오가피(五加皮) 추출액(抽出液)이 면역(免疫), 항암(抗癌) 및 비만(肥滿)에 미치는 실험적 효과

노영호,이금수,김천중,전병관,정현우,Rho, Young-Ho,Lee, Geum-Su,Kim, Cheon-Joong,Jeon, Byung-Gwan,Jeong, Hyun-Woo 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.2

This experimental Study was designed to investigate the effects of Acanthopanacis Cortex Extract(ACE) on the immunity, anti-cancer and obesity in mice. The results were as follows; ACE was significantly increased in the proliferation of thymocytes and splenocytes, and NO production from peritoneal macrophages in normal mice. ACE was significantly increased in the proliferation of thymocytes and splenocytes, and NO production from peritoneal macrophages in L1210 cells transplanted mice. ACE was significantly decreased in the proliferation of L1210 cells in L1210 cells transplanted mice. ACE was significantly inhibited body weight and tumor weight in S-180 cells transplanted mice. ACE was significantly increased in the mean survival days in S-180 cells transplanted mice. ACE was significantly decreased in the body weight in rats fed high fat diet. ACE was significantly decreased in the serum total cholesterol level, free fatty acid level, total lipid level, phospholipid level in rats fed high fat diet. According to above results, the authors suggest that ACE is able to be used for the herb of physiological-action.

靑皮活性分劃이 虛血性 腦損傷에 미치는 실험적 연구

노영호(Young Ho Rho),정현우(Hyun Woo Jeong),이원석(Won Suk Lee) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.5

오갈피 에탄올 추출물이 뇌혈류 및 혈압에 미치는 효과

노영호(Young Ho Rho),정현우(Hyung Woo Jeong),전병관(Byung Gwan Jeon) 한의병리학회 2006 동의생리병리학회지 Vol.20 No.4

乾癬의 임상 치험례 보고

노영호(Young Ho Rho),엄현섭(Hyun Sup Eom),김경철(Gyeong Cheol Kim),신순식(Shin Soon Shik) 한의병리학회 2005 동의생리병리학회지 Vol.19 No.2

五加皮 抽出液이 免疫, 抗癌 및 肥滿에 미치는 실험적 효과

정현우(Hyun Woo Jeong),노영호(Young Ho Rho),이금수(Geum Su Lee),김천중(Cheon Joong Kim),전병관(Byung Gwan Jeon) 한의병리학회 2005 동의생리병리학회지 Vol.19 No.2

단일 기관에서의 질식분만과 제왕분만의 장단점에 대한 분석

류지원 ( Ji Won Ryu ),노영호 ( Young Ho Rho ),한상원 ( Sang Won Han ),하현용 ( Hyun Yong Ha ),김의혁 ( Euy Hyuk Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6

목적: 분만방법에 따라 분만 후 산모와 태아에 대한 영향과 부작용에 대해 비교 분석하기 위해 시행되었다. 연구방법: 본원에서 2007년 1월부터 2009년 7월까지 36주 이후에 단태아를 분만한 총 528명의 환자들을 후향적으로 분석하였다. 그들 중 질식분만을 한 군을 그룹 A군, 계획된 제왕절개술을 한 군을 그룹 B군, 그리고 응급 제왕절개술을 받은 군을 그룹 C군으로 나누었다. 우리는 분만 전과 분만 후에 혈색소 수치를 비교하였고 내외과적 소파술 여부와 항생제 추가 사용에 대해 평가하였다. 태아 결과 평가를 위해서는 1분 5분 아프가 점수, 신생아 중환자실 입원 여부와 태변 흡입 여부를 조사하였다. 결과: 분만 후 혈색소 감소치와 분만 후 입원 기간은 각 그룹 간에 통계학적으로 의미 있게 차이가 있었다(1.28 g/dL vs. 1.88 g/dL vs. 2.58 g/dL, 3.5일 vs. 5.9일 vs. 6.6일; P<0.001). 외래 방문수는 그룹 C군에서 그리고 외래에서의 항생제 사용은 그룹 A군에서 통계학적으로 의미 있게 가장 많았다. 신생아의 관점에서 볼 때 1분 5분 아프가 점수가 그룹 B군에서 가장 높았으며 신생아집중치료실 입원율과 태변흡입증후군 비율 역시 그룹 B군에서 가장 낮았다(8.0% vs. 3.2% vs. 16.3%, P=0.002; 4.5% vs. 0% vs. 7.5%, P=0.001). 결론: 질식분만은 출혈량, 재원기간 그리고 퇴원 후 외래 내원 횟수 면에서 좋은 결과를 가진다. 계획된 제왕절개술은 다른 분만 방법에 비해 산모의 심각한 부작용이 적고 태아의 좋은 결과를 가진다. Objective: To compare the postpartum maternal and neonatal effects and complications according to delivery modes. Methods: Five hundred twenty eight singleton pregnant women, who delivered after 36 gestational weeks in National Health Insurance Corporation Ilsan Hospital between July 2007 and July 2009, were retrospectively analyzed. They were categorized into 3 groups: group A, vaginal delivery; group B, elective cesarean delivery; and group C, emergent cesarean delivery. We evaluated the difference in hemoglobin decrement and postpartum hospital stays, medico-surgical curettage, and antibiotics usage. From the view point of neonates, 1 and 5 minute Apgar scores and Neonatal Intensive Care Unit (NICU) admission rates and meconium aspiration rates were evaluated. Results: Postpartum hemoglobin decrement and postpartum hospital days were statistically different among the groups, which results were 1.28 vs. 1.88 vs. 2.68 g/dL and 3.5 vs. 5.9 vs. 6.6 days, respectively (P<0.001). Number of out-patient-department follow-up was highest in group C and additional antibiotics usage was highest in group A with statistical signifi cance. The Apgar score was highest in group B (8.0% vs. 3.2% vs. 16.3%, P=0.002). NICU admission rate and meconium aspiration were also lowest in group B (4.5% vs. 0% vs. 7.5%, P=0.001). Conclusion: Although vaginal delivery showed advantage over blood loss related to procedure, hospital days and number of follow up, elective cesarean delivery has advantage carrying less severe complication of mother and better outcome for the baby than other delivery methods.

