토끼 심방근 및 혈관 평활근에서의 $Na^{+}/Ca^{2+}$ 교환기전에 관한 연구

김희주,문형로,엄융의,호원경,Kim, Hee-Ju,Moon, Hyung-Ro,Earm, Yung-E,Ho, Won-Kyung 대한생리학회 1988 대한생리학회지 Vol.22 No.1

In order to elucidate the regulatory mechanism of intracellular calcium ion concentrations, contractions or contractures induced by $Na^{+}-removal$, calcium-application or ouabain-treatment as an index of $Na^+/Ca^{2+}$ exchange activity were studied in atrial muscle or vascular smooth muscle (aorta and renal artery) of the rabbit. The magnitude of low sodium contractures in atrial trabeculae increased with sigmoid shape when external sodium concentrations were reduced to sodium-free condition, whereas that of calcium contracture intensified in a parabolic pattern when external calcium concentrations were elevated to 8 mM. $Na^{+}-removal$ contractures were induced in a duration-dependent manner to $K^{+}-free$ exposure and same findings were observed with ouabain treatment. $Na^{+}-free$ contractures were not affected by verapamil treatment, but stimulated by $100{\mu}M\;Mn^{2+}$ and inhibited by high concentrations of $Mn^{2+}\;(2{\sim}8mM)$ in a dose-dependent manner. Ryanodine which is known to suppress the release of calcium from internal store abolished spontaneous twitch contractions induced by $K^{+}-free$ solution, but had no effect on the development $Na^{+}-free$ contractures. Na-free contractures were not always induced in vascular smooth muscle preparations. Contractures by $O\;mM\;Na^+$ were usually seen in aorta, but not often in renal artery.$50\;mM\;K^+$, noradrenaline (NA) and angiotensin II (AII) always evoked very large contraction in all preparations of vascular smooth muscle. Contractures developed by $O\;mM\;Na^+$ were not sensitive to verapamil treatment as in atrial trabeculae, but were abolished by $100{\mu}M\;Mn^{2+}$. In contrast to $Na^{+}-free$ contractures, $Mn^{2+}(100{\mu}M)$ had no effect on the contractures induced by NA or 50 mM$K^+$. Caffeine in the concentration of 10 mM evoked transient contracture in the distal renal artery. The rate of spontaneous relaxation in caffeine contracture was dependent upon the concentrations of external sodium, and had double component of relaxation when the rate of relaxation was plotted in the semilogarithmic scale of relative tension versus time. Especially late components of relaxation had more direct relation to $Na^+$ concentrations. It could be concluded that $Na^+/Ca^{2+}$ exchange mechanism in the heart has a large capacity, inhibited by $Mn^{2+}$ but not by verapamil and ryanodine, while $Na^+/Ca^{2+}$ exchange system in vascular smooth muscle has a very low capacity especially in small artery, inhibited by low concentration of $Mn^{2+}\;(100{\mu}M)$ but not affected by verapamil and ryanodine.

열다한소탕(熱多寒少湯) 가감방(加減方)의 자가탐식(自家貪食) 유도 활성과 관련 단백질 탐색

김희주,배나영,장문희,양현옥,안택원,Kim, Hee-Ju,Bae, Na-Young,Jang, Moon-Hee,Yang, Hyun-Ok,Ahn, Taek-Won 사상체질의학회 2013 사상체질의학회지 Vol.25 No.3

Objectives Modified Yeolda-Hanso tang (MYH) is a traditional herbal formula in Korea for various diseases. MYH is containing the 10 herbs : Pueraria lobata (Willd.) Ohwi, Angelica tenuissima Nakai, Scutellaria baicalensis Georgi, Platycodon grandiflorum (Jacq), Angelicae Dahurica, Cimicifuga heracleifolia Kom, Raphanus sativa L., Polygala tenuifolia (Willd), Acorus gramineus Soland and Dimocarpus longan Lour. The 10 herbs is constituted as a ratio of the 6:4:2:1:2:2:2:4:6:6. We investigated neuroprotective effects of MYH on human neuroblastoma SH-SY5Y cells and evaluated the ability of MYH to prevent and treat for neurodegenerative diseases such as Parkinson's disease via basal autophagy enhancement. Methods Pharmacological induction of Autophagy by MYH in SH-SY5Y cells: Induction of autophagy by MYH in human neuroblastoma SH-SY5Y cells was carreid out by immunoblot analysis with several autophagy markers. SH-SY5Y cells were treated with MYH at the concentration of 400 and $800{\mu}g/ml$ for 24 hr. Specifically, the autophagosome proteins LC3 II and Atg5 levels were increased and autophagy pathway related proteins such as beclin-1, PI3 Kinase class III protein, ULK1, mTOR and AMPK were activated. Conclusions MYH can enhance the induction of autophagy through key regulator AMPK, mTOR, and Beclin-1 and it should be considered as a possible candidate of neuroprotective agents for such as Parkinson's disease.

