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전신성 홍반성 루푸스 환자에서의 STAT-6 유전자 다형성에 관한 연구
노영희 ( Young Hee Rho ),김효진 ( Hyo Jin Kim ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.1
Objectives: To investigate whether the new polymorphism at position 2964 (G/A) in the 3` untranslated region of the STAT-6 gene is associated with susceptibility to systemic lupus erythematosus (SLE) and its clinical features. Methods: A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the STAT-6 in 90 SLE patients and 148 healthy controls. Clinical and serological manifestations were analyzed in each patient and correlated with the genotypes. Results: The genotype distribution of the STAT-6 differed significantly between SLE patients and control subjects (AA, AG, GG genotypes 7, 74, 9 vs. 1, 119, 28 controls respectively, p=0.003). The frequency of AA genotype (7.8%) is significantly increased in SLE patients compared with controls (0.7%)(OR=12.398, 95% CI 1.50∼102.5, Fisher`s exact test, p=0.005). Clinically in the lupus patients according to the STAT-6 genotypes, there was no significant difference in age at onset, anti-ds-DNA titer, C3, C4 level, SLEDAI, SLICC/ACR Damage Index, or autoantibodies such as RF, anti-Ro, La, RNP, Sm antibodies, except for renal involvement. The frequency of lupus nephritis was significantly higher in the AA genotype in comparison with GG genotype (Fisher`s exact test, p=0.019). Conclusion: Our data show that the STAT-6 AA genotype may contribute to susceptibility to SLE and may be associated with development of lupus nephritis.
노영희 ( Young Hee Rho ),홍정유 ( Jeong Yoo Hong ) 한국환경농학회 2014 한국환경농학회지 Vol.33 No.1
BACKGROUND: The present study is an exploratory research to establish national biosafety regulation systems through a survey on the recognition of safety regulation systems for the living modified organism(LMO). METHODS AND RESULTS: We have conducted a survey on an awareness of LMO safety regulation systems in scientific working groups. The data of 235 respondents were analyzed using various statistical methods. As a result, 72.8% of the respondents were male; 27.2% were female, and 43.4% of them work in the university. A total of 33.2% of the respondents majored in general biology, and their most common job position was the laboratory safety manager. The difference of an awareness on LMO law and regulatory system was not statistically significant by either work places or job positions. CONCLUSION: For the rapid settlement and the efficient implementation of LMO safety management policy, we conclude that it is required to reduce the gap between the recognition and fulfillment of safety management. Furthermore, the mutual exchanges of information among researchers are needed with the settlement of the safety management system and the harmony of policy with improvement of the absurd regulations. The ongoing and specialized training, inspections, and the strengthening of public relations are also required along with the efforts to improve the absurd regulations.
노영희 ( Young Hee Rho ),최성재 ( Seong Jae Choi ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),최경묵 ( Kyung Mook Choi ),백세현 ( Sei Hyun Baik ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Objective: Metabolic syndrome is a constellation of metabolic abnormalities such as obesity, hypertension, glucose intolerance, and hyperlipidemia. The association of metabolic syndrome and hyperuricemia is well known, but not with gout. Therefore, the association of gout and metabolic syndrome is investigated through comparing the prevalence of metabolic syndrome in normal controls and patients with gout. Methods: This is a case-historical control study of 64 patients with gout recruited from Korea University Anam and Guro Hospital. Clinical factors were checked according to the diagnostic criteria of metabolic syndrome from the ATP III guidelines. Additional waist circumference adjustment was done according to the WHO Asia-Pacific obesity criteria recommendations. The prevalence was compared with historical control studies from the US and Korea. Results: The prevalence of metabolic syndrome in patients with gout was 42.2% according to ATP III criteria and 59.4% with waist circumference adjustment and is significantly higher than control studies (23.7% (US), 6.8% (Korea), ATP III), 10.9% (Korea, WHO Asia-Pacific obesity criteria)(p<0.001 in all cases). Multivariate logistic regression analysis revealed that high BMI and low HDL levels (both ATP III/WHO Asia-Pacific obesity criteria) and the presence of hypertension (ATP III) are the statistically significant risk factors of having metabolic syndrome in gout patients. Conclusion: The prevalence of metabolic syndrome in patients with gout is significantly higher than normal control groups. This indicates an association between gout and metabolic syndrome. Especially, being obese or hypertensive, or having low HDL levels are risk factors for the metabolic syndrome in gout patients.
