全羅道 泰仁의 寬谷 崔瑞林과 龍溪書院

김철배 ( Chul Bae Kim ) 전북대학교 인문학연구소 2012 건지인문학 Vol.8 No.-

This paper aims to study Choi Seorim (Gwan-gok), who lived in Taein, Jeongeup in the 17th century, and Yonggye Seowon (alecture hall or a memorial hall for Confucianist services to honor distinguished scholars) where Choi Seorim is enshrined. Choi Seorim (1632~1698) is the central figure of Yonggye Seowon. His family originated from Jinju, Gyeongsangnam-do, his pen name is Gwangok, and his second names are Yeobal and Gyeomtoi. The Manchu war of 1636 broke out when he was five years old, so he had to flee for refuge from Seoul to Younggwang and Muan, Jeollanam-do, and moved to Gohyeonnae in Taein, Jeongeup Jeollabuk-do after the war. His family settled down in Gohyeonnae because his aunt was married to Kim Yeobaek from Dogang Kim family, which was very influential in the town. Furthermore, as his academic career was closely related to the school of Kim Jip (Sindokjae), it was quite natural that his family moved to Taein from the south area like Naju, Muan, Hampyeong, and Haenam of Jeollanam-do where the school of Dongin was more influential. Choi Seorim passed the civil service examination in 1661 (the 2nd reign of King Hyeonjong), but refused to go into government service and stayed in Taein only to study and teach students. Lee Ik (Seongho) introduced Choi Seorim in his book Seonghosaseol that as he taught well, there were lots of students who adored and followed him. In the student list called ``Munsaenglok``, there are 178 literary men listed. Among them, 15 students passed minor civil examinations and three students passed higher level ones. Choi Seorim followed the disciplinary flow of Honam whose representatives were Jeong Geugin and four gentlemen from Taein (Song Serim, Jeong Eonchung, Kim Yakmuk, and Kim Gwan), and he became the second origin that was followed by Eun Jeonghwa and Hwang Jeon. Choi Seorim`s learning is said to be a part of Honam school in that Hwang Yunseok (Yijae), one of the greatest Confucianists of the 18th century, is the son of Hwang Jeon who was the student of Eun Jeonghwa. Yonggye Seowon was built at the place where Choi Seorim had given lectures to his students in 1701 (the 27th year of King Sukjong`s reign) which was two years after he passed away, and he and his five students are enshrined in Yonggye Seowon.

신체 계측 특성 및 식사습관에 따른 노인여성에서 당뇨병 및 공복혈당장애의 유병률

김철식(Chul-Sik Kim),정은경(Eun-Kyong Jeong),박진아(Jina Park),조민호(Min Ho Cho),박종숙(Jong-Suk Park),남주영(Joo-Young Nam),김똘미(Dol-Mi Kim),안철우(Chul-Woo Ahn),차봉수(Bong-Soo Cha),임승길(Sung-Kil Lim),김경래(Kyung-Rae Kim),이현철 대한임상노인의학회 2004 대한임상노인의학회지 Vol.5 No.4

