근위축성측삭경화증 환자의 사상체질 특성

박수정,정호현,장은수,김상혁,김성철,주종천,Park, Soo-Jung,Jeong, Ho-Hyun,Jang, Eun-Su,Kim, Sang-Hyuk,Kim, Sung-Chul,Joo, Jong-Cheon 사상체질의학회 2014 사상체질의학회지 Vol.26 No.2

Objectives The purpose of this study was to analyze the Sasang constitution and psychological traits of amyotrophic lateral sclerosis (ALS) patients and to utilize the results in treatment and management. Methods The differences of Sasang Constitution distribution, psychological characteristics, comorbid disorders between ALS group of 26 patients and general group of 1132 persons were investigated and analyzed. Results There was no significant different distribution of Sasang Constitution between ALS group and general group but there was Yang-like personality tendency in ALS group than general group. In overall constitution, ALS group had the high prevalence rate of musculoskeletal disorders and diabetes than general group. In Soyangin constitution, ALS group had a high prevalence rate of musculoskeletal disorders than genral group. In Taeeumin constitution, ALS group had a high prevalence rate of diabetes and hypertension than general group. Conclusion ALS patients have the Yang-like personality. It is due to the adaptation of personality on the environmental change or coping strategy on diseases rather than the characteristics of congenital Sasang Constitution.

Fentanyl PCA Monotherapy and Fentanyl TTS Combination Therapy in Post-Operative Pain Management: Analyses of Spontaneous Adverse Drug Reaction Reports

박수정,정경혜,김은영,Park, Soo Jung,Jeong, Kyeong Hye,Kim, Eun Young Korean College Of Clinical Pharmacy 2018 한국임상약학회지 Vol.28 No.2

Objective: There have been many cases of spontaneous adverse drug reactions to fentanyl at a regional pharmacovigilance center in the hospital. To assess the factors causing the adverse drug reactions reported in patients receiving fentanyl patient-controlled analgesia (PCA) monotherapy or in combination with fentanyl transdermal therapeutic system (TTS) for acute post-operative pain management. Methods: We conducted a retrospective cohort study with all patients prescribed fentanyl PCA for pain management after orthopedic surgery at a single university hospital from June 2012 to May 2013. We analysed the factors causing adverse drug reactions reported by a spontaneous reporting system in patients receiving fentanyl PCA monotherapy and those receiving fentanyl TTS in combination with fentanyl PCA. Results: Based on the spontaneous adverse drug reaction reporting, the risk ratio for the incidence rate of adverse drug reaction in the fentanyl TTS combination therapy group was 3.04 (95 % CI: 2.4-4.00, P < 0.0001), which was approximately 3-fold higher than that reported for fentanyl PCA monotherapy. Only 60 % of the adverse drug reactions were reported. Conclusion: It is inappropriate to add fentanyl TTS to fentanyl PCA to manage post-operative acute pain. There is a need to improve adverse drug reaction reporting. We expect that regular analysis of adverse drug reactions reported at regional pharmacovigilance centre would aid in appropriate drug utilization by patients.

수열합성법으로 합성된 산화구리 나노막대의 일산화질소 가스 감지 특성

박수정,김효진,김도진,Park, Soo-Jeong,Kim, Hyojin,Kim, Dojin 한국재료학회 2014 한국재료학회지 Vol.24 No.1

We report the nitrogen monoxide (NO) gas sensing properties of p-type CuO-nanorod-based gas sensors. We synthesized the p-type CuO nanorods with breadth of about 30 nm and length of about 330 nm by a hydrothermal method using an as-deposited CuO seed layer prepared on a $Si/SiO_2$ substrate by the sputtering method. We fabricated polycrystalline CuO nanorod arrays at $80^{\circ}C$ under the hydrothermal condition of 1:1 morality ratio between copper nitrate trihydrate [$Cu(NO_2)_2{\cdot}3H_2O$] and hexamethylenetetramine ($C_6H_{12}N_4$). Structural characterizations revealed that we prepared the pure CuO nanorod array of a monoclinic crystalline structure without any obvious formation of secondary phase. It was found from the gas sensing measurements that the p-type CuO nanorod gas sensors exhibited a maximum sensitivity to NO gas in dry air at an operating temperature as low as $200^{\circ}C$. We also found that these CuO nanorod gas sensors showed reversible and reliable electrical response to NO gas at a range of operating temperatures. These results would indicate some potential applications of the p-type semiconductor CuO nanorods as promising sensing materials for gas sensors, including various types of p-n junction gas sensors.

