정상인과 요추 추간판 탈출증 환자에서 구두 뒷굽 높이에 따른 요추전만도의 변화

문동철,권영실,송주영,남기원,송주민,김동현,백수정,구현모,최진호,김진상,Moon, Dong-Chul,Kown, Young-Shil,Song, Ju-Young,Nam, Ki-Won,Song, Ju-Min,Kim, Dong-Hyun,Baek, Su-Jeong,Ku, Hyun-Mo,Choi, Jin-Ho,Kim, Jin-Sang 대한물리치료학회 2001 대한물리치료학회지 Vol.13 No.2

The purpose of this study was to evaluate changes of static lumbar lordosis by different heel heights in normal adults and patients with herniation of nucleus pulposus(HNP). The lumbar lordosis was examined while standing on barefoot, on heel support with 4cm heel, and with 8cm heel in 10 normal adults and 10patients with HNP. Standing lumbar lateral view was performed by 20 minutes adaptation with corresponding shoe types. The angle of lumbar lordosis was taken with Wiltse and Winter's method(angles between upper margin of 1 st lumbar body and upper margin of 5th lumbar body). The results of this study were as follow: 1. Significant statistical decrease in lumbar lordosis was observed as heel heights were increased from barefoot to 8cm high heel in normal adults(p<0.05). 2. There were no significant differences in lumbar lordosis according to three different heel heights in patients with HNP(p>0.05). 3. In comparison of barefoot, There were statistically significant decrease in HNP patients compared with normal adults in terms of lumbar lordosis(p<0.05).

엉덩관절 안쪽돌림 조절을 위한 비탄력 테이핑 방법이 엉덩관절 근활성도에 미치는 영향 -예비연구-

배송의,정주현,문동철,Song-Ui Bae,Ju-Hyeon Jung,Dong-Chul Moon 대한고유수용성신경근촉진법학회 2023 PNF and Movement Vol.21 No.3

Purpose: This study investigated the effects of the non-elastic taping method for controlling internal hip joint rotation on internal and external hip rotator muscle activity in healthy people. Methods: In this study, 18 healthy volunteers were instructed to perform the small knee bending (SKB) test. All participants completed the test following two methods (using non-elastic taping and not using taping). Muscle activation during the two methods was measured using a surface electromyography (EMG) device. Surface EMG data were collected from the gluteus medius, gluteus maximus, and tensor fasciae femoris muscles while performing the SKB test with and without non-elastic taping. Results: Muscle activity in the gluteus maximus was significantly higher during the SKB test with non-elastic taping than during the conventional SKB test with taping (p < 0.05). Tensor fasciae latae muscle activity was lower during the SKB test with non-elastic taping than during the conventional SKB test (p < 0.05). Conclusion: The findings suggest that the non-elastic taping method for controlling internal hip joint rotation effectively activates the hip's external rotator muscles and minimizes unwanted internal rotator muscle use during the SKB test. Therefore, the non-elastic taping method for controlling internal hip joint rotation could be an effective intervention for those who cannot control the internal rotation of their hips.

유연성 평발에 적용한 로우다이 테이핑에 의한 균형 수행력의 변화

엄주리 ( Ju Ri Eom ),문동철 ( Dong Chul Moon ),김종순 ( Jong Soon Kim ) 대한물리의학회 2014 대한물리의학회지 Vol.9 No.4

PURPOSE: The purpose of this study was to determine the immediate effect of low-dye taping on balance performance in subjects with flexible flatfoot. METHODS: Fifteen asymptomatic volunteers who had flexible flatfoot (age, 21.7±1.81years; height, 164.80±7.57cm;weight, 56.47±10.48kg) were participated for this study. Navicular drop test was used to evaluate pronation of foot in three different conditions; non-weight bearing position without low-dye taping, weight bearing position without low-dye taping, weight bearing position with low-dye taping. And balance performance (anterio/ posterior, medial/lateral, and overall) was evaluated using the Biodex Balance System in three different conditions; one-leg standing without low-dye taping, one-leg standing with low-dye taping, and one-leg standing with low-dye taping in one week later. Repeated-measures analysis of variance (ANOVA) was used to assess navicular height and balance performance across the three testing conditions. RESULTS: Significant and clinically meaningful improvement in navicular height was found after application of the low-dye taping. However, there was no statistically significant change in balance performance. CONCLUSION: The results of this study provide evidence to suggest that low-dye taping does not affect balance performance.

