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남성형 탈모증 환자에서 시행한 모속이식술 52예에 대한 치료효과 분석
민복기,황성주,김도원,정상립,김정철,나건연 ( Pok Kee Min,Sung Joo Hwang,Do Won Kim,Sang Lip Chung,Jung Chul Kim,Gun Yoen Na ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5
Background: There have been numerous methods to treat androgenetic alopecia but few methods to treat it effectively and permanently. Objective : The purpose of this study was to evaluate bundle hair grafting as an effective treatment for patients with androgenetic alopecia. Methods : Bundle hair grafiing was performed on 52 patients with androgenetic alopecia who had visited the department of dermatology, Kyungpook National University Hospital and Fatima Hospital. Questionaires regarding cosmetic satisfaction, side effects and general efficacy were recorded by patients themselves one year after hair grafting. Results : The results are as follows : 1. The loss of transplanted hair was most common during the third week(48.1%) after hair grafting. 2. The regrowth of the hair on the recipient site was most common during the 4th month(59.6 %) after the hair graft. 3. Bundle grafting afforded excellent cosmetic satisfaction even after one session in the alopecic area, 4. Facial edema, temporary sensory loss on the donor site, folliculitis and small pitted scarring were seen 19.2%, 5.8%, 1.9% and 3.8% of patients, respectively. 5. The disadvantages were the time necessary to carry out the procedure and the need for an experienced operator and assistants. Conclusion : We concluded that bundle hair grafting was an effective and safe therapeutic method for patients with androgenetic alopecia. (Korean J Dermatol 1997;35(5): 893-901)
피부 표면 온도의 변화와 diffusion chamber내의 온도 변화에 따른 경표피수분손실 및 피부 장벽 회복률의 변동
민복기 ( Pok Kee Min ),김도원 ( Do Won Kim ),전재복 ( Jae Bok Jun ),정상립 ( Sang Lip Chung ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6
Background: The epidermal permeability barrier resides in the intercellular spaces of the stratum corneum and is composed of lipids. Objective : The purpose of this study was to measure the changes of transepidermal water loss (TEWL) and the recovery rate of the epidermal permeability barrier according to the skin surface temperature(SST) using an evaporimeter after tape-stripping in vivo and after treatment with several kinds of solvent in vitro. Methods : In the in vivo study, basal TEWL and SST were measured on both flanks of the neonatal rats consisting of an!.sthetized and non-anesthetized groups. The epidermal barrier was disrupted by repeated tape-strippings which were terminated when the TEWL reached 20-50 gram/m/h. TEWL and SST were measured immediately and 2.5, 6, 10, 24, 48 and 72 hours after tape-stripping. For the in vitro study, sheets of epidermis were separated from the circumcised prepuce, and were pretreated with acetone, petroleum ether or distilled water for 6 minutes. A piece of the separated epid~ermis was placed in a diffusion chamber, and TEWL was measured with an evaporimet,er that was placed onto the top of the chamber over a temperature range of 25 37C in the chamber. Results : In the in vivo study, SST increased according to the elevation of the ambient temperature in neonatal rats with a statistical significance(p<0.05). The recovery rates of both non anesthetized and anesthetized groups increased in the higher SST especially during the first 10 hours. We observed the effect of the temperature in the diffusion chamber on TEWL after treatment with several kinds of solvent in vitro. The data obtained was plotted semi-logarithmically with TEWL as a function of temperature in the chamber, but there was no a statistical difference among the solvent treated grorps. Conclusion. According to the results of the study, SST should be clearly rnentioned in any kind of studies concerning TEWL measurement. Further studies of the relationships between TEWL and SST are needed. ~(Kor J Derrnatol 1996;34(6): 875-885)
소규모 의원의 Joint Commission International 인증: 사례보고
황연수 ( Yeon-soo Hwang ),이혜원 ( Hae Won Lee ),김은희 ( Eun Hee Kim ),민복기 ( Pok-kee Min ) 한국보건정보통계학회(구 한국보건통계학회) 2021 보건정보통계학회지 Vol.46 No.2