Block-Quantized 이진 위상 홀로그램을 이용한 효율적인 광학적 perfect shuffle의 구현

김희주,허현,반재경,Kim, Hee-Ju,Huh, Hyun,Pan, Jae-Kyung 대한전자공학회 1996 전자공학회논문지-A Vol.33 No.5

In this paper, we introduced the BQBPH method for making the grating of high efficiency which was improtant in implementing optical PS. The pattern of graing was obtianed by computer simulations using iterative method, and the diffraction efficeincy of designed grating was about 67% through BPM simulation. The grating was fabricated by laser beam writer, and the diffraction efficiency BPM simulation. The grating was fabricated by laser beam writer, and the diffraction efficiency was 47%. We implemented the optical PS with the grating and showed that optical experimental output patterns were good agreement with PS output patterns and first order was main diffraction order.

저상굴절차량의 주행에 따른 파이프트러스교의 충격계수 산정

김희주,전명일,황원섭,Kim, Hee-Ju,Jun, Myung-Il,Hwang, Won-Sup 한국전산구조공학회 2010 한국전산구조공학회논문집 Vol.23 No.1

본 논문에서는 새로운 차량의 도입으로 건설되는 신형식 교량의 동적거동을 확인하기 위해 상용 유한요소 프로그램을 이용하여 해석을 실시하여 충격계수를 산정하였으며, 국내뿐만 아니라 각국에서 적용되고 있는 충격계수에 관한 설계기준을 조사하여 비교 검토하였다. 연구에서 제시되어진 교량형식은 파이프트러스 형식으로 각각 34m, 44m, 54m로 모델링하였으며 각각의 지간길이에 따른 충격계수의 영향을 산정하였다. 차량모델은 실제 교량 위를 통과하는 2축과 3축 저상굴절차량과 박영석(1997)이 제시한 147kN 덤프트럭 모델을 적용하였으며, 각 차량별로 10km/h~100km/h까지의 속도대역에 따른 충격계수를 산정하여 이에 따른 영향을 검토하였다. 또한 차량 및 지간길이에 따라 산정되어진 지간 중앙에서의 충격계수를 바탕으로 우리나라 및 외국의 설계규정과 비교 검토하였다. This paper estimated the impact factor using the finite element program to confirm the dynamic behavior of new type of bridges constructed by introduction of new vehicles and compared the design criteria about the impact factor applied to domestic as well as each country. The study estimated effects of the impact factor according to pipe truss types modeled as respectively 34m, 44m, 54m and span length. The vehicle models are vehicle for bimodal tram of two axis and three axis which passes on actual bridge and dump truck model proposed by Park Young suk(1997). Each vehicle is estimated the impact factor according to velocity from 10 to 100(km/h) and examined. Also, the study investigated and compared the design regulation of domestic and a foreign country based on the impact factor on span center calculated in accordance with vehicle and span length.

강재교각 기초부의 연결상세 개선을 위한 실험적 연구

김희주,함준수,양성돈,황원섭,Kim, Hee-Ju,Ham, Jun-Su,Yang, Sung-Don,Hwang, Won-Sup 한국강구조학회 2012 韓國鋼構造學會 論文集 Vol.24 No.5

현재 강재교각 기초부의 설계에 적용되어지고 있는 형식은 기초 콘크리트 내부에 앵커프레임을 설치하여 교각부와 연결하는 형태로 설계 및 시공을 하고 있다. 이는 복잡한 설계와 시공으로 인하여 기초부의 크기가 커지고, 과대 설계되는 경향이 있다. 본 연구에서는 고성능강을 이용한 교각 기초부의 연결상세와 관련하여 새로운 형상을 제안하기 위하여 기존 설계기준에 의한 시험체와 고장력 앵커를 사용한 새로운 연결형상 시험체 등 총 3개의 시험체를 제작하여 실내 시험을 실시하였다. 이를 통하여 각 시험체의 성능을 비교 분석하여 연결형식에 따른 구조물의 거동특성을 분석하였다. Generally, a steel pier-foundation has been designed and constructed with a anchor frame. However, because of the complicated design and construction, the foundation's size has become large and has been overdesigned. In this study, three specimens were made and the tests were conducted to suggest a new shape in regard to the pier-foundation's joint details using the high performance steel. One of the specimens was made up of the general anchors and the anchor frame. Another specimen consisted of the high tension anchors and the studs, and the other specimen was composed of the high tension anchors and the inner steels. After the performance of each specimen was compared and analyzed, the behavior characteristics according to the joint were analyzed.

