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김현섭,김병옥,한경윤,Kim, Hyun-Sub,Kim, Byung-Ok,Han, Kyung-Yoon 대한치주과학회 1993 Journal of Periodontal & Implant Science Vol.23 No.1
The purpose of the this study was to research the interrelationship of periodontal status and patient's age between diabetic group and non-diabetic group and compare that of periodontal status according to the blood sugar level and duration of diabetics. The participants of this study were 52 diabetic patients and 51 non-diabetic patients. The diabetic group and non-diabetic group were further divided into four subgroups according to the age(under 35 years old, 36 - 45 years old, 46 - 55 years old, over 56 years old) and the diabetic group was further divided into three subgroups according to the duration of diabetics (under 5 years, 6 - 10 years, over 11 years) and blood sugar level(under 140mg/100ml, 140-200mg/100ml, over 200mg /100ml), respectively. Author evaluated such periodontal status as plaque index and calculus index, gingival lndex, loss of attachment, papillary bleeding index, tooth mobility and missing teeth, and then data was statistically analyzed by SPSS/PC+ using ANOVA, respectively. The results were as follows: 1. The mean value of plaque index, gingival index, loss of attachment, papillary bleeding index, tooth mobility and missing teeth of diabetic patients were significantly higher than that of non-diabetic patients, respectively(p <0.01, p<0.01, p<0.01, p<0.01, p<0.001, p<0.001), but there was no significant difference between diabetic group and non-diabetic group in calculus index(P>0.05). 2. According to the increase of age, loss of attachment and missing teeth were increased in both group, and correlation of each subgroup was statistically significant, respectively(p<0.05, p<0.001). 3. According to the elevation of blood sugar level of diabetics, plaque index, gingival index, loss of attachment, papillary bleeding index, tooth mobility and missing teeth were increased in diabetic group, and correlation of each subgroup was statistically significant, respectively (p<0.05, p<0.05, p<0.05, p<0.05, p<0.001, p<0.001). 4. According to the duration of diabetics, plaque index, gingival index, loss of attachment, papillary bleeding index, tooth mobility and missing teeth were increased in diabetic group, and correlation of each subgroup was statistically significant, respectively(p<0.05, p<0.05, p<0.05, p<0.05, p<0.001, p<0.001).
유전 및 육종 : 혈액세포의 텔로미어 함량을 이용한 소의 연령예측
김현섭 ( Hyun Sub Kim ),최창용 ( Chang Yong Choe ),전광주 ( Gwang Joo Jeon ),손시환 ( Sea Hwan Sohn ),최나은 ( Na Eun Choi ) 한국동물자원과학회 ( 구 한국축산학회 ) 2010 한국축산학회지 Vol.52 No.5
텔로미어란 진핵세포의 염색체 양 말단에 있는 DNA-단백질 복합체로서, 특정단백질과 TTAGGG의 반복염기서열로 구성되어있다. 이들의 기능은 핵 내 염색체의 안정성에 본질적으로 작용함으로 세포의 노화와 직접적 관련이 있다고 알려져 있다. 본 연구에서는 소의 간기상태의 백혈구 세포를 대상으로 연령별, 품종별, 성별간 telomeric DNA 함량을 분석하여 이러한 요인들이 텔로미어 함량에 미치는 영향을 살펴보고 또한, 텔로미어 함량을 이용한 개체의 연령예측 가능성을 제시하고자 하였다. 소의 텔로미어의 함량 분석은 l개월령에서 166개월령의 한우 및 홀스타인종 460두를 대상으로 telomeric DNA probe를 이용한 Q-FISH 방법으로 분석하였다. 분석 결과 소에 있어서 연령이 증가함에 따라 telomeric DNA 함유율이 일관되게 점진적으로 감소되는 양상을 보였다. 소의 품종간 telomeric DNA 함유율을 비교한 결과 한우의 telomeric DNA 함량이 홀스타인종에 비해 유의적으로 높게 나타났으며, 성별 간에도 수컷이 암컷에 비해 유의적으로 높은 telomeric DNA 함유율을 나타내어 품종별, 성별 모두 텔로미어 함유율의 유의적인 차이가 있음 확인 할 수 있었다(P<0.01). 따라서 요인별 유의적 차이가 있음으로 한우 암컷 및 홀스타인 암컷에 대한 각기 연령예측 회귀함수를 추정하였다. Telomeric DNA 함량을 독립변수(X)로 하고, 연(월)령을 종속변수(Y)로 설정하여 2차회귀식을 도출한 바 한우 암컷의 경우 Y=38.102X2-220.103X+318.309(P<0.0001, R2=0.8019)이고, 홀스타인 암컷은 Y=42.799X2-199.682X+242.106(P<0.0001, R2=0.8379)으로 분석되었다. 