목적: 환자의 안전과 의료의 질에 대한 관심이 증가함에 따라 병원 인증이 세계적으로 증가하고 있다. 국제의료기관평가위원회(Joint Commission International, JCI) 인증이 가장 대표적인 병원 국제인증이다. JCI 인증기준에 속하는 광범위한 척도들은 실제적으로 큰 기관들에게 더 유리하다. 그러나, 소규모 의원의 역량에 적합한 JCI 체계를 구축하는 것이 가능하다. 이 사례 보고는 소규모 의원에서의 인증 관련 업무 경험을 요약하고, JCI 인증 전후 기간 동안 외래 환자 진료시에 이러한 인증에서 얻은 교훈을 논의하고자 하였다. 방법: 2016년에 성공적으로 JCI 인증을 받은 한 소규모 의원을 3년 동안 관찰하였다. JCI 인증 업무를 담당한 직원과의 면담을 통하여 자료를 수집하였다. JCI 인증 전후 기간 동안 외래 환자 진료시에 이러한 인증에서 얻은 교훈과 함께, 국제 환자 안전 목표 및 투약관리에 집중하여 연관 경험을 요약하였다. 결과: 인증을 위한 업무과정에 참여하고 3년 동안 후속 관찰한 결과, 이 의원의 환자의 안전 및 의료의 질 개선을 위한 기준 만족 수준이 초기에는 낮았고, 이후 유의하게 개선되었다. 결론: 결론적으로, 이 사례 보고에 따르면, 소규모 의원에서의 JCI 인증으로 관심과 역량이 고취되어 의료의 질을 성공적으로 개선하였다. Objectives: The increased focus on patient safety and quality of health care has continually led hospital accreditation to grow internationally. Joint Commission International (JCI) accreditation is the most representative entity in the international context. The extensive parameters used in JCI accreditation standards make bigger facilities have a greater advantage in practical terms. However, it is possible to establish the JCI framework into a more suitable form for the capacity of smaller medical facilities. This case report aimed to summarize its relevant experiences in a small-scale clinic whilst working on the accreditation, and to discuss the lessons from such interventions in outpatient care during the period of before and after JCI accreditation. Methods: This study with a three-year follow up was conducted in a small-scale local clinic in which JCI accreditation was successfully passed in 2016. Data was collected by conducting interviews with the staff in charge of handling JCI accreditation, and the relevant experiences focusing on international patient safety goals and medication management were summarized, with the lessons from such interventions in outpatient care during the period of before and after JCI accreditation. Results: Participating in the accreditation process and the three-year follow-up analysis revealed that the initial low levels of compliance with standards to improve patient safety and quality of healthcare in this clinic have been much improved. Conclusions: Based on finding of the case report, JCI accreditation in small-scale clinic may enhance its awareness and capacity to achieve successful quality improvement.
나건연 ( Gun Yoen Na ),김용현 ( Young Hyeon Kim ),민복기 ( Pok Kee Min ),황성주 ( Sung Joo Hwang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
A 6-month-old female infant pre~sented with multiple, slightly depressed pea-sized erythematous macules on. the abdomen and the chest since birth, which together with obese, short stature, short neck, and round face suggested Albrights hereditary osteodystrophy(AHO). Some of the lesions were palpable as hard nodules or plaques in deep dermis. After 3 months follow up, the erythem- atous hue faded out, subcutaneous nodules and plaques enlarged. Skin biopsy specirnen demonstrated a bone formation in deep dermis. Serum calcium and phosphorus levels were lower and upper normal ranges, respectively and serum parathyroid hormone was increased in 69.1 pg/ml (normal, 9-55pg/ml). As pseudohypoparathyroidism including this case mostly exhibit characteristic morphologic features of AHO, the subcutaneous ossification may be a presenting feature. (Kor J Dermatol 1996;34(5): 842-846)
Methotrexate로 치료한 타카야수 동맥염에 동반된 괴저성 농피증
김종근 ( Jong Keun Kim ),서준혁 ( Jun Hyuk Seo ),윤준철 ( Jun Cheol Yoon ),박도회 ( Do Hwae Park ),조민재 ( Min Jae Jo ),이찬우 ( Chan Woo Lee ),백애란 ( Ae Lan Paik ),민복기 ( Pok Kee Min ),나건연 ( Gun Yoen Na ),오동호 ( Dong Ho 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
Pyoderma gangrenosum (PG) is a vasculitic process, often associated with systemic diseases, including Takayasu`s arteritis (TA), rheumatoid arthritis, and inflammatory bowel disease. Most cases of PG associated with TA have been observed in Japan. However, this association is not commonly observed in North American and European patients. PG is often refractory to therapy, requiring high dosages of glucocorticoids. Here, we describe a case of recalcitrant PG that was associated with TA and successfully treated with methotrexate.
