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폐경기 증후군 환자에서 홍삼 복방 제품의 임상적 유용성
노흥태(Heung Tae Noh),손성경(Sung Kyong Son),고지환(Jee Hwan Ko),오영균(Young Kyun Oh),김용일(Yong Il Kim),박명한(Myung Han Park),김나미(Na Mi Kim),전병선(Byeong Seon Jeon) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A The most dramatic endocrine event associated with aging in women is the cessation of normal, cyclic ovarian activity. The loss of ovarian function is reflected by alterations in ovarian steroid secretion, which result in the discontinuation of menstruation. This process appears to be related to some of the classic features of the climacteric, such as hot flushes, altered reproductive tract histology, and accelerated bone loss. Oral estrogen therapy can cause endometrial hyperplasia and carcinoma, in addition to systemic side effects. Therefore, alternative therapeutic agents are currently being developed. Korean Red Ginseng has been used in the Orient as an elixer for hundred of years. However, the demonstrable actions of Korean Red Ginseng components have not been fully explored and knowledge concerning the mode of action is fragmented. Recent data has shown that Korean Red Ginseng is effective in treating various perimenopausal symptoms. We investigated the clinical efficacy and safety of Korean Red Ginseng in 30 patients who suffered postmenopausal symptoms. The drug was administered orally at a dose of 6 capsules daily for 12 consecutive weeks between April and July 2001. Data were analyzed using the student's t test with p<0.05 considered valid. The result were as follows: 1. The distribution of clinical symptoms in the studied patients prior to treatment was: fatigue, 63.3%; arthralgia, 56.7%; sweating and dry mouth, 53.3%; palpitation, 46.7%; followed by urinary symptoms, insomnia, headache, hot flushes. 2. The efficacy rate after treatment with Korean Red Ginseng was 100.0% for gastrointestinal symptoms, 91.6% for hot flush, 85.6% for palpitation, 76.4% for arthralgia, followed by fatigue, sweating and dry mouth, insomnia, neuropsychological symptoms. 3. The average level of estradiol was 9.16pg/ml prior to the treatment. The level increased to 11.76pg/ml, 15.60pg/ml, and 21.30pg/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). The FSH level changed from 46.24 mIU/ml, pre-treatment, to 51.08 mIU/ml, 48.52 mIU/ml, and 48.55 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p>0.05). The LH levels increased from 21.30 mIU/ml, pre-treatment, to 22.16 mIU/ml, 22.48 mIU/ml, and 23.01 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). 4. Most patients suffered mild symptoms that were below 20 on the menopausal index scale. The index value was 14.36 prior to the treatment, which dropped to 8.60 after 4weeks, 8.30 after 8weeks, and 5.46 after 12 weeks of treatment. These values were statistically significant. (p<0.05) 5. No definite evidence of side effects was observed during the study. 6. There were no differences in vital signs, body weight, and body mass index between before and after the treatment.
골반내 악성종양과 유사한 만성 골반염에 합병된 결합조직염 1 예
노흥태(Heung Tae Noh),홍달수(Dal Soo Hong),이윤이(Yun Ee Rhee),서광선(Kwang Sun Suh) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
Pelvic inflammatory disease(PID) is a common disease associated with gynecologic infection, occurring mainly in fertile women. We report a case of phlegmon caused by chronic PID mimicking pelvic malignancy in a 39-year-old woman. The patient suffered from chronic pelvic pain, intermittent fever, and dysuria. A palpable lower abdominal mass was associated with progressive weight loss. A pelvic MRI revealed a 9×8×7cm sized, ill-defined soft tissue mass in the right pelvic cavity. On exploratory laparotomy, the pelvic mass was severly adhesed to the small intestine, mesentery, and urinary bladder. An incisional biopsy of the pelvic mass was performed. Histologically, the pelvic mass was composed of inflammed fibrous tissue with granulation tissue proliferation. The patient was treated with metronidazole and ciprofloxacin for two weeks. Fever and abdominal pain were relived. On a follow up abdomino-pelvic CT, the pelvic mass was not visible. Awareness of such an unusual case of chronic PID mimicking pelvic malignancy will facilitate a more accurate diagnostic approach for a variety of pelvic mass lesion.
