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김흥열 ( Heung Yeol Kim ),김한수 ( Han Soo Kim ),조은별 ( Eun Byul Cho ),박은주 ( Eun Ju Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.10
Blue nevus is a neoplasm composed of pigmented dendritic dermal melanocytic cells in the reticular dermis. The lesion clinically presents as a well dermacated cerulean-blue or bluish black colored papule or plaque that usually measure less than 1 cm in diameter. Pilar sheath acanthoma is a rare, benign follicular hamartoma commonly affecting middle-aged and elderly individuals. It is characterized by a small, solitary, skin colored papule situated on the head and neck, particularly around the upper lip. We report a rare case of a blue nevus associated with a pilar sheath acanthoma in a 26 year-old man presented with a bluish papule on the neck. (Korean J Dermatol 2013;51(10):814∼816)
김흥열 ( Heung Yeol Kim ),박새보미 ( Sae Bo Mi Park ),박은주 ( Eun Ju Park ),권인호 ( In Ho Kwon ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.8
Amelanotic maliganat melanoma is a comparatively rare disease. It accounts for 1.8∼8.1% of all malignant melanoma. It is sometime difficult to diagnose amelanotic malignant melanoma because there is no pigmentation, clinically. Polypoid melanoma is a variant of nodular melanoma, which in depth seldom reaches the reticular dermis. The main part of the tumor is located above the nearby epidermis, raised in the form resembling cauliflower. We report a rare case of amelanotic malignant melanoma with polypoid feature in a 78-year-old woman who presented a single bright red nodule on the left thigh.
지루각화증과 유사한 임상 양상을 나타낸 안면부 병변의 임상 및 병리조직학적소견에 대한 연구
김흥열 ( Heung Yeol Kim ),김한수 ( Han Soo Kim ),조은별 ( Eun Byul Cho ),박은주 ( Eun Ju Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.7
Background: The most of typical seborrheic keratoses (SKs) can be clinically differentiated with ease from other dermatoses. However, its differential diagnosis can sometimes be difficult and recently reported cases clinically suggest that SKs with the skin biopsy result being some other diseases can bring on the need for further evaluations. Objective: The aim of this study is to examine the diagnostic yield in submitting clinically diagnosed SKs which showed single discoid lesions of the face for routine microscopic examinations. Methods: We conducted a retrospective review of cases for histological examinations with a clinical diagnosis of SKs or with a differential diagnosis that includes SKs which shows single discoid lesion of the face. A total of 94 pathology reports containing a diagnosis of SKs in the clinical information field were identified. The accuracy of the clinical diagnosis and clinic histopathological correlations were studied. Results: In this study, 45.7% of patients was clinically assumed to have SKs but turned out to be some other diseases according to the histopathology test results - a total of 19 cases (44.2%) with some considered to be precancerous (actinic keratosis 25.6%, benign lichenoid keratosis 16.3% or cancerous (basal cell carcinoma 9.3%, squamous cell carcinoma 4.7%). Conclusion: Lesions suggested to be SKs need more examinations and lesions of atypical clinical appearances which cannot completely exclude the possibility of precancerous or malignant lesions are strongly recommended for skin biopsies. (Korean J Dermatol 2013;51(7):494∼500)
김흥열 ( Heung Yeol Kim ),김병철 ( Byung Chul Kim ),박은주 ( Eun Ju Park ),권인호 ( In Ho Kwon ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.7
Squamous cell carcinoma on the lip is a common oral malignancy, and it is responsible for >30% of all oral squamous cell carcinomas. Numerous factors have been implicated in the development of squamous cell carcinoma on the lip, but the most frequently identified risk factors include chronic exposure to ultraviolet radiation. Squamous cell carcinoma on the lip is more prevalent in elderly men, with a male-to-female ratio of 5:1. We report an interesting case of squamous cell carcinoma mimicking herpes simplex on the lip in a 35-year-old woman who presented with erythematous grouped vesicles on the upper lip.
