인진청간탕(茵蔯淸肝湯)이 인체 간암세포의 혈관생성인자 발현에 미치는 영향

김철우,김영철,이장훈,우홍정,Kim, Chul-Woo,Kim, Young-Chul,Lee, Jang-Hoon,Woo, Hong-Jung 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1

Objectives: This study was designed to investigate the effects of Injinchunggan-tang(Yinchenqinggan-tang) on expression of angiogenic factors in HepG2 cells. Materials and Methods : The mRNA expression levels and protein secretion levels of angiogenic factors were measured using quantitative RT-PCR, Western blot and ELISA assay respectively in Injinchunggan-tang-treated and untreated HepG2 cells. Results : Injinchunggan-tang(Yinchenqinggan-tang) reduced mRNA expression levels and protein secretion levels of angiogenic factors, especially VEGF, bFGF and $TGF{\beta}1$ in HepG2 cells. Conclusion: Results indicate that Injinchunggan-tang (Yinchenqinggan-tang) inhibits expression of angiogenic factors in HepG2 cells. Further, results suggest that Injinchunggan-tang (Yinchenqinggan-tang) inhibits angiogenic effects in HCC.

근삽에 의한 음나무의 무성번식

김철우,송재모,배찬호,박봉재,문흥규,황석인,이재선,Kim, Chul-Woo,Song, Jae-Mo,Bae, Chan-Ho,Park, Bong-Jae,Moon, Heung-Kyu,Hwang, Suk-In,Yi, Jae-Seon 강원대학교 산림과학연구소 2001 Journal of Forest Science Vol.18 No.-

본 연구는 음나무의 증식을 위해 근삽을 이용하여 대량번식방법의 체계를 확립하고자 실시하였다. 조사된 결과는 다음과 같다. 1. 음나무의 근삽시 생장조절물질의 처리는 고농도보다 저농도가 효과적인 것으로 나타났으며, 생장조절물질 처리에 따른 부정아 발생율은 IBA, NAA 300mg/L 처리구에서 96.6%로 가장 높게 나타났으나 무처리 역시 90.0%로 높은 부정아 발생율을 나타내었다. 또한 엽의 특성(엽수, 엽신, 엽폭)은 무처리와 생장조절물질 처리간에 큰 차이를 나타내지 않았다. 2. 근의 방향에 따른 근삽은 가로근삽(100%)과 세로근삽 (92.5%) 이 모두 90% 이상의 부정아 발생율을 보여 두 처리 모두 높은 부정아 발생율을 나타내었고, 부정아 발생수 및 엽 특성(엽수, 엽병, 엽신 및 엽폭)에 있어서 세로근삽이 가로근삽보다 모두 높게 나타났다. 3. 바로묻기 한 것이 거꾸로묻기 한 것보다 부정아 발생율, 부정아 발생수 및 엽특성(엽수, 엽신, 엽폭)에서 높은 값을 나타냈으며, 거꾸로묻기 한 경우 세근의 발달이 없거나 미약하며, 부정아 발생의 경우 기극 부근에서 발생하여 지면으로 올라오는 경우를 나타냈다. This research was carried out to establish the large quantity propagation system for Kalopanax pictus using root cutting. The results are as follows. As there was no significant difference in the promotion of adventitious shoot development from the root cuttings of Kalopanax pictus among kinds (IBA, NAA and Kinetin) and concentrations (0 to 2000 mg/L) of growth regulators, no application is recommended, which showed more than 90% of shoot development. Horizontal and vertical placement of rooting showed more than 93% of shoot occurrence, but the latter showed more desirable growth traits in the number of shoot development, number of leaf, petiole length, and leaf length and leaf width Polarity was observed and thus normal vertical placement of root cutting is preferred. However, root cuttings placed upside down showed the shoot development at the distal end, which indicates further sophisticated test is necessary to investigate this phenomenon.

