediate breast reconstruction for resectable invasive breast cancer between 2002 and 2010 at a single center was conducted. These cases were matched to patients who underwent mastectomy alone in the same time period, performed by 1:2 matching. Matching control variables included age, tumor size, axillary lymph node metastasis, and estrogen receptor status. Overall, 189 patients were identified in the IBR group, and 362 patients were matched to this group. Results: In the IBR group, 75 patients (39.7%) underwent conventional total mastectomy, 78 (41.3%) underwent skin-sparing mastectomy (SSM), and 36 (19.0%) underwent nipple-sparing mastectomy (NSM). The IBR group was significantly younger than the control group (41.9 and 45.1 years, respectively) (p=0.032), in spite of matching between three age groups. The DFS rates were similar between the IBR group and mastectomy alone group, at 92.0% and 89.9%, respectively, at 5-year follow-up (log-rank test, p=0.496). The 5-year LRFS was 96.2% in the IBR group and 96.4% in the mastectomy alone group (log-rank test, p=0.704), similar to data from previous reports. Subgroup analyses for SSM or NSM patients showed no differences in LRFS and DFS between the two groups. Additionally, in stage III patients, IBR did not cause an increase in recurrence. Conclusion: IBR after mastectomy, including both SSM and NSM, had no negative impact on recurrence or patient survival, even in patients with advanced disease.

장애인의 미충족 치과의료 현황 및 관련 요인 분석

박신후,황성완,안병기 경희대학교 경영연구원 2019 의료경영학연구 Vol.13 No.3

In this study, the current status and related factors of unmet dental care were analyzed using the 2016 Korea Medical Panel data. 913 persons with disabilities were selected and analyzed. Types of disabilities were classified as dental and non-disabled. The results of this study need to provide quality services to meet the unmet dental care needs of people with disabilities and complement policies to address the problem of dental access for people with disabilities. Among the study subjects, 643 (70.4%) were unsatisfied, and in general characteristics, Gangwon-do area, disabled people who were not economically active, severely disabled persons in the disability class, and dental disabled persons in the disability type did not have access to dental care. Came out. This was statistically significant. As a result of hierarchical logistic regression analysis to determine factors related to unsatisfactory dental care, the type of disability in Model 1 was 1.77 times higher than that of non-dentally disabled persons and 1.83 times higher in Model 2. In addition, it was confirmed that 1.45 times of disabled people who were not economically active and 2.04 times of unsatisfied dental medical treatment occurred in Jeolla Province. This was statistically significant. The results of this study need to provide quality services to meet the unmet dental care needs of people with disabilities and complement policies to address the problem of dental access for people with disabilities.

양식 강도다리, Platichthys stellatus 및 넙치, Paralichthys olivaceus에서 분리된 marine birnavirus(MABV)의 phylogenetic 분석

박신후 ( Shin Hoo Park ),박명애 ( Myoung Ae Park ),조미영 ( Mi Young Cho ) 한국어병학회 2009 한국어병학회지 Vol.22 No.3

장애인의 치과의료 이용 접근성 비교 분석

박신후 ( Shin Hoo Park ),김호종 ( Ho Jong Kim ),정재연 ( Jae Yeon Jeong ),홍민정 ( Minjung Hong ),김나영 ( Nayoung Kim ),박종연 ( Chong Yon Park ),신의철 ( Euichul Shin ) 대한보건협회 2021 대한보건연구 Vol.47 No.1

