학생용 책걸상의 표준규격에 관한 연구

정병용,박경주,Jeong, Byeong-Yong,Park, Gyeong-Ju 대한인간공학회 1986 大韓人間工學會誌 Vol.5 No.1

This study intends to improve the efficiencies of school works by proposing a method of determining the standard sizes of chairs and desks. To achive this purpose, eight measurements were taken of 1248 school children. The main results drawn from this study are : 1. There are significant correlations between stature and popliteal height and between stature and elbow height (seated). 2. There are significant differences between men and women of similar stature in respect of popliteal height. 3. The standard sizes of chairs and desks ought to be based on the characteristics of human body size and their relationship.

구강편평세포암종 세포주에서 유로키나제형 플라스미노젠 활성제 및 제일형 플라스미노젠 활성억제제 발현

유연상(Yeon Sang Yu),천윤권(Yun Gueon Cheon),박경주(Gyeong Ju Park),이종헌(Chong Heon Lee) 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.6

Tumor cell biological factors, such as urokinase plasminogen activator(uPA) and its inhibitor plasminogen activator inhibitor-1(PAI-1) play a role in tumor invasion, metastasis, and proliferation. These factors in patients with primary oral squamous cell carcinoma(Oral SCC) will be evaluated and correlated with clinicopathologic variables. However, relatively rarely has been known in oral squamous cell carcinoma in vivo and in vitro study. The purpose of this study were to investigate the protein expression of uPA and PAI-1 in oral SCC cell lines cell line compared to NHOK and to study migration and adhesion assay. All the cell lines were cultured under KBM bullet kit at 37℃ in a 5% CO2 incubator. We studied a possible association between cytosolic uPA and PA-1 concentrations in oral SCC cell line compared to NHOK using an enzyme-linked immunoassay(ELISA). Cell adhesion and migration assay were done in all the cell lines. In migration assay oral SCC cell lines were about 70 folds higher than NHOK. In adhesion assay oral SCC cell line were about 7-12 folds higher than NHOK. uPA cytosolic concentrations was about 15-19 folds and PAI-1 was 3 to 4.5 folds than that of NHOK. Both uPA and PAI-1 concentrations were correlated with migration and adhesion assay. High cytosolic concentrations of uPA and PAI-1 were correlated with migration and adhesion assay. It suggested that these markers might be specific for oral SCC cell line and these results would be contributed to treatment and prognosis of human oral squamous cell carcinoma.

백서에서 편측 저작이 하악 과두에 미치는 조직 변화와 세포활성에 관한 연구

이동준(Dong Jun Lee),차경석(Kyung Suk Cha),이진우(Jin Woo Lee),박경주(Gyeong Ju Park) 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.6

The aim of this study is to find out histomorphologic change and cellular activity of condyle resulted from unilateral mastication by comparison of cell proliferation and apoptosis activity. 30 adult rats were dived to 15 experimental group and 15 control group randomly. Right upper and lower molars were gently extracted in experimental group, to make unilateral mastication environment. All subjects were sacrificed at 1 week, 2 weeks and 4 weeks by chloroform, and their tissues were prepare to observation. Streptovidin-biotin system for BrdU stanning, was used to determine cellular proliferative activity. TUNEL method was used to determine apoptotic activity. The result for cellular activity was recorded at both of anterior portion and posterior portion of condyle. Hematoxylin and Eosin stanning was used for histiomorphological change. The results were as follows. There were more change in superficial layer than deep layer of condyle in cellular activity. In anterior portion of condyle cartilage, cellular proliferative activity of experimental group was lower than control group and apoptotic activity of experimental group was higher than control group. And apoptotic activity of extracted side in experimental group is the most. In posterior portion of condyle cartilage, cellular proliferative activity of extracted side in experimental group was higher than non-extracted side and control group, And apoptotic activity of extracted side in experimental group was the low. As a result of histomorphological change, there was hyperplasia in posterior region of extracted side condyle in experimental group, but there was no change in unextracted side in experimental group. There was histomorphological hyperplasia in posterior condyle of experimental group as results of high cellular proliferative activity. There was mainly apoptotic change of anterior portion condyle in experimental group. But there was no histomorphologic change. In other words, there was hyperplasia by increasing of cellular proliferative activity in posterior portion of nonfunctional side condyle. In functional side condyle, there was no histomorphological change in functional condyle, but there was change in cellular activity.

