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탈단백 우골을 이용한 상악동 거상술 후 즉시 임플란트 식립에 대한 임상적 평가
김현국,김진욱,김진수,Kim, Hyun-Kuk,Kim, Jin-Wook,Kim, Chin-Soo 대한악안면성형재건외과학회 2011 Maxillofacial Plastic Reconstructive Surgery Vol.33 No.3
Purpose: Placement of endosseous implants in the atrophic maxilla is often restricted because of the lack of supporting bone. In this article, augmentation of the maxillary sinus floor with deproteinized bovine bone to enable insertion of endosseous implants is described. The technique is aimed at providing a cortical layer on top of the graft to ensure a reliable seal of the maxillary sinus and to achieve optimal stability of the bone graft in case of simultaneously placement of dental implants. Methods: The procedure was used in 200 patients (839 implants), using deproteinized bovine bone. The mean follow-up was 28.5 months. No inflammation of the bone grafts nor of the maxillary sinus occurred. The patients received implant supported overdentures or bone-anchored bridges. Results: The survival rate of implant restoration of this study was 97.6%. The total average of marginal bone loss in radiographs was $0.20{\pm}0.38$ mm. Insufficient primary stability, bony quality, and infection were thought to be associated factors in the failed cases. Conclusion: This study documented that deproteinized bovine bone, when used as a grafting material for augmentation of the sinus floor, may lead to proper osseointegration of a endosseous implant.
탈질능을 가진 Pseudoomonas sp.의 분리 및 특성
김현국,김성구,이병헌,서근학,공인수,Kim, Hyun-Kuk,Kim, Sung-Koo,Lee, Byung-Hun,Suk, Keun-Hack,Kong, In-Soo 한국생명과학회 1998 생명과학회지 Vol.8 No.1
양어장에서 어류의 배설물이나 사료에 의해 생성된 암모니아성 질소 제거를 위한 수처리 공법의 하나로써 질산화 세균 및 탈질화 세균을 고정화 방법의 개잘리 필요한 실정이다. 이를 위해서는 우수한 고정화 방법의 개발이 필요한 실정이다. 이를 위해서는 우수한 질산능과 탈질능을 가지는 미생물의 분리가 선행되어야 하므로 denitifier consortium으로부터 여러 균주를 선별, 동정하여 이를 Pseudomonas sp. KH2-2으로 명명하였다. 분리된 균의 탈질능은 최적의 생육을 보일 때 가장 강하게 나타났다. $30{\circ}C보다는 40{\circ}C$에서 배양하였을 때 최적의 성장을 보여주었고, 탈질능도 현저히 높았다. pH에 있어서는 pH7에서 가장 강한 탈질능을 나타내었다. pH5에서는 균의 성장이 이루어지지 않았고 pH9에서는 $NO_3$^-환원능은 높았으나 $NO_2$^-환원능은 낮았다. Pseudomonas sp. KH2-2 had the denitrifying ability adn was isolated from the denitrifier consortium in order to remove nitrogen compounds from waste water in aquaculture system. When this strain was reached stationary phase, it has the maxium denitrification activity. Denitrification activity of the isolated strain was shown the growth associated pattern. Optimal temperature for cell growth and denitrification activity was 40$\circ$C and optimal pH was 7.
비후성 심근병증 환자에 동반한 완전 폐색을 보이는 심근교에 대한 스텐트 삽입술 후 10년간의 임상 경과
김현국 ( Hyun Kuk Kim ),정명호 ( Myung Ho Jeong ),김민아 ( Min Ah Kim ),안영근 ( Young Keun Ahn ),조정관 ( Jeong Gwan Cho ),박종춘 ( Jong Chun Park ) 대한내과학회 2016 대한내과학회지 Vol.90 No.6
본 증례는 갑자기 악화된 흉통으로 내원한 환자에서 시행한 초음파에서 비후성 심근병증이 발견되어 이에 대한 약물치료를 하였으나 증상이 완화되지 않았고, 심근허혈이 의심되어 시행한 관상동맥조영술에서 긴 길이의 완전 폐색을 동반한 심근교가 관찰되어 혈관내 초음파 유도하 중재술을 시행하였던 예이다. 시술 후 증상은 호전되었고, 약물 치료하면서 10년간 좋은 임상 경과를 보여 보고하는 바이다. Intracoronary stent implantation can improve coronary hemodynamics and myocardial ischemia in patients with symptomatic bridging. However, percutaneous coronary intervention for this lesion is limited due to the high prevalence of restenosis and risk of complications. We present a case of a totally occluded long-segment myocardial bridge in a patient with hypertrophic cardiomyopathy who was successfully implanted with a bare metal stent under intravascular ultrasound guidance without complications. The patient has been free of ischemic symptoms with stent patency for 10 years. (Korean J Med 2016;90:533-536)
루이보스티 섭취가 운동시 흰쥐의 혈중 지질 및 항산화 방어체계에 미치는 영향
김현국(Kim Hyun-kuk),김태식(Kim Tae-sik) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.4
The Rooibos tea mote caffeine without being contained entirely polyphenol inorganic compounds such as green tea be included, and refer to SOD similarity material that have activity that is various physiological thing and pharmacy enemy that there is aging control effect. Therefore, the purpose of this study is to investigate the effects of Rooibos tea on blood lipids and antioxidant system during exercise in rats. Twenty-eight male Sprague Dawley rats were used as the subject. They were divided into four groups as control (CON), exercise (EXE), Rooibos tea ingestion (RT), and Rooibos tea ingestion with exercise (RTE), respectively. They have exercised on the treadmill and exercised 5 day per week for 4 weeks. They were sacrificed by decapitation at 10 minute after 60 minute treadmill running (25m/min, 7°). This investigation demonstrated body weight and that blood TC, HDL-c, TG, glucose, and FFA were analyzed using enzymatic methods and LDL-c was calculated by reported previously. SOD and MDA were analyzed to prove antioxidant effect of Rooibos tea. Body weight in each group was not significantly different in groups. Stored-fat weight (mesentery, abdomen) in each group was not different in groups. However, epididymal fat was significantly higher in CON (p<.05). FFA was significantly lower in CON (p<.05). However, blood TC, TG, HDL-c, LDL-c, and glucose were not significantly different in groups. SOD activity was significantly higher in EXE and RTE (p<.05). MDA content was significantly lower in RTE (p<.05). In conclusion, Rooibos tea ingestion with exercise seemed to have beneficial effects for reducing oxidative stress via enhancing the SOD activities and reducing the MDA production.
