참당귀 초임계 이산화탄소 선택 추출물의 항염 효능

박소현,이광원,박신성,신문삼,박수인,Park, So Hyeon,Lee, Kwang Won,Park, Shinsung,Shin, Moon Sam,Park, Su In 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

본 연구에서는 참당귀(Angelica gigas Nakai)의 핵심 유효 성분인 decursin과 decursinol angelate를 높은 수율로 추출한 초임계 이산화탄소 선택 추출물의 항염증 효능을 에탄올 추출물과 비교하여 측정하였다. 항염증 효능을 측정하기 위해 염증 매개 인자인 nitric oxide(NO), 염증성 사이토카인인 interleukin(IL)-6, IL-8 생성량을 측정하였다. NO 생성량은 lipopolysaccharide(LPS)로 염증 반응을 유도한 Raw 264.7 세포를 대상으로 Griess assay를 통해 측정하였고, IL-6 및 IL-8 생성량은 tumor necrosis factor(TNF)-α로 염증 반응을 유도한 human keratinocyte cell line(HaCaT) 세포를 대상으로 enzyme-linked immunoadsorbent assay(ELISA)를 통해 측정하였다. NO 생성량은 초임계 이산화탄소 추출물이 에탄올 추출물에 비해 뛰어나게 억제하였다. IL-6 및 IL-8 생성량 또한 에탄올 추출물은 오히려 증가시키는 반면, 초임계 이산화탄소 추출물은 6.25 ㎍/mL의 농도에서 통계적으로 유의하게 억제하였다(P<0.01). 우리는 이러한 결과를 통해 참당귀 초임계 이산화탄소 선택 추출물이 아토피 피부염을 완화시키는 항염증 코스메슈티컬 소재로써 활용 가능함을 확인하였다.

한의학적 치료를 받은 자폐 스펙트럼 장애 환아 63례에 대한 후향적 차트리뷰

박소현,김예지,박슬기,이선행,이지홍,박용석,김재현,장규태,이진용,Park, So Hyun,Kim, Ye Ji,Park, Sul Gi,Lee, Sun Haeng,Lee, Jihong,Park, Yong Seok,Kim, Jae Hyun,Chang, Gyu Tae,Lee, Jin Yong 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.3

Objectives This study aimed to analyze the clinical characteristics of 63 patients with autism spectrum disorder (ASD) who received Korean medicine treatment. Methods This study identified and retrospectively reviewed the first visit records and clinical characteristics of all of the patients who visited the Kyung Hee University Korean Medicine Hospital and Kyung Hee University Korean Medicine Hospital at Gangdong in South Korea with ASD as their chief complaints. The herbal medicines that were prescribed according to the patient's symptoms were analyzed by separating them into categories. Results The data of 83 children with ASD were collected. Among them, the primary medical record charts of 63 patients were reviewed. Additional analysis was performed for 56 patients who were treated with herbal medicine. Through a retrospective chart review, the patients' clinical characteristics and the tendency of the prescribed herbal medicine was identified. Conclusions This study was conducted to provide preliminary data that proposes Korean medicine as a new alternative medical treatment. Our study is meaningful as it used the demographic and clinical records of 63 patients with ASD in Korea who visited an Korean medicine hospital in the last 11 years to identify tendencies and analyzed the prescriptions of two or more Korean medicine pediatricians.

처음 진단받은 여성 유방암 환자와 갑상선암 환자에서 나타나는 불안, 우울 및 불면 증상

박소현,최희연,임원정,문병인,임우성,Park, So-Hyun,Choi, Hee-Yeon,Lim, Weon-Jeong,Moon, Byung-In,Lim, Woo-Sung 대한생물정신의학회 2017 생물정신의학 Vol.24 No.4

Objectives In this study, we identified the symptoms of insomnia, anxiety, and depressed mood in newly diagnosed women breast and thyroid cancer patients. Methods The subjects of this study were 1794 women patients who visited the Ewha Womans University Cancer Center for Women. They included 1119 newly diagnosed primary breast cancer patients and 675 newly diagnosed primary thyroid cancer patients. The patients completed the National Cancer Center Psychological Symptom Inventory (NCC-PSI) during their first follow-up visit after surgery, before starting chemotherapy or radiotherapy. The NCC-PSI is composed of the modified distress thermometer (MDT) and the modified impact thermometer (MIT) for insomnia, anxiety, and depressed mood. Results Anxiety severity was found to be greater in breast cancer patients than in thyroid cancer patients. Significant levels of anxiety, depressed mood and insomnia were present in 28, 24.5, and 20.7% in all the subjects, respectively. Moreover, anxiety symptoms, depressed mood and insomnia interfered with the daily lives of 20, 18.4, and 14.2% of all the subjects, respectively. Dealing with anxiety (18.8%) was found to need the most help, followed by dealing with insomnia (8.9%) and depressed mood (8.7%). Conclusions A significant level of distress was found in about 40% of the total subjects. Nearly 30% of newly diagnosed breast cancer patients reported significant anxiety symptoms and interferences with daily living caused by anxiety, which most commonly needed special care. Early assessment and management of psychological distress, especially anxiety, in breast and thyroid cancer treatment are very important to establish integrated cancer care.

