흑색가토에 있어서 Apraclonidine 의 초자체강내 주입후 모양체 상피세포의 형태학적 변화

노세현(Sae Heun Rho),유기수(Ki Su Yoo) 대한안과학회 1991 대한안과학회지 Vol.32 No.6

한국인에서 광간섭단층촬영술 수치의 나이에 따른 차이

하성우,노세현,Sung-Woo Ha,Sae-Heun Rho 대한안과학회 2005 대한안과학회지 Vol.46 No.12

개방각녹내장에서 수지온도 회복지연과 야간 혈압하강 및 녹내장성 시야진행의 상관관계

김남영,서홍융,노세현,Nam Yeong Kim,Hong Ryung Seo,Sae Heun Rho 대한안과학회 2015 대한안과학회지 Vol.56 No.1

Purpose: To investigate the effects of a delay in finger temperature recovery rate on the hand cold provocation test (HCPT) and a nocturnal dip greater than 10% (dipper) on the progression of glaucomatous visual field (VF) defects in open-angle glaucoma patients when the intraocular pressure (IOP) was well controlled lower than the target pressure. Methods: 30 patients (58 eyes) with normal tension glaucoma (NTG) and 13 patients (24 eyes) with primary open angle glaucoma, and 12 normal controls (24 eyes) were retrospectively enrolled in this study. We performed HCPT, 24 hour ambulatory blood pressure monitoring (24-hr ABPM), Goldmann applanation tonometer measurements, and VF tests on all subjects. The delay in finger temperature recovery rate was defined as a delay longer than 15% of the mean finger temperature of normal controls over 2 intervals among 5, 10, 15, and 20 minutes after the immersion of cold water. We examined the relationships among the delay in finger temperature recovery rate, dipper, and the progression of glaucomatous VF defects. Results: The finger temperature recovery rate in NTG patients was significantly delayed more than that of normal controls at 5, 10, and 15 minutes after the immersion. The delay in finger temperature recovery rate significantly correlated with dipper in NTG patients. Glaucomatous VF defects were significantly progressed in the presence of dipper in NTG patients. Delay in finger temperature recovery rate was significantly related to the progression of glaucomatous VF defects in NTG patients. In the binary logistic regression test, delay in finger temperature recovery rate was the only factor that was strongly related to the progression of glaucomatous visual field in NTG patients. Conclusions: When glaucomatous VF defects progressed despite the IOP being well controlled, 24-hr ABPM and HCPT for detecting vascular dysregulation might be helpful for diagnosis and treatment of glaucoma. J Korean Ophthalmol Soc 2015;56(1):70-79

Dynamic Contour Tonometry와 골드만 압평 안압계의 비교

서장원,신동민,노세현.Jang Won Seo. MD. Dong Min Shin. MD. Sae Heun Rho. MD 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To compare dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) and investigate the influence of central corneal thickness (CCT) onintraocular pressure. Methods: In a prospective study of 165 eyes with glaucoma (135 eyes), glaucoma suspect (14 eyes), and ocular hypertension (16 eyes), intraocularpressure was measured with DCT and GAT, and followed by measurement of the CCT with ultrasound pachymetry. Statistical analysis were performed with simple linear regression analysis and t-test using SPSS (Statistical software, ver. 10; SPSS Inc., Chicago, IL). Results: A clear correlation between DCT and GAT was found (r =0.733, p<0.001). The average intraocular pressure was 14.92±2.28 mmHg with DCT and 13.97±3.12 mmHg with GAT, and the intraocular pressure with DCT was 0.95±2.49 mmHg higher than with GAT. A meaningful correlation was shown between GAT and CCT (r2=0.145, p<0.001), but was not demonstrated between DCT and CCT (r2=0.012, p=0.081). In addition, the difference of intraocular pressure between GAT and DCT (GAT-DCT) showed a significant correlation with CCT (r2=0.145, p<0.001). Conclusions: DCT appears to be a reliable method for intraocular pressure measurement, which is not influenced by CCT, unlike GAT.