폐암에서 microRNA 155의 발현 양상과 임상병리학적 의의

김미경(Mi Kyeong Kim),문동철(Dong Chul Moon),현혜진(Hye Jin Hyun),김종식(Jong-Sik Kim),최태진(Choi Tae Jin),정상봉(Sang Bong Jung) 한국생명과학회 2016 생명과학회지 Vol.26 No.9

폐암은 전세계적으로 높은 발병율과 사망률을 보이는 암종으로 소세포암종과 비소세포암종으로 구분되어지며, 비소세포암이 75-80%를 차지하고 있다. miR-155의 유전자의 과 발현은 갑상선암, 유방암, 대장암, 자궁 경부암, 췌장선암(PDAC), 폐암 등의 고형암에서 관찰된다. 본 연구에서는 한국인 폐암 환자의 조직에서 특이적으로 발현되는 miRNA의 양상을 양성 폐질환자 와 비교 분석하고, 폐암환자의 임상병리학적 특성과의 상관성을 분석하여 miRNA가 암 진단의 생물표지자로서의 가능성을 조사하여 향후 암의 조기 진단 및 치료, 예후 연구에 기초 자료를 제공하고자 하였다. 파라핀 포매 된 비소세포폐암환자 및 양성 폐 질환자의 블록에서 total RN를의 분리하여, 정량 실시간연쇄중합반응을 통해 miR-155의 발현량을 정량 분석을 실시하였으며, miR-155의 발현과 폐암환자의 임상적 특징과의 상관관계를 분석하였다. 폐암 환자군과 양성 폐질환자의 miR-155의 △Ct 값을 분석한 결과 폐암 환자군에서 유의하게 높게 발현되었다(p<0.001). 병리조직학적 분류에 따라서는 편평상피세포암종에서 선암종에 비해 높게 발현되었다. 분화도에 따라서는 저분화 암에서 고분화암에 비해 유의하게 높게 발현되었다(p=<0.001). 또한 miR-155의 과발현은 림프절 전이와도 통계적으로 유의성 나타내었다(p<0.05). 생존분석결과 miR-155의 과발현은 폐암환자의 생존률과 유의한 상관관계를 나타내었다(p<0.05). 본 연구의 결과로 miR-155의 발현은 폐암의 진행 및 전이에 중요한 역할을 할 것으로 생각되며, 폐암의 조기진단과 예후의 예측을 위하여 보다 다양한 종류의 miRNAs에 대한 연구가 이루어져야 할 것으로 판단된다. Lung cancer is currently the most common malignant disease and the leading cause of mortality in the world and non-small cell lung cancer (NSCLC) accounts for 75-80% of lung cancer cases. miR-155 gene was found to be over expressed in several solid tumors, such as thyroid carcinoma, breast cancer, colon cancer, cervical cancer, pancreatic ductal adenocarcinoma (PDAC) and lung cancer. The aims of this study were to define the expression of miR-155 in lung cancer and its associated clinic-pathologic characteristics. Total RNA was purified from formalin-fixed, paraffin-embedded NSCLC tissues and benign lung tissues. Expression of miR-155 in human lung cancer tissues were evaluated as mean fold changes of miR-155 in cancer tissues compared to benign lung tissues by quantitative real-time reverse transcriptase polymerase chain reaction (real-time qRT-PCR) and associations of miR-155 expression with clinic-pathologic findings of cancer. Compared with the benign control group, miR-155 expression was significantly overexpressed in NSCLCs (p=<0.001). miR-155 was more overexpressed in squamous cell carcinoma than in adenocarcinoma. Poorly differentiated tumors showed significantly overexpression of miR-155 than well-differentiated tumors (p=<0.001). Overexpression of miR-155 was significantly associated with lymph node metastasis (p=<0.05). In survival analysis for all NSCLC patients, high miR-155 expression was significantly correlated with worse overall survival (p=<0.05). These results suggested that miR-155 might play an important role in lung cancer progression and metastasis.