연구배경: 본 연구는 국민건강 영양조사자료(1998)를 토대로 노인여성에서 당뇨병과 공복혈당장애의 유병률을 추정하고, 우리나라 국민들의 식사습관 및 과일섭취량을 조사함과 동시에, 식사습관 및 과일 등의 식품섭취량이 노인여성에서 당뇨병 및 공복혈당장애의 유병률과의 관계를 분석하고자 실시하였다. 방법: 본 연구는 1998년 11월 1일에서 12월 30일까지 시행된 국민건강 영양조사 자료를 이용하였으며, 조사는 전국을 대표하는 12,189가구의 전체 가구원 39,331명 중 건강검진을 실시한 20세 이상의 인구 7,962명과 식품섭취조사를 실시한 11,267명 중 20세 이상의 인구 8,166명 중에서 여성인구 3,472명을 대상으로 하였다. 결과: 본 연구의 결과는 다음과 같다. 1) 당뇨병과 공복혈당장애 유병률은 전체 자료에서 남․녀 모두에서 연령이 많을수록 높았고, 남성의 유병률이 여성보다 높았다. 공복혈당을 기준으로 분석한 당뇨병 유병률은 여성은 60~69세 군의 유병률이 15.92%로 가장 높았고, 남성은 50~59세 군에서 18.21%로 가장 높았으며, 공복혈당장애의 유병률은 여성은 70세 이상 군에서 19.87%로 가장 높았고, 남성은 60~69세 군에서 16.53%로 가장 높았다. 2) 식품섭취 및 식사습관과 당뇨병 및 공복혈당장애의 관계를 분석한 여성을 대상으로 다시 세부분석을 시행한 결과, 여성에서 당류섭취량이 증가하면 당뇨병의 위험률이 감소하는 것으로 결과가 해석되었으나 통계학적으로 유의하지 않았다. 3) 공복혈당이 126 mg/dl 이상을 당뇨병 군으로 정의하였을 때 이에 영향을 미치는 요인은 연령, 중성지방, 고혈압이었으며, 공복혈당장애에 영향을 미치는 요인은 여성은 연령, 중성지방이었다. 결론: 본 연구에서 단면적 연구설계의 제한점으로 식사습관의 당뇨병 및 공복혈당장애와의 통계적 유의성을 밝히지 못하였으나, 최근 들어 국내 노인여성에서 당뇨병 유병률의 증가와 함께 결식이나 과식을 하는 경향이 많고 과일의 섭취량이 급격히 증가하고 있으므로, 전향적 코호트 연구에 기반하여 체계적이고 지속적인 연구가 이루어져야 할 것으로 생각한다. Background: This study is based on the National Health and Nutrition Examination Survey in Korea (1998). By analyzing the data, we were able to predict the prevalence of diabetes mellitus (DM) and impaired fasting glucose (IFG) in elderly women in Korea, and by investigating their dietary habits and amount of fruit intake, we have tried to establish a relationship between those factors and the prevalence of DM and IFG in elderly women. Methods: The study is comprised of data collected from November 1 to December 30, 1998 in the National Health and Nutrition Examination Survey in Korea. Among 39,331 family members of 12,189 families across the country, 7962 persons aged over 20, who have undergone medical examination, were taken into the study. Also, from 11,267 subjects who have participated in our surveys on dietary habits, 3,472 females, aged over 20, were included in the study. Results: The following results were obtained. 1) The prevalence of DM and IFG correlated well with the age of subjects in both males and females, and the higher prevalence was observed in males. The prevalence of DM was highest in a group consisting of subjects aged between 60 and 69 years in females with 15.92%, and in a group aged between 50 and 59 years in males with 18.21%. 2) When the relationship between eating habits and DM or IFG in females was analyzed, an increased amount of glucose intake seemed to be in a negative correlation with the risk of developing DM, but this was not statistically significant. 3) When considering a fasting glucose level of 126 mg/dl or higher as the diagnostic point for DM, age, triglyceride, and hypertension had significant effects in the development DM, while age and triglyceride were risk factors for developing IFG in females. Conlusion: Although this study had not made to demonstrate a significant relationship between dietary habits and DM or IFG due to its limited study design, recently, there has been an increased prevalence of DM in elderly women in Korea along with the increased amount of glucose intake and overeating incidence. Therefore, an organized, anterograde cohort study will be carried out in the future to better understand their relationship.

Glucomannan이 노인성 제2형 당뇨병 환자의 당질 및 지질 대사에 미치는 영향

김철식(Chul-Sik Kim),박종숙(Jong-Suk Park),남주영(Joo-Young Nam),남지선(Ji-Sun Nam),조민호(Min-Ho Cho),박진아(Jina Park),김똘미(Dol-Mi Kim),안철우(Chul-Woo Ahn),차봉수(Bong-Soo Cha),임승길(Sung-Kil Lim),김경래(Kyung-Rae Kim),이현철(Hyun 대한임상노인의학회 2004 대한임상노인의학회지 Vol.5 No.4