가미서경탕(加味舒經湯)을 이용한 상부관절와순파열로 진단받은 견비통 환자 치험 2례

박소현,노해린,Park, So-Hyun,Ro, Hae-Rin 척추신경추나의학회 2011 척추신경추나의학회지 Vol.6 No.1

Objectives : The propose of this study is to find out the clinical application of conservative treatment for SLAP lesion. Methods : We examined 2 patients with SLAP lesion who admitted Jaseng Hospital of Oriental Medicine. The patients were treated by conservative treatments including herbal mixture, acupuncture, pharmacupuncture. Results : In this study, in the end of continuous conservative treatment, patient's shoulder pain has improved. Visual Analog Score(VAS) were also decreased. Conclusions : A conservative treatment for SLAP lesion was effective in restore of functional activities, but usefulness of this treatment needs more study.

순차 적응 최근접 이웃을 활용한 결측값 대치법

박소현,방성완,전명식,Park, So-Hyun,Bang, Sung-Wan,Jhun, Myoung-Shic 한국통계학회 2011 응용통계연구 Vol.24 No.6

비모수적 결측치 대치법인 k-최근접 이웃(k-Nearest Neighbors; KNN) 대치법을 개선한 적응 최근접 이웃(Adaptive Nearest Neighbor; ANN) 대치법과 순차 k-최근접 이웃(Sequential k-Nearest Neighbor; SKNN) 대치법의 장점들을 결합한 순차 적응 최근접 이웃(Sequential Adaptive Nearest Neighbor; SANN) 대치법을 제안하고자 한다. 이 방법은 ANN 대치법의 장점인 자료의 국소적 특징을 반영할 뿐 아니라, SKNN 대치법과 같이 결측값 대치가 이루어진 개체를 다음 결측값을 대치할 때 사용함으로써 효율성에 개선이 있을 것으로 기대한다. In this paper, we propose a Sequential Adaptive Nearest Neighbor(SANN) imputation method that combines the Adaptive Nearest Neighbor(ANN) method and the Sequential k-Nearest Neighbor(SKNN) method. When choosing the nearest neighbors of missing observations, the proposed SANN method takes the local feature of the missing observations into account as well as reutilizes the imputed observations in a sequential manner. By using a Monte Carlo study and a real data example, we demonstrate the characteristics of the SANN method and its potential performance.

압박 벨트와 비탄력 테이프를 이용한 골반압박이 엎드려 고관절 신전 시 체간과 고관절 신전근의 근 작용에 미치는 영향: 요통 경험군과 요통 비경험군 비교 연구

박소현,김선엽,Park, So-hyun,Kim, Suhn-yeop 대한정형도수물리치료학회 2021 대한정형도수물리치료학회지 Vol.27 No.2

Background : Prone hip extension (PHE) is commonly used for exercises and tests in patients with low back pain. Previous studies have shown that pelvic compression belts (PCB) and non-elastic taping (NET) contribute greatly to improvements in lumbopelvic stability. This study aimed to compare the effect of two lumbopelvic stability methods such as PCB and NET on the trunk and hip extensor muscle activities during PHE tests. Methods: Subjects who experienced low back pain (low back pain group, LBPG; n=20) and those who did not experience low back pain (non-LBPG; n=20) participated in this study. The subjects were instructed to perform PHE with and without a PCB and NET. PHE tests were performed in the condition wherein the two stabilization methods were applied, and the actions of the muscles at that time were measured using surface electromyography (EMG). EMG data were collected from the hamstring, gluteus maximus, erector spine (ES), and multifidus (MF) muscles. The data were collected three times for 5 s with a 1-min rest between each of the three sets. Results: In the LBPG, EMG of the ES muscle was significantly reduced when NET or a PCB was applied (p<.05). There was no difference in the change in the ES muscle activity when NET and a PCB were applied. The ratio of MF/ES muscleactivity showed a significant increase in the LBPG with NET (p<.05). Conclusion: Both NET and PCB applied to subjects who experienced low back pain significantly reduced the ES muscle activity during PHE exercises and helped control the balance of the superficial and deep trunk extensor muscles.