당뇨병 환자에서 Tc - 99m - DISIDA Scintigraphy 를 이용한 담낭의 기능분석

황인섭(In shup Hwang),류광현(Kwang Hyun Rhu),김홍남(Hong Nam Kim),노영호(Young Ho Rho),한신(Sin Han),김윤권(Youn Kwon Kim),김소연(So Yon Kim),조민구(Min Koo Cho),이권전(Gwon Jun Lee) 대한내과학회 1998 대한내과학회지 Vol.54 No.4

N/A Objectives : Diabetic autonomic neuropathy is a common complication of long standing diabetes mellitus and is well known to induce the motor dysfunction of cardiovascular system, genitourinary system and digestive system. Although many studies have done to evaluate the diabetic autonomic neuropathy, gallbladder motor function and biliary dynamic study to evaluate the change of gallbladder function in diabetic patients is relatively rare. This study was performed to measure the gallbladder ejection fraction using Tc- 99m-DISIDA with fatty meal in order to evaluate the gallbladder motor function in diabetic patients and to examine the usefulness of it in analyzing diabetic autonomic neuropathy. Methods : 51 diabetic patients(males 31, females 18, mean age 57yr(36-77yr)) and 1H control subjects(males 14, females 4, mean aged 47yr(31-70yr)) without gallstone and impaired liver function were enrolled in our study. Also the diabetic patients were categorized by age, disease duration, body weight and diabetic complications such as retinopathy, peripheral neuropathy and cardiovascular autonomic neuropathy accompanying with or not. Results : 1) Median value and interquartile range of gallbladder ejection fraction(%) were 66%(48-79%) in diabetic patients group and 75%(64-80%) in control subjects. There was no statistically significant difference between the two groups, but the mean value of diabetic patients was slightly lower than that of control subjects. 2) There was no significant difference between the two groups in mean value of gallbladder ejection fraction in every age group(P>0.05). 3) Median value of gallbladder ejection fraction in diabetic groups with less than 10 years of duration (both under 5 years and 5 to 10 years groups) was similar to that of control subjects. However in patients whose diabetic conditions last more than 10 years, the median range of gallbladder ejection fraction was significantly lower than that of control subjects(P<0.05). 4) Median range of gallbladder ejection fraction in obese diabetic patients group was significant lower than those of control subjects and non- obese diabetic patients(p<O.C6). 5) Median value of gallbadder was lower in diabetic patients group with complications like retinopathy, peripheral neuropathy or cardiovascular autonomic neuropathy (p<0.05) in comparison with those of control subjects and diabetic patients group without diabetic complication (p>0.05). Also seven diabetic patients whose gallhladder ejection fraction was reduced under,35% have had at least two diabetic complications. Conclusion : We observed that gallbladder ejection fraction of diabetic patients was reduced compared with that of control subjects. This is due to the reduced gallbladder muscle contractility resulting from diabetic autonomic dysfunction. These results suggest that the assessment of gallbladder ejection fraction using 99m- Tc-DISIDA would be useful to diagnose diabetic autonomic neropathy.

