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페닐알킬 피페라진 유도체 합성과 ${\alpha}$-Glucosidase 저해활성
장인혜,이은영,황보경,김인규,손경희,최란,이응석,우미희,손종근,나영화,Chang, In-Hye,Lee, Eun-Young,HwangBo, Kyoung,Kim, In-Kyu,Sohn, Kyung-Hee,Choi, Lan,Lee, Eung-Seok,Woo, Mi-Hee,Son, Jong-Keun,Na, Young-Hwa 대한약학회 2011 약학회지 Vol.55 No.6
As an effort to find a new scaffold for ${\alpha}$-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their ${\alpha}$-glucosidase inhibitory activities. Compounds 8 ($IC_{50}=2.73{\pm}0.075mM$) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to ${\alpha}$-glucosidase. The result indicated that proper substituents on the piperazine can engender ${\alpha}$-glucosidase inhibitory activities on the piperazine derivatives.
강일우 ( Il-woo Kang ),로네쉬 ( Ronesh Sharma ),전성민,박선 ( Sun Park ),이성호,나영화 ( Young-hwa Na ),배진수 ( Jinsoo Bae ),정민아 ( Min-a Jung ),이연우 ( Yeonwoo Lee ),이성로 ( Seong-ro Lee ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2
현재 측위에 대한 측정 대상이 점점 작아지면서, 그에 따른 정확도 까지 높아지고 있다. 실내 측위에 관한 기술은 대표적으로 단말기의 수신신호의 세기방식인 RSS(Received Signal Strength), 수신신호의 도달시간 방식 TOA(Time of Arrival), 수신 신호의 도달 시간차 방식 TDOA(Time Difference of Arrival), 수신신호의 입사각 방식인 AOA(Angle of Arrival) 등 여러 가지 기술이 활발히 진행되고 있다. 본 논문은 특수 장비를 사용하지 않고, 무선 네트워크 기반의 실내 측위 중에 정확도가 높은 Fingerprinting 방법을 택하였다. WLAN 기반 실내측위에 가장 많이 사용되는 KNN은 k개의 이웃수와 RP의 수에 따라 민감하다. 본 논문에서는 KNN 성능을 향상 시키기 위해 SVM 이용하여 SNR 데이터를 군집화를 적용한 KNN과 SVM을 혼합한 알고리즘을 제안하였다. 제안한 알고리즘은 신호잡음비 데이터를 KNN 방법에 적용하여 k개의 RP를 선택한 후 선택된 RP의 신호잡음비를 SVM에 적용하여 k개의 RP를 군집하여 분류한다. 실험 결과 위치 오차가 2m이내에 KNN/SVM 혼합 알고리즘이 KNN 알고리즘보다 성능이 우수하다.
연구논문(硏究論文)(재록(再錄)) : 의약화학 ; 2,4,6-삼치환 피리딘: 합성, 토포이소미라제 1 및 2 저해활성, 세포독성과 구조활성관계
알준바스넷 ( Arjun Basnet ),프리텀다빠 ( Pritam Thapa ),라다깔끼 ( Radha Karki ),나영화 ( Young Hwa Na ),장영동 ( Yurng Dong Jahng ),정병선 ( Byeong Seon Jeong ),정태천 ( Tae Cheon Jeong ),이종순 ( Chong Soon Lee ),이응석 ( Eung Seo 영남대학교 약품개발연구소 2007 영남대학교 약품개발연구소 연구업적집 Vol.17 No.-
강혜영,신경은,장현지,나영화,조은희 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2
Purpose : The purpose of this study was to investigate drinking motives and the drinking-related problems of Korean high school students at a city in Jeonbuk province. Methods : There were 657 students from two academic and two vocational high schools at J city in Jeonbuk province. The sample was collected using a stratified sampling method and the data was collected from June 30th to July 16th 2003. The study instrument used to examine drinking motive was a 20.item summated scale (Cronbach's α = .95) and for drinking-related problems was an 18 item summated scale (Cronbach's α = .91). The data was analyzed using SPSS/PC+ by percentage, χ2.test, t-test and correlations. Results : 1. Drinking experience: Among the high school students, 74.3% of them had drinking episodes. Female students started drinking later (χ2 = 12.857, p = .002) and had more drinking friends (χ2 = 7.785, p = .020) than males. Vocational school students drank more frequently (χ2 = 32.138, p = .001), had more heavy drinking episodes (χ2 = 40.370, p = .001). 2. Drinking motives & Drinking-related problems: The mean score of drinking motives was 31.2 ± 11.12 out of 80 and that of drinking-related problems was 21.8 ± 5.85 out of 72 points. Neither score were stronger was significantly different according to gender and grade. On the other hand, both drinking motives (t = .4.077, p = .001) and drinking-related problems (t = .3.423, p = .001) were stronger in vocational school students than in academic school students. The correlation between drinking-related characteristics and problems were weak (from r = .286 to r = .520) but the correlation within the subcategories of drinking motives was high such as between enhancement and coping (r = .822) and enhancement and social motives (r = .822). Conclusion : The majority of Korean high school students start to drink during their junior high school days. Drinking motives and drinking-related problems were not serious but the drinking motives and the drinking-related problems are stronger among vocational school students. As a result, school-based health education and counseling programs should focus on solving drinking motives than on drinking-related problems.