원격 치매 조기 진단 시스템 설계

최종명,전경숙,김선경,최정민,류동영,윤숙,Choi, Jongmyung,Jeon, Gyeong-Suk,Kim, Sunkyung,Choi, Jungmin,Rhyu, Dong Young,Yoon, Sook 한국사물인터넷학회 2020 한국사물인터넷학회 논문지 Vol.6 No.4

인구 고령화에 따라 치매환자가 크게 늘어나고 있으며, 이에 따른 사회 경제적 부담이 커지고 있다. 현재 치매환자를 효과적으로 관리하는 방법은 조기에 치매 초기 환자를 파악하는 것이다. 그러나 의료진이 부족한 농촌과 섬 지역에서는 병원을 방문해서 조기 검사를 받기 어려운 문제가 있다. 이 문제를 해결하는 방법으로 본 논문에서는 원격 치매 조기 검사 시스템을 제안한다. 원격 치매 조기 검사 시스템은 환자가 실시간 화상 통신을 기반으로 한 원격 의료 기술을 활용하여 원격의 치매 전문가에게 검사 및 진료를 받을 수 있는 시스템이다. 치매 원격 조기 검진 시스템은 섬 지역의 보건지소 의료진이 사용하는 로컬 클라이언트 시스템, 영상을 전송 및 저장/관리하는 화상 서버, 원격 치매 전문가가 활용하는 전문가 클라이언트로 구성된다. 로컬 클라이언트는 환자가 보건지소의 의료진과 같이 사용할 수 있도록 함으로써 현 의료법의 원격협진 기준을 만족시킨다. 또한 전문가 클라이언트는 치매 전문가가 사용하며, 환자의 정보를 저장/관리하고, 환자의 이력 정보를 분석하고 향후 치매 진행 정도를 예측할 수 있다. Along with the aging of the population, the number of dementia patients is increasing, and the social and economic burden is also increasing. Currently, the effective way to manage dementia patients is to identify patients with dementia early. However, in rural and island areas where medical staff are scarce, there is a problem that it is difficult to visit a hospital and get an early examination. Therefore, we propose a remote early detection system for dementia to solve the problems. The remote dementia early diagnosis system is a system that allows a patient to receive examination and treatment from a remote dementia expert using remote medical technology based on real-time image communication. The remote early diagnosis system for dementia consists of a local client system used by medical staff at health centers in the island, an image server that transmits, stores and manages images, and an expert client used by remote dementia experts. The local client subsystem satisfies the current medical law's remote collaboration by allowing the patient to use it with the health center's medical staff. In addition, expert clients are used by dementia experts, and can store/manage patient information, analyze patient history information, and predict the degree of dementia progression in the future.

삼색싸리 메탄올 추출물의 3T3-L1지방세포와 db/db 마우스에서의 PPARγ 작용제와 인슐린 유사효과를 통한 혈당조절 개선효과

박철민 ( Chul-min Park ),김휘 ( Hui Kim ),류동영 ( Dong-young Rhyu ) 한국응용생명화학회(구 한국농화학회) 2019 Journal of Applied Biological Chemistry (J. Appl. Vol.62 No.4

이 연구의 목적은 당 대사에 대한 삼색싸리(Lespedeza maximowiczii var. tricolor Nakai; LMTN)의 효과를 조사하는 것이다. LMTN 추출물은 대조군과 비교하여 3T3-L1 지방 세포에서 당 섭취능 및 지질축적을 유의하게 향상시켰다. 또한, 3T3-L1 지방 세포에서 LMTN 추출물은 퍼옥시좀 증식제 활성화 수용체(PPAR)γ, 인슐린수용체기질-1 (IRS-1) 및 포도당수송체(GLUT)4의 단백질 발현을 유의하게 증가시켰다. LMTM 추출물의 당 섭취능 또는 인슐린 신호 전달계의 조절 효과는 양성 대조물질인 트로글리타존 또는 피니톨보다 낮았지만 PPARγ 단백 활성화는 증가하였다. 또한, LMTM 추출물은 인슐린 유사효과를 나타냈다. db/db 마우스에서, LMTN 추출물(250 mg/kg BW)은 물과 식이 섭취량, 혈당, 중성지방과 총 콜레스테롤 함량을 유의적으로 감소시켰다. 더불어 지방과 근육조직에서의 PPARγ 및 GLUT4 mRNA의 발현도 LMTN 추출물 투여군에서 유의적으로 증가되었다. 따라서, 본 연구의 결과는 LMTN 추출물이 3T3-L1 지방세포 및 db/db 마우스에서 PPARγ 및 인슐린 유사효과를 통해당 대사를 조절하는 것으로 밝혀졌다. The aim of this study is to investigate the effect of Lespedeza maximowiczii var. tricolor Nakai (LMTN) on glucose metabolism. LMTN extract significantly enhanced the glucose uptake and lipid accumulation in 3T3-L1 adipocytes compared with control. Also, LMTN extract in 3T3-L1 adipocytes significantly increased the protein expression of peroxisome proliferatoractivated receptor (PPAR)γ, insulin receptor substrate-1, and glucose transporter (GLUT)4. The regulatory effect on glucose uptake or insulin signal transduction of LMTM extract was lower than troglitazone or pinitol such as the positive control, but increased PPARγ activation. Additionally, LMTM extract has an insulin-mimetic effect. In db/db mice, LMTN extract (250 mg/kg BW) significantly reduced water and food intake, blood glucose, and level of plasma triglyceride and total cholesterol. Furthermore, the expression of PPARa and GLUT4 mRNA in adipose or muscle tissue effectively was increased by oral treatment of LMTN extract. Thus, our results suggest that LMTN extract improves the glucose metabolism through PPARγ and insulinmimetic effect in 3T3-L1 adipocytes and db/db mice.