고혈압을 동반한 만성 치주염 환자의 치은 조직에서 C-reactive protein과 macrophage colony-stimulating factor의발현

김철우,박진우,서조영,조제열,이재목,Kim, Chul-Woo,Park, Jin-Woo,Suh, Jo-Young,Cho, Je-Yoel,Lee, Jae-Mok 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.4

Purpose: The purpose of this study was to quantify and compare the expressions of CRP and M-CSF in the gingival tissues of the patients with chronic periodontitis associated to hypertension. Methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Clinically healthy gingival tissue samples from systemically healthy 12 patients were categorized as group 1 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis were categorized as group 2 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis associated with hypertension were categorized as group 3 (n=12). Tissue samples were prepared and analyzed by Western blotting. The quantification of CRP and M-CSF were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. Results: There were significant differences between group 1 and group 2 and between group 1 and group 3 in both CRP and M-CSF. The differences between group 2 and group 3 were not statistically significant in both proteins. However, the expression levels of CRP and M-CSF in hypertensive inflammatory gingiva showed increased tendency compared to non-hypertensive inflammatory gingiva. Conclusions: It is suggested that CRP and M-CSF might be used as inflammatory and bone resorption markers in periodontal diseased tissue. It is assumed that hypertension may be associated with the progression of periodontal inflammation and alveolar bone resorption.

A Study on Traffic-Induced Vibration of Steel Girder-Bridge by Three-Dimensional Vehicle Model on Random Road Profile

김철우,카와타니 미츠오,이우현,Kim, Chul Woo,Kawatani, Mitsuo,Lee, Woo Hyun Korean Society of Steel Construction 1997 韓國鋼構造學會 論文集 Vol.9 No.1

교량(橋梁)의 동적응답(動的應答)을 파악하기 위해서는 노면(路面)조도에 의해 영향을 받는 차량의 거동 파악이 중요하게 된다. 최근, 교량의 상판(床版)등에서 발생되는 피로(疲勞)의 영향에 대한 관심이 고조되어 서서히 교통진동의 3차원 모델링에 대한 중요성이 대두되고 있다. 이에 본 연구에서는 교량에 발생되는 교통진동(交通振動)의 영향을 좀더 정확히 표현하기 위하여 3차원 해석 방법을 제시한다. 해석방법으로 유한 요소법이 이용되었고, 차량 모델링은 하나의 전축(煎軸)과 두 개의 후축(後軸)을 갖는 8자유도계(自由度系) 차량 모델을 이용하여 수치 시뮬레이션을 수행하였다. 동적(動的) 연립미분방정식(聯立微分方程式)의 해법에서는 Newmark-${\beta}$법(法)을 이용하였고, 가상 노면요철(凹凸)모델링에서는 정상불규칙과정(定常不規則過程)으로 가정하여 노면 요철(凹凸)을 생성하여 시뮬레이션에 사용하였다. 또한 실제 차량 및 교량에서의 실측치와 비교하여 모델의 검증을 수행하였다.

삼차원 해석에 의한 강합성교 바닥판의 교통유발진동 응답 평가

김철우,카와타니 미츠오,이우현,Kim, Chul Woo,Kawatani, Mitsuo,Lee, Woo Hyun 한국강구조학회 1998 韓國鋼構造學會 論文集 Vol.10 No.2

최근 교량상 주행 차량의 중량화 및 대형화 그리고 교통량의 증대로 교량의 바닥판 등의 피로 손상이 문제화되고 있다. 이러한 손상의 주 요인은 교량의 노면 및 신축 이음부의 단차 위를 주행하는 차량의 동적 접지력으로 볼 수 있다. 이에 대해 바닥판의 거동을 적절하게 해석 할 수 있는 삼차원 동적 응답 해석이 필요하게 되었다. 따라서 본 연구에서는 삼차원 차량 및 교량 모델을 구축하여 바닥판의 동적 응답 및 차량의 동적 접지력을 계산하고, 신축 이음부에 개재된 단차의 영향에 따른 바닥판의 응답을 평가 해보았다. 해석치는 일본 오오사카의 판신(Hanshin)고속도로 매전(Umeda) 입로교에서 수행한 실측치와 비교하였다. Recently, it is frequently reported that fatigue damages of deck slabs and floor systems of highway bridges occur under the conditions of increasing weight and traffic of heavy vehicles. These troubles are affected by dynamic wheel load of heavy vehicles running on roadway surface roughness with bump at expansion joint. It is required that this kind of traffic-induced vibration of highway bridges must be analyzed by using three-dimensional models of bridge and vehicle. In this study, the three-dimensional dynamic analysis is carried out, and dynamic responses of deck slab and wheel loads of moving vehicle are estimated according to different vehicle speeds and bump heights. Analytical responses of bridge deck slab are compared with experimental ones which were measured at Umeda entrance bridge of Hanshin Expressway in Osaka.

