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원발성 담즙성 경변증 16예의 임상상 : 단일 센터 경험
박동일(Dong Il Park),고광철(Kwang Cheol Koh),이준혁(Jun Hyek Lee),최문석(Moon Seok Choi),강태욱(Tae Wook Kang),문원(Won Moon),류민규(Min Kyoo Ryu),이용욱(Yong Wook Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),장재권(Jae Kwon Jang) 대한내과학회 2000 대한내과학회지 Vol.59 No.6
N/A Background : Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. The disease is relatively common in western countries, but so far, only about 20 cases have been reported in Korea. Thus, the purpose of our prospective study was to evaluate the clinical characteristics of PBC in Korea. Methods : Between October 1994 and February 1999, 16 patients diagnosed as PBC at our department were enrolled in this study. We analyzed these patients for the distribution of age and sex, initial symptoms and signs, associated disorders, laboratory, endoscopic, and radiologic and histologic findings. Results : Of the 16 patients, the ratio of male to female was 1:7 and the average age was 57.5 years. Pruritus (37.5%) was the most frequent presenting symptom followed by xerostomia and xerophthalmia (12.5%), jaundice (6.3%), chronic fatigue (6.3%), melena (6.3%). Associated disorders were Sj gren's syndrome (25%), arthropathy (12.5%), Raynaud's phenomenon (6.3%) and diabetes (6.3%). Abnormalities of liver function were found frequently. Antimitochondrial antibody (100%), antinuclear antibody (31.25%) and rheumatoid factor (31.25%) were found. Long-term administration of UDCA improved both clinical and biochemical signs in most patients, however, 2 patients experienced exacerbation during UDCA therapy. Conclusions : We experienced 16 cases of PBC within a short period. It is expected that we can find these patients more frequently if we suspect this disease in patients with pruritus and unexplained obstructive pattern of liver function abnormality.(Korean. J. Med 59:634-640, 2000)
19세기 남명학파의 동향 일고찰 -월촌(月村) 하달홍(河達弘)의 삶과 교유활동을 중심으로-
박동일 ( Dong Il Park ) 경상대학교 남명학연구소 2014 남명학연구 Vol.44 No.-
月村 河達弘은 19세기 강우지역에서 활동했던 학자이다. 그는 실용 을 중시하는 학문경향을 가지고 南冥 曺植과 謙齋 河弘度를 존숭하며 慕寒齋에서 강학활동을 전개하였다. 이로써 인근의 학자들을 운집시키 고 그들에게 남명학파로서의 의식을 고취시켰다. 이때 月皐 趙性家ㆍ 溪南 崔琡民ㆍ東寮 河載文ㆍ克齋 河憲鎭ㆍ斗山 姜柄周ㆍ尼谷 河應魯 등이 그의 문하에서 종유하였다. 이후 조성가와 최숙민은 하달홍의 인도 아래 보다 체계적인 학문을 위해 노사학단에 나아가 奇正鎭에게 수학하였다. 한편 하재문과 하헌 진은 본거지로 돌아가 寒州 李震相과 교유하였고, 강병주와 하응로는 性齋 許傳에게 나아가 집지하였다. 조성가와 최숙민이 노사학단의 핵심인물로 자리매김한 것에 비해 하재문이 한주학단에서나 강병주가 성재학단에서 차지하는 비중은 그 리 크지 않다. 그러나 이들 모두는 남명을 존숭하고 학문의 실천성을중시하는 남명학파로서의 정체성을 가지고 있었다. 이를 통해 두 가지 사실을 알 수 있는데, 하나는 하달홍의 모한재 강학이 남명학파의 정체성을 확립하는데 큰 역할을 했다는 것과, 다른 하나는 하달홍이 노사학파와 친밀성이 깊다는 점이다. 다시 말해 하달홍은 19세기 하동과 인근 강우지역의 문인들에게 남 명의 학문과 사상을 계승하고 보다 큰 학문을 접할 수 있도록 발판의 역할을 해 주었으며, 이를 통해 그 문인들은 남명학파로서의 정체성을 가지고 각자의 학문을 발전시켜 나갔던 것이다. Ha Dal-hong(河達弘, 1809~1877) was a scholar who worked in the Rainfall Area. He respected Nammyeong(南冥) Jo-Sik(曺植)ㆍ Kyumjae(謙齋) Ha Hongdo(河弘度) besides had a practical academic tendency. And gatherd the young scholars around as inspired the Nam-myoung school``s consciousness. Especially scholars such as Wolko(月皐) Cho Sung-ga(趙性家), Gyenam(溪南) Choi Suk-Min(崔琡民) gatherd there When he was studying at Ha Hongdo``s school Mohanjae(慕寒齋). Since then, Cho Sung-ga and Choi Suk-Min enterd the Nosa School of Ki Jung-jin(奇正鎭) for systematic studying under his leadership. Other scholars enterd the Han-ju School of Yi jin-sang or Sung Jae School of Heo Jeon. Even though they said they had a different academic orientation emphasized the practical academic tendency. And they had a identity as Nam-myoung school``s scholar. So Ha Dal-hong had a great influence in that Rainfall Area``s people had a identity as Nam-myoung school``s scholar, Through this, he receives a rating that succeed to the Ha Hongdo``s learning.
