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김혜윰,리향,이윤정,서환호,조남근,강대길,이호섭,Kim, Hye-Yoom,Li, Xiang,Lee, Yun-Jeong,Seo, Hwan-Ho,Cho, Nam-Geun,Kang, Dae-Gill,Lee, Ho-Sub 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The vasorelaxant effect of an extract of Lophatherum gracile Brongn (ELB) and its possible action mechanism were ascertained in aortic tissues isolated from rats. ELB relaxed endothelium-intact thoracic aorta in a dose-dependent manner. However, the induced vascular relaxation was abolished by removal in endothelium of the thoracic aorta. Pretreatment of endothelium-intact vascular tissues with $N^G$-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-$\alpha$]-quinoxalin-1-one (ODQ) significantly inhibited vascular relaxation induced by ELB. Moreover, ELB significantly increased cGMP production in aortic tissues, which was blocked by pretreatment with L-NAME or ODQ. The vasorelaxant effect of ELB was attenuated by tetraethylammonium (TEA), and glibenclamide. ELB-induced vasorelaxation was not blocked by atropine, propranolol, indomethacin, verapamil, and diltiazem. Taken together, the present study demonstrates that ELB dilates vascular smooth muscle via an endothelium-dependent NO-cGMP signaling pathway, which may be at least in part related with the function of $K^+$ channels.
다층 건물을 위한 Wi-Fi 기반의 저 복잡도 층간 위치 측위 기법
석건(Jian Shi),리향(Xiang Li),정홍규(Honggyu Jung),김진오(Jinoh Kim),신요안(Yoan Shin) 대한기계학회 2014 大韓機械學會論文集A Vol.38 No.2
최근 들어, 다층 건물 내 층간 위치 측위(Floor Determination)는 다양한 위치 기반 응용 서비스를 만족하기 위해 빠르게 해결해야 되는 문제가 되었다. 본 논문에서는 다층 건물 환경에서 Wi-Fi 신호를 기반으로 한 저복잡도 층간 위치 측위 기법을 제안한다. 제안 기법에서는 WAP(Wireless Access Point)에 대한 자세한 좌표 정보가 필요 없이, 사용자 단말기에 나온 각 WAP 의 층수와 각 WAP 의 수신 신호세기(Received Signal Strength) 값만을 이용한다. 제안 기법의 성능을 검증하기 위해 본 논문에서는 Multi-Wall-Floor 모델을 사용하였으며, 모의실험 결과를 통해 각층의 WAP 배치 밀도가 충분히 높을 경우 제안 기법의 정확도가 100%에 도달함을 보였다. 그리고 각층의 WAP 수가 적은 경우에서도 우수한 층간 위치 측위 성능을 보였으며, 특히 심지어 WAP 가 하나도 없는 층이 있어도 층간 위치 측위가 가능한 것을 보임으로써 제안된 기법의 우수성을 확인하였다. Floor number determination has attracted considerable attention because many applications require accurate floor number information for providing better localization services in multistory buildings. This paper describes a Wi-Fi-based, low-complexity floor number determination method for multistory buildings. In our scheme, with the exception of floor ID and received signal strength of each WAP, detailed information on the wireless access point(WAP) coordinates is not needed. The multi-wall-floor model is used for the simulation and analysis. The simulation results show that the floor determination accuracy is nearly 100 given an adequate deployment density of WAPs on each floor. The results also show that the proposed method provides a good estimate of floor number even when only a few WAPs are implemented on each floor. Specifically, the proposed method can work under extreme conditions, i.e., where there are no WAPs on a floor.
고지방 식이로 유도된 당뇨병성 죽상경화 마우스 모델에서 밀몽화의 효능 연구
황선미 ( Sun Mi Hwang ),이윤정 ( Yun Jung Lee ),김은주 ( Eun Ju Kim ),김혜윰 ( Hye Yoom Kim ),리향 ( Xiang Li ),최용준 ( Yong Jun Choi ),조남근 ( Nam Geun Cho ),이호섭 ( Ho Sub Lee ),강대길 ( Dae Gill Kang ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.4
Objectives: This study was designed to investigate the effects of an aqueous extract from Buddleja officinalis Maxim (ABO) on vascular dysfunction in low-density lipoprotein receptor deficient (LDLr KO) mice. Methods: Present study showed that LDLr KO mice were fed a high fat diet consisting of 60 kcal% fat, with or without 200 mg/day/kg ABO of diet, for 14 weeks. Results: High fat diet-LDLr KO mice were treated with ABO were completely normalized by lowering glucose. ABO reduced intima/media thickness in a high fat diet-LDLr KO mice without affecting plasma cholesterol and triglyceride levels. ABO caused endothelium-dependent relaxation in the acetylcholine-precontracted aorta of high fat diet-LDLr KO mice. ABO increased eNOS expression, while decreased cell adhesion molecules expression in high fat diet-LDLr KO mice. Conclusions: In conclusion, chronic treatment with ABO improved hyperglycemia and endothelium-dependent vascular relaxation as well as exhibited anti-inflammatory effect in diabetic atherosclerotic mouse model, independent of effects on plasma lipids.