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김태운,박상서,김상훈,김명기,신말순,Seong-Hyun Kim 한국운동재활학회 2024 JER Vol.20 No.1
Stress during pregnancy has a negative effect on the fetus. However, maternal exercise has a positive effect on the cognitive function of the fetus and alleviates the negative effects of stress. This study aimed to demonstrate whether exercise before pregnancy has a protective effect on prenatal stress-induced impairment of memory, neurogenesis and mitochondrial function in mice offspring. In this experiment, immunohistochemistry, Western blot, measurement of mitochondria oxygen respiration, and behavior tests were performed. Spatial memory and short-term memory of the offspring from the prenatal stress with exercise were increased compared to the offspring from the prenatal stress. The numbers of doublecortin-positive and 5-bromo-2’-deoxyuridinepositive cells in the hippocampal dentate gyrus of the offspring from the prenatal stress with exercise were higher compared to the offspring from the prenatal stress. The expressions of brain-derived neurotrophic factor, postsynaptic density 95 kDa, and synaptophysin in the hippocampus of the offspring from the prenatal stress with exercise were enhanced compared to the offspring from the prenatal stress. Oxygen consumption of the offspring from the prenatal stress with exercise were higher compared to the offspring from the prenatal stress. Exercise before pregnancy alleviated prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function. Therefore, exercise before pregnancy may have a protective effect against prenatal stress of the offspring.
양측 협부 근점막 피판을 이용한 2차성 연구개 비인강 폐쇄 부전의 치료: 증례보고
김태운,최진영,Kim, Tae-Woon,Choi, Jin-Young 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.5
Velopharyngeal insufficiency is defined as a status in which nasal cavity and oral cavity can not be sepa-rated when speaking, swallowing by any reason. It has been treated by palatorrhaphy, pharyn-geal flap, local flap, free flap etc. When the size of the defect is small, it can be restored by palatorrhaphy, pharyngeal flap etc. But they are not proper for treatment of the large size of defect. In that case, local flap and free flap are more beneficial. Although large defect can be restored by free flap technique, but it is very complex, time-consuming and may bring about esthetical, functional complications of donor site. Buccinator myomucosal flap is a kind of local flap and reported for the first time by Bozola et al in 1989 and it has become a useful way for reconstruction of large intraoral defect. Authors experienced the use of buccinators myomucosal flap for treating secondary velopharyngeal insufficiency with large soft palate defect and obtained good result. So we report the case with literature reviews.
오패산(烏貝散)과 보두(寶豆)의 병용투여(倂用投與)가 위장관(胃腸管)에 미치는 영향(影響)
김태운,조종관,Kim, Tae-Woon,Cho, Chong-Kwan 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.2
In order to investigate the effect of BODUOPAE-SAN(BOS), experiments were performed on analgesic effect induced by acetic acid, duration of hypnosis induced by pentobarbital-Na in mice and gastric ucler in Shay rats and indomethacin induced gastric ulcer, HCI-ethanol induced gastrci lesion in rats and gastric juice secretion in Shay rats. The results are as followings. 1. BOS showed significantly an analgesic effect induced by acetic acid. 2. BOS prolonged the duration of hypnosis induced by pentobarbital-Na in rats 3. BOS rised the spontaneous motility of isolatied ileum of mice temporarily. 4. BOS depressed the gastric motility of rats significantly. 5. BOS showed an anti-ulcer effect in Shay rats and indometacine-induced ulcer rats significantly. 6. BOS reduced the ulcer index of the HCl-ethanol induced gastric lesion in rats. 7. BOS reduced the gastric juice secretion in Shay rats. From above results think BOS is more effective in comparison to the OPAESAN alone on gastrointestinal disorder.
