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Capsaicin 약침(藥鍼)이 흰쥐의 급성(急性) 염좌(捻挫)에 마치는 효과
박상연,최윤영,전인숙,구성태,김경식,손인철,김재효,Park, Sang-Yeon,Choi, Yoon-Young,Jeon, In-Sook,Koo, Sung-Tae,Kim, Kyoung-Sik,Sohn, In-Chul,Kim, Jae-Hyo 경락경혈학회 2006 Korean Journal of Acupuncture Vol.24 No.2
Objectives: Pharmacopuncture which is a combination of acupuncture and herbal medicine helps to prevent and treat the diseases and symptoms including various pains. However, little was known about the therapeutic effects and its mechanisms on acute pain, although pharmacopuncture has been used frequently in acupuncture clinics. Acupuncture is known for producing analgesia for persistent ankle sprain pain in human. Furthermore, it also produces analgesia in a rat model of ankle sprain pain. Methods: To illuminate the underlying mechanisms of capsaicin pharmacopuncture-induced analgesia, weight bearing force (WBF) was observed on the acute ankle sprained rat model. Ankle sprain was induced in the rat by manually hyper-extending ligaments of the right ankle. Capsaicin pharmacopuncture was applied to SI6 (Yanglo) on the left forelimb (contralateral to the sprained ankle). Results: In behavioral test, capsaicin pharmacopuncture produced marked analgesic effects on acute ankle sprained animals as measured by WBF of the affected limb similar to manual acupuncture. Capsaicin pharmacopuncture was also suppressed by serotonin (5-HT) receptor antagonist methysergide (2 mg/kg, Lp.), but not by opioids receptor antagonist naltrexone (10 mg/kg, Lp.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, Lp.). Conclusion: The data suggest that capsaicin pharmacopuncture-induced analgesia is accomplished by activating the descending serotonergic inhibitory systems.
천자 배액후 Trichloroacetic Acid를 이용하여 치료한 다발성 피지낭종
박상연 ( Sang Yeon Park ),이해진 ( Hae Jin Lee ),정예진 ( Ye Jin Jung ),최응호 ( Eung Ho Choi ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.7
Steatocystoma multiplex is a clinical condition characterized by numerous dermal cysts that have their origin in the pilosebaceous duct, which appear and grow at puberty. The cystic nodules range from 3 mm to 3 cm in size, and they are soft and freely movable. Although there are numerous reports of different treatment methods, the long-term management of steatocystoma multiplex remains to be difficult. We, herein, report on a case of 23-year-old man with steatocystoma multiplex on the buttock. He was successfully treated with dot peeling of 100% trichloracetic acid after aspiration of the oily contents without any complications, such as atrophy, scarring and skin necrosis. We report the combination therapy of needle aspiration and trichloroacetic acid peeling as new therapeutic modality for multiple steatocystoma multiplex. (Korean J Dermatol 2012;50(7):644∼646)
박상연 ( Sang Yeon Park ),최응호 ( Eung Ho Choi ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.9
Localized scleroderma, also known as morphea, is characterized by skin hardening caused by increased collagen deposition. Since lesions are usually limited to the skin and subcutaneous fat tissue, its prognosis is usually good. However, it can extend over muscular fascia, muscle tissue and tendons; thus, early diagnosis and treatment are important. Although the diagnosis of scleroderma is based on clinical manifestations and histopathologic findings, it is sometimes delayed due to nonspecific clinical appearances. Magnetic resonance imaging (MRI) visualizing the internal structures of the body can evaluate soft tissue lesions very well and is helpful in diagnosis as well as diagnosing extension of scleroderma. A 49-year-old woman complained of a 10-cm-diameter skin colored hard plaque on her right upper arm, which was suspicious due to muscular involvement. The MRI revealed subcutaneous fat and interlobular septa over the deltoid muscle showing high signal, but no change in the underlying muscle or bone. We report here a case of localized scleroderma that developed in a 49-year-old Korean woman. The diagnosis was assisted by MRI with regards to the depth and extension of invasion. (Korean J Dermatol 2014;52(9):651∼653)
합곡(合谷)(LI4)의 고주파 온침 자극이 흰쥐의 족과(足과) 관절염(關節炎)에 미치는 효과
박상연 ( Sang Yeon Park ),권오상 ( Oh Sang Kwon ),최원종 ( Won Jong Choi ),김재효 ( Jae Hyo Kim ),김경식 ( Kyung Sik Kim ),손인철 ( In Chul Sohn ),안성훈 ( Seong Hun Ahn ) 대한경락경혈학회 2009 Korean Journal of Acupuncture Vol.26 No.2
