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위암에서 Collagen-4 및 Type-4 Collagenase의 발현과 예후인자로서 임상적 응용
노성훈(Sung Hoon Noh),이종인(Chong In Lee),정현철(Hyun Cheol Chung),박준오(Joon Oh Park),조재용(Jae Yong Cho),라선영(Sun Young Ra),유내춘(Nae Chun Yoo),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),민진식(Jin Sik Min),김병수(Byung Soo K 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: In Korea, gastric cancer is the commonest cancer and the leading cause of cancer-related death. Though the most effective treatment for gastric cancer is radical resection, there are many patients with gastric cancer inoperable at the time of diagnosis. Collagen-IV, one of the major intrinsic components of the basement membrane, has cell adhesion function and it is known to be associated with tumor invasion or penetration. Type- IV collagenase, a metallo- proteinase purified from highly metastatic tumor cells, has been implicated in the process of invasion of epithelial and endothelial basement membranes in several steps of tumor invasion and metastasis. Methods: We retrospectively reviewed the clinical records of SO patients with histologically proven gastric cancer who had been treated in Yonsei University Medical Center and Yonsei Cancer Center between June l985 and June 1990. We perfonned immunohistochemical staining of surgically resected specimens of stomach cancers to investigate the expression rate and clinical relevance of collagen-lV and type-IV collagenase as prognostic niarkers. Results: Collagen- IV expression rate was 50% in 40 gastric cancers and type-IV collagenas expression rate was 76% in 50 gastric cancers. Six cases(30%) recurred in 20 collagen-IV positivc cases and six cases(30/c) recurred in 20 collagen-IV negative cases(p=1.00000). Eleven cases(29%) recurred in 38 type-P' collagenase positive cases and four cases(33%) recurred in 12 type-IV collagenase negative cases(p=0.77255). In the collagen-IV positive and negative group, 5-ye.ar disease-free survival rate was 607c and 67%, respectively(p=0.6725), and 5-year overal] survival rate was 71% and 827o, respectively(p=0.3953). In the type-IV collagenase positive and negative group, 5-year disease-free survival rate was 63% and 60%, respectively(p=0.6407), and 5-year ovevall survival rate was 78% and 60%, respectively (p=0.3822). Conclusions: Collagen-IV and type-lV collagenase were found in gastric tissues. However, together with recurrence rate and survival rat:, expressions of collagen- IV and type-IV collagenase were not significantly correlated with T state, nodal status, TNM stage and histologic differentiation of gastric cancer. Further studies to define the biological role of collagen-IV and type-IV collagenase is required. (Korean J Gastroenlerol 1996;28:1 - 10)
문성록,이형식,김귀언,안기정,서창옥,노준규,민진식,이경식,김병수,노재경,고은희,Moon, Sun-Rock,Lee, Hyung-Sik,Kim, Gwi-Eon,Ahn, Ki-Jung,Suh, Chang-Ok,Kyu, John-Juhn,Min, Jin-Sik,Lee, Kyung-Sik,Kim, Byung-Soo,Noh, Jae-Kyung,Koh, Eun-Hee The Korean Society for Radiation Oncology 1990 Radiation Oncology Journal Vol.8 No.1
유방암의 일차 치료후 흉벽이나 국소임파절에 국한된 재발은 비교적 흔하게 관찰된다. 방사선치료는 이러한 국소재발유암 환자에게 효과적인 치료법으로 사용되어 왔으나 국소병변의 관해에도 불구하고 많은 경우에서 이차개발 또는 원격전이로 인해 불량한 예후를 보이므로 최근에는 다방면 병용요법을 시도하여 환자의 수명을 연장시키고 관해율을 증가시켰다는 고들이 있다. 이에 저자들은 국소 재발유암 환자의 특성과 치료결과, 치료후 실패양상, 생존율에 영향을 미치는 예후인자를 분석하여 향후치료의 지침으로 삼고자, 1974년 부터 1986년까지 연세대학교 의과대학 치료방사선과에서 방사선치료를 받은 53명을 대상으로 후향적분석을 통해 다음과 같은 결과를 얻었다. 32예 ($60.4\%$)가 단일 병소에, 21예 ($39.4\%$)가 다발병소에 재발하였다. 방사선치료후 31예 ($58.4\%$)에서 완전관해를 보였으나 그 중 7예는 치료부위에 다시 재발하였다. 전체환자의 5년 생존율과 무병생존율은 각각 $27\%,\;15\%$였다. 각각의 예후인자에 대한 단일변량분석에서는 최초 수술당시의 액와임파절전이 숫자, 보조적 화학요법의 시행 유무, 경도의 유무 등이 통계적 유의성을 보였고, 다변량분석법을 통한 분석에서는 최초수술당시의 액와임파절전이의 수, 경도의 유무, 재발시 병변의 크기, 치료후 관해기간 등이 생존율에 통계적으로 유의한 영향을 끼치는 예후인자였다. Between January,1974 and December 1980, fifty eight patients with locoregional recurrent breast carcinoma who did not have evidence of distant metastasis after initial treatment of surgery with or without adjuvant chemotherapy were treated with radiation therapy. Among them, five patients were excluded from this study because of incomplete record or incomplete treatment. The 5-year overall survival and disease free survival from the time of locoregional recurrence was $27\%\;and\;15\%$ respectively. In univariate analysis of prognostic variables, the clinical stage at initial diagnosis, recur duration, number of recurrence sites, size of recurrences, response to the treatment, remission duration were all found to have no significant effect on survival or disease free survival. On the other hand, menopausal status at initial diagnosis, number of positive node at initial surgery, whether or not the use of adjuvant chemotherapy after initial mastectomy had definite prognositc significance. In multivariate analysis of prognostic variables, remission duration, menopausal status at diagnosis, number of axillary node at mastectomy had definite prognostic significance. On the other hand, remission duration more than 12 months, premenopaus at initial mastectomy, less than four positive axillary lymph nodes at mastectomy predicted a good prognosis.
노재경,김계남,윤견일,박이갑,박문규,최용만,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.4
The nonfunctioning islet cell tumors of pancreas are not associated with obvious sign and symptoms of hormone overproduction. Symptoms, most commonly pain and jaundice, are due to the mass effect of the tumor and invasion of the surrounding structures, and unlike functioning tumors, the location of the tumor has a direct bearing on the patient's symptoms. We have experienced a case of benign nonfunctioning islet cell tumor of the pancreas in 47-year-old female. She was admitted to our hospital due to palpable large mass of her abdomen. She had no obvious sign and symptoms of hormone overproduction. The exploratory laparatomy was done under the impression of retroperitoneal tumor with the information of radiologic finding and abdominal C-T scan. The pathologic diagnosis was benign nonfunctioning is-let cell tumor of the pancreas.
김계남,노재경,김영채,이순남,경난호,박이갑 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.3
A case of hypokalemic familial periodic paralysis is presented and the litures are reviewed. A 15-year-old boy was admitted to Ewha Womans University Hospital with chief complaints of paralysis of both extremities and trunk on awaking in the morning. He had a history of quadriplegia, 8 months ago. Laboratory study revealed a hypokalemia(1.6mEq/L) and biopsy specimen taken from the gastrocnemius muscle showed mild vacuolization. After treatment with potassium chloride, paralysis was completely recovered.