db/db 마우스에서 비파의 혈당 저하 효과

김은 ( Eun Kim ),김민숙 ( Min Sook Kim ),류동영 ( Dong Young Rhyu ),민오진 ( Oh Jin Min ),백흠영 ( Hum Young Baek ),김용재 ( Yung Jae Kim ),김현아 ( Hyeon A Kim ) 韓國食品營養學會 2009 韓國食品營養學會誌 Vol.22 No.2

E. japonica is a well-known medicinal plant in Japan. The leaves of E. japonica were reported to have a hypoglycemic action. However, seeds of E. japonica are discarded and not used. To elucidate for anti-diabetic effects of E. japonica, Type 2 diabetic mice were allocated to control group, E. japonica leaf, and seed extract group. Animals were fed a 2018S Teklad global 18% protein rodent diet. Animals were received daily oral injections of E. japonica leaf or seed extract at a dose of 200 ㎎/㎏ body weight for 6 weeks. Body weight, food intake and water intake, and total adipose tissue weight of animals were significantly reduced by feeding of E. japonica leaf extract. All E. japonica extract groups significantly decreased fasting blood glucose, glycosylated hemoglobin levels, size of adipocytes and serum adiponectins. However, they did not have a beneficial effect on the serum triglyceride and cholesterol in the diabetic animals. These results suggest that E. japonica seed and leaf extracts have a antidiabetic effect by controlling of blood glucose and decrease of size of adipocytes in db/db mice and seed extract is more effective in hypoglycemic action than leaf extract.

옥덩굴 에탄올 추출물의 당 대사 및 인슐린 민감성 개선효과

박철민 ( Chul-min Park ),타쿠리랙스미센 ( Laxmi Sen Thakuri ),류동영 ( Dong-young Rhyu ) 한국응용생명화학회(구 한국농화학회) 2021 Journal of Applied Biological Chemistry (J. Appl. Vol.64 No.1