윈도우즈 NT에서 고속 수송 프로토콜의 구현 및 성능 평가

김철우(Chul-Woo Kim),이완직(Wan-Jik Lee),함진호(Jin-Ho Hahm),김수연(Su-Youn Kim),한기준(Ki-Jun Han) 한국정보과학회 1995 정보과학회논문지 : 시스템 및 이론 Vol.22 No.11

본 논문에서는 고속 수송 프로토콜을 Windows NT 환경에서 구현하고 그 성능을 평가하였다. 이벤트 구동방식으로 HSTP 프로토콜을 설계하였고, C 언어와 DDK(Device Driver Kit)을 사용하여 Windows NT 3.1 커널 내부에 프로토콜 드라이버 형태로 구현하였다. 구현한 프로토콜의 모든 기능은 Windows NT 환경에서 직접 구현한 여러 응용 프로그램과 성능분석 프로그램 및 커널 디버깅 도구를 사용하여 테스트되었다. 이 논문의 결과는 Windows NT 상에서 멀티미디어 전송에 활용될 수 있을 것이며 OSI의 다른 계층의 설계와 구현 시 바로 활용될 수 있을 것이다. This paper describes our work of implementation and evaluation of a High Speed Transport Protocol on the Windows NT. We designed the protocol by an event-driven method and implemented it using the C language and the Device Driver Kit(DDK) of the Microsoft Co. For a functional test of our protocol. we used performance testing tools, kernel utilitics and various applications including a file transfer program. It is expected that our work may be utilized for developing multimedia applications and for designing and implementing other OSI layers' drivers.

일반논문 : 권한위임이 조직구성원의 독립적,비판적 사고에 미치는 영향 및 다양성관리와 의사소통 능력의 조절효과 검증

김철우 ( Chul Woo Kim ) 한국인사행정학회 2013 한국인사행정학회보 Vol.12 No.3

지식창조사회로 접어들면서 조직의 관료적인 구조는 점점 수평적으로 바뀌고 있으며, 결과적으로 관리자들은 구성원들에게 더 많은 참여를 요구하고 있다. 이러한 상황에서 조직의 성과를 높이기 위해서는 관리자뿐만 아니라 조직구성원의 역할이 조화롭게 수행되어야 할 것이다. 특히 조직구성원들이 관리자가 최선의 결정을 내릴 수 있도록 조직에 도움이 되는 건설적인 대안을 제시하는 역할이 필수적이다. 그리고 이러한 역할에는 독립적·비판적 사고를 하는 능력이 더욱 중요하게 여겨지고 있다. 본 논문에서는 관리자의 권한위임이 조직구성원의 독립적·비판적 사고에 미치는 영향과 관리자의 다양성관리 및 의사소통 능력이 두 변수의 관계를 조절하는 효과가 있는지를 실증적으로 분석하는데 연구의 주목적을 둔다. 이를 위해 이론적 논의를 통해 가설을 정립하고 실제 자료 분석을 통해 가설을 검증하였다. 분석 자료는 2008년 미국연방정부 인적자원조사에 참여한 비관리직 11만 명의 설문조사자료를 사용하였다. 분석결과에 의하면, 관료들이 인식하는 관리자의 권한위임, 다양성관리와 의사소통 능력은 조직구성원들의 독립적·비판적 사고에 긍정적이고 유의한 영향을 미치는 것으로 나타났다. The purpose of this study was to explore the impact of delegation on public employees` independent critical thinking. Using data from a large-scale survey of employees in US federal government agencies administered by the Office of Personnel Management in 2008, the study also examined the possible moderating roles of public manager`s diversity management and communication skills. The results indicated that the independent critical thinking of public employees have increased when they perceived high degree of delegation from their managers. In addition, employees` independent critical thinking also increased when managers have strong diversity management and communication skills. Lastly, when diversity management skill is higher, the perceived relationship between delegation and independent critical thinking is stronger.