만성 간질환에서 Propranolol의 문맥압 감소 효과 : 경직장 문맥 신티그라피를 이용한 평가 Evaluation by Perrectal Portal Scintigraphy

김영중,김학수,윤수진,박병익,한신,노영호,조민구,김소연,이권전,김윤권 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.4

Purpose: Propranolol is known to decrease portal pressure by reducing blood flow of portal vein. Per-rectal portal scintigraphy with Tc-99m pertechnetate has been introduced to evaluate the portal circulation and early diagnosis of liver cirrhosis. We evaluated the effects of propranolol on portal circulation by using per-rectal portal scintigraphy. Materials and Methods: We analyzed the portal hemodynamics by per-rectal portal scintigraphy in 51 patients with liver cirrhosis, 10 chronic hepatitis and 10 normal subjects. 38 patients with cirrhosis underwent per-rectal portal scintigraphy before and after propranolol medication. Per-rectal portal scintigraphy was performed after per-rectal administration of 370 MBq of Tc-99m pertechnetate. The shunt index was calculated as the ratio, expressed as a percentage of heart radioactivity to the sum of heart and liver radioactivity during the first 30 seconds. Results: The shunt index in 40 patients with cirrhosis (59.8±27.2%) was significantly higher than that of nrmal control (5.0±1.2%, p<0.01) and chronic hepatitis (11.4±3.5%, p<0.01). Shunt index was significantly different according to Child's classification and the degree of esophageal varix (p<0.01). After propranolol medication, shunt index was significantly decreased from 59.9±27.3% to 51.3±15.3% (p<0.01) in 38 patients with liver cirrhosis. There was no significant difference of the amount of shunt index reduction after propranolol according to Childs' classification and the degree of esophgageal varix. Conclusion: The effect of propranolol on portal circulation was demonstrated as decreasing shunt index on per-rectal portal scintigraphy in patients with liver cirrhosis. Per-rectal portal scintigraphy may be useful to evaluate the portal circulation and to predict the effect of propranolol in patients with liver cirrhosis. (Korean J Nucl Med 1999;33:388-97)

종양양 위 전정부 폐쇄를 동반한 미만성 호산구성 위장관염 1 예

윤수진,노영호,조민구,김소연,이권전,반금진,한신,시석 대한소화기학회 1999 대한소화기학회지 Vol.33 No.5

Eosinophilic gastroenteritis is a rare disease characterized by tissue eosinophilia that can involve different layers of the gut wall. The pathogenesis and pathophysiology of this condition are poorly understood. Its clinical feature depends on the type of layer and location involved. The endoscopic and radiologic findings of eosinophilic gastroenteritis mimicked many other gastrointestinal diseases. We experienced a case of diffuse eosinophilic gastroenteritis in a 21-year-old male who presented severe vomiting and weight loss. After performing gastrofiberoscopy, barium study for upper gastro intestinal tract and abdominal computed tomography, we concluded that the lesion was gastric tumo with severe antral obstruction. Then, we carried out subtotal gastrectomy. We could confirm the diagnosis of eosinophilic gastroenteritis by full-thickness biopsy of the stomach wall. We report this case with a brief review of the literatures.

淸暈化痰湯加味方이 局所腦血流量 및 평균혈압에 미치는 실험적 연구(Ⅲ)

정현우,노영호,김천중 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

Cheonghunhwadam-tang have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CHT Gamypang(CTG) was CHT adding Aurantii Fructus(AF). The effects of CTG on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) is not known. The mechanical Study of CTG on the cerebral hemodynamics is not known too. Therefore, purpose of this Study was to investigate effects of CTG on the rCBF and MABP, mechanism of CTG on the cerebral hemodynamics in rats. The changes of rCBF and BP was determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; CTG extract was significantly decreased rCBF in a dose-dependent, but the change of MABP was not shown. Pretreatment with propranolol(3㎎/㎏, i.v.) was significantly increased CTG(10 ㎎/㎏, i.v.) induced decrease of rCBF. Pretreatment with indomethacin(3㎎/㎏, i.v.) and methylene blue(10㎍/㎏, i.v.) were increased CTG induced of rCBF too. This results suggest that the mechanism of CTG is mediated by adrenergic β-receptor, guanylate cyclase and cyclooxygenase.