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Antibiotic chemotherapy of acute pyelonephrihis remains a therapeutic problem. A c h i cal study was done on 20 cases of uncomplicated, bacteriologically poi-en, acute pyelone-phritis who were admitted to the Cepartment of Internal Medicie, Chcng Kam Kanonal University Hospital from July 1081 to January 1982. The cases were evaluated with daily dose of lgm of cefadroxil. Mean duration of administration was 6.7 days. All the organisms were eliminated after zdministration of cefadroxil. The overall mire rate wa3 13C%. Side effects such a s derangement of hepatic, hematologic and renai iilnction mere not found. Though the number of the evaluated patients was small, cefadroxil was thought to be an excellent therapeutic agent for acute pyelonephritis.
In order to develop questionnaire estimating vinyl chloride monomer(VCM) exposure levels, to reset selection criteria for detailed tests, to measure current VCM exposure levels, to evaluate the mutagenic effects of VCM exposures and to develop multiphasic screening method of PVC- or VCM-handing workers, VCM concentrations of work environments were measured and tentaive self-administrative questionaire, physical examination, sister chromatid exchange(SCE) test and some clinical chemical test were applied to 195 men who had been working in factories producing or handing VCM or PVC(Exposed Group) and 37, in the same factories without exposure to VCM or in polyethylene- or polypropylene-related factories(Control Group). Mean VCM concentrations of work environments were 0.268 ±0.183 ppm under PVC synthesis processes, 0.160±0.200 ppm under VCM synthesis processes, 0.076±0.111 ppm under PVC pipe producing processes, 0.090±0.108 ppm under PVC wall paper, sheet, or film producing processes, 0.071±0.051 ppm under PVC floor producing processes, 0.243±0.250 ppm under PVC sash producing processes, and 0.020±0.031 ppm under triming process. VCM levels of work environments under manual resin mixing processes(0.209±0.168 ppm) were higher than those of the others (0.209±0.168 ppm)(p-value<0.05). There was no VCM-related symptoms, the positive response rates of which were higher in the Exposed Group. Overall abnormal rate in clinical chemistry test of the Exposed Group was higher than that of the Control Group, but due to extremely low exposure level of exposure group and to small sample size of the Control Group, no statistical significance was found(p-value>0.05). SCE frequencies of the Exposed Group were significantly higher than those of the Control Group(p-value>0.05) and those of test-abnormal persons were higher than those of test-normal persons. SCE frequencies linearly increased with not only current but also cumulative VCM exposure levels(p-value>0.05). These results suggest that adverse health effect may ensue from VCM exposure to as low as 1 ppm. But SCE frequencies had no statistically correlation with drinking amounts, smoking amounts or radiation dose equivalents. Questinnaire was revised to these results and fomula estimating cumulative VCM exposure levels based on occupational history in questionnaire were made. In addition, were presented methods evaluting work environments and multiphasic screening test for PVC workers.
One hundred twenty six cases of primary hepatic carcinoma who were diagnosed at the Department of Internal Medicine, Chungnam National University Hospital from Jan. 1980 to June 1981 were clinically studied. The results were summerized as follows: 1. Hepatomegaly was observed in 82.5% of patients with primary hepatic carcinoma and it was most frequent abnormal physical finding. 2. The most common abnormality of liver function test was elevated serum alkaline phosphatase(75.4%). 3. The HBsAg were positive in 48.9% of cases and there was no significant difference between age and sex. 4. The elevated serum AFP were observed in 61.1% of cases and in 29.4% of patients, the serum AFP were over 400ng/ml. 5. The cold area on liver scan were observed in almost all cases.
Background: A new tumor marker, TAG-72 has been identified using monoclona] antibody B72.3. It is found in a wide variety of carcinomas but rarely expressed in normal adult tissue and benign lesions. Methods: The presence of TAG-72 in serum samples from patients with gastric carcinoma and benign gastrointestinal disease has been evaluated using the CA72-4 assay. Results: Elevated levels of serum TAG-72 antigen were found in 25(39.1%) of 64 gastric carcinoma patients and none of 32 benign gastrointestinal disease patients. The serum concentrations of TAG-72 were compared to those of CEA. The positive rate of CEA in gastric carcinoma and benign gastroin- testinal disease patients were 37.5% and 9.4%, respectively. These results indicate a preferential expression of TAG-72 compared to CEA in gastric carcinoma patients versus in patients with benign disorder. Combinatinn assay using CA72-4 and CEA RIAs unchanged positive rate(50%, p$gt;0.05). In patients with the more advanced stage of gastric carcinoma revealed the higher positive rate of serum CA72-4 and the levels were increased in all patients with recurrent gastric carcinomo. Conclusions: These results suggest that the measurement of serum CA72-4 in patients with gas1ric carcinoma serve as a complementary role to differentiate the disease from benign gastric lesions and may be useful to predict tbe disease recurrence in postoperative patients.
Background: A new tumor marker, TAG-72 has been identified using monoclonal antibody B72.3. It is found in a wide variety of carcinomas but rarely expressed in normal adult tissue and benign lesions. Methods: The presence of TAG-72 in serum samples from patients with gastric carcinoma and benign gastrointestina1 disease was evaluated using the CA72-4 assay. Results: Elevated levels of serum TAG-72 antigen were found in 2S(39.1%) of 64 gastric carcinona patients and none of 32 benign gastrointestinal disease patients. The serum concentrations of TAG-72 were compared to those of CEA. The positive rate of CEA in gastric carcinoma and benign gastrointestinal disease patients was 37.5% and 9.4%, respectively. These resu]ts indicate a preferential expression of TAG-72 compared to CEA in gastric carcinoma patients versus in patients with a benign disorder. Combination assay using CA72-4 and CEA RIAs unchanged positive rate(50%, p$gt;0.05). Patients with the tnore advanced stage of gastric carcinoma revealed the higher positive rate of serum CA72-4 and the ]evels were increased in all patients with recurrent gastric carcinoma. Conclusions: These results suggest that the measurement of serum CA72-4 in patients with gastric carcinoma serve a complementary role to differentiate the disease from benign gastric lesions and may be useful to predict the disease recurrence in postoperative patients.