김흥열 ( Heung Yeol Kim ) 대한폐경학회 2008 대한폐경학회지 Vol.14 No.3
Bisphosphonates are widely used, though gastrointestinal tolerance is a problem on daily administration. Intermittent regimen, from once weekly to once yearly, is now available in overseas and can overcome GI adverse events. New generation of anti-resorptive agents (anti-RANKL antibody and a new SERM, bazedoxifene) are promising and will be soon available for the treatment of osteoporosis. Anabolic agents such as teriparatide and strontium ranelate have marked effects on BMD and reduction on fracture risk. While none of these options is suitable for everyone, the range of future available therapies does mean that most patients can find an intervention that is effective and acceptable. Now I introduce new antiresorptive drugs (Denosumab, Integrin inhibitor, Cathepsin K inhibitor) and new bone formation drugs (PTH-Teriparatide, Strontium Ranelate, Antisclerostin Ab-Sclerostin inhibitor, 2MD, Other Wnt-signaling related drugs).
김흥열 ( Heung Yeol Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.1
일반적으로 폐경여성에서 에스트로겐치료를 하면 열성홍조와 mood disturbances가 좋아지고 수면에 현저한 향상을 느끼지만 모든 객관적인 자료가 치료에 따른 증상의 개선과 항상 일치하지는 않는다. 따라서, 증상 개선의 원인으로 호르몬 치료 및 행동 조건 (behavioral conditioning)이 그 역할을 한 것으로 설명될 수 있으리라 생각되며, 폐경 여성이 수면 장애를 호소할 때 여성 호르몬 부족으로만 생각할 것이 아니라 다른 원인에 대해서도 고려해야 할 것이다.
폐경기 여성에서 저용량 에스트로겐 대체요법으로 인한 지질대사의 변화에 관한 연구
김흥열(Heung Yeol Kim),어완규(Wan Kyu Eo) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
목적 : 실험대조군 연구를 통해 폐경 후 여성에서 저용량 에스트로겐의 지질 효과를 알아보고자 하였다. 연구 대상 및 방법 : 2000년 3월부터 2002년 3월까지 고신대학교 복음 병원 산부인과 외래를 방문하여 자궁의 양성 질환으로 자궁적출술을 시행 받은 여성 중 에스트로겐 제재로만 0.625 ㎎의 에스트로겐 보충요법을 1년간 시행받은 75명의 폐경여성 (1군)과 0.31 ㎎의 저용량 에스트로겐 보충요법을 1년간 시행받은 55명의 폐경여성 (2군)을 대상으로 하여 치료 시작전, 치료 6개월 후, 치료 12개월 후 혈청 지질을 측정하였다. 결과 : 1군, 2군 두군 모두 기저치에 대한 혈중 총 콜레스테롤 농도의 비는 투여기간 내내 감소하였으나 유의한 차이는 없었다. 1군, 2군 두군 모두 기저치에 대한 혈중 중성지방 콜레스테롤 농도의 비는 투여기간 내내 증가하였으나 통계적으로 유의한 차이가 없었다. 1군, 2군 두군 모두 기저치에 대한 혈중 HDL 콜레스테롤 농도의 비는 투여기간 내내 증가하였으며, 유의한 증가를 보였다 (p<0.05). 1군, 2군 두군 모두 기저치에 대한 혈중 LDL 콜레스테롤 농도의 비는 투여기간 내내 감소하였으며, 유의한 감소를 보였다 (p<0.05). 결론 : 저용량 호르몬 대체요법은 패경증상의 치료와 심혈관질환 예방에 어느 정도 안전하고 효과적인 치료방법으로 기존의 용량보다 부작용의 빈도가 낮아 치료의 순응도를 높일 수 있는 효과적일 것으로 생각한다. Objective : To evaluate the effects of low dose estrogen replacement therapy on the lipid profile in the postmenopausal women. Methods : This prospective randomized clinical trial examined the effects of low dose conjugated equine estrogen on lipid profile in 140 postmenopausal women. Treatment included 0.625 mg conjugated equine estrogen (group I, n=75), or 0.31㎎ conjugated equine estrogen (group Ⅱ, n=55) for 12 months, Lipid profile were performed at months 6 and 12 months. Results : HDL cholesterol increased significantly during the treatment in Group I and Group Ⅱ. LDL cholesterol decreased significantly during the treatment in Group I and Group Ⅱ. Total cholesterol in Group I and Group Ⅱ decreased during treatment, but not significantly. As triglyceride increased slightly during the treatment in Group I and Group Ⅱ but not significantly. Conclusion : The low dose conjugated equine estrogen is also positive changes on lipid profile.