연구배경: 본 연구자들은 소장에서 당분과 지방질의 흡수를 저해하는 효과가 있는 것으로 알려져 있는 glucomannan을 노인성 제2형 당뇨병 환자에게 투여하여 혈당, 지질 및 인슐린저항성에 어떠한 영향이 있는지 조사하고자 하였다. 방법: 연세대학교 의과대학 내분비내과에 내원한 혈청 총콜레스테롤 농도가 높은 당뇨병 환자 중 60세 이상의 76명을 대상으로 실험군 39명, 대조군 37명으로 나누어 실험군에게는 하루 glucomannan을 대조군에게는 placebo 약제를 총 8주간 투여하였다. 공복혈당과 식후 2시간 혈당은 치료 0, 4, 8주에 측정하였으며, 치료 0, 8주에는 당화혈색소 및 총콜레스테롤, 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤을 측정하였으며 혈청 인슐린, C-peptide를 측정하고 인슐린저항성을 파악하기 위해 HOMA score를 산출하였다. 결과: 본 연구를 시행한 결과 다음과 같은 결과를 얻었다. 1) 공복혈당은 glucomannan을 8주간 투여한 후에 유의한 감소를 나타내었으며 식후 2시간 혈당은 glucomannan을 투여한 후 4주부터 감소하였으며 8주째에도 유의한 감소를 보였다. 2) 혈청 총콜레스테롤, 중성지방, 저밀도 지단백 콜레스테롤은 glucomannan 투여 후에 유의한 감소를 보였으나 고밀도 지단백 콜레스테롤은 유의한 변화가 없었다. 3) glucomannan을 8주간 투여한 후 HbA₁c는 투여 전에 비하여 유의하게 감소하였다. 4) HOMA-IR 값은 glucomannan 투여 후에 감소하였으며, HOMA-β 값은 투여 8주에 유의한 증가를 나타내었다. 5) glucomannan 투여가 간기능, 신장기능 및 전해질에는 특별한 영향을 미치지 않았다. 결론: 이상의 연구 결과를 통하여, 노인성 제2형 당뇨병 환자에게서 glucomannan은 혈당 및 지질대사 개선에 효과가 있는 것으로 확인되었다. glucomannan의 작용기전은 식후 고혈당 개선을 통한 인슐린저항성 감소 및 인슐린분비능의 개선으로 생각된다. Background: Glucomannan is known to be effective in reducing glucose and lipid absorption from small intestine. In this study, we tried to investigate the relationship between glucomannan and glucose, lipid profile, and insulin resistance in the elderly type 2 diabetes patients. Method: We have taken 76 type 2 diabetes patinets with hypercholesterolemia, aged over 60 years old, who have visited our endocrine clinic of Yonsei University of Medical College and categorized them into two groups. The experimental group, which consisted of 39 subjects, received daily glucomannan, while the control group, which consisted of 37 patients, received daily placebo for 8 weeks. We have measured fasting glucose, 2hr post-prandial glucose at 0, 4, 8 weeks and HbA1C, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, insulin, c-peptide levels at 0, 8 weeks, and calculated HOMA score in order to determine insulin resistance. Results: The following results were obtained. 1) 2hr postprandial glucose level was significantly reduced after taking glucomannan for 4 and 8 weeks, and fasting glucose level declined after taking glucomannan for 8 weeks. 2) Serum total cholesterol, triglyceride, LDL-cholesterol levels were significantly lowered after treatment. Serum HDL-cholesterol level had a tendency to increase in the experimental group, but was not statistically significant. 3) HbA₁c was significantly decreased after taking glucomannan for 8 weeks. 4) HOMA-IR was reduced at 8 weeks, and HOMA-β showed a significant increase at 8 weeks. 5) Glucomannan did not have adverse effects on CBC, liver function, renal function, and electrolyte levels. Conclusion: The above study results demonstrate that glucomannan is effective in improving glucose and lipid metabolism in elderly type 2 diabetes patients. Glucomannan enhances insulin resistance by lowering postprandial gluocse level and stimulating insulin secretion.

정신분열병 환자의 인슐린저항성 결정인자

김철식 ( Chul Sik Kim ),조민호 ( Min Ho Cho ),남지선 ( Ji Sun Nam ),박종숙 ( Jong Suk Park ),남윤영 ( Yoon Young Nam ),김찬형 ( Chan Hyung Kim ),안철우 ( Chul Woo Ahn ),김경래 ( Kyung Rae Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.6