투명한 p형 반도체 CuAlO₂ 박막의 일산화질소 가스 감지 특성

박수정,김효진,김도진,Park, Soo-Jeong,Kim, Hyojin,Kim, Dojin 한국재료학회 2013 한국재료학회지 Vol.23 No.9

We investigated the detection properties of nitrogen monoxide (NO) gas using transparent p-type $CuAlO_2$ thin film gas sensors. The $CuAlO_2$ film was fabricated on an indium tin oxide (ITO)/glass substrate by pulsed laser deposition (PLD), and then the transparent p-type $CuAlO_2$ active layer was formed by annealing. Structural and optical characterizations revealed that the transparent p-type $CuAlO_2$ layer with a thickness of around 200 nm had a non-crystalline structure, showing a quite flat surface and a high transparency above 65 % in the range of visible light. From the NO gas sensing measurements, it was found that the transparent p-type $CuAlO_2$ thin film gas sensors exhibited the maximum sensitivity to NO gas in dry air at an operating temperature of $180^{\circ}C$. We also found that these $CuAlO_2$ thin film gas sensors showed reversible and reliable electrical resistance-response to NO gas in the operating temperature range. These results indicate that the transparent p-type semiconductor $CuAlO_2$ thin films are very promising for application as sensing materials for gas sensors, in particular, various types of transparent p-n junction gas sensors. Also, these transparent p-type semiconductor $CuAlO_2$ thin films could be combined with an n-type oxide semiconductor to fabricate p-n heterojunction oxide semiconductor gas sensors.

HLA-Identical Sibling Bone Marrow Transplantation in Younger patient with Chronic Lymphocytic Leukemia

박수정 ( Soo Jeong Park ),이종욱 ( Jong Wook Lee ),엄기성 ( Ki Seong Eom ),서정곤 ( Jung Gon Suh ),민창기 ( Chang Ki Min ),김동욱 ( Dong Wook Kim ),민우성 ( Woo Sung Min ),김춘추 ( Chun Choo Kim ) 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

급성 골수성 백혈병에서 busulfan, thiotepa, 그리고 melphalan 3제 알킬화제제 전처치를 이용한 동종 골수이식

박수정(Soo Jeong Park),민우성(Woo Sung Min),김희제(Hee Je Kim),박은정(Eun Joung Park),엄기성(Ki Seong Eum),엄현석(Hyeon Seok Eum),민창기(Chang Ki Min),김동욱(Dong Wook Kim),이종욱(Jong Wook Lee),진종률(Jong Yul Jin),한치화(Chi Wha Ha 대한내과학회 2001 대한내과학회지 Vol.60 No.2

N/A Background : The purpose of this study was to evaluate the toxicity and efficacy of high-dose chemotherapy with busulfan, thiotepa and melphalan (BTM) as a myeloablative regimen in allogeneic bone marrow transplantation (allo-BMT) for patients with acute myelogenous leukemia (AML). Methods : Twenty-seven patients with AML were enrolled; Sixteen patients had standard risk (SR) diseases (first complete remission (CR1) and de novo AML) and eleven patients had high risk (HR) diseases (second, or subsequent remission, secondary AML, relapsed, or refractory AML, CR marrow with persisting extramedullary manifestation (chloroma), or hypoplastic acute leukemia). The conditioning regimen included busulfan 4 mg/kg/day for a total dose of 12 mg/kg; thiotepa 250 mg/m2/day for a total dose of 500 mg/m2; and melphalan 50 mg/m2/day for a total dose of 100 mg/m2. Cyclosporine A and short-course methotrexate were used for graft-versus-host disease (GVHD) prophylaxis. Results : The median time to recovery a granulocyte count of 0.5 x 109/L was 14 days (range 10∼25 days) and platelet transfusion independence was 30 days (range 12∼49 days). The major regimen-related toxicities were gastrointestinal-related symptoms including oral mucositis, nausea, vomiting, and diarrhea. All patients experienced oral mucositis (≥ grade 1) and the patients with oral mucositis of equal and greater than grade 3 were 44% in SR and 45% in HR. The toxicities associated with lung, skin, heart and brain were minimal. Three (11%) patients had severe or fatal veno-occlusive disease (VOD). There were five treatment-related death (19%) (hepatic VOD with multiorgan failure (n=3), pneumonia and ARDS (n=2)) within the first 100 days after allo-BMT. There was not a significant difference between SR and HR group (p=0.167). The incidence of acute GVHD equal or greater than grade II was less than 10%. The actual survival at 2 year was 70.4%(95% confidence interval (CI), 54.7%∼86.1%)(SR; 81.3% (95% CI; 63.4∼99.1%) vs HR; 54.6% (95% CI; 28.7∼80.4%), p=0.154). After a median follow-up of 630 days, 18 of 27 (67%, 355∼1062 days) patients are alive without evidence of disease. Three of the 27 patients relapsed (SR; 0% vs HR; 55.6% (95% CI; 19.6∼71.3%), p=0.004). Conclusion : The BTM regimen followed by allo-BMT is associated with acceptable toxicity and appears to have significant activity in patients with AML. It should be used with caution in patients with prior hepatopathy or refractory state who have an increased risk of severe VOD. Busulfan, thiotepa, and melphalan is an effective and alternative myeloablative regimen for patients with AML.(Korean J Med 60:156-166, 2001)