이 연구의 목적은 Caulerpa okamurae 에탄올 추출물(COE)이 제2형 당뇨병 치료의 약물 표적 중 하나인 당 대사 및 인슐린 민감성에 미치는 영향을 평가하는 것이다. COE는 in vitro 실험에서 단백질 티로신 포스타제 1B (PTP1B)와 디펩티딜 펩티데이즈-IV (DPP-IV) 효소 활성을 유의하게 억제시켰다. 또한, COE는 3T3-L1 지방세포와 제브라피쉬에서 당 흡수, 인슐린 수용체 기질(IRS-1) 및 당 수송체(GLUT4) 단백의 발현을 대조군에 비해 유의하게 향상시켰다. L6 근육세포의 덱사메타손(dexamethasone)으로 유도된 인슐린 저항성 모델에서도 COE는 인슐린 신호전달 및 당 흡수 단백의 발현을 효과적으로 증가시켰다. 더불어 인슐린 저항성 지표로 알려진 IRS-1 Ser307의 인산화 활성도 COE 첨가에 의해 유의하게 억제되었다. 그러나 COE는 췌장 베타세포의 인슐린 분비에는 아무런 영향을 미치지 않았다. 결론적으로 COE는 인슐린 표적세포와 제브라피쉬에서 인슐린 신호전달과 당 수송체 GLUT4 단백 발현의 조절을 통해 당 대사 및 인슐린 민감성을 개선시키는 것으로 밝혀졌다. The aim of this study is to examine the effect of Caulerpa okamurae ethanol extract (COE) on glucose metabolism and insulin sensitivity as one of the drug targets for treatment of type2 diabetes. COE significantly inhibited protein tyrosine phosphatase (PTP1B) and dipeptidyl peptidase-IV (DPP-IV) enzyme activities in vitro assay. Also, COE significantly enhanced the glucose uptake and the expression of insulin receptor substrate-1 (IRS-1) and glucose transporter4 (GLUT4) proteins in 3T3-L1 adipocytes or zebrafish larvae compared with control. In dexamethasone-induced resistance model of L6 myotubes, the protein expression of insulin signaling and glucose uptake was effectively increased by the treatment of COE. In contrast, the elevated phosphorylation of IRS-1 Ser307 was normally suppressed by treatment of COE. However, COE had no effect on insulin secretion in pancreatic beta cells. Thus, our results suggest that COE improves the glucose metabolism and insulin sensitivity through the regulation of insulin signaling and GLUT4 protein in insulin’s target cells and zebrafish larvae.

SD계 랫트와 db/db 마우스에서 Curcuma longa L. 가 비만과 인슐린저항성에 미치는 영향

유미경 ( Mi Kyoung You ),김민숙 ( Min Sook Kim ),류동영 ( Dong Young Rhyu ),김현아 ( Hyeon A Kim ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.1

In this study, the effect of Curcuma longa L. on ibesity and insulin resistance was investigated in animals fed a moderate high fat diet. The animals used in this study were normal weight Spargue-Dawley (SD) rats and type 2 diabetic obese db/db mice. Accumulation of abdominal adipose tissue and weight gain were inhibited in the animals fed the C. longa extract. C. longa decreased fasting insulin and HOMA-IR in the SD rats, and effectively decreased blood glucose and hemoglobin Alc in db/db mice. C. longa decreased serum free fatty acid level in the SD rats. FFA in db/db mice fed C. longa tended to decrease. C. longa significantly decreased serum triglyceride level. Our results collectively represent that C. longa prevented fat accumulation and insulin resistance in both nomal weight SD rats and type 2 diabetic obese db/db mice fed a moderate high fat diet.

論文(논문) : 달 착륙선 지상시험모델의 경로 추종을 위한 추력기 기반 제어기 설계

김광진 ( Kwang Jin Kim ),이정숙 ( Jeong Sook Lee ),이상철 ( Sang Chul Lee ),고상호 ( Sang Ho Ko ),류동영 ( Dong Young Rhyu ),주광혁 ( Gwang Hyeok Ju ) 한국항공운항학회 2011 한국항공운항학회지 Vol.19 No.4

Lunar exploration program has been prepared with the aim of launch in the 2020`s. As part of it, a lunar lander demonstrator has been developed which is the model for verifying all the system, such as structure, propulsion and control system before launch to deep space. After verifying all the system, the demonstrator will be evaluated by flight test. This paper deals with path tracking controller based on thrusters for the demonstrator. For this, first we derive equations of motion according to the allocation of thrusters and design the path tracking controller. The signal generated from the controller is continuous so PWPF(Pulse-Width Pulse-Frequency) modulator is adopted for generating on/off signal. Finally MATLAB simulation is performed for evaluating the path tracking ability and the final landing velocity.

달 탐사선의 동역학 모델링 및 관성 모멘트 추정에 관한 연구

심상현 ( Sang Hyun Shim ),김광진 ( Kwang Jin Kim ),이상철 ( Sang Chul Lee ),고상호 ( Sang Ho Ko ),류동영 ( Dong Young Rhyu ),주광혁 ( Gwang Hyeok Ju ) 한국항공운항학회 2010 한국항공운항학회지 Vol.18 No.4

This paper deals with attitude determination and parameter estimation problems for a lunar module. For this we first derive equations of motion for the lunar module by considering allocation locations (configurations) of reaction thruster and a reaction wheel assembly. The lunar module is assumed as a rigid body. In order to include the effect of fuel sloshing on the dynamics of the lunar module, we model it as a spherical pendulum for a simple analysis. For estimating angular rates and moment of inertia of the module, we employ an extended Kalman filter and the least mean square algorithms, respectively. Finally we construct a dynamical model for the lunar module by combining all these elements.