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고령층 특성을 반영한 실감 영상 콘텐츠 개발: 멀티 디스플레이 영상 구현을 중심으로
문대혁,Dae-Hyuk Moon 대한산업경영학회 2023 산업융합연구 Vol.21 No.7
노인을 위한 문화·여가 활동 서비스에 대한 수요는 늘어나고 있다. 대표적인 문화·여가 활동 중 TV 방송과 온라인 미디어 시청은 빠르게 늘어나고 있으며 실감 영상을 이용한 양질의 서비스 요구도 커지고 있다. 고해상도 디스플레이 장치는 대중화 되어 가격이 예전에 비해 저렴해지고 있으며 다면 영상 구현을 위한 하드웨어도 쉽게 구성할 수 있다. 하지만 노인의 신체적, 정신적 특성이 반영된 고해상도 다면 영상은 보기 쉽지 않다. 이번 연구는 고령층 노인인구를 대상으로 멀티스크린을 이용한 콘텐츠 제작 모델과 접근성이 가능한 촬영 방법을 제시하였다. 본 연구를 바탕으로 실감 영상 기술을 활용한 노인 문화·여가 활동을 위한 다양한 콘텐츠를 적극적으로 개발함으로써 고령 친화 산업 육성에 크게 이바지할 수 있을 것으로 기대한다.
역전사 중합효소 연쇄반응 ( RT-PCR ) 에 의한 HCV-RNA 의 검출 Biotin 및 방사성옥소 표지 Primer 로 구성된 Kit 의 이용
문대혁(Dae Hyuk Moon),류진숙(Jin Sook Ryu),이영상(Young Sang Lee),정영화(Young Hwa Chung),천준홍(Jun Hong Cheon),정윤영(Yoon Young Chung),박흥동(Hung Dong Park) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.2
N/A This study was performed to evaiuate the clinical applicability of the reverse t.ranscription polymerase chain reaction (RT-PCR) kit of HCV-RNA using biotinylated and radioiodinat.ed primers. Study subjects were 118 patients with positive anti-HCV. HCV-RNA in patient.s serurn was ext.racted by guanidium thiocyanate method. After first amplification, the product. was reamplified by primers labelled with biotin and I-125. The final amplification product was de- tected by counting t,he radioactivity after incubation in avidin coated tubes. In 51 samples, t.he test was repeated for evaluation of reproducibility. This new method was also compared with conventional RT-PCR rnethods in 34 samples from patients with chronic liver disease. The results were as follows, 1) HCV-RNA was positive in 85(97%)of 88 patients with chronic liver disease, and in 23 (73%) of 30 pat.ients with normal liver function. 2) In comparison with conventional method, HCV-RNA was detected in 32(94%) of 34 patient.s with new method, whereas in 27(79% ) of the same group with conventional method, 3) Repeated test with new rnet.hod in 52 samples demonstrat.ed 82% of concordant result. In conclusion, new rnethod with biotinylated and radioiodinated primers was rnore sensitive than conventional method. However, great care must be taken for quality control because there were considerable interassay variat,ion and possiblity of false positivity and false negativity.
급성 및 간헐성 총담관폐쇄에서의 99mTc - DISIDA 간담도 스캔의 진단적 가치
문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee),김명환(Myung Hwan Kim),이영상(Young Sang Lee),민영일(Young Il Min) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A We examined patients with suspected acute or intermittent biliary obstruction using hepatobiliary scintigraphy, ultrasonography and contrast cholangiography. Of 16 patients with confirmed common bile duct obstruction, sonography and scintigraphy disagreed in 8(50%). Scintigraphy revealed partial or complete common bile duct obstruction in 13 patients (81.3%) and 6 of them had no evidence of dilated biliary trees. It is concluded that disagree, ment between sonography and scintigraphy is not rare in patients with acute or intermittent biliary obstruction and hepatobiliary scintigraphy is useful in diagnosing obstruction prior to ductal dilatation.