新羅 下代 行守制 試論

박수정(Park Soo Jeong) 한국고대사학회 2017 韓國古代史硏究 Vol.0 No.87

行守制는 秦漢代 이래 관리 試用 방식이었던 行官(攝行權理)과 試官(試守)에 연원이 있으며, 唐代에는 官階(散官)와 官職(職事官)의 품계차를 표시하는 제도로 사용되었다. 운용 방법은 階高職卑면 行, 階卑職高면 守를 관직 앞에 붙이는 것이었지만, 예외적인 용법이 없는 것은 아니었다. 한편 高麗에서는 중국과 동일하게 實職 앞에 행수를 붙이도록 되어 있었지만 그 기준은 관계가 아닌 散職에 두었다. 이는 행수제 자체에 탄력적 운용 가능성이 내재되어 있음을 의미한다. 新羅의 행수제는 금석문에서 855년 이후 등장한다. 이는 당 관제의 영향임이 분명하나, 그 기준은 신분·관등 그리고 당에서 받아 온 文散階 등 여러 가지였다. 가장 많은 사례는 문산계를 기준으로 하는 것으로, 당의 문산계와 신라의 관직을 직접 연결해 표시하는 방식으로 적용되었다. 이는 신라에서 관등 이외에도 당의 문산계가 관인의 등급을 나타내는 방편으로서 기능했음을 보여준다. 또한 이러한 문산계+신라 관직의 병기 방식은 왕의 승인을 전제로 할 것이므로, 이를 통해 측근 세력의 중심의 정치를 추구한 왕의 의도를 엿볼 수 있다. 아울러 이와 같이 신라에서 행수제를 융통성 있게 적용했던 경험이 고려의 행수제로 이어졌을 것이다. During Ch’in(秦) and Han(漢) dynasty, the Xíngjik(行職) was to carry out the duties of former officer, in an office where there was a temporary vacancy. At the same time, shŏujik(守職) was probationary, prefix to a title during the appointee’s first year in service, only after which he was normally entitled to substantive status and full salary. In Tang(唐) period, the so-called Xíng-shŏu system(行守制) was a method of indicating the ‘discrepancy’ between one’s rank(官階) and the grade of one’s post(官職). However, when the Xíng-shŏu system employed by Goryeo(高麗), it was much different from its Chinese counterparts. It was based on one’s sanjik(散職, honorary) not on the rank. This means that Xíng-shŏu system was very resiliently operated. The Xíngjik and the shŏujik first appeared in 855 on the epigraph in Silla(新羅). It is clear that this is the influence of Tang’s political system, the criteria was diverse like one’s position, official rank or the Munsangye(文散階, civil service prestige title) given from Tang dynasty. The most common case is the third, which was used in such a way that it directly linked the Munsangye given from Tang and the grade of post in Silla. This means that, the Tang’s prestige title restrictively functioned as a means of expressing one’s rating in Silla. It can be seen that the intention of the king, who intended to place a group of officials, graded in a different way than the existing bureaucratic appointment based on the Golpum(bone-rank) system(骨品制), to his aide. And the Silla’s experience of differentiating the application criteria from China has led to the Goryeo dynasty.

지르코니아의 표면처리 방법에 따른 압축강화형 복합레진 (TESCERA™ ATL)전장의 결합강도

박수정(Soo-Jeong Park),이성복(Richard Leesungbok),이석원(Suk-Won Lee),안수진(Su-Jin Ahn),임호남(Ho-Nam Lim) 대한턱관절교합학회 2011 구강회복응용과학지 Vol.27 No.1

백제(百濟)의 좌보(左輔)와 우보(右輔)

박수정 ( Soo Jeong Park ) 韓國古代學會 2008 先史와 古代 Vol.28 No.-

줄기 절단정도가 감나무 실생의 생장과 비구조적 탄수화물의 경시적 변화에 미치는 영향

박수정(Park Soo-Jeong) 한국원예학회 1997 한국원예학회 학술발표요지 Vol.15 No.1