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엉겅퀴의 스코폴라민 유도 인지능 손상에 대한 개선 효과 및 보호 기전 탐색
김민정 ( Min Jeong Kim ),노병욱 ( Byeong Wook Noh ),팡치치 ( Qi Qi Pang ),이상현 ( Sanghyun Lee ),김지현 ( Ji-hyun Kim ),조은주 ( Eun Ju Cho ) 강원대학교 농업생명과학연구원 2022 강원 농업생명환경연구 Vol.34 No.1
Scopolamine induces cholinergic dysfunction and oxidative stress, which leads to cognitive impairment. In the present study, we investigated the mechanisms by which Cirsium japonicum var. maackii (CJM) improved cognitive impairment in scopolamine-injected mice. Mice were administered an ethyl acetate fraction of CJM (EACJM, 50 and 100 mg/kg) for 14 days, and were injected intraperitoneally with scopolamine (1.5 mg/kg) for 8 days. To determine the protective effect of EACJM against memory loss in mice, T-maze, novel object recognition (NOR), and Morris water maze (MWM) tests were conducted using a scopolamine-treated mouse model. The protective mechanisms of EACJM in the brain were studied using western blotting. Scopolamine-induced memory dysfunction in mice was confirmed using behavioral tests, including T-maze, NOR, and MWM. However, results showed that EACJM effectively alleviated memory impairment in scopolamine-treated mice. Brain weight of EACJM-treated mice increased compared to that of scopolamine-injected mice. EACJM also downregulated acetylcholinesterase and upregulated brain-derived neurotrophic factor and phosphorylated cAMP response element-binding protein, indicating that EACJM ameliorated scopolamine-induced cognitive impairment. In addition, EACJM downregulated the B-cell lymphoma-2-associated X protein/B-cell lymphoma-2 ratio, indicating that EACJM blocked the apoptosis of neuronal cells. These results indicated that EACJM may be a useful therapeutic agent for preventing cognitive impairment in neurodegenerative diseases.
Hot-Spot 응력을 이용한 하중전달형 십자형 필렛 용접재의 피로강도 평가
박종민(Jong-Min Park),최원식(Won-Sik Choi),권순홍(Soon-Hong Kwon),노병욱(Byeong-Wook Noh) 한국기계가공학회 2007 한국기계가공학회지 Vol.6 No.1
In this study, fatigue strength of load-carrying cruciform fillet welded joints were evaluated using a new method proposed by Yamada, for geometric or structural stress in welded joint, that is, one-millimeter stress below the surface in the direction corresponding to the expected crack path. Validity of the method is verified by analyzing fatigue test results for load-carrying cruciform welded specimens has different size of weld toe radius, leg length and plate thickness reported in literature. Structural stress concentration factor for 1㎜ below the surface was calculated by finite element analysis for each specimen respectively. When compared to the basic fatigue resistance curve offered by BS7608, the one-millimeter stress method shows conservative evaluation for load-carrying cruciform fillet welded joints.