Tc-99m DISIDA 간담도 신티그라피에서 간 실질의 분절형 배설지연의 임상적 의의
문대혁(Dae Hyuk Moon),이희경(Hee Kyung Lee),류진숙(Jin Sook Ryu),김명환(Myung Hwan Kim),이성구(Sung Koo Lee),강도영(Do Young Kang) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2
N/A Purpose: Segmental parenchymal excretion delay on Tc-99m DISIDA scan is caused by intrahepatic bile duct obstruction. However, the diagmostic value for intrahepatic bile duct obstruction is unknown. We conducted this study to assess the positive predictive value of segmental excretiom delay for the diagnosis of intrahepatic bile duct obstruction, and additional benefit over other noninvasive radiologic studies. Materials and Methods: The study population consisted of 43 patients (48 scans) Who showed segmental parenchymal excretion delay on Tc-99m DISIDA scan. The results of abdominal CT or ultrasonography, which was done within 1 month of Tc-99m DISIDA scan, were compared with scintigraphic findings. Results: The etiology of segmental parenchymal excretion delay was determined by ERC or PTC in 31 scans, and follow-up studies in 13 scans. No causes were identified in 4 scans. The positive predictive value of segmental parenchymal excretion delay for intrahepatic bile duct obstruction was 92% (44/48). On the other hand, 13% (5/38) of CT and 28% (5/18) of ultrasonography were normal. In 18% (7/38) of CT and 17% (3/18) of ultrasonography, only intraheipatic bile duct dilatation was noted without any diagnostic findings of intrahepatic bile duct obstruction. Conclusion: Segmental parenchymal excretion delay on Tc-99rn DISIDA scan had a high positive predictive value for the diagnosis of intrahepatic bile duct obstruction. Tc-99m DISIDA scan may be useful for the diagnosis of intrahepatic bile duct obstruction, especially in patients with nondiagnostic CT or ultrasonography. The diagnostic usefulness need to be confirmed by further prospective studies. KW: Tc-99m DISIDA, Segmental parenchymal excretion delay, Intrahepatic bile duct obstruction.
신장 이식후에 발생한 무혈관성 골괴사 - 발생 빈도 및 골 SPECT의 유용성에 관하여 -
문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),최윤영(Yun Young Choi),이희경(Hee Kyung Lee),류진숙(Jin Sook Ryu) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.4
N/A Avascular necrosis(AVN) of bone can be resulted from various causes that distrub vascular supply to bone tissue, includinrg steroid therapy after renal transplantation. In this study, we determine the prevalence of the avascular necrosis of bone after renal transplantation and compare the role of the bone scan, SPECT and MRI. In 301 patients with transplanted kidney, the prevalence of avascular necrosis was determined clinically. Site of bone necrosis was evaluated by clinical symptom, bone scan, SPECT and MRI. Bone scan was done in all patients with AVN. Bone SPECT and MRI were done in six cases; and MRI was done in two cases. The prevalence of AVN was 3.3% (10/301), and the site of AVN was 16 femoral heads in 10 patients (bilateral: 60%) and bilateral calcaneal tuberosity in one patient. Bone scan showed typical AVN (cold area with surrounding hot uptake) in 13 lesions, only hot uptake in three lesions (including two calcaneal tuberosities), decreased uptake in one lesion, and normal in one lesion. Decreased uptake and normal lesion showed an equivacal cold area without surrounding hot uptake on SPECT. A symptomatic patient with positive bone SPECT showed normal finding on MRI. The prevalence of AVN of bone after renal transplantation was 3.3%, and whole body bone scan showed multiple bone involvement. Two symptomatic hip joints without definite lesion on whole body bone scan or MRI showed cold defect on SPECT. Threfore, we conclude that bone SPECT should be perfomed in a symptomatic patient with negative bone scan or MRI in case with high risk of AVN after renal transplantation.
뇌종양의 재발과 방사선 괴사의 감별을 위한 탈륨 SPECT의 역할
문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),이정교(Jung Kyo Lee),권병덕(Byung Duk Kwun) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4
N/A Following radiation therapy for brain tumors, patients often have clinical deterioration due to either radiation necrosis or recurrent tumor progression in the treatment field. The distinction between these entities is important but difficult clinically or even with CT or MRI. T1-201 has been known to accumulate in various tumors and be useful to grade, predict prognosis or detect recurrence of glioma. The aim of this study was to evaluate the usefulness of T1-201 SPECT in the differentiation of recurrent tumor from radiation necrosis. Of 67 patients who did T1-201 brain SPECT imaging with clinically suspected recurrent tumor or radiation necrosis, 20 patients underwent histopathological examination and constituted the study population. T1-201 uptake indices on T1-201 brain SPECT imaging were calculated and correlated with histopathological diagnosis. Of 20 patients, 15 were histopathologically confirmed as recurrent original tumor or malignant transformation of benign tumor and 5 were diagnosed as radiation necrosis. On T1-201 SPECT, 18 of 20 had T1-201 index above 2.5 which was regarded as positive indicator for the presence of tumor. Seventeen cases showed concordance, which consisted of 15 true positive and 2 true negative. Discordant 3 cases were all false positive. There was no case of false negative. The sensitivity, specificity, positive and negative predictive value of T1-201 SPECT were 100%, 40%, 83% and 100%. In conclusion, T1-201 brain SPECT is a sensitive diagnostic test in the detection of recurrent tumor following radiation therapy and is useful in the differentiation of recurrent tumor from radiation necrosis. Relatively low specificity should be evaluated further in larger number of patients in consideration of sampling error and referral bias for pathologic examination.