연구목적 : 본 연구는 장애인과 비장애인의 치과의료 이용 현황을 파악 및 비교분석하고, 치과의료 이용과 관련된 특성을 보정 후 장애가 치과의료 이용 접근성에 미치는 영향을 파악하고자 하였다. 연구방법 : 2016년도 국민건강보험공단의 건강정보자료를 이용해서 장애인 251,497명, 비장애인 4,888,249명을 선별하고, 장애가 치과의료 이용 접근성에 미치는 영향을 분석하기 위해 통제변수인 성별, 연령, 의료보장유형, 소득수준, 지역, 흡연, 고위험 음주, 만성질환 여부를 통제한 상태에서 다중 로지스틱 회귀분석(multiple logistic regression)을 실시하였다. 연구결과 : 치과의료 이용률은 장애인 42.0%, 비장애인 43.2%로 장애인이 비장애인 보다 0.97배 낮게 나타났다. 그리고 통제변수를 통제한 상태에서 로지스틱 회귀분석 결과, 치과의료 이용 접근성과 관련된 특성을 통제하였을 때 장애인이 비장애인보다 치과의료 이용을 경험할 확률이 0.97배 낮은 것으로 나타났다. 결론 : 이상의 결과를 종합하여 살펴보면, 장애인은 보정 후에도 비장애인보다 치과의료 이용을 경험할 확률이 낮아 장애인의 치과의료 접근성이 낮은 것을 확인 할 수 있었다. 따라서 장애인의 치과의료 이용에 대한 접근성을 높이기 위한 정책적 방안이 필요하다. Background : The purpose of this study was to compare the current status of dental service utilization between People with Disabilities and People without Disabilities, and to investigate the effects of disability on access to dental service after adjusting the characteristics related to dental service utilization. Methods : Data used in this study from National Health Insurance Service 2016 health information data. Sample size were 251,497 People with Disabilities and 4,888,249 People without Disabilities. Analysis method in this study was multiple logistic regression analysis in which control variables were gender, age, health insurance type, income level, region, smoking, high-risk drinking and chronic disease. Results : Dental service utilization rate was 42.0% for the People with Disabilities and 43.2% for the People without Disabilities, which was 0.97 times lower than for the People without Disabilities. The result of logistic regression analysis with controlled variables indicated that the People with Disabilities was 0.97 times less likely to experience dental care than the People without Disabilities when the characteristics related to access to dental service utilization were controlled. Conclusion : In summary, People with Disabilities are less likely to experience dental service utilization than People without Disabilities, even after adjusting. Therefore, policy measures are needed to increase access to dental service utilization for the People with Disabilities.

수입산 관상어로부터 분리된 tetracycline 내성 Aeromonas spp에 tet (M) 및 tet (G) 유전자의 특성 분석

박신후 ( Shin Hoo Park ),전려진 ( Lyu Jin Jun ),조기택 ( Ki Taek Cho ),진지웅 ( Ji Woong Jin ),정현도 ( Hyun Do Jeong ) 한국수산과학회 2012 한국수산과학회지 Vol.45 No.3

In this study, the molecular structures of tet(M) and tet(G) carried by tetracycline (Tc) resistant bacteria in intestinal microflora from the imported ornamental fish were characterized and compared with each other depend on the imported countries. Of the total isolates, approximately 8.9% of the Ent-lac+ (lactose fermentative bacteria on coliform media) Tc resistant isolates in fish from three different countries, Singapore, Taiwan and Brazil, were appeared to contain tet (M). Three representative isolates of different countries, Aeromonas spp. JSM-1 (Singapore), JTM-1 (Taiwan) and JBM-1 (Brazil), were isolated and analyzed the molecular structures of tet (M) gene. Interestingly, partial sequence tet (M) genes (1099 bp) in JBM-1 (Brazil) showed 99.5% homology with the tet (M) found in the Vibrio spp. RV16 isolate, obtained from marine fish in Korea and known to carry Tn1545 parent type of tet (M). In contrast, tet (M) gene JSM-1 and JTM-1 showed mosaic structure of Tn1545 and Tn916, and 100% homology with each other. It may suggest the presence of various characteristics in terms of tet (M) gene structure. The determined sequence of the tet(G) from Aeromonas spp. JSG-1 and JBG-1 isolated from Singapore and Indonesia ornamental fish respectively showed similar nucleotide sequence homology but revealed a few nucleotide changes in comparison with the sequence of the prototype tet (G) gene (S52437 in GenBank).