한반도 안보위기에 미치는 국제 언론의 영향력 고찰

김철우 ( Kim Chul-woo ) 한국군사학회 2017 군사논단 Vol.92 No.-

This article is based upon a underlying perspective that the Korean peninsula’s security crisis is closely related with the international media’s news coverage on it. With the perspective, the paper focuses on the distinctive aspects of news-framing of 2017’s escalations of military confrontations between North Korea and the USA. Specifically, the author points out that the news coverage on the crisis should not be regarded as a ‘fake news’, rather be accepted as a reflection of public opinion of the international community. Mainstream international media are not facts-oriented messengers but significant influencers in formulating national policies toward the Korean peninsula. Sometimes the media may act as amplifiers or check-valves for the crisis itself. While acknowledging these influences of international media, the North Korean regime have induced lots of foreign reporters into Pyongyang and tried to spread out its intended messages. Kim Jong-Un’s calculations of counter-positioning himself with US president Donald Trump have mixed with media-oriented propaganda maneuvers and assertive provocations. Therefore military and security leaders of South Korea should enhance the mind-set and capabilities of strategic communication with clear understanding of the role of international media’s news framing on the Korean security crisis.

미국과 이란의 군사충돌 의사결정 특징 고찰 - 드론 공격에 의한 솔레이마니 폭살을 중심으로 -

김철우 ( Kim Chul-woo ) 한국군사학회 2020 군사논단 Vol.101 No.-

This paper is focused on the decision making of President Trump who called the shot for the targeted killing of Qassem Soleimani by US drone attack on January 3, 2020. After summarizing backgrounds, procedures, and aftermaths of the drone attack, the paper pointed out distinctive features of Trump’s unpredictable approaches as the commander in chief of US military. Iranian leader’s rhetorical determinations of harsh retaliations have scaled down to 15 ballistic missile launches toward two bases in Iraq to avoid the full scale war with US. Overall implications of the targeted killing of Soleimani may have valuable significance in terms of the crisis management of the Korean Peninsula. Similarities of North Korea and Iran and their connections for nuclear and missile development under heavy economic sanctions underline the seriousness of decisive nature of military options which should not be perceived as whimsical bluffing of the President Trump. The paper also points out the increasing threats of drone attack operations and recommends for the synchronizations of national intelligence and military operational readiness of ROK.

지역생활체육 활성화를 위한 서비스 만족도와 개선에 관한 연구

김철우 ( Chul Woo Kim ),곽이섭 ( Yi Sub Kwak ) 한국스포츠리서치 2007 한국 스포츠 리서치 Vol.18 No.4

This purpose of this study was to investigate service satisfaction and improvement for activating sport for all in community. The subjects of this study is 250 women who participate in participation sport for all. The measurement instrument was the questionnaire, which was used after testing reliability and validity of the items through the pre-test. The statistical analysis methods were conducted such as frequency analysis and one-way ANOVA. The date was collected by using spss 12.0. The independent variable is social population(ages, school career, incomes) and dependent variables was service satisfactions(instructor, facility, other service) and improvements. First, there was any difference between the ages of customer and instructor`s service satisfaction(p<.05). Second, there was any difference between the ages of customer and Facility`s service satisfaction(p<.05). but, there wasn`t any difference between the ages of customer and other service satisfaction(p>.05). Third, there wasn`t any difference between the school careers of customer and service satisfactions(p>.05). Fourth, there wasn`t any difference between the incomes of customer and service satisfactions(p>.05). Fifth, the improvements for activating sport for all was belly dance program and exercise prescription.