목적: 정신분열병 환자는 일반인에 비해 비만 및 당대사 장애의 발생 위험이 높은 것으로 알려져 있으며 정신분열병 치료를 위해 사용하는 항정신병 약물은 체중증가를 유발할 수 있기 때문에 그 위험이 더욱 높아지게 된다. 그러나 항정신병 약물의 영향을 받지 않은 상태에서 정신분열병 환자의 인슐린저항성 유발인자에 대한 연구는 드물다. 따라서 본 연구에서는 항정신병 약물의 영향을 받지 않은 상태의 정신분열병 환자를 대상으로 인슐린저항성에 영향을 미치는 인자를 알아보고자 하였다. 방법: DSM-IV 기준에 의해 정신분열병을 처음 진단받은 환자 또는 이미 진단받고 추적관리하고 있는 환자 중 최소한 6주 이상 항정신병 약물을 투여 받지 않은 환자 19명(남:녀=4:15)과 이들과 성별, 나이를 맞춘 정상 대조군을 19명 선정하여 이들의 체질량지수 및 체지방률을 측정하고 인슐린저항성 관련 위험인자를 비교하였다. 또한 각 군에서 인슐린저항성지표(HOMA-IR)와 신체계측, 임상적 특성의 연관성을 알아보았다. 결과: 양 군 간의 체질량지수, 허리둘레 및 체지방률은 차이는 없었다. 또한 정신분열병 환자군에서 중성지방의 농도가 높았지만 혈압, 혈당, 당화혈색소, 인슐린, HOMA-IR, 총콜레스테롤, HDL-콜레스테롤 및 LDL-콜레스테롤 값의 차이는 없었다. 정상 대조군에서는 나이(r=0.685, p=0.002), 허리둘레(r=0.617, p=0.014)가 인슐린저항성지표인 HOMA-IR과 관련이 있었지만 정신분열병 환자에서는 24시간 소변 유리코티졸 수치가 연관성이 있었다(r=0.797, p=0.002; β=0.646, p=0.023). 결과: 본 연구를 통하여 항정신병 약물의 영향을 받지 않은 상태에서 정신분열병 환자의 인슐린저항성의 위험인자는 정상 대조군과 별 차이가 없었으나 인슐린저항성을 결정하는 주된 위험인자는 정상 대조군과는 달리 정신분열병 환자에서 증가하는 코티졸임을 알아냈다. Background/Aims: As compared with the general population, patients with schizophrenia have a higher risk of obesity and glucose metabolism impairment. Moreover, some antipsychotic drugs add to this risk owing to side effects such as weight gain. However, few reports exist regarding the pathophysiology of insulin resistance in drug-naive or drug-free schizophrenic patients. Therefore, the aim of the present study was to investigate the factors that contribute to insulin resistance in antipsychotic drug-naive and drug-free schizophrenic patients. Methods: Nineteen (4 men, 15 women) drug-naive or drug-free subjects with schizophrenia and nineteen age- and sex-matched controls were recruited for participation in this study. We measured weight, height, waist circumference, biochemical profiles, body fat percentage, and calculated body mass indices (BMI) in all patients. Furthermore, we correlated HOMA-IR, a marker for insulin resistance, with anthropometric measures and clinical characteristics. Results: There were no significant differences in BMI, waist circumference, or body fat percentage between the two groups. In addition, there were no differences in blood pressure, glucose, HbA1c, insulin, HOMA-IR, total cholesterol, HDL-cholesterol, or LDL-cholesterol; however, triglyceride levels and 24 hr urine free cortisol levels were higher in schizophrenic patients. There was also a significant correlation between HOMA-IR and both age and waist circumference in the control group. Additionally, HOMA-IR was significantly correlated with 24 hr urine free cortisol levels in schizophrenic patients. Conclusions: The study shows that risk factors for insulin resistance in drug-naive or drug-free schizophrenic patients do not differ from those of the control group; however, the major determinant of insulin resistance in schizophrenia patients was that of increased cortisol levels. (Korean J Med 75:673-679, 2008)

가상세포를 활용한 항염증 효능 응용모델 연구

김철,예상준,김진현,김상균,장현철,김안나,남기엽,송미영,Kim, Chul,Yea, Sang-Jun,Kim, Jin-Hyun,Kim, Sang-Kyun,Jang, Hyun-Chul,Kim, An-Na,Nam, Ky-Youb,Song, Mi-Young 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

CoFe1.9Y0.1O₄의 Sol-gel 합성과 자기적 성질 연구

김우철(Woo Chul Kim),김삼진(Sam Jin Kim),명보라(Bo Ra Myung),김진옥(Jin Ok Kim),윤성로(Sung Ro Yoon),김철성(Chul Sung Kim),윤성현(Sung Hyun Yoon) 한국자기학회 2001 한국자기학회 학술연구발표회 논문개요집 Vol.11 No.1

Zaltman의 은유유도기법을 이용한 호텔 브랜드 자산가치에 관한 연구

김철원(Kim Chul Won),김연선(Yeon Sun Kim) 한국마케팅과학회 2005 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

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