근막이완기법에 의한 유연성 및 혈장 카테콜라민의 변화

김종순(Jong-Soon Kim),문동철(Dong-Chul Moon),장경수(Kyung-Soo Chang) 한국콘텐츠학회 2012 한국콘텐츠학회논문지 Vol.12 No.3

최근 일부 연구자에 의해 근막의 자율신경지배가 보고되고 있다. 그러나 근막이완술의 효과에 대한 신경생리학적 설명과 근거는 없는 실정이다. 이에 본 연구의 목적은 근막이완술에 의해 자율신경계의 흥분이 변화될 수 있는지의 여부를 알아보고자 하였다. 본 연구에서는 건강한 20대 피검자 30명을 15명씩 무작위로 근막이완술군(MG)과 위약대조군(PCG)로 배치하였다. 근막이완술군으로 배정된 피검자들에게는 치료대에 바로 누운 자세에서 두개 기저부 이완기법(cranial base release)을 5분간 적용하였고 위약대조군으로 배정된 피검자들은 같은 자세와 절차를 거치지만 실제 근막이완술을 적용하지 않는 위약 치료를 적용하였다. 근육의 유연성은 경부의 관절가동범위로 측정하였으며 자율신경계의 변화는 심박수, 혈압 그리고 에피네프린과 노르에피네프린의 수치로 측정하였다. 본 연구의 결과는 다음과 같다. 1. 근막이완술군에서 신전과 측방굴곡의 가동범위 변화율이 유의하게 증가하였다. 2. 심박수와 혈압, 그리고 에피네프린의 변화율은 두 군간 유의한 차이가 없었다. 3. 노르에피네프린의 변화율은 두 군간 유의한 차이가 있었다. 본 연구의 결과 근막이완술이 자율신경계의 흥분을 변화 시킬 수 있다는 근거는 없었다. In recent years, some researchers reported that myofascia was innervated by the autonomic nervous system. However, there is no neurophysiological explanation and evidence for the effects of myofascial release(MFR). Thus, the aim of this study was to determine whether the excitability of the autonomic nervous system is modulated by MFR. In this study, thirty healthy subjects in their 20s were randomly assigned to a myofascial release group(MG) and a placebo control group(PCG); each group had 15 subjects. The MG conducted 5 minutes of cranial base release in supine position, and the PCG performed sham cranial base release. Muscle flexibility was measured with the neck range of motion and the changes of the autonomic nervous system excitability was measured by heart rate, blood pressure, and concentration of plasma epinephrine and norepinephrine. The results were as follows: 1. The percentage changes in the cervical range of motion for extension and side flexion were significantly increased in the MG, signifying that more muscle relaxation. 2. There was no significant percentage changes in heart rate, blood pressure, and concentration plasma epinephrine between MG and PCG. 3. The percentage change in concentration plasma norepinephrine was significantly different between MG and PCG. The result of this study suggests that there is no evidence that MFR can modulate the autonomic nervous system excitability.

혼합용매중(混合溶媒中)에서의 식용(食用) Tar색소(色素)의 해리정수(解離定數)에 관(關)한 연구(硏究) (제 1 보)(第 1 報) -2',4',5',7'- Tetraiodofluorescein Sodium염(鹽)에 대(對)하여-

김박광,이민화,조영미,김길수,문동철,Kim, Bak-Kwang,Lee, Min-Hwa,Cho, Young-Mee,Kim, Kil-Su,Moon, Dong-Chul 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.3

The dissociation constant of erythrosine in the mixed solvent systems of water-alcohols and water-acetone at various pH and in concentration media were determined by spectrophotometric method. Methanol, ethanol, and acetone were employed as solvents and studied the changes of pK values of erythrosine according to the kind and change of concentration of organic solvent which is mixed into water solution. The effect of organic solvent on pK is negligible at 40% while in the case of above 40% mixing, it is not negligible.

