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백수오(白首烏)와 비주화(啤酒花) 복합물의 에스트로겐 활성과 파골세포 분화 억제효과
박동준,이홍구,민경인,박형국,진무현,조호성,Park, Dongjun,Lee, Hong Gu,Min, Kyoungin,Park, Hyoungkook,Jin, Mu Hyun,Cho, Ho Song 대한본초학회 2022 大韓本草學會誌 Vol.37 No.5
Objectives : This study aimed to investigate the synergistic effect of combining Cynanchi Wilfordii Radix extract with Humuli Lupuli Flos extract on estrogenic and anti-osteoclastogenic activity. Methods : Estrogenic effect of a mixture of Cynanchi Wilfordii Radix extract and Humuli Lupuli Flos extract (CWHL), Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin (an active ingredient of Cynanchi wilfordii Radix extract) and 8-prenylnaringenin (an active ingredient of Humuli Lupuli Flos extract) were examined by proliferation E-screen assay and expression of estrogen inducible gene, pS2 via Real Time-PCR (RT-PCR) in MCF-7 estrogen responsive cells. And their estrogenic activities were investigated how to modulate Estrogen receptor 𝛽 by binding affinity assay. Inhibitory effect of CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin on RANKL-induced osteoclast differentiation were tested by TRAP (Tartrate-resistant acid phosphatase) staining in osteoclastogenic RAW 264.7 cells. Results : CWHL, Humuli Lupuli Flos extract and 8-prenylnaringenin accelerated the proliferation of MCF-7 and the expression of pS2 in MCF-7. CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin bind to estrogen receptor 𝛽. CWHL, Cynanchi Wilfordii Radix extract, Humuli Lupuli Flos extract, caudatin and 8-prenylnaringenin inhibited RANKL-induced osteoclastogenesis in osteoclastogenic RAW 264.7. CWHL is more effective for all markers than Cynanchi Wilfordii Radix extract or Humuli Lupuli Flos extract alone. Conclusions : CWHL may a potential therapeutic agent for menopause and osteoporosis as a natural food resource. CWHL as a natural food source has therapeutic potential in cases of menopause and osteoporosis.
골담초꽃 추출물의 연골 보호 및 염증 억제 효과에 관한 연구
박동준,이홍구,고충호,박형국,진무현,조호성,Park, Dongjun,Lee, Hong Gu,Ko, Chung Ho,Park, Hyoungkook,Jin, Mu Hyun,Cho, Ho Song 대한본초학회 2022 大韓本草學會誌 Vol.37 No.6
Objectives : This research aimed to investigate chondro-protective and anti-inflammatory effects of Caraganae Sinicae Flos 50% ethanol extract and its compound, tilianin. Methods : Caraganae Sinicae Flos was extracted with 50% ethanol. Tilianin in Caraganae Sinicae Flos 50% ethanol extract was quantified by HPLC analysis method. To investigate chondro-protective effects of Caraganae Sinicae Flos 50% ethanol extract, ATDC5 chondrogenic cells were co-treated with Caraganae Sinicae Flos 50% ethanol extract (or tilianin) and tumor necrosis factor-𝛼 (TNF𝛼) for 24 hours. After treatement for 24 hours, media supernatant was used for quantifying protein level of matrix metalloproteinase-3 (MMP3) by ELISA and harvested cells were used for analyzing mRNA expression level of matrix metalloproteinase-13 (MMP13) by reverse transcription PCR. To identify anti-inflammatory effects of Caraganae Sinicae Flos 50% ethanol extract, RAW 264.7 macrophage cells were co-treated with Caraganae Sinicae Flos 50% ethanol extract (or tilianin) and lipopolysaccharide (LPS) for 24 hours. media was used for quantifying the level of prostaglandin E2 (PGE2), interleukin-6 (IL6) by ELISA and nitric oxide by Griess reagent asssay. Results : Caraganae Sinicae Flos 50% ethanol extract and tilianin attenuated protein level of MMP3 and mRNA expression level of MMP13 in TNF𝛼-activated ATDC5 cells. Caraganae Sinicae Flos 50% ethanol extract inhibited the level of PGE2, IL6 and NO in LPS-activated RAW 264.7 cells in dose dependent manner, though tilianin inhibited PGE2 only. Conclusions : These results presented that Caraganae Sinicae Flos 50% ethanol extract could be used as natural medicines for osteoarthritis.