좌측 신주위 ( Perirenal Space ) 에 생긴 췌장가성낭포
박동일(Dong Il Park),오민구(Min Gu Oh) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
Extrapancreatic fluid collection is well known comp1ication of pancreatitis. Involvernent of the left perirenal space is extremely rare and it is often difficult to differentiate from the cystic disease of renal and ureteral origin. We present 1 case of pancreatic pseudocyst which is located at the left perirenal space. We did distal pancreatectomy with splenectomy to disconnect the communicating duct frorn the cyst and the huge cyst was drained externally.
중증 궤양성 대장염에서 치료 성적의 예측인자와 Cyclooxygenase - 2 발현과의 관계
박동일(Dong Il Park),김영호(Young Ho Kim),성인경(In Kyung Sung),이용육(Yong Wook Lee),이준행(Jun Haeng Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),장재권(Jae Kwon Jang),손희정(Hee Jung Son),이풍렬(Poong Lyul Rhee),김재준(Jae J . K 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Background/Aims: Percutaneous endoscopic gastrostomy (PEG) has been widely performed for patients who require prolonged tube feeding support. A retrospective study was conducted to evaluate the complications of PEG and determine the predictors of wound infection. Methods: Medical records of 144 cases of PEG that was per- formed between January 1996 and June 2000 were reviewed to examine the types and frequency of complication, difference in wound infection rates according to age, sex, and underlying diseases. We also analyzed the effects of antibiotics prophylaxis on wound infection and the result of culture from wound infection site. Results: In 28 of 144 PEG cases (19.4%), several complications developed after procedure. Wound infection was the most common complication and occurred in 22 of 144 cases (15.3%) and Pseudomonas aeruginosa was the most common pathogenic microorganism. Other complications included bleeding from gastrostomy site, stomal leaks, and gastroesophageal reflux. There was no statistical difference in wound infection rates according to underlying diseases and antibiotics prophylaxis. However, wound infection developed more frequently in diabetes patients (p<0.05). Old age and underlying diabetes were predictors for developing wound infection after PEG in multiple logistic regression analysis. Conclusions: Old age and DM can be predictors of wound infection associated with PEG. (Korean J Gastroenterol 2001;38:23-28)
위암에서 Cyclooxygenase - 2 와 Inducible Nitric Oxide Synthase 의 발현
박동일(Dong Il Park),이종철(Jong Chul Rhee),손희정(Hee Jung Son),송상용(Sang Yong Song),김영호(Young Ho Kim),이풍렬(Poong Lyul Rhee),김재준(Jae J . Kim),백승운(Seung Woon Paik),최규완(Kyoo Wan Choi),손태성(Tae Sung Son) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
Background/Aims: It has been expected that chronic expression of cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(Inos) may play an important role in gastric carcinogenesis. The purpose of our study was to investigate the role of COX-2 and Inos Mrna expression in gastric carcinogenesis and the correlation between the expression of COX-2 and Inos Mrna in patients with gastric cancer. Methods: Twenty-three gastric carcinoma tissue specimens and their adjacent normal mucosa specimens were obtained from surgical resection. The