척수 운동신경원의 기능과 관련된 생존운동신경원 단백질의 역할

송주영,권영실,남기원,송주민,김동현,김석범,문동철,최진호,김진상,Song, Ju-Young,Kown, Young-Shil,Nam, Ki-Won,Song, Ju-Min,Kim, Dong-Hyun,Kim, Suk-Bum,Moon, Dong-Chul,Choi, Ji-Ho,Kim, Jin-Sang 대한물리치료학회 2001 대한물리치료학회지 Vol.13 No.2

This review highlights the ontogenesis and the differentiation of motor neuron in spinal cord, and introduce the survival motor neuron(SMN) which is associated with growth and survival of motor neurons. The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord. This signal is Sonic hedgehog(Shh). The early development of motor neurons involves the inductive action of Shh. The SMN gene is essential for embryonic viability. SMN mRNA is also expressed in virtually all cell types in spinal cord, including large motor neurons. The SMN protein is involved in RNA processing and during early embryonic development is necessary fer cell survival. Two SMN genes are present in 5q 13 in humans: the telomeric gene(SMNt), which is the SMA-determining gene, and the centromeric analog gene(SMNc). The majority of transcripts from the SMNt gene are full length but, major transcripts of the SMNc gene have a high degrees of alternative splicing and tend to have little or no exon 7. The SMN is involved in the RNA processing(the biogenesis of snRNPs and pre-mRNA splicing), the anti-apoptotic effects, and regulating gene expression.

약물과 PVC Infusion Bag과의 상호작용

한건(Kun Han),조영화(Young Hwa Cho),문동철(Dong Chul Moon) 대한약학회 1989 약학회지 Vol.33 No.4

Twenty-six injectable drug products, many of which are administered by i.v. infusion, were studied for loss from aqueous solutions stored in polyvinyl chloride (PVC) infusion bags for various periods of time. The PVC infusion bags were stored in the dark room at room temperature for up to one month. Drugs stored in glass bottle served as controls. The solutions were assayed Spectrophotometrically at regular intervals. The effect of drug concentration and pH on the loss of drug from solution were studied. Octanol-water partition coefficients were used as a guage of lipid solubility of drugs. The elution of di(2-ethylhexyl)phthalate(DEHT) from PVC infusion bags was studied. For most of the drug studied, minimal loss from the aqueous solutions were observed over periods of storage time. Six of the drug products - Thiopental sodium, Hydralazine HCl, Thioridazine HCl, Trifluoperazine 2HCl, Metronidazole, Chlorpromazine HCl - were found to be lost a substantial extent. DEHP was found to be migrating from PVC infusion bags.

근전도 바이오피드백을 이용한 숏 풋 운동이 정적으로 선 자세 동안 발의 안쪽 세로활 유지에 미치는 영향

차상민(Sang-min Cha),강민혁(Min-hyeok Kang),문동철(Dong-chul Moon),오재섭(Jae-seop Oh) 한국전문물리치료학회 2017 한국전문물리치료학회지 Vol.24 No.1

Background: Short foot exercise (SFex) is often prescribed and performed in the sport and rehabilitation fields to strengthen intrinsic foot muscles. However, SFex is difficult to perform because of lack of feedback methods. Objects: The aim of this study was to compare the effects of SFex with and without electromyography (EMG) biofeedback on the medial longitudinal arch (MLA) of healthy individuals who maintained a static standing position. Methods: All participants (14 males and 12 females) were randomly divided into two groups(biofeedback and non-biofeedback groups). The EMG activity of the abductor hallucis (AbdH) and tibialis anterior (TA) and the MLA angle on the dominant leg side were measured with the participant in the standing position in the pre- and post-intervention conditions. The intervention session consisted of 15 minutes of SFex with (biofeedback group) or without (non-biofeedback group) EMG biofeedback. The groups were compared using two-way repeated measures analysis of variance. Results: The post-intervention activities of the AbdH muscle (p<.05) and the AbdH/TA ratio (p<.05) were significantly greater in the biofeedback group than in the non-biofeedback group. The activity of the TA (p<.05) and the MLA angle (p<.05) in the biofeedback group were significantly lower in the post-intervention condition than in the pre-intervention condition. Conclusion: The present findings demonstrate that the combination of SFex and EMG biofeedback can effectively facilitate the muscle activity of the AbdH and strengthen the medial longitudinal arch.

식품 중 프로필렌글리콜의 분석법 개발

김희연(Hee-Yun Kim),홍기형(Ki-Hyoung Hong),최장덕(Jang-Duck Choi),박성관(Sung-Kwan Park),정시섭(Si-Sub Jung),최우정(Woo-Jeong Choi),이신호(Shin-Ho Lee),문동철(Dong-Chul Moon) 한국식품과학회 2005 한국식품과학회지 Vol.37 No.6