마가자(馬家子) 추출물의 연골 보호 및 항염 효과에 관한 연구
박동준,이홍구,고충호,박형국,진무현,조호성,Park, Dongjun,Lee, Hong Gu,Ko, Chung Ho,Park, Hyoungkook,Jin, Mu Hyun,Cho, Ho Song 대한본초학회 2022 大韓本草學會誌 Vol.37 No.6
Objectives : From this study, we sight to identify chondro-protective and anti-inflammatory effects of Sorbi Commixtae Fructus extract and its compound, chlorogenic acid. Methods : Sorbi Commixtae Fructus were extracted by 50% ethanol. And chlorogenic acid in Sorbi Commixtae Fructus 50% extract was quantified by high performance liquid chromatography (HPLC). To investigate chondro-protective effects, we treated Sorbi Commixtae Fructus 50% ethanol extract and chlorogenic acid in TNF𝛼-activated ATDC5 murine chondrogenic cells. After 24 hours, protein level of matrix metalloproteinase-3 (MMP3) and mRNA level of matrix metalloproteinase-13 (MMP13) were measured by using ELISA or reverse transcription PCR, respectively. To examine anti-inflammatory effects, we treated Sorbi Commixtae Fructus 50% ethanol extract and chlorogenic acid in LPS-induced RAW 264.7 murine macrophages. We measured the level of inflammatory mediators, such as Prostaglandin E2 (PGE2), Interleukin-6 (IL6) by ELISA and nitric oxide (NO) by Griess reagent assay. Results : A concentration of chlorogenic acid in Sorbi Commixtae Fructus 50% ethanol extract was 3.9 mg/g. Sorbi Commixtae Fructus 50% ethanol extract and chlorogenic acid attenuated protein level of MMP3 and mRNA level of MMP13 in TNF𝛼-activated ATDC5 cells. Sorbi commixtae Fructus 50% ethanol extract inhibited the level of PGE2, IL6 and NO in LPS-activated RAW 264.7 cells in dose dependent manner, but chlorogenic acid has no anti-inflammatory effects. Conclusions : These findings demonstrated that Sorbi Commixtae Fructus 50% ethanol extract has chondro-protective and anti-inflammatory effects showing possible therapeutics to ease the symptoms related with osteoarthritis.
CFD를 이용한 예배당에서의 COVID-19 집단감염 분석
박동준(Park, Dongjun),강경모(Kang, Kyungmo),김태연(Kim, Taeyeon) 한국생태환경건축학회 2021 한국생태환경건축학회 학술발표대회 논문집 Vol.21 No.2
Recently, there have been serious problems that were caused by the increasing cases of mass infection in public places. This research studies the specific outbreaks that occurred in a religious facility in Korea. CFD analysis uses the droplet nuclei diffusion method of the person who was infected the first. This study proves how indoor natural ventilation affects droplet concentration and airflow pattern. In conclusion, CFD analysis shows that the indoor airflow pattern affects the change in droplet concentration. In addition, natural ventilation reduces the droplet concentration by 21%.