해면 Callyspongia elegans에 서식하는 세균군집의 계통학적 다양성

박소현,김지영,김영주,허문수,Park, So-Hyun,Kim, Ji-Young,Kim, Young-Ju,Heo, Moon-Soo 한국미생물학회 2014 미생물학회지 Vol.50 No.2

이 논문은 Callyspongia elegans에서 서식하는 세균군집에 관한 내용이다. 해양세균은 marine agar를 사용하여 해면동물 C. elelgans에서 분리하였다. 그 결과 112균주를 분리하였으며, 본 연구에 사용하였다. 현미경 및 그람 염색을 통해 형태학적 표현형질을 측정하였다. 분리균주의 집락 색소는 노란색, 갈색, 아이보리색, 흰색으로 나타났다. 그람염색 결과 37균주는 그람양성균이였으며, 75균주는 그람 음성균이었다. 균주의 형태는 분리균주 중 79균주는 구균형태로 관찰되었고, 16균주는 간균이었다. 16S rDNA 유전자 염기서열 분석을 통해 분리균주들의 계통학적 특성을 파악하였다. 그 결과, 분리된 112균주는 5개의 주요 계통군이 확인되었으며, Alphaproteobacteria는 39%, Gammaproteobacteria는 22%, Acinobacteria는 14%, Firmicutes는 9%, Bacteroidetes는 6%에 속하는 것으로 나타났다. 그리고 16S rDNA 유전자 염기서열을 통해 계통분석 결과 15균주가 새로운 속 또는 종으로 분류될 가능성을 나타났으며, 앞으로 추가적인 실험이 필요한 실정이다. The aim of this study was to investigate the bacterial community inhabited in Callyspongia elegans. Marine bacteria were isolated from the marine sponge C. elegans using marine agar. The resulting 112 isolated pure cultures were then used for further study. They were characterized by determining morphological characteristics through Gram's staining and morphological observation. The colony pigments of bacterial isolates were characterized as yellow, brown, ivory, and white. Thirty-seven strains were found to be Gram-positive and 75 strains were Gram-negative. Seventy-nine strains were coccus-shaped, while 16 strains were rod-shaped. On the basis of the results of the comparative analyses of 16S rDNA gene sequences, the 112 isolated bacteria were divided into 5 major groups: Alphaproteobacteria (39%), Gammaproteobacteria (22%), Actinobacteria (14%), Fimicutes (9%), and Bacteroidetes (6%). It is strongly suggested that fifteen isolates are candidates for a new genera or species, based on the analyses of 16S rDNA gene sequences.

만성 요통 및 하지방사통 환자에서 감압치료(KNX $7000^{(R)}$)와 견인치료의 단기 치료 효과

박소현,김철승,이동규,안상호,Park, So-Hyun,Kim, Chul-Seoung,Lee, Dong-Gyu,Ahn, Sang-Ho 대한물리치료학회 2011 대한물리치료학회지 Vol.23 No.5

Purpose: The purpose of this study is to evaluate the short term effects of the traction and decompression device, which is a newly developed domestic medical device, on pain and functional activity in patients with chronic low back pain with or without radicular pain. Methods: Forty patients with chronic low back pain were included and allocated to decompression (n=20) and traction groups (n=20). They received decompression or traction therapy for 20 minutes a day, 3 days per week for two weeks. For evaluating pain and functional activity, a visual analogue scale (VAS) for low back pain and the Oswestry back pain disability index (ODI) were obtained on pre-treatment, and at 6, 12 and 15 days after treatment. Patients'satisfaction levels were measured 15 days after treatment. Results: VAS was significantly decreased at 12 days and 15 days post-treatment compared to pre-treatment in both groups (p<0.05). ODI was significantly decreased at 12 days and 15 days post-treatment compared to pre-treatment in the decompression group (p<0.05). However, there was no significant difference between the two groups in the VAS and ODI scales (p>0.05). Patients' satisfaction levels were significantly higher in the decompression group than in the traction group (p<0.05). Conclusion: These findings suggest that decompression therapy might be effective for increasing functional activity in patients with low back pain and could provide patients with higher satisfaction than traction therapy. This study provided validity data for the therapeutic effects of the decompression device in patients with low back pain and it will be useful for medical cost development and patient education of this device.

양성자 치료 전산모사를 위한 Geant4 전자기 물리 모델 정확성 검증

박소현,라정은,신정욱,박성용,윤세철,정원균,서태석,Park, So-Hyun,Rah, Jeong-Eun,Shin, Jung-Wook,Park, Sung-Yong,Yoon, Sei-Chul,Jung, Won-Gyun,Suh, Tae-Suk 한국의학물리학회 2009 의학물리 Vol.20 No.4

