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DBA/2J 생쥐에서 점안 안압하강제 투여 후 망막신경세포구성의 변화
박명희,이경민,권재성,문정일.Myoung-Hee Park. M.D.. Kyung-Min Lee. M.D.. Jae-Sung Kwon. Ph.D.. Jung-Il Moon. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: The DBA/2J (D2) mouse is a transgenic mouse with pigmentary glaucoma. In a previous study, we found a reduction of inner retinal thickness in D2 mice. We attempted to discover the effect of eye drops on the retina of D2 mice. Methods: Ten-month-old D2 mouse eyes were treated with Timoptic XE?, Cosopt?, and Xalacom? eye drops for a 1-month period. Immunohistochemical staining was performed on the mouse eye sections for analysis. Results: In the control group, GABA and OPN immunoreactivity were markedly decreased and NOS immunoreactivity was increased. In all experimental group, GABA and OPN immunoreactivity were increased, and OPN immunoreactivity was markedly increased especially in the Cosopt?group. NOS immunoreactivity was decreased in all experimental groups. There was no difference in glycine immunoreactivity between the control and experimental groups. Conclusions: Combination anti-glaucoma eye-drops to the D2 mouse changed the retinal neuronal population and these drugs might play an important role in the mechanisms of retinal neuronal death; potential strategies for neuroprotection should therefore be evaluated.
공초점주사레이저편광계와 빛간섭단층촬영기의 결과가 일치하지 않는 경우의 녹내장 진단
박명희,황호식,문정일,Myoung-Hee Park,M,D,Ho-Sik Hwang,M,D,Jung-Il Moon,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: To investigate the coincidence of visual field loss in cases with different GDx VCC and Stratus OCT results, and to analyze the cause of these differences. Methods: We retrospectively reviewed the medical records of patients who had visited our hospital for glaucoma evaluation from September 2003 to August 2005 for sensitivity, specificity, positive predictive rate, and negative predictive rate of GDx and OCT. In order to analyze the cause of discrepancy between the GDx and OCT results, we divided patients into Group A, consisting of GDx abnormal and OCT normal eyes, and Group B, consisting of GDx normal and OCT abnormal eyes. We compared optic disc tilting, peripapillary atrophy, and cup-disc ratio between the two groups. Results: In cases of differing results between GDx and OCT, sensitivity, specificity, positive predictive rate and negative predictive rate were higher in Stratus OCT than in GDx. Peripapillary atrophy did not represent a statistically significant difference between group A and group B (p=0.601), where as the difference in cup-disc ratio between the two groups was statistically significant (p=0.000). Conclusions: OCT parameters coincided better than GDx with cases having different results on GDx and OCT. In cases with a large cup/disc ratio, there was a tendency to be normal according to GDx and abnormal by OCT.