국립암센터에서 치료한 설암 환자의 생존율 분석을 통한 예후인자 분석
김태운,조세형,민승기,이종호,김명진,박주용,최성원,Kim, Tae-Woon,Jo, Sae-Hyung,Min, Seung-Ki,Lee, Jong-Ho,Kim, Myung-Jin,Park, Joo-Yong,Choi, Sung-Weon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.6
Purpose: The objective of this study is to evaluate the survival rate and influencing factors. Patients and Methods: We studied 104 patients who were diagnosed for squamous cell carcinoma of tongue and received curative treatment in oral oncology clinic of National Cancer Center from June 2001 to December 2009. Results: We found the following results. 1. The overall 5-year survival rate of tongue cancer was 67.0% and there was no significant statistical difference between male and female. 2. A lower survival rate was shown in patients under 40 years (42.2%) than over 40 years (75.5%)(P < 0.05). 3. 5-year survival rates of patients with tongue cancer classified by pTNM classification were 87.4% in early stage and 43.3% (P < 0.05). 4. A higher survival rate was seen in patients without cervical lymph node metastasis (82.0% > 44.1%)(P < 0.05). 5. A higher survival rate was seen in patients of tongue cancer with higher differenciation grade (P < 0.05). 6. It is well known that drinking and smoking have great influence on the survival rate of patients of squamous cell carcinoma of tongue. But these was no statistical significance. Conclusion: The overall 5-year survival rate of tongue cancer was 67.0% and it was mostly influenced by factors like age, pTNM stage, cervical lymph node metastasis, differentiation of cancer cell etc.
소적백출산(消積白朮散)이 Bleomycin의 부작용감소(副作用減少)와 항암효과(抗癌效果)에 미치는 영향(影響)
김태운,손창규,조종관,Kim, Tae-Woon,Son, Chang-Kyu,Cho, Chong-Kwan 대한암한의학회 1999 大韓癌韓醫學會誌 Vol.5 No.1
l. Sojeokbaekchoolsan compound treatment decreased pulmonary fibrosis induced by Bleomycin. 2. At 1 and 2 days after bleomycin treatment, Sojeokbaekchoolsan compound treatment decreased the number of neutrophils in bronchoalveolar lavage than those of bleomycin alone treatment. 3. Sojeokbaekcoolsan compound treatment increased the Fc receptor mediated rosette activity of alveolar macrophage decreased by bleomycin treatment. 4, At 10 days after bleomycin treatment, Sojeokbaekchoolsan compound treatment decreased the lipid peroxidation of lung tissue than those of bleomycin alone treatment. 5. Anti-tumor activity of Sojeokbaekchoolsan and bleomycin compound group was higher than those of bleomycin alone treated group to ascitic tumor caused by Sarcoma-180 tumor cells.
다중선형 회귀분석을 이용한 고립지역에서의 AADT 추정방안 연구
김태운,오주삼,Kim, Tae-woon,Oh, Ju-sam 대한토목학회 2015 대한토목학회논문집 Vol.35 No.4
본 연구에서는 고립지역의 과거 AADT 자료와 사회 경제지표를 활용하여 장래 AADT를 추정하였다. 과거 교통량 추이 활용 시와 사회 경제지표 활용 시 장래 AADT를 추정했으며, 사회 경제지표를 활용하여 다중회귀 분석방식을 통한 장래 AADT 추정 시 높은 설명력과 낮은 오차율을 보였다. 지리적 특성별 AADT에 미치는 사회 경제지표 분석 결과 고립일반지역은 다양한 사회 경제지표가 AADT에 영향을 미쳤으며, 고립해안지역은 유류가격과 연관성을 보이는 것으로 나타났다. 고립지역의 장래 AADT 추정 모형은 $R^2$, MAPE 분석 시 우수한 것으로 나타났다. 이는 고립지역에서는 통과 교통량이 적고 교통량 변동이 적기 때문에 사회 경제지표를 활용한 장래 AADT 추정방식이 정확하다고 볼 수 있다. This study estimates future AADT using historical AADT and socio-economic factors in isolated area. Multiple linear regression method by socio-economic factors are lower MAPE and higher R-square than using historical AADT. Analysis of socio-economic factors influence AADT in isolated typical areas, varied socio-economic factors influence on AADT. In isolated coastal areas, oil price influence on AADT. AADT forecasting model in isolated area is excellent when analysising $R^2$ and MAPE. It is assume that estimation of AADT in isolated area using multiple linear regression is accurate because of a little passed traffic volume and traffic volume fluctuation.