김현국 ( Hyun Kuk Kim ),박종춘 ( Jong Chun Park ),김성수 ( Sung Soo Kim ),최홍상 ( Hong Sang Choi ),심두선 ( Doo Sun Sim ),윤남식 ( Nam Sik Yoon ),윤현주 ( Hyun Ju Yoon ),홍영준 ( Young Joon Hong ),박형욱 ( Hyung Wook Park ),김주 대한내과학회 2009 대한내과학회지 Vol.77 No.1
Background/Aims: The elasticity of the aorta modulates the entire cardiovascular system. Increasing arterial stiffness with the loss of aortic elasticity is not only a surrogate marker for early atherosclerosis, but also a predictor of cardiovascular events. Methods: This study included 203 patients (57.6±14.7 years, 117 male) who underwent diagnostic transesophageal echocardiography. We investigated the correlation between the arterial stiffness index (β stiffness index), which is calculated from the distensibility of the descending thoracic aorta and blood pressure, and known serologic markers of atherosclerosis and cardiovascular events. Results: The β stiffness index correlated significantly with the brachial-ankle pulse wave velocity (R2=0.243, p<0.001) and in-tima-media thickness of the descending thoracic aorta (R2=0.470, p<0.001). It also correlated with age (r=0.465, p<0.001) and the presence of diabetes mellitus (r=0.250, p<0.001). The β stiffness index was significantly positively correlated with the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), glucose, HbA1c, apolipoprotein (Apo) A-I, and erythrocyte sediment rate. A multivariate regression analysis demonstrated that the β stiffness index was associated with the levels of NT-proBNP, hsCRP, HbA1c, and Apo A-I. Conclusions: The β stiffness index for the distensibility of the descending thoracic aorta significantly correlates with other parameters of arterial stiffness and serologic markers for atherosclerosis. Therefore, the β stiffness index can be used as a parameter of cardiovascular events in diseases requiring transesophageal echocardiography, such as atrial fibrillation and mitral stenosis. (Korean J Med 77:68-75, 2009)
만성기침 환자의 주관적 증상과 비후두경 소견 및 객담 호산구 증가증과의 관련성
김현국 ( Hyun Kuk Kim ),최은영 ( Eun Young Choi ),이재승 ( Jae Seung Lee ),배윤정 ( Yun Jeong Bae ),송진우 ( Jin Woo Song ),김태범 ( Tae Bum Kim ),조유숙 ( You Sook Cho ),문희범 ( Hee Bom Moon ),이상도 ( Sang Do Lee ),오연목 ( Yeo 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.5
Background: Rhinolaryngoscopy and sputum examination are popular tests for the evaluation of chronic cough. Little is known about the relationship between symptoms and rhinolaryngoscopic findings or sputum eosinophilia in chronic cough patients. Methods: One hundred patients, who had chronic cough with normal chest radiography and who also had undergone both rhinolaryngoscopy and induced sputum analysis, were reviewed retrospectively. Eleven associated symptoms of chronic cough were asked; postnasal drip (PND) and laryngopharyngeal reflux (LPR) were examined by rhinolaryngoscopy. Induced sputum analysis was performed for evaluation of sputum eosinophilia. Cross tabulation analyses with chi-square tests were used to evaluate the relationship between symptoms and objective findings. Results: The most frequent symptom was sputum (70%). The prevalence of PND and LPR on rhinolaryngoscopy were 56% (56/100) and 25.6% (22/86), respectively. Sputum eosinophilia was observed in 23 (23.7%) of 97 patients. The dyspnea (p=0.001), sputum (p=0.003), nasal obstruction (p=0.023), and postnasal drip sense (p=0.025) were related with PND on rhinolaryngoscopy. LPR on rhinolaryngoscopy was not related with any symptoms. Dyspnea (p=0.003), wheezing (p=0.005), nasal obstruction (p=0.013), and belching (p=0.018) were related with sputum eosinophilia. Conclusion: Any symptoms might not be related with LPR on laryngoscopy. Some symptoms might be related with PND on rhinoscopy or with sputum eosinophilia.
만성 혈전색전성 폐고혈압 환자에서 폐동맥 혈전내막제거술의 효과
김현국 ( Hyun Kuk Kim ),홍석찬 ( Suck Chan Hong ),이재원 ( Jae Won Lee ),홍상범 ( Sang Bum Hong ),오연목 ( Yeon Mok Oh ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Don 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.6
특발성 폐동맥고혈압과 만성혈전색전성 폐고혈압의 임상상 비교
김현국 ( Hyun Kuk Kim ),나주옥 ( Joo Ock Na ),안종준 ( Jong Joon Ahn ),박용범 ( Yong Bum Park ),임재민 ( Jae Min Lim ),홍상범 ( Sang Bum Hong ),오연목 ( Yeon Mok Oh ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Youn S 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.2