야간혈압하강이 녹내장의 진행에 미치는 영향

서홍융,류원열,노세현,Hong Ryung Seo,Won Yeol Ryu,Sae Heun Rho 대한안과학회 2010 대한안과학회지 Vol.51 No.11

Purpose: To investigate the effect of nocturnal dip influence on the progression of glaucomatous visual field defect. Methods: We performed 24hr ABPM and V/F tests on patients diagnosed with NTG (140 patients, 280 eyes) and POAG (84 patients, 168 eyes). Nocturnal dips below 10% were classified as non-dippers, and those above 10% were noted as dippers. The correlations among nocturnal dip, progression of glaucomatous visual field defect, and hypertension treatment were examined. Results: In NTG, dippers in both systolic and diastolic blood pressure furthered glaucomatous visual field defects, with a relative risk of approximately three times that of non-dippers. Hypertension treatment was not influenced by the progression of glaucomatous visual field defect but was influenced by dips in the systolic and diastolic pressures in NTG and in diastolic pressure in POAG. Nocturnal dips were more frequent in the group with progression of the visual field compared to those in the group with non-progression of the visual field in NTG. Conclusions: Dipper caused a progression of glaucomatous visual field defects in NTG and was influenced by hypertension treatment in NTG and POAG. Performing 24hr ABPM should be helpful for glaucoma patients with progression of a glaucomatous visual field defect even when the IOP is less than the target pressure. In addition, hypertension treatment should be considered an important factor in the treatment of glaucoma. J Korean Ophthalmol Soc 2010;51(11):1471-1478

정상, 고안압증, 녹내장 의증, 녹내장안에서 매트릭스 시야계와 험프리 표준 자동 시야계간의 결과 비교

천현철,정우진,노세현,Hyun Chul Cheon,M,D,Woo Jin Jeung,M,D,Sae Heun Rho,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.5

Purpose: To study the correlation between the Humphrey standard automated perimetry (SAP) and the Humphrey Matrix Frequency Doubling Technology (FDT) perimetry and diagnostic usefulness of the Humphrey Matrix FDT perimetry. Methods: This study included 170 eyes of 170 patients. The 170 eyes were classified into 50 normal eyes, 20 ocular hypertensive eyes, 50 glaucoma-suspect eyes and 50 glaucomatous eyes. All subjects were examined with the Humphrey Matrix perimetry and the Humphrey standard automated perimetry. We studied the correlations between mean deviation (MD) and pattern standard deviation(PSD) of the Humphrey SAP and those of the Humphrey Matrix perimetry, respectively, in each of the classified group. Results: Overall, MD and PSD of the Humphrey SAP were significantly correlated with MD and PSD of the Humphrey Matrix perimetry, respectively. However, MD and PSD of the Humphrey Matrix perimetry were not showed a significant correlation in normal subjects (P>0.05). Conclusions: In this study, there were significant correlations between the MD and PSD of the SAP and those of the Humphrey Matrix perimetry in glaucoma, glaucoma-suspect and ocular hypertension. These finding suggests the Humphrey Matrix perimetry has performance characteristics similar to SAP and diagnostic value.

결막하원개부에 (結膜下圓蓋部) 발생한 상피성 (上皮性) 낭포 (囊胞)

김홍복 , 윤준달 , 노세현 ( Hong Bok Kim , Joon Dal Yoon , Sae Heun Rho ) 대한안과학회 1979 대한안과학회지 Vol.20 No.3

개방각녹내장에서 야간혈압하강, 경동맥혈류저하, 뇌의 허혈성 변화가 녹내장 진행에 미치는 영향

서홍융,진상욱,노세현,Hong Ryung Seo,Sang Wook Jin,Sae Heun Rho 대한안과학회 2013 대한안과학회지 Vol.54 No.9