expression of COX-2 and Inos Mrna were examined by comparative reverse transcriptase-polymerase chain reaction. Results: COX-2 and Inos Mrna were expressed significantly higher in gastric cancer tissues than in adjacent normal tissues. There was a significant correlation between the level of COX-2 and Inos Mrna in carcinoma tissues. There was no significant correlation between the level of COX-2 or Inos Mrna expression and clinicopathological parameters such as tumor size, depth of invasion, differentiation, Laurens classification, lymph node metastasis, perineural and vascular invasion in these patients. Conclusions: The expression of COX-2 and Inos may be one of the factors that contribute to the early stage of gastric carcinogenesis. (Korean J Gastroenterol 2001;38:161-168)
Mongolian gerbil에서 Helicobacter pylori 감염 후 발생되는 Microsatellite Instability에 관한 연구
박동일 ( Dong Il Park ),김민경 ( Min Kyung Kim ),김재준 ( Jae J. Kim ),유태우 ( Tae Woo Yoo ),박정호 ( Jung Ho Park ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),손정일 ( Chung Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( Byung 대한내과학회 2006 대한내과학회지 Vol.71 No.1
목적: H. pylori (HP) 감염성 위염에서 HP는 DNA 손상복구기능에 장애를 유발하여 위 상피세포의 유전자에 발생하는 돌연변이를 축적시켜 위암의 발생 위험을 증가시킬 수 있다. 본 연구는 Mongolian gerbil (MG)animal model을 이용한 in vivo 실험에서 만성적인 HP감염이 위 점막의 MSI를 발생시키는 지 알아보고자 하였다. 방법: 7주된 수컷 MG에 HP CA20 균주를 감염시킨 후 일정한 시점마다 동물을 희생시켜 위를 절제하였다. 위염부위의 위 상피를 미세박리하여 DNA를 추출한 후 Fam이나 Hex로 표지시킨 다섯 가지 gerbil MSI marker를 이용하여 중합효소연쇄반응을 실시한 후 310 genetic analyzer를 이용하여 MSI 분석을 시행하였다. 결과: MSI는 정상부위(식도)에서는 관찰되지 않았고, 위염이 없는 부위에 비해 위염부위에서 빈번히 관찰되었다(p<0.05). 위염부위 중 6예에서는 low level MSI를 1예에서는 high level MSI를 관찰하였다(p<0.05). 결론: 본 연구로 MG에서 만성적인 HP 감염이 MSI유발에 관여함을 입증하였다. 이와 같이 HP는 위상피세포내의 DNA mismatch repair 단백 발현을 저하시켜 위상피세포 유전자에 발생하는 돌연변이의 축적을 유발할 수 있을 것으로 생각한다. Background: During Helicobacter pylori (HP) gastritis, the organisms cause an impairment of DNA repair that results in accumulation of mutations in the genome of epithelial cells and an increased risk of gastric carcinoma. The aim of this study was to determine whether microsatellite instability (MSI) could be induced by chronic HP infection in the Mongolian gerbil model. Methods: Seven-weeks old, specific pathogen-free male Mongolian gerbils were infected with the HP strain CA20. They were sacrificed at the each time points (1, 2, 3, 6, 9, 12 months). Areas of gastritis were carefully microdissected. DNA from tissues was analyzed for the presence of MSI by genomic DNA amplification with five gerbil microsatellite markers per sample. Gerbil markers labelled with Fam or Hex were obtained to perform MSI analysis using the 310 Genetic Analyzer. Results: MSI was more frequent in the area of gastritis than in that of normal (p<0.05). Six showed MSI-low and one showed MSI-high within the area of gastritis (p<0.05). Conclusions: This study shows that chronic HP infection in the Mongolian gerbil induces MSI. This finding indicates that HP infection causes a decrease in DNA MMR proteins in epithelial cells of the stomach that may reach critically low levels, allowing for the accumulation of mutations such as those seen in microsatellite regions.(Korean J Med 71:17-23, 2006)