Objectives: The warm needling technique is a method which combines the effects of acupuncture with those of moxibustion. The purpose of this study was to find the stimulus effects of a high frequency warm needling device when stimulating acupoint LI4 on the carrageenan-induced arthritis. Methods: This study was to observe the effects to edema reaction, WBF(weight bearing force), NO concentration, nNOS expression after the electro high frequency stimulus of high frequency warm needling device on LI4 with insulated acupuncture needle. Results: The effect of the high frequency warm needling device is to rise up the temperature in proportion to the current intensity. After stimulating on the acupoint LI4 of the carrageenan-induced arthritis in rats with the high frequency warm needling device, it significantly reduced edema in the rat`s foot. In addition, WBF, NO concentration of spinal cord (n㏖/㎎), and nNOS relative expression were reduced. Conclusions: The above results support the idea that stimulus by the high frequency warm needling device on LI4 produces a potent analgesic effect in the arthritis pain model of the rat. Moreover, stimulus by the high frequency warm needling device modulates endogenous NO through the suppression of nNOS protein expression.
박상연(Park Sang Yeon),신동수(Shin Dong-soo),이현구(Lee Hyun Gu),김희숙(Kim Hee Sook) 기본간호학회 2008 기본간호학회지 Vol.15 No.2
Purpose: This study was done to examine the level of compliance and the relation of related factors of nosocomial infection control among nurses in emergency rooms. The data will provide fundamental information for developing program s for nosocomial infection control in the emergency room. Method: Study participants were 183 nurses working in emergency rooms in general hospitals that had more than 500 beds and were located in Daegu, Daejeun, and Pusan. The survey was carried out from March 7 to March 26, 2006 and a structured questionnaire was used. Descriptive statistics, t-test, ANOVA and Sheffe test with SPSS 14.0 were used to analyze the data. Results: The average level for practice of infection control was relatively low. Levels of compliance were high when the participants had: 1) regular conferences for nosocomial infection control, 2) positive perception of protection devices, 3) knowledge of whom to report and experiences of reporting needle stick injuries, 4) hospital guidelines for infection control and 5) enough equipment supplies from the hospital. Conclusion: Nosocomial infection control among emergency room nurses could be improved via personal, psychosocial, and organizational factors and related education.
Capsaicin 약침(藥鍼)이 흰쥐의 급성념좌(急性捻挫)에 미치는 효과
박상연 ( Sang Yeon Park ),최윤영 ( Yoon Young Choi ),전인숙 ( In Sook Jeon ),구성태 ( Sung Tae Koo ),김경식 ( Kyoung Sik Kim ),손인철 ( In Chul Sohn ),김재효 ( Jae Hyo Kim ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.2
Objectives: Pharmacopuncture which is a combination of acupuncture and herbal medicine helps to prevent and treat the diseases and symptoms including various pains. However, Little was known about the therapeutic effects and its mechanisms on acute pain, although pharmacopuncture has been used frequently in acupuncture clinics. Acupuncture is known for producing analgesia for persistent ankle sprain pain in human. Furthermore, it also produces analgesia in a rat model of ankle sprain pain. Methods: To illuminate the underlying mechanisms of capsaicin pharmacopuncture-induced analgesia, weight bearing force (WBF) was observed on the acute ankle sprained rat model. Ankle sprain was induced in the rat by manually hyper-extending Ligaments of the right ankle. Capsaicin pharmacopuncture was applied to SI6 (Yanglo) on the Left forelimb (contralateral to the sprained ankle). Results: In behavioral test, capsaicin pharmacopuncture produced marked analgesic effects on acute ankle sprained animals as measured by WBF of the affected Limb similar to manual acupuncture. Capsaicin pharmacopuncture was also suppressed by serotonin (5-HT) receptor antagonist methysergide (2 mg/kg, i.p.), but not by opioids receptor antagonist naltrexone (10 mg/kg, i.p.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, i.p.). Conclusion: The data suggest that capsaicin pharmacopuncture-induced analgesia is accomplished by activating the descending serotonergic inhibitory systems.