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수면다원검사를 시행한 환자들의 각성지수와 임상양상과의 관계
김성경 ( Sung Kyoung Kim ),이상학 ( Sang Haak Lee ),강현희 ( Hyeon Hui Kang ),강지영 ( Ji Young Kang ),김진우 ( Jin Woo Kim ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Par 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3
Background: Repeated arousals during sleep have been known to be associated with excessive daytime sleepiness and cardiovascular complications. We investigated the relationship between arousal indices and clinical parameters. Methods: We retrospectively reviewed medical records of 41 patients who performed polysomnography for a diagnosis of obstructive sleep apnea syndrome. We defined total arousal index (TAI) as the number of arousals per hour and respiratory arousal index (RAI) as the number of arousals associated with apnea or hypopnea per hour. Results: There were significant positive correlations between arousal indices and apnea-hypopnea index (AHI) (RAI vs. AHI, r=0.958, p<0.001; TAI vs. AHI, r=0.840, p<0.001). RAI and mean oxygen saturation showed a significant negative correlation with each other (r=-0.460, p=0.002). TAI revealed a significant positive correlation with mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP) (TAI vs. MSBP, r=0.389, p=0.014; TAI vs. MDBP, r=0.373, p=0.019). There was no significant correlation between arousal indices and parameters of sleepiness. RAI had a significant positive correlation with body mass index (BMI) and neck circumference (NC) (RAI vs. BMI, r=0.371, p=0.017; RAI vs. NC, r=0.444, p=0.004). When partial correlation analysis was performed to adjust for other variables, there was significant correlation between RAI and AHI (r=0.935, p<0.001). Conclusion: This study shows that respiratory arousal index could be a useful index reflecting of severity of obstructive sleep apnea syndrome. Arousal during sleep would be concerned in the development of cardiovascular complication of obstructive sleep apnea. And some anthropometric factors would contribute to the development of arousals during sleep. Further studies are needed to clarify any cause-effect relationship.
폐쇄성 수면 무호흡증후군 환자에서 혈압 및 폐기능의 변화에 관한 연구
문화식 ( Hwa Sik Moon ),이숙영 ( Sook Young Lee ),최영미 ( Young Mee Choi ),김치홍 ( Chi Hong Kim ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Par 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.2
담배 연기에 의한 Muc5ac 유전자 발현에 관여하는 세포 내 신호 전달 경로로서의 ERK1/2와 p38 MAPK
김용현 ( Yong Hyun Kim ),윤형규 ( Hyoung Kyu Yoon ),김치홍 ( Chi Hong Kim ),안중현 ( Joong Hyun Ahn ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),박성학 ( Sung Hak Par 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.6