박찬수 ( Chan Su Park ),서우종 ( Woo Jong Seo ),조영재 ( Yeong Jae Cho ),차경우 ( Kyeung Woo Cha ),이찬우 ( Chan Woo Lee ),오동호 ( Dong Ho Oh ),김태권 ( Tae Gwun Kim ),민복기 ( Pok Kee Min ),김도원 ( Do Won Kim ),장윤환 ( Yun Hwa 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3
Psoriatic arthritis and avascular necrosis of the femoral head each are relatively common diseases. However, avascular necrosis of the femoral head in psoriatic arthritisis extremely rare disease and a few cases have been reported to date. It is suggested that the use of steroids or chemotherapeutic agents, hyperuricemia, alcohol abuse, immunologic disorders, coagulopathies are risk factors of the development of avascular necrosis of the femoral head in psoriatic arthritis. This report describes a 58-year-old female patient without any of forementioned risk factors who underwent total hip replacement for femoral head avascular necrosis associated with psoriatic arthritis.
조영재 ( Young Jae Cho ),이상우 ( Sang Woo Lee ),임성택 ( Seung Taek Lim ),김종근 ( Jong Keun Kim ),김영호 ( Young Ho Kim ),이찬우 ( Chan Woo Lee ),오동호 ( Dong Ho Oh ),민복기 ( Pok Kee Min ),나건연 ( Gun Yoen Na ),박지영 ( Ji Yo 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Sweet`s syndrome is an uncommon reactive dermatosis characterized by fever, poly-morphonuclear leukocytosis, painful erythematous cutaneous plaques and dense dermal infiltrate of neutrophils at the skin lesions. Unlike Sweet`s syndrome associated with patients with malignancies, autoimmune diseases, antecedent infectons-most commonly the upper respiratory infections, it is reported to be rarely associated with systemic lupus erythematosus (SLE). Here we report a rare case of young female with Sweet`s syndrome and SLE presenting with high fever.
메조테라피 약제가 모낭의 기관배양 및 모유두 세포배양에 미치는 효과
이원주 ( Weon Ju Lee ),최윤석 ( Yoon Seok Choe ),이재철 ( Jae Chul Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),민복기 ( Pok Kee Min ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.10
Background: Hair loss including androgenetic alopecia and chronic telogen effluvium is recognized increasingly as a physically and psychologically harmful medical condition. Mesotherapy is considered as a new therapeutic modality for hair loss. Objective: We studied to determine the effect of medications used in mesotherapy on hair organ culture and culture of dermal papilla cells. Methods: First, occipital hair follicles were collected from patients with androgentic alopecia and separated into single hair follicles. The single hair follicles were cultured in William E media mixed with mesotherapy medications such as lidocaine, placental extract, Pondil(R), CRP-1000(R), and mixture of all these medications at different concentrations (1, 10, 50㎕). On the 8th day, the cultured single hairs were stained with H&E and the length of those was measured under a microscope to compare with control group. Immunofluorescent study was performed to check expression of Ki-67, Bcl-2 and Bax on the hairs. Second, dermal papilla cells were isolated from occipital anagen hairs of patients with androgenetic alopecia and cultured in Dulbeco`s modified Eagle`s medium (DMEM). The mesotherapy medicines were added to the medium with one and two thousand dermal papilla cells, respectively. At the 3rd day, survival of the cells was evaluated with ELISA method comparing with control group. Results: There were no statistical differences of the length of the hairs and the survival of the dermal papilla cells between experimental and control groups. With Bcl-2, we couldn`t see any differences between experimental and control groups. With Ki-67, experimental groups showed less expression than control group. On the contrary, experimental groups showed more expression than control group in case of Bax. Conclusion: We can conclude from the results that the four medications used in mesotherapy are not effective for growth of cultured hair follicles and survival of cultured dermal papilla cells. However, more study would be needed for the establishment of objective and scientific evidences supporting mesotherapy and we should be in search for new medications for mesotherapy. (Korean J Dermatol 2006;44(10):1178~1185)