원전사고에 따른 토양.지하수 방사성오염의 효과적인 관리 연구

김희주,현윤정,김영주,황상일,Kim, Hee-Joo,Hyun, Yun-Jung,Kim, Young-Ju,Hwang, Sang-Il 한국지하수토양환경학회 2011 지하수토양환경 Vol.16 No.6

In this study, we suggested the management scheme of analyzing the national and oversea related policy against soil and groundwater contamination by radioactive materials due to nuclear accidents. In Korea, we need to remedy swiftly the contaminated land due to intensive land development demand. So, we need to develop more effective management scheme to recover actively the land contaminated by radioactive materials. We require to improve monitoring network, to expand media-specific monitoring system, to prepare management system for remediation of contaminated land, and to develop flow work for soil and groundwater remediation.

국내 결혼이민자의 출판물 이용 동기와 만족에 관한 연구

김희주(Kim Hee Ju) 한국출판학회 2016 한국출판학연구 Vol.42 No.3

본 연구는 국내 결혼이민자를 대상으로 하여 다문화 출판물의 이용 동기와 수용자가 요구하는 다문화 출판물의 내용에 대하여 알아보고자 하였다. 이용동기는 자아실현, 문화적응, 정보습득, 오락추구 등 총 4가지로 나누어 측정하였으며, 수용자들의 다문화 출판물에 대한 만족도 요인에 관한 내용을 살펴보았다. 응답자들은 주로 자아실현과 문화적응을 위하여 다문화 출판물을 이용하고 있었는데 특히 고학력자일수록 자아실현을 중요하게 생각하였으며, 한국어를 능숙하게 구사할 수 있게 해주는 교육적인 내용, 한국 생활에 적응하기 위한 다양한 정보 제공의 내용, 문화의 다양성을 알 수 있는 수필이나 에세이 등의 논픽션류를 필요로 하였다. 본 연구는 향후 국내 결혼이민자들이 다문화 출판물을 왜 필요로 하는지에 대한 분석으로써 이용하는 동기에 대한 파악을 가능하게 하며, 국내 결혼이민자들의 기대심리를 반영하고 있는 결과이기 때문에 현재 다문화 출판물을 제작하는 방향성에 대해서도 시사하는 바가 크다고 볼 수 있다. This study aims to determine the usage motivation of multi cultural publications of marriage-based immigrants in Korea and the contents of publications requested by consumers. Usage motivations were measured by dividing them into 4 kinds - self-realization, acculturation, information acquisition and entertainment pursuit. Satisfaction factors and demanded contents of multi-cultural publications were also examined. The findings show that respondents use publications for self-realization and acculturation. Especially to highly-educated respondents, self-realization is the major factor and they required educational contents to speak Korean fluently, information acquiring content helping them adapting to Korea and fictions to understand cultural diversity. This study is about analyzing the needs of marriage-based immigrants which reflects their psychology of expectations and usage motivations. Therefore it has significance in providing directions for the current production of multi-cultural publications.

무인항공기를 위한 최적의 3차원 비행경로 추천 시스템 설계 및 구현

김희주(Hee Ju Kim),이원진(Won Jin Lee),이재동(Jae Dong Lee) 한국멀티미디어학회 2021 멀티미디어학회논문지 Vol.24 No.10

소몽 채기중의 항일독립운동

김희주 ( Hee Ju Kim ) 동국대학교 동국역사문화연구소 2002 동국사학 Vol.38 No.-

전분 종류에 따른 토란맛탕의 품질 특성

김희주 ( Hee Ju Kim ),이경미 ( Gyeong Mi Lee ),김진선 ( Jinseon Kim ),박주안 ( Juan Park ),신정규 ( Jung Kue Shin ) 한국산업식품공학회 2016 산업 식품공학 Vol.20 No.2

Taro is an alkaline food containing a lot of protein, vitamin C, and minerals. Matang is a food prepared by frying a starch-containing material in oil and glazing with honey or starch syrup and it is widely enjoyed as simple snack or dessert in Asian countries including Korea. In this study, to increase the usability of taro having high nutritional values, taro matang was prepared by varying the types of starch while the physical and sensory properties were investigated. The taro matang was prepared by mixing corn starch, sweet potato starch, potato starch, and sticky rice starch with taro. The chromaticity of taro matang samples were measured, and the results showed that the corn starch taro matang was the brightest (L=40.48±1.17) and the potato starch matang was the darkest (L=33.81±1.33). The pH of the taro matang samples were within the range of 6.16-6.26 with no significant difference. The physical properties of the prepared taro matang samples were measured. The hardness and fracturability of the sweet potato starch taro matang were the highest at 3,414.79 and 1,570.03, respectively. The springiness and chewiness of the corn starch taro matang were the highest at 0.95 and 1,773.24, respectively. With regard to sensory properties and preference, the taro matang samples having lower hardness and brighter chromaticity were preferred. The preference for the flavor, crispness, softness, taste, and overall preference of the potato starch taro matang were the highest. Therefore, taro matang prepared as snack or dessert by mixing with potato starch may satisfy consumers’ demand.