문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee),김명환(Myung Hwan Kim),민영일(Young Il Min),석재동(Jae Dong Suk) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1
N/A Extracorporeal shock vave lithotripsy (ESWI.) with adjunctive oral ]itholytic therapy has proven to be a useful treatment in selected patients with gallbladder stones. To study the effect of ESWL on gillbladder dynamics, 99mTc-DISIDA hepatobiliary scintigraphy was done for 25 patients with symptomatic gallstones and 10 norrnal controls. Of these 25 patients, 15 were treated with ESWL and adjunctive oral litholytic agents (ESWL group) and 10 were treated only with oral litholytic agents (UDCA group). After overnight fast and gallbladder visualization on a routine hepatobiliary scintigra- phy with 7mCi of 99mTc-DISIDA, subjects were given fatty meal and imaged with a gamma camera interfaced to a computer (I frame/minute for i0minutes). A galibladder time-activity curve was generated and latent period (LP), ejection period (EP), ejection fraction (EF) ancl ejection rate (ER) v,ere calcutated, ESWL group were studied before, lday after and 2weeks after ESWL, and UDCA group were studied before and 2weeks after starting oral medication Mean basal EF was significantly reduced in patients but other parameters were not reduced. In ESlVL group, mean EF and mean ER at 1day after ESWL were reduced. In 3 of them, gallbladder was not visualized at all. Two weeks after ESWL, however, all parameters were recoverd to basal level. In UDCA group, all parameters were not changed significantly during medication. We can conclude that ESWL has such immediate adverse effect on gallbladder dynamics as reducing contractility ancl nonvisuaiization of gallbladder but it has no long-term effect.
자발생 두개내 저압 환자의 방사성 동위원소 뇌조조영술 소견
문대혁(Dae Hyuk Moon),이희경(Hee Kyung Lee),류진숙(Jin Sook Ryu),신중우(Jung Woo Shin),정동진(Dong Jin Jung),김재승(Jae Seung Kim),임주혁(Joo Hyuk Im),이명종(Myoung Chong Lee),정선주(Sun Joo Jung) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.6
N/A Purpose: Radionuclide cisternography may be helpful in understanding pathophysiology of postural headache and low CSF pressure in patients with spontaneous intracranial hypotension. The purpose of this study was to characterize radionuclide cisternographic findings of spontaneous intracranial hypotension. Materials and Methods: The study population consists of 15 patients with spontaneous intracranial hypotension. Diagnosis was based on their clinical symptoms and results of lumbar puncture. All patients underwent radionuclide cisternography following injection of 111 to 222 MBq of Tc-99m DTPA into the lumbar subarachnoid space. Sequential images were obtained between 1/2 hour and 24 hour after the injection of Tc-99m DTPA. Radioactivity of the bladder, soft tissue uptake, migration of radionuclide in the subarachnoid space, and extradural leakage of radionuclide were evaluated according to the scan time. Results: Radionuclide cisternogram showed delayed migration of radionuclide into the cerebral convexity (14/15), increased soft tissue uptake (11/15), and early visualization of bladder activity at 30 min (6/10) and 2 hr (13/13). Cisternography also demonstrated leakage site of CSF in 4 cases and 2 of these were depicted at 30 min. Epidural blood patch was done in 11 patients and headache was improved in all cases. Conclusion: The characterstic findings of spontaneous intracranial hypotension were delayed migration of radionuclide and early visualization of the soft tissue and bladder activity. These scintigraphic findings suggest that CSF leakage rather than increased CSF absorption or decreased production may be the main pathophysiology of spontaneous intracranial hypotension. Early and multiple imaging including the bladder and soft tissue is required to observe the entire dynamics of radionuclide migration.