이상의 두 회귀식 모두 유의한 함수로 결정계수(R2) 또한 0.8 이상의 높은 상관 값을 보임에 따라 본 회귀식으로 소의 연령 예측이 가능함을 제시하고자 한다. Telomeres at the end of chromosomes consist of tandem repeats of (TT AGGG)n DNA sequence and associated proteins. Telomeres have the essential functions in chromosome stability and genome integrity and are hence related to cell senescence and cancer. This study was carried out to quantify the amount of telomeric DNA and establish age prediction equations by using the quantity of telomeric DNA for cattle. Analysis of the telomere quantity of the lymphocytes was performed at different age, across breeds and between different sexes of cattle. We quantified the amount of telomeric DNA by the Q-FISH technique using the telomeric DNA probe in 460 cattle at age of 1-166 months in Korean Cattle and Holstein breeds. In results, we found that the amount of telomeric DNA decreased gradually with age. The amount of telomeric DNA of Korean Cattle was significantly higher than that of Holstein breed (P<0.01). In addition, the amount of telomeric DNA in male was significantly higher than that in female (P<0.01). Using the relationship between age and the amount of telomeric DNA in cattle, age predicting equations were established as a result of regression analysis. Because sex and breeds influenced telomeric DNA quantity, the age prediction equations were estimated separately in Korean Cattle females and Holstein females. The regression equations were Y = 38.102X2 - 220.103X + 318.309 (P<0.0001, R2=0.8019) in Korean Cattle females and Y = 42.799X2 - 199.682X + 242.106 (P<0.0001, R2 = 0.8379) in Holstein females, where the X was quantity of telomeric DNA and Y was predicted age in months. These equations predicted the age of cattle with high significance and accuracy and have high R square values. Thus, it could be possible to scientifically predict the age using the above equations for Korean Cattle and Holstein females.
김현섭(Hyun-Sub Kim),전병한(Byeong-Han Jeon) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.10
본 연구에서는 여러 사업장에서 많이 사용되는 대표적 독성 물질인 염소를 누출 물질로 선정하여 화학사고 통계자료에 따라 사고 발생 빈도가 높은 여름철 기상조건을 인자로 한 대안의 시나리오와 기존의 시행방법인 연평균 기상조건을 인자로 한 대안의 시나리오 비교분석을 통해 개선방안을 제시하고자 하였다. 2014년 1월부터 2016년 12월까지 발생한 총 296건의 화학 사고를 분석한 결과 사계절 중 여름에 가장 많은 사고가 발생하는 것으로 조사되었으며 전체 사고 발생건수의 35.81%를 차지하였다. 실제 염소를 취급하는 사업장을 대상으로 위험성 평가 결과 2016년의 경우 연평균 기상조건하에서 산출된 영향범위는 발생원으로부터 반경 712.4 m, 영향범위 내 주민 수는 20,090 명이였으며, 여름철 평균 기상조건하에서 산출된 영향범위는 발생원으로부터 반경 796.2 m, 영향범위 내 주민 수는 27,143 명으로 나타났다. 이와 같은 결과는 특정 조건하에서 현 대안의 시나리오 상의 영향범위가 포괄할 수 없는 부분이 존재함을 의미한다. 따라서 화학 물질별 특성을 고려한 Case Risk Assessment가 이루어져야 한다는 위험성 평가 제도의 발전방향을 제시한다. In this study, we selected chlorine, a typical toxic material used in many workplaces, as the leakagematerial, and through the analysis of alternative scenarios based on the meteorological conditionsin the summer frequently encountered in accidents, we suggest ways to improve the (method of analysis/accident scenario modeling).The analysis of 296 chemical accidents from January 2014 to December 2016 found that the highest rate of occurrence was in summer, accounting for 35.81% of the total. According to the risk assessment, the influence range and number of inhabitants in the influence area were 712.4 m and 20,090 under the annual mean weather conditions and 796.2 m and 27,143 people underthe summer mean weather conditions, respectively. This result implies that, under certain conditions, the range of impacts in the current alternative scenario is incomplete. Therefore, risk assessment systemsneed to be improved in order to take into consideration the characteristics of each chemical substance.
고 영각의 델타익을 지나는 와유동에 관한 수치해석적 연구
김현섭(Hyun Sub Kim),김희동(Heuy Dong Kim),손명환(Myong Hwan Sohn) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.5
This paper dispicts the vortex flow characteristics of a delta wing using the computation analysis. This<br/> study is focused on investigating and visualizing the effects of the angle of attack, free steam velocity, the<br/> development and interaction of vortices and the relationship between the suction pressure distribution and the<br/> vortex flow characteristics. Computations are applied to the three dimensional, compressible, Navier-Stokes<br/> Equations. For computations, the free stream velocity is changed between 20m/s and 60m/s and the angle of<br/> attack of the delta wing is changed between 16° and 24°. Computational results are compared with the<br/> previous experimental ones. It is found that the present CFD results predict the vortical flow characteristics of<br/> the delta wing well, and with an increase in the free stream velocity, the leading edge vortex moves outboard<br/> and its strength is increased.