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D-, L- methotrexate에 의하여 誘發되는 사람 染色體上의 시말염색분체교환의 分布에 關한 硏究
金明寬,朴承澤,鄭然泰,金在百 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.1
To investigate the cytotoxicity of the D-methotrexate and compared to L-methotrexate at same doses in cultured phytohemagglutinin activated human lymphocytes an attempt was made. The results obtained were as follows : The SCE frequencies were found to be 11.00 ±0.31, 13.99±0.27, 16.97±0.32, 21.00±0.43 and 7.85±0.26 in treated with 10^-6, 10^-5 M D-,L-methotrexate and the control respectively. L-methotrexate was found to be more potent for inducing SCE than D-methotrexate. The regions generally vulnerable to D~, L-methotrexate were 1p31, 1q23 in chromosome I, 2q21, 2q31 in chromosome 2 and 3p21, 3q23 in chromosome 3. The authors also found that susceptible regions are primarily located within the interbands of G-band.