Purpose: To investigate the effect of nocturnal dip, carotid artery blood flow, and brain ischemic change on the progression of glaucomatous visual field defect in open-angle glaucoma (OAG) when IOP is less than the target pressure. Methods: We classified OAG patients (74 patients, 148 eyes) who maintained IOP less than the target pressure as normal tension glaucoma (NTG; 52 patients, 104 eyes) or primary OAG (POAG; 22 patients, 44 eyes). Additionally, we performed 24-hr ambulatory blood pressure monitoring (24-hr ABPM), carotid artery color Doppler U/S (CAD), brain MRI, and visual field (V/F) tests on the patients. Nocturnal dips less than 10% were classified as non-dippers, and dips greater than 10% as dippers. The relationships among nocturnal dip, carotid artery blood flow, brain ischemic change, and progression of glaucomatous V/F defect were examined. Results: In the case of dippers, glaucomatous V/F defects were aggravated, with a relative risk of approximately 1.74 (NTG) and 2.91 (POAG) times that of non-dippers. In NTG, decreased carotid artery blood flow and brain ischemic change furthered glaucomatous V/F defects, with a relative risk of approximately 2.40 and 2.54 times that of normal carotid artery blood flow and brain MRI findings, respectively. However, in POAG, decreased carotid artery blood flow and brain ischemic change were not influenced by the progression of glaucomatous V/F defects. Conclusions: In dippers, decreased carotid artery blood flow and brain ischemic change caused a progression of glaucomatous V/F defects in NTG and POAG patients. Thus, performing 24-hr ABPM, CAD, and brain MRI should be helpful for glaucoma patients with progression of glaucomatous V/F defects even when the IOP is less than the target pressure. In addition, this analysis provides useful information regarding glaucoma diagnosis and treatment.

한국인의 스펙트럼영역빛간섭단층촬영 변수의 나이에 따른 차이

서지영,서홍융,노세현,Ji Young Suh,Hong Ryung Seo,Sae Heun Rho 대한안과학회 2013 대한안과학회지 Vol.54 No.2

Purpose: We evaluated the thickness of RNFL and optic nerve head parameters with age in normal eyes using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods: A total of 128 normal Korean volunteers in different age groups were recruited (age range, 20-70 years). Results: A significant negative correlation in average RNFL thickness with increasing age was found. The inferior areas (130.31 ± 3.33 μm) were significantly thicker than other areas (superior area 119.05 ± 2.12 μm, nasal area 71.80 ± 0.57 μm, temporal area 77.72 ± 0.16 μm). The average C/D ratios (mean 0.38 ± 0.14) and vertical C/D ratios (mean 0.35 ± 0.11) both showed significant increases with age, and the vertical C/D ratio correlation coefficient was higher (average C/D ratio r = 0.249, vertical C/D ratio r = 0.537). However, rim area, disc area, and cup volume were not correlated with age. Conclusions: From these findings, we conclude that, in normal Koreans, the mean RNFL thickness decreases and the C/D ratio increases with age, with the increase in the vertical C/D ratio being greater.

레이저 각막절삭 가공성형술을 이용한 노안 및 굴절교정수술 후 눈물막과 각막지각의 변화

허문정,권윤형,노세현.Mun Chong Hur. MD. Yoon Hyung Kwon. MD. Sae Heun Rho. MD. PhD 대한안과학회 2011 대한안과학회지 Vol.52 No.12

Purpose: To evaluate the changes in break-up time (BUT) and corneal sensitivity following LASIK surgery for refractive error correction with presbyopia in patients older than 45 years. Methods: The authors of the present study measured the BUT and corneal sensitivity of 92 eyes that received LASIK surgery for correcting refractive error with presbyopia. The eyes were divided into groups according to gender and preoperative refractive error before surgery and 1, 3, 6 and 12 months after LASIK. Results: The mean age of patients was 52.01 ± 5.51 years, and the male to female eye distribution was 31:61. The value of BUT before surgery and 1, 3, 6, and 12 months postoperative was 5.31 ± 2.03 sec, 4.47 ± 1.67 sec, 4.04 ± 1.58 sec, 4.53 ± 1.51 sec, and 4.87 ± 1.46 sec, respectively; corneal sensitivity was 56.35 ± 5.94 mm, 40.07 ± 14.21 mm, 46.42 ± 10.41 mm, 50.75 ± 8.04 mm, and 52.92 ± 7.51 mm, respectively. BUT was not significantly different relative to refractive error and was significantly shorter in the female group than the male group at 1 month postoperative. Corneal sensation of myopia at 12 months postoperative was statistically higher than at other time points; however, there was no difference between genders. BUT and corneal sensitivity at 12 months postoperative recovered to 91.6% and 93.9% of the preoperative value, respectively. Conclusions: BUT and corneal sensitivity after LASIK for presbyopia were decreased until 12 months postoperative and recovered slowly, but did not return to preoperative levels. J Korean Ophthalmol Soc 2011;52(12):1419-1426