Geant4 toolkit은 전자기적 상호작용(electromagnetic interactions)에 대한 다양한 물리적 모델을 제공한다. 이러한 물리적 모델들에 대한 검증은 신뢰성 있는 Geant4 응용을 위해서 중요한 역할을 한다. 그러므로, 본 연구의 목적은 양성자 치료 전산모사를 위해 Geant4가 제공하는 물리적 모델 중 전자기 물리 모델의 정확성을 검증하는 것이다. 검증은 물, 뼈, 지방 그리고 원자번호가 다른 물질에 대해 양성자의 CSDA 비정(continuous slowing down approximation range)과 저지능(stopping power) 데이터를 미국 국립기술표준원(National Institute of Standards and Technology, NIST)의 데이터를 각각 비교하는 방법으로 이루어졌다. 물, 뼈 그리고 지방에 대해 0.01 MeV에서 10 GeV 범위의 입사 에너지의 CSDA 비정과 저지능 전산모사 결과와 NIST값을 비교한 결과, CSDA 비정의 평균 차는 각각 1.0%, 1.4% 그리고 1.4%를 나타내었고, 저지능에 대한 평균 차는 각각 0.7%, 1.0% 그리고 1.3%를 나타내었다. 또한, 각 물질에 대한 NIST 값과의 유의성을 분석하기 위해 kolmogorov-smirnov Goodness-of-Fit 통계분석 방법을 이용한 결과, 전자기 물리 모델의 전산모사 결과 데이터와 NIST 데이터 사이의 유의성을 나타내는 p-value가 유의 수준 0.05 이상 값을 가진다는 것을 확인 하였으며, 이를 통해 Geant4 전자기 물리 모델의 정확성을 검증할 수 있었다. Geant4 (GEometry ANd Tracking) provides various packages specialized in modeling electromagnetic interactions. The validation of Geant4 physics models is a significant issue for the applications of Geant4 based simulation in medical physics. The purpose of this study is to evaluate accuracy of Geant4 electromagnetic physics for proton therapy. The validation was performed both the Continuous slowing down approximation (CSDA) range and the stopping power. In each test, the reliability of the electromagnetic models in a selected group of materials was evaluated such as water, bone, adipose tissue and various atomic elements. Results of Geant4 simulation were compared with the National Institute of Standards and Technology (NIST) reference data. As results of comparison about water, bone and adipose tissue, average percent difference of CSDA range were presented 1.0%, 1.4% and 1.4%, respectively. Average percent difference of stopping power were presented 0.7%, 1.0% and 1.3%, respectively. The data were analyzed through the kolmogorov-smirnov Goodness-of-Fit statistical analysis test. All the results from electromagnetic models showed a good agreement with the reference data, where all the corresponding p-values are higher than the confidence level $\alpha=0.05$ set.

이 충무공 관련 고문헌에 대한 보존처리

박소현,신효영,홍순천,조안나,박지희,Park, so hyun,Shin, hyo young,Hong, soon chon,Cho, anna,Park, ji hee 국립문화재연구소 2012 保存科學硏究 Vol.33 No.-

천연재료를 사용하는 지류유물의 손상은 재질적 특성상 어떤 한 가지 요인에 의한 훼손보다는 물리적, 화학적, 생물학적 복합요인에 의한 손상 가능성이 높다. 문화재보존과학센터는 2009년 12월 현충사 관리소로 부터 이 충무공관련 유물의 상태조사 및 보존처리를 의뢰받아 조사한 결과 위와 같은 다양한 훼손요인을 확인할 수 있었다. 조사결과를 토대로 각 유물의 손상정도를 파악한 후 적절한 보존방안을 수립하고, 2010년부터 약 2년에 걸쳐 보존처리를 실시하였다. 이 충무공 관련 유물 중 고문서, 전적류 등과 같이 형태가 다른 고문헌에 대한 손상유형과 보존처리 내용을 소개함으로서 보존처리방법을 선택하는 하나의 예시를 제안하고자 하였다. 지류유물에 대한 보존처리는 유물의 노화주기를 연장시키고 2차 손상을 방지하지만, 유물의 노화를 완전히 멈추게 하는 과정이 아니므로 유물에 대한 정기적 점검이 필요할 것이다. Paper relics, which are made of natural ingredients, are more likely to be damaged by a compendium of complicated causes (e.g., physical, chemical, and biological causes) rather than by a sole cause. In December 2009, Culture Heritage Conservation Science Center discovered several damages in paper relics related to Chungmugong Yi Sunsin, and requested for conservation treatment from the Hyeonchungsa Shrine office. By conducting a comprehensive research to determine the damage level of each artifact, the center was able to establish a proper conservation method, and for two years after its completion of such research in 2010, it has been conducting treatment. This study suggests the proper ways to select adequate conservation treatment based on the type of paper relics - Documents and Books - through the case of artifacts related to Chungmugong Yi, Sunsin. Even though the conservation treatment on paper relics can suppress damaging speed and prevent another damages, it is impossible to stop aging process of relics. Therefore regular inspection is essential for prevent second damage.