양윤석 ( Yun Seok Yang ),노흥태 ( Heung Tae Noh ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.4
목적: 폐경 전 여성과 폐경 후 여성에서 골밀도 예측인자를 통해 골밀도를 얼마나 설명할 수 있는지를 알아보고자 연구하였다. 방법: 골밀도에 영향을 주는 여러 위험요인 중 본 연구에서는 환자연령, 초경나이, 폐경연령, 폐경 후 기간, 신장, 체중, 신체량 지수, 분만 횟수, 유산 횟수, 수유 횟수 등을 이용하여 회귀분석 (multiple regression analysis)을 하였다. 결과: 폐경 후 여성의 골밀도 (BMD, g/cm2)= 0.563-0.0077 (폐경 후 경과기간) + 0.0054 (환자 체중) (p<0.001, R2=0.30)이며 폐경전 여성의 골밀도=0.23+0.0048 (height) (p<0.001, R2=0.05)이다. 폐경 전후 골밀도 감소 예측인자가 서로 달라 폐경 후 여성은 폐경 후 경과기간과 환자의 체중인 반면, 폐경 전 여성의 골밀도 예측인자는 신장이었다. 전체여성에서 골밀도 예측 인자를 가지고 척추 골밀도 설명은 52%로 변별력이 있으나 폐경 후 여성에서 30% 정도밖에 되지 않아 정확한 골밀도를 예측하기엔 부족하며, 폐경 전 여성은 폐경 후 여성에 비해 골밀도 결정계수가 더욱 낮았다. 결론: 전체 여성과 폐경 전후 여성에서 골밀도 예측 인자 및 예측도가 다르기 때문에 골밀도 예측 모델은 폐경 전후 여성으로 구분하여 만들어야 하며, 향후 폐경 전후에 따른 다양한 인자를 추가하여 정밀한 골밀도 예측 모델을 만든다면 한국여성을 대상으로 하는 컴퓨터 분석 골밀도 예측이 가능할 것으로 사료 된다. Objective: The need for early and correct prescription for bone densitometry led to the research for decision model useful for clinicians to address women to bone densitometry. there are few studies that have focused on both pre- and postmenopausal groups simultaneously in healthy pre-and postmenopausal Korean women. Methods: The authors analyzed the easily obtained biometrical variables such as factors used at clinical decision rules for BMD testing and evaluated predictive values and robustness of a decision model for prediction of lumbar BMD in total , pre-and postmenopausal Korean women. Results: After stepwise multiple regression analysis, Lumbar BMD in total population is 1.083-0.153 (status of menopause)-0.007 (age of menopause)+0.0039 (body weight) (R2=0.52). Postmenopausal women is 0.563-0.0077 (duration after menopause)+0.0054 (body weight) (R2=0.30) and premenopausal women is 0.23+0.0048 (height) (R2=0.05). Although its validity (52%) in total population was sufficiently high for the prediction of lumbar BMD in clinical settings, In postmenopausal women only 30% of the decision model can be explained by the predictors of bone demineralization which is not completely satisfactory in determining lumbar BMD and in premenopausal women 5% is the very low explanatory value which is necessary for identifying possible factors influencing BMD. Conclusions: Because of difference in underlying risk, as well as differences in the distribution of different risk factors according to menopausal status, this study present different robustness of prediction models according to menopausal status and suggest that it be need to design prediction models divided by menopausal status. More research is needed for computer-based screening aids useful to clinician which overcome some limitation of our study.
방사선에 의한 난포 퇴축과 난포 대식세포에 관한 형태학적 연구
송근일 ( Keun Il Song ),노흥태 ( Heung Tae Noh ),이윤이 ( Yun Ee Rhee ),손성경 ( Sung Kyong Son ),김원식 ( Won Sik Kim ),김수일 ( Su Il Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 방사선이 난포 퇴축을 일으키는 난포과립층세포들에 미치는 영향과 난포내 대식세포의 일부역할을 형태학적으로 살펴보기 위해 본 연구를 수행하였다. 연구 방법 : 3주령의 Sprague-Dawley계 흰쥐를 실험동물로 8 Gy의 방사선을 조사하고, 조사 후 6시간, 12시간 및 24시간에 각각 희생하여 난소를 채취하고 통상적인 방법으로 처리한 후 광학현미경적 및 투과전자현미경적 관찰, TUNEL 및 대식세포 면역조직화학을 실시하였다. 결과 : 1) 방 Objective : It is well known that X-ray induces follicular atresia, but the exact mechanism of atresia is not still unveiled completely. In addition, the role of macrophage related with clean-up the dead granulosa cells and other functions within the ovar