시험,연구용 유전자변형생물체(LMO) 안전관리를 위한 안전교육 활성화 방안
노영희 ( Young Hee Rho ),민완기 ( Wan Kee Min ),정규진 ( Gyu Jin Jeong ) 한국안전학회(구 한국산업안전학회) 2014 한국안전학회지 Vol.29 No.2
Biosafety has become quite sensitive issues according to dramatic development of biotechnology and LMO (Living Modifying Organism) is one of the key issue in biosafety. This study is an exploratory research for investigating the activation strategy of biosafety training management in LMO research field. Based on the survey data, main results are derived through various statistical analysis methodology such as descriptive analysis, factor analysis, reliability analysis, analysis of variance and regression analysis. According to the analysis results, some activation strategies are required to reach the target such as extension of specialized biosafety training program, enhancement of safety consciousness from the undergraduate courses, introduction of appropriate safety regulations, unification of safety management and establishment of safety management system.
최성재 ( Seong Jae Choi ),노영희 ( Young Hee Rho ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ),김애리 ( Ae Ree Kim ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
We report a patient with scleroderma who had the unusual development of an anaplastic large/null cell malignant lymphoma of her breast at the time of diagnosis of scleroderma. It is well known that patients with scleroderma have malignant neoplasms such as lung cancer, breast cancer, and lymphoproliferative diseases more frequently than normal population. Although it is not well known about disease process of underlying cancer in patients with scleroderma, there must be some possible explanations. In brief, one disease may increase the risk of the other as a direct complication or as a result of the treatment given. Alternatively, the two disorders may share common risk factors. So it seems very important to emphasize that associated malignancy might be validated properly on rapidly developing scleroderma.
전신성 홍반성 루푸스에 합병된 살모넬라에 의한 갑상선 농양
황병연 ( Byung Yoen Hwang ),김용현 ( Yong Hyoen Kim ),노영희 ( Young Hee Rho ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Infectious disease took the leading cause of death in patients with systemic lupus erythematosus (SLE). Especially Salmonella infection occurs more common in SLE patients. We report a case of thyroid abscess caused by Salmonella Group D in a patient with SLE. A patient, 29-year-old female, with SLE was admitted with a painful swelling of the left neck and diarrhea. The painful swelling of neck was revealed as an abscess of the thyroid and Salmonella Group D was isolated from the aspirated material of the thyroid abscess. The patient recovered after surgical drainage and administration of intravenous 3rd cephalosporin.
김정선(Kim Jeong-Sun),공수자(Gong Soo-Ja),김현숙(Kim Hyun-Suk),노영희(Rho Young-Hee),김옥현(Kim Ok-Hyun),박경숙(Park Kyung-Sook),선정주(Sun Joenh-Ju) 질적연구학회 2006 질적연구 Vol.7 No.1
Purpose: This study is to understand how the elderly act to maintain their life of bliss(i.e. ‘Bok’) based on their experience. Method: This study was analyzed by Colaizzi’s phenomenological method(1978) with 7 elderly participants who are over the age of 70. Results: The essential meanings of life of bliss in elderly ware as following; Life of having a companion to talk with about inner mind, Life of having well-grown children, Life of living together to an old age, Life of having contentment without greed, Life of being recognized, Active and merry life, and Economically-stabilized life. The conditions for the meaning ware as following; Living a life having priority over children, Pray for bliss, To be faithful to current life, Concerning for others, Making an effort for keeping health, Preparing for own death. Conclusion: According to these result, a heath carer who takes care of elderly should understand that they need to show enormous amount of effort and attitude to keep their bliss of life. The result of this study would provide a direction of nursing intervention of the elderly and the fundamental data in the elderly health promotion program. Also, it is regarded that this research would contribute to the elderly nursing theory development which is adjust to Korean traditional culture throughout expanding the knowledge system of the elderly nursing in Korea in the future.