정헌 고인석 교수 정년퇴임기념호 / 경희한약개발연구소편 : 신석의 간장독작용과 감초의 해독에 관한 연구

류경수(Kyung Soo Ryu),김명회(Myung Hoe Kim) 경희대학교 동서약학연구소 1986 경희약대 논문집 Vol.14 No.-

상백피에 관한 연구 (Ⅱ) : 상백피의 생약학적 연구

류경수(Kyung-soo Ryu),도정애(Chung-ae Toh) 한국생약학회 1980 생약학회지 Vol.11 No.2

In our country there are five species of Morus genus including Morus alba L.. Also their varieties and hybrids are distributed so much. In secession of previous report we collected control and marketing specimens of Mori Cortex Radicis, comparative experiments were pharmacognostically carried out to identify the control specimen by the differences of external and internal morphology. It was difficult to identify marketing specimens by external morphology, because they are similar in spite of conparating with control specimen which the origin is definite. In internal morphology, medullary ray is developed near the cambium to primary bark in control specimen A (Morus alba series) and C(M. Lhou series), but less developed in B(M. bombycis series). The defference of these three series was observed. The thickness of cork layer is almost the same(7∼12 layers) in A and C series, but B is thin layer and sample E(that on the market) is generally more thick and has a stick cork cell. The kinds of starch, Ca-oxalate and latex, cell contents were same, but it was easy to identify them by the differences of their distribution. The bast fibre of D(wild specimen) and E were light lignified, latex tube of A and C series was richer distributed than others. These results show that the origin of Mori Cortex Radicis on the market can be appreciated in four groups of Korean Morus genus which are M. alba, M. bambycis, M. Lhou series and the others.

상백피에 관한 연구 (Ⅰ) : 상백피의 본초서지학적 분석

류경수(Kyung-soo Ryu),안덕균(Dug-Kyun Ahn) 한국생약학회 1980 생약학회지 Vol.11 No.2

In this paper, we studied what the drug name of Sang-Baik-Pi (桑白皮 Mori Cortex Radicis) is, how to collect it; and how the chief symptoms had changed in the Chinese medical references and herbological literatures and formularies. Also we bibliographically analyzed in the herbological way the drugs combinated with Sang-Baik-Pi and their active principles among the prescriptions in the famous medical book; Doug-Ui-Bo-Gan, (東醫寶鑑) of our country. Finally, we concluded as follow. Numerous names of botainical origin were described, but it was not recorded that San-Keun-Baik-Pi (桑根白皮) in old days is different from root bark of Morus sp. in this times. Sang-Baik-Pi has been a common designation since Ming dynasty (AD 1500). Collections of it were independent of seasons, it could effect perfectly over 10 years old. And its cork layer should be removed after collections, it was especially emphacised that root bark an ground was poisonous. The chiefly cured symptoms with Sang-Baik-Pi were constantly not different from the contents of Shin-Nong-Bon-Chau-Kyung (神農本草經) in ancient times, but it has been developed since Ming dynasty. Its uses are widely extended to a surgical and dermatologic decease; rheumatic, beriberi and diabetes in this times, and its efficacies depend upon curing. Prescriptions on Sang-Baik-Pi that were prescribed in Dong-Ui-Bo-Gam are there, 177 drugs combinated with it. Glycyrrhizae Radix is most frequently combinated with Sang-Baik-Pi(frequently 68%). It is proved that Armeniacae Semen, Platycodi Radix etc, in the order take strong effects on anti-tussive, anti-phlogistic, diuretic, anti-pyretic etc. It is expressed 34 times, frequently, that a dose is 3.75g, and it shows that a usual does is 2-4g. As the above prescriptions are classified, the results is as follows, respiratory tract decease is most frequently in 69 prescriptions, the next gastrointestinal tract 13 times, diuretic 12 times, and antypyretic 11 times. Therefore, Sang-Baik-Pi contains a good remedial value chiefly of the effects upon the respiratory diseases.

강활성분 Koreanin의 화학구조

류경수(Kyung Soo Ryu) 대한약학회 1968 약학회지 Vol.12 No.3,4

A new furocoumarin C16H14O5., slightly laevo-rotatory white needles m.p. 129~130 o has been isolated from the roots of the Angelica koreana MAXIMOWICZ and its structure has been established as 8-(beta,gamma-oxido-iso-amyl)-psoralene, a stereoisomer of heraclenin.

고속액체크로마토그라피에 의한 생약제제중의 계피산 계피알데히드의 정량

류경수(Kyung-Soo Ryu),송보완(Bo-wan Song) 한국생약학회 1980 생약학회지 Vol.11 No.2

The decoctions and extracts were prepared on the traditionally prescribed four kinds (Kejigamcho-tang, Kejibanha-tang, Keji-tang, Kejinsam-tang) of preparations containing Cinnamoin Raulus. The contents of cinnamic acid and cinnamic aldehyde in these preparations were determined by high performance liquid chromatography using reverse phase partition column, and 12% MeOH as eluting solvent. The sample was determined using the two wave length, 254㎚ and 280㎚. This method was sucessfully applied to the analysis of cinnamic acid and cinnamic aldehyde of various preparations containing Cinnamons.

