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김현식(Hyun Shig Kim),조경아(Kyung A Cho),황도연(Do Yean Hwang),김건욱(Kuhn Uk Kim),강용원(Yong Won Kang),박원갑(Weon Kap Park),윤서구(Seo Gue Yoon),이광렬(Kwang Real Lee),이종균(Jong Kyun Lee),이중달(Jung Dal Lee),김광연(Kwang Yun K 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Granular cell tumor is rare and is thought to originate from neurogenic cells. The tumor rarely occurs in the colon and its occurrence in the appendix is extremely rare. We report a case of granular cell tumor developed in the appendix for the first time in Korea. The tumor was discovered incidentally during colonoscopy and removed by using an endoscopic polypectomy. The expression of S-100 protein and lack of desmin represent that the tumor is relatd with Schwann cell originally. (Kor J Gastroenterol 2000;36:404 - 407)
위장관 ; 경도 및 중등도 활동성 궤양성 대장염 환자에서의 VSL#3의 효능
이지현 ( Ji Hyun Lee ),문규 ( Gyoo Moon ),권혁진 ( Hyeok Jin Kwon ),정우진 ( Woo Jin Jung ),서평주 ( Pyoung Ju Seo ),백태윤 ( Tai Yoon Baec ),이주형 ( Ju Hyeong Lee ),김현식 ( Hyun Shig Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2
Background/Aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC. Methods: Twenty-four eligible patients with mild to moderate UC received open-label VSL#3 4 sachets daily in 2 divided doses for 8 weeks. The disease activity pre- and post-VSL#3 therapy was assessed by ulcerative colitis disease activity score and colonic tissue cytokine profiling done at baseline and at week 8. Results: Twenty-four patients (mean age, 43.7 years; range, 20-70 years; male/female, 15/9) were enrolled and 2 patients did not have the final endoscopic assessment. A total of 22 patients were analyzed. Intent to treat analysis demonstrated remission in 45.8% of subjects (n=11); partial response in 20.8% (n=5); no change or worse in 25.0% (n=6) of subjects. The mean ulcerative colitis disease activity index (UCDAI) scores decreased from 7.09±1.81 to 1.45±1.29 in patients with a remission (p<0.001). The mean endoscopic scores had also significantly decreased from 1.91±0.54 to 0.63±0.50 in patients with a remission (p<0.001). The concentrations of colonic cytokines did not change significantly during treatment in patients with a remission. Conclusions: Our study demonstrated that VSL#3 is effective in achieving clinical responses and remissions in patients with mild-to moderately active UC, further supporting the potential role in UC therapy. (Korean J Gastroenterol 2012;60:94-101)