What Advantages can the Near-infrared Fluorescence Technique Provide to Lymph Node Dissection during Laparoscopic Distal Gastrectomy

Shin-Hoo PARK(박신후),Jong-Ho CHOI,Felix BERLTH,Yun-Suhk SUH,Seong-Ho KONG,Hyuk-Joon LEE,Han-Kwang YANG 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.5

중간엽줄기세포(MSC)를 이용한 허혈성 혈관질환 치료를 위한 세포치료제 개발: 기초연구에서 임상연구

이은지,박신후,서정호,안효경,남시현,권상모 한국생명과학회 2022 생명과학회지 Vol.32 No.7

최근 인구 고령화로 인해 허혈성 심장질환, 허혈성 뇌졸중, 말초 동맥 질환 등의 허혈성 혈관질환의 유병률이 지속적으로 증가하고 있다. 허혈성 질환에 대한 현재 표준화된 치료법은 약물 요법 및 수술을 통한 재관류요법이다. 재관류요법은 손상된 동맥의 기능을 회복시킬 수 있지만 허혈로 인해 손상된 주변 조직의 기능 회복에 있어 효율적이지 않다. 그러므로 허혈 질병을 안전하고 효과적으로 치료하고 주변 조직의 기능을 회복시킬 수 있는 새로운 치료전략의 개발이 필요하다. 이러한 한계를 극복하기 위해 손상된 부위를 재생하는 줄기세포 기반 치료가 허혈성 혈관질환의 유망한 전략으로 연구되어 왔다. 다양한 조직에서 분리할 수 있는 중간엽줄기세포(MSC)는 면역 조절, 혈관 신생 촉진 및 다양한 관련 인자의 분비를 통해 손상된 조직을 재생함으로써 허혈성 질환의 치료에 유망한 것으로 나타났다. 또한, 줄기세포 치료 효과를 높이기 위해 3D 배양법을 이용하거나 세포 프라이밍(Cell Priming)과 같은 MSC 기능을 강화하여 이식 효율을 높이는 새로운 접근법이 연구되고 있다. 이 논문에서는 MSC를 허혈성 질환 치료에 사용하는 다양한 전략을 제공하고 허혈성 부위에서 MSC의 분화(Differentiation), 증식(Proliferation) 및 생착(Engraftment)과 같은 이식의 문제에 대해 논의한다.

Repetitive Transcranial Magnetic Stimulation for Wernicke-Korsakoff Syndrome: A Case Report

정소원,박신후,서영재,김재형,이찬호,임종엽 대한재활의학회 2017 Annals of Rehabilitation Medicine Vol.41 No.1

A 57-year-old man who was diagnosed with Wernicke-Korsakoff syndrome showed severe impairment of cognitive function and a craving for alcohol, even after sufficient supplementation with thiamine. After completing 10 sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS) at 100% of the resting motor threshold over the left dorsolateral prefrontal cortex, dramatic improvement in cognitive function and a reduction in craving for alcohol were noted. This is the first case report of the efficacy of a high-frequency rTMS in the treatment of Wernicke-Korsakoff syndrome.