한방용약에 관한 생약학적 조사연구(Ⅱ) : 상용 식물성 한약의 기원

류경수(Kyung Soo Ryu),조해월(Hae Wal Cho) 한국생약학회 1976 생약학회지 Vol.7 No.1

This study was carried out to investigate number of items of oriental drugs which were widely used in Korea, their origins and amounts of consumption. Number of the botanical drugs which have been used at the Kyung Hee Medical center during the past four years from 1971 to 1974 were 282 items. Of these drugs original plants were 280 kinds. They include 9 formas and varieties, 271 species, 231 genera and 102 families. Among these items, Coicis Semen was used with the highest amounts in consumption and Calophyllum was with the lowest.

상백피에 관한 연구 (Ⅲ) : 노상근피의 성분

류경수(Kyung-Soo Ryu),박경환(Kyung-whan Park),송보원(Bo-wan Song) 한국생약학회 1981 생약학회지 Vol.12 No.1

The root-bark of the mulberry tree has been used as a medicine with antitussive, antiphlogistic, diuretic etc. in Korea. Among many kinds of mulberry trees, Morus Lhou has been widlly cultivated in our country. In this experiment, thee substances were obtained from the root-bark of Morus Lhou removed its cork layer by column chromatography of methanol extract. One of the substances was supposed as α-amyrin acetate, another was alyceride, the other was confirmed as β-sistosterol by chemical and physical methods.

상백피에 관한 연구(제 4 보) : 시판상백피의 성분검색

류경수(Kyung-Soo Ryu),송형종(Hyung-Jong Song) 한국생약학회 1982 생약학회지 Vol.13 No.1

저자들은 앞서 상백피의 본토서지학적인 분석을 하였고 시판품 및 기준품 등을 재료로 하여 이들 상호간의 형태 및 조직학적인 차이점에 의한 기원식물의 구명에 대하여 보고하였으며 또 우리나라 뽕나무재배면적의 1.2%를 차지하는 노상의 근피에서 α-amyrinacctate 및 β-sitosterol등을 분리보고 한바 있다. 시판상백피는 거의 모두가 뽕나무속 식물의 각종 변 품종 및 잡종의 근피가 서로 섞이거나 대치품 및 위화물 등이 혼일되어 있어 생약의 품질관리 대책에 지장을 초래하고 있는 실정이다. 본보에서는 상백피에 관한 계속 연구로서 막대한 약용부존자원을 현대의 약품으로 개발하는데 있어 필요로 하는 기본자료를 얻고자 본속식물의 3계열의 기준품 및 야생품과 시판 및 대치품등 품목을 대상으로 하여 이들 상호간의 성분상을 박층크로마토법으로 검색하고 비교검토 하였다. 시판상백피는 코트크층의 제거 및 물로 씻는 등의 조제수치와 건조, 저장등의 과정에서 성분의 손실과 변질등의 우려가 있는 것이라 사려되이며 기준품과의 비교 동정은 쉽지 않으나 대치품인 구지뽕 및 아카시나무 근피와의 감별은 가능하였다.

대도시 준주거지역의 토지이용 및 특성에 따른 개선방향 연구 - 대구시와 대전시를 중심으로 -

류경수(Ryu, Kyung-Soo),안윤상(Ahn, Yune-Sang),정응호(Jung, Eung-Ho) 한국주거학회 2021 한국주거학회 논문집 Vol.32 No.6

It is necessary to carefully examine whether the purpose and purpose of designation of newly introduced quasi-residential areas are consistent in consideration of land use. As a result of a comparative analysis of land use and characteristics of two Metropolitan City, it is necessary for Daegu to review the easing of development density and subdividing quasi-residential areas only when various uses and functions including housing are introduced. In the case of Daejeon, it is possible to flexibly respond to reflecting government policies such as supplying public rental housing or designating urban convergence special zones due to the easing of behavior restrictions and high development density. The common matters of the quasi-residential areas of the two cities are mostly used for residential purposes in the current state of land use, and the difference appears to be that there are differences in the application of the floor area ratio depending on the specific use. Accordingly, in the direction of improvement of quasi-residential areas, it is necessary to introduce various uses and functions such as the use of buildings through urban planning ordinances, and to manage them in additional subdivisions and types according to the type of land use and location reflecting regional characteristics.

국산 길초근의 Monoterpenoid

류경수(Kyung Soo Ryu) 한국생약학회 1974 생약학회지 Vol.5 No.1

Essential oils were separated by steam distillation from the roots of four species of the genus Valeriana and subjected to gas chromatography to screen monoterpenic hydrocarbons and related components. The amounts of the common components were contained in the following order: camphene, α-pinene, bornyl-, myrtenyl isovalerate, myrtenylacetate and β-pinene, and small amounts of terpineol and terpinylacetate were also contained. Of the four species, the root of Valeriana fauriei BRIQUET var. dasycarpa HARA contained the largest amounts of these components and the root of V. dageletiana NAKAI ex MAEKAWA the least. Since the root of V. dageletiana contained for less amounts of pinene, camphene and bornylacetate and none of dipentene and terpineol, this plant appears to be distinguished from the other three species.