실버세대 및 자율성 저하 노인을 위한 문화매개활동 연구 -프랑스어권 사례를 중심으로
박동준 ( Dongjun Park ) 연세대학교 유럽사회문화연구소 2016 유럽사회문화 Vol.0 No.16
Le guide se rattache au developpement d’approches de mediation culturelle destinees aux aines. Le guide de bonnes pratiques a ete realise dans le territoire de la Monteregie au Canada. Les personnes ainees : de qui parle-t-on? Il n’existe aucun consensus sur la definition d’une personne ainee. Dans une perspective de prevention et afin d’inciter a un vieillissement actif, on a besoin de certains moyens. L’art est en constante interaction avec la societe, la ou se tissent les liens entre politique, culture et espace public. Ce processus de mise en relation entre les spheres de la culture et du social est aussi connu sous le nom de mediation culturelle. On entend par activites de mediation culturelle des initiatives qui facilitent l’appropriation de la culture par les citoyens. Ces actions creent une opportunite de rencontres et d’echanges personnalises favorisant le contact des clienteles avec les oeuvres et les createurs. Elles permettent de faire le pont entre le citoyen et l’offre culturelle professionnelle. Les pratiques et les oeuvres artistiques dont il est question ici sont le fait de professionnels et ne doivent pas etre confondues avec celles relevant des loisirs culturels. Ainsi, les projets de mediation culturelle inities ou portes par des organismes ou des municipalites feront appel a des artistes ou a des travailleurs culturels professionnels. Dans la meme logique, il importe de comprendre la mediation culturelle comme un metier. a mesure que le champ de la mediation se concretise, les formations se developpent. Les mediateurs culturels developpent leurs competences en poursuivant des etudes universitaires ou en acquerant, comme artistes ou travailleurs culturels, une experience professionnelle.
참조 테이블 기반 스칼라 곱 알고리즘에 대한 충돌 특성을 이용한 향상된 수평상관분석
박동준(Dongjun Park),이상엽(Sangyub Lee),조성민(Sungmin Cho),김희석(HeeSeok Kim),홍석희(Seokhie Hong) 한국정보보호학회 2020 정보보호학회논문지 Vol.30 No.2
FBC(Fixed-Base Comb)는 사전계산된 참조 테이블을 활용하여 ECDSA(Elliptic Curve Digital Signature Algorithm) 서명 생성의 핵심 연산인 스칼라 곱을 효율적으로 연산하는 방법이다. FBC는 비밀정보에 의존하여 테이블을 참조하고 테이블의 값은 공개되어 있기 때문에 단일파형 부채널 공격 기법인 수평상관분석(HCA, Horizontal Correlation Analysis)에 의해 그 비밀정보가 드러날 수 있다. 그러나 HCA는 통계 분석의 일종으로 하나의 스칼라 곱 파형으로부터 충분한 수의 단위 연산 파형을 얻을 수 있어야만 공격에 성공할 수 있다. ECDSA 서명 생성에 쓰이는 스칼라 곱의 경우 RSA 거듭제곱에 비해 HCA에 이용 가능한 단위 연산 파형의 수가 현저히 적어 공격에 실패할 수 있다. 본 논문에서는 FBC와 같은 참조 테이블 기반 스칼라 곱에 대하여 향상된 HCA를 제안한다. 제안하는 기법은 충돌 분석으로 중간값이 같은 단위 연산 파형을 식별함으로써 공격에 이용되는 단위 연산 파형의 수를 증가시켜 HCA의 공격 성능을 향상시킨다. 제안하는 기법은 사용된 타원곡선 파라미터의 보안 강도가 높을수록 공격 성능이 향상하는 특징이 있다. The FBC(Fixed-Base Comb) is a method to efficiently operate scalar multiplication, a core operation for signature generations of the ECDSA(Elliptic Curve Digital Signature Algorithm), utilizing precomputed lookup tables. Since the FBC refers to the table depending on the secret information and the values of the table are publicly known, an adversary can perform HCA(Horizontal Correlation Analysis), one of the single trace side channel attacks, to reveal the secret. However, HCA is a statistical analysis that requires a sufficient number of unit operation traces extracted from one scalar multiplication trace for a successful attack. In the case of the scalar multiplication for signature generations of ECDSA, the number of unit operation traces available for HCA is significantly fewer than the case of the RSA exponentiation, possibly resulting in an unsuccessful attack. In this paper, we propose an improved HCA on lookup table based scalar multiplication algorithms such as FBC. The proposed attack improves HCA by increasing the number of unit operation traces by determining such traces for the same intermediate value through collision analysis. The performance of the proposed attack increases as more secure elliptic curve parameters are used.