대학생 코칭역량 척도개발

도미향,박신후,심정자 한국코칭학회 2021 코칭연구 Vol.14 No.5

본 연구는 대학생의 코칭역량 척도개발을 목적으로 대학생의 코칭역량 구성 요인을 살펴보고 이를 바탕으로 척도문항을 개발하는데 목적이 있다. 대학생의 코칭역량 척도의 구성요인과 예비문항을 구성하기 위해 선행연구 및 문헌조사를 실시하였으며, 전문가 인터뷰를 진행하여 대학생 코칭역량의 개념을 정의하고 구성요인을 도출하여 예비문항을 구성하였다. 구성된 예비문항으로 코칭전공 교수 2인, 코칭전공 석사 2인, 코칭전공 박사과정 5인, 코칭을 경험한 대학생 3인 등 12명을 선정하여 1차ㆍ2차 전문가 내용타당도를 검증하였다. 1차ㆍ2차 전문가 내용타당도를 통해 추출된 예비척도 89문항의 척도 요인 및 문항 구성을 확인하기 위해 서울, 경기, 충청, 경상 및 전라 등 전국적으로 512의 설문 자료로 요인분석을 실시하였으며 탐색적 요인분석을 통해 6개 요소 35개의 문항을 추출하였다. 추출된 문항으로 확인적 요인분석을 실시하여 모형 적합도를 살펴보았으며, 집중타당성과 판별타당성을 확보하였다. 연구결과 대학생 코칭역량 척도의 구성요인은 자기다움 역량군의 자기이해 역량 5문항ㆍ자기관리 역량 5문항, 커뮤니케이션 역량군의 관계형성 역량 6문항 ㆍ의사소통 역량 6문항, 행동변화를 이끄는 역량군의 질문 역량 6문항ㆍ목표설 정 및 실행 역량 7문항으로 총 6가지 역량요소와 35개의 문항으로 대학생의 코칭역량 척도를 확정하였다. The purpose of this study is to examine the components of college students' coaching competence and develop and validate scale questions based on them. Preliminary studies and literature research were conducted to organize the components and preliminary questions of the coaching competence scale of college students, and focus group interviews (FGI) were conducted to define the concept of college students’ coaching competence and derive components to form preliminary questions. As a preliminary question, 12 people, including two coaching professors, two master's degrees in coaching, five doctorates in coaching, and three college students who have experienced coaching, were selected to verify the content feasibility through two rounds. In order to identify the 89 preliminary scale factors and questions extracted from the 1st and 2nd expert's content feasibility verifications, factor analysis was conducted with 512 survey data nationwide, including Seoul, and Gyeonggi, Chungcheong, Gyeongsang, and Jeolla Provinces. Through an exploratory factor analysis, 35 questions were extracted. Verifiable factor analysis was conducted with extracted questions to examine model adequacy, and intensive feasibility and discriminative feasibility were obtained. As a result of the study, the components of the coaching competency scale of college students confirmed a six competence factors and 35 questions for competence scales with five self-understanding capabilities, five self-management capabilities, six communication capabilities, six communication capabilities, seven action capabilities.

Risk Factors of Microscopic Invasion in Early Gastric Cancer

최종호,서윤석,박신후,공성호,이혁준,김우호,양한광 대한위암학회 2017 Journal of gastric cancer Vol.17 No.4

Purpose: This study aimed to evaluate the clinical significance of microscopic invasion to determine the adequate resection margin in early gastric cancer (EGC). Materials and Methods: A retrospective review was performed that included patients who underwent gastrectomy for clinical early gastric cancer (cEGC) at Seoul National University Hospital between January 2007 and December 2010. After subtracting the microscopic resection margin from the gross resection margin for each proximal or distal resection margin, microscopic invasion was represented by the larger value. Microscopic invasion and its risk factors were analyzed according to the clinicopathologic characteristics. Results: In total, 861 patients were enrolled in the study. Microscopic invasion of cEGC was 6.0±12.8 mm, and the proportion of patients with microscopic invasion ≥0 mm was 78.4%. In the risk group, tumor location, pT stage, and differentiation did not significantly discriminate the presence of microscopic invasion. The microscopic invasion of EGC-IIb was 13.9±16.8 mm, which was significantly greater than that of EGC-I. No linear correlation was observed between the overall tumor size and microscopic invasion (R=0.030). The independent risk factors for microscopic invasion ≥20 mm were EGC-IIb vs. EGC-I/IIa/IIc/III (odds ratio [OR], 3.103; 95% confidence interval [CI], 1.533–6.282; P=0.002) and male vs. female sex (OR, 1.655; 95% CI, 1.012–2.705; P=0.045). Conclusions: Male sex and EGC-IIb were independent risk factors for microscopic invasion ≥20 mm. Examination of intraoperative frozen sections is highly recommended to avoid resection margin involvement, especially in cases of EGC-IIb.