치수절단술에 사용되는 약제가 백서 치배 및 치배주위조직세포에 미치는 영향에 관한 ^3H-thymidine을 이용한 자기방사법적인 연구

박경주,이종헌,임창윤 단국대학교 치의학연구소 1992 논문집 Vol.4 No.-

Formocresol(FC) had been widely used as medicament for pulpotomy, but because FC have strong toxicity, carcinogenic potential, and strong diffusible properties in tissues, Glutaraldehyde, another medicament for pulpotomy was greatly presented by many investigators and practitioners. Although many investigators had studied difference of two medicament's effects on periodontal tissues and tooth germ, there were no manuscripts of cellular activity about these medicaments applied to teeth, but there were almost clinical, histopathological studies. Especially in the investigative effects on tooth germ, the results were controversal. Thus to investigate about effects on cellular actiity of perigerminal tissue and tooth germ of rat, author presented the cellular activity and the pathologic change through calculating Thymidine labelling index(TLI) from autoradiographic technique using 3H-thymidine after these medicaments were applied to tooth. The obtained results were as follows. 1. Inflammation was initiated after one week of FC and two weeks of GA. It was thought that diffusible property of GA was lesser than that of FC. 2. In group treated with FC, inflammation, vasodilation and bone destruction continuously increased for all periods of experiment and the feature of 8 weeks was very severe. But in group treated with GA, inflammation, vasodilation and bone destruction slightly incresed for all period of experment. 3. TLI was increased after two weeks of FC, but decreased after four weeks because of different accumulative concentration between 2 and 4 weeks. 4. GA treated group which did not show the change of the cellular activity of perigerminal tissue and tooth germ presented the slight effects on these cells. 5. Changes of cellular activities in FC treated group did not result from inflammation, but formocresole's property itself. And bone destruction was derived from secondary effects of inflammation. 6. The fact that FC arose severe inflammation and change of cellular activity reflected that FC might affected

DMBA유도 햄스터 협낭암종 발생에 관한 조직병리학적연구

박경주 단국대학교 치의학연구소 1994 단국대치의학연구소논문집 Vol.6 No.1

DMBA유도 햄스터 협낭암종 발생에 관한 조직병리학적연구

박경주 단국대학교 치의학연구소 1994 논문집 Vol.6 No.1

After authors used 2-3 months, 150-200gm, male Golden Syrian Hamster 25 and divided control 10, experimental 15, these animals were painted with 0.5% DMBA(9,10-dimethyl-1,2-bezanthracene) 3 times weekly for 12weeks. According to groups, these animals were sacrificed at 2, 6, 8, 12, 16 weeks and were fixed in Carnoy's solution for 2 or 3 hours. And paraffin sections were stained with hematoxyline and eosin, which were examined with light microscope. The results were as follows. 1. Histopathogic findings of 2 week showed mild basilar hyperplasia, inflammatory cell infiltration, acnthosis, hyperchromatism, and moderate keratin and granular cell layer hyperplasia. 2. Histopathogic findings from 6 to 8 week showed moderate basilar hyperplasia, inflammatory cell infiltration acnthosis, and severe keratin and granular cell layer hyperplasia, which was considered as leukoplakia. 3. Histopathogic findings 12 week showed a decreased keratin and granular cell layer hyperplasia, and prominantly increased hyperchromatism, pleomorphism, mitosis and loss of polarity in basal cell layer, and prominant nucleoli, which was considered as carcinoma in situ. 4. Histopathogic findings of 16 week showed mainly exophytic growth, and invasive dysplastic cells, and keratin formation as cancer pearl, which was well differentiated squamous cell carcinoma.