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유방암의 원발 종양 및 전이 림프절의 p53 변이양상 및 MIB-1 Index 비교
민연기(Youn Ki Min),조성진(Seong Jin Cho),김남렬(Nam Ryeol Kim),조민영(Min Young Cho),정석인(Suk In Jung),배정원(Jeong Won Bae),원남희(Nam Hee Won),서성옥(Sung Ock Suh),김영철(Young Chul Kim),구범환(Bum Whan Koo),황정웅(Cheung Wung W 대한외과학회 2001 Annals of Surgical Treatment and Research Vol.61 No.4
한국 유방암 환자의 체질량지수(BMI) 분포 및 부가 치료로서의 호르몬 치료에 미치는 영향
민연기(Youn Ki Min),박중민(Choong Min Park),김완배(Wan Bae Kim),조성진(Sung Jin Cho),김애리(Aeree Kim),김남렬(Nam Ryeol Kim),조민영(Min Young Cho),정석인(Suk In Jung),배정원(Jeoung Won Bae),구범환(Bum Hwan Koo) 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.62 No.4
위 선암종에서의 E-cadherin, $\beta$-catenin 및 c-Met 단백 발현에 대한 연구
조성진,김민경,신봉경,민연기,조민영,서성옥,원남희,채양석,Cho Seong Jin,Kim Min Kyung,Shin Bong Kyung,Min Youn Ki,Cho Min Young,Suh Sung Ock,Won Nam Hee,Chae Yang Seok 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: E-cadherin is an adhesion molecule essential for tight connection between cells, forming the cadherin/catenin complex. Truncated $\beta$-catenin disrupts the interaction between E-cadherin and $\alpha$-catenin, leading to the loss of intercellular adhesion. Met protein, the hepatocyte growth factor receptor, plays important roles in signal transduction. We investigated the relationships between the expressions of E-cadherin, $\beta$-catenin, and c-met protein and the clinicopathological and prognostic parameters in gastric adenocarcinomas. Materials and Methods: The patterns of E-cadherin, $\beta$-catenin, and c-met protein expression were studied using immunohistochemistry in formalin-fixed, paraffin-embedded archival tissues from 76 surgically resected gastric adenocarcinomas. Results: Increased expressions of E-cadherin, $\beta$-catenin, and c-met were more significantly correlated in early gastric cancers (EGC) than in advanced gastric cancers (AGC) (P=0.002, P=0.003 and P=0.026). The positive immunoreactivities of all three markers were markedly lower in signet ring-cell type and poorly differentiated type lesions than in intestinal-type lesions. Decreased expression of the $\beta$-catenin protein correlated well with increased tumor invasion depth (P=0.039), and increased lymph node metastasis correlated well with reduced expression of c-met (P=0.046). Conclusion: In gastric cancers, reduced expressions of the E-cadherin, $\beta$-catenin, and c-met proteins may play some role in poorer tumor differentiation, deeper tumor invasion, and increased lymph node metastasis. Also, the c-met gene is thought to play a specific role in the mechanism of the yet unknown catenin action.