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양영일,김찬환,강신광,주종은,Yang, Young-Il,Kim, Chan-Hwan,Khang, Shin-Kwang,Joo, Joung-Eun 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
Cryptococcosis is a systemic mycosis that most often involves the central nervous system, followed by subclinical or symptomatic pulmonary involvement. We describe a case of unsuspected pulmonary cryptococcosis in a 69-year-old woman, diagnosed by sputum cytology. Sputum smears revealed numerous yeast like organisms typical of Cryptococcus neoformans measuring from 7 to 17 um in diameter. Mucicarmine, PAS, and methenamine sliver stains showed positive reaction of capsule and cell wall of Cryptococcus neoformans.
유방 섬유낭성 질환의 세포학적 진단의 분류 - 세포학적 소견에 의한 등급점수표의 이용에 대한 제안 -
윤혜경,김찬환,주종은,강신광,Yoon, Hye-Kyoung,Kim, Chan-Hwan,Joo, Jong-Eun,Khang, Shin-Kwang 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2
Fine needle aspiration biopsy has been proved as a safe, accurate and cost-effective diagnostic modality in palpable breast lesions. Cytologically, fibrocystic disease can be classified into 3 categories as nonproliferative breast disease, proliferative breast disease without atypia, and proliferative breast disease with atypia. This terminology for fine needle aspirates is compatible with that of diagnostic histopathology. Cytologic differentiation of nonproliferative disease from proliferative breast disease is important, since the risk of cancer development in cases of atypical hyperplasia is 4-5 times higher than that of general population. Twenty five fine needle aspirates of fibrocystic disease confirmed by subsequent histopathology were re-evaluated and classified into 3 categories depending on their architectural and nuclear features. In addition, these aspirates were scored according to the cytologic grading system, devised by Masood et al. and based on six cytologic criteria. Concordance rates between cytomorpholgic diagnosis and cytologic diagnosis using the cytologic criteria grading system and histologic diagnosis were 88% and 92%, respectively.
윤혜경,박설미,강미선,양영일,김찬환,Yoon, Hye-Kyoung,Park, Seol-Mi,Kang, Mi-Sun,Yang, Young-Il,Kim, Chan-Hwan 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Fine needle aspiration of the breast is an important diagnostic tool in malignant lesions, but is also useful in differentiation of inflammatory breast diseases mimicking carcinoma clinically and radiologically. Recently, the authors have experienced eight biopsy-proven cases of chronic inflammatory diseases of the breast, which consisted of 4 cases of duct ectasia, 2 cases of fat necrosis, and a case of tuberculous mastitis and granulomatous mastitis respectively. Their cytologic features mainly based on the components and the relative frequency of inflammatory cells were evaluated for differential diagnosis of chronic inflammatory breast diseases. The results are as follows; 1. In cases of duct ectasia, varying amount of neutrophils, mononuclear leukocytes, histiocytes and multinucleated giant cells were intermixed with benign epithelial cell clusters. 2 Abundant fat tissue fragments were diagnostic for fat necrosis. Histiocytes and mononuclear cells were main components but not rich, and neutrophils and giant cells were infrequently observed. 3. Characteristic granulomas composed of epithelioid cells, mononuclear leukocytes and Langhans' type giant cells and lymphocytic infiltrates were conspicuous in tuberculous mastitis, and occasionally neutrophils, necrotic materials and epithelial cell clusters were found 4. In granulomatous mastitis, epithelioid cell granulomas were also noted but numerous neutrophils and histiocytes were intermingled within or outside the granulomas.
기관배양을 통한 추간판 재생용 나노파이버 및 온도 감응성 지지체에 대한 검증
이용재,신지원,신호준,김찬환,박기동,배진우,서형연,김영직,신정욱,Lee, Yong-Jae,Shin, Ji-Won,Shin, Ho-Jun,Kim, Chan-Hwan,Park, Ki-Dong,Bae, Jin-Woo,Seo, Hyoung-Yeon,Kim, Young-Jick,Shin, Jung-Woog 대한의용생체공학회 2007 의공학회지 Vol.28 No.4
The purpose of this study is to investigate the potential of a novel tissue engineering approach to regenerate intervertebral disc. In this study, thermosensitive scaffold (chitosan-Pluronic hydrogel) and nanofiber were used to replace the nucleus pulposus (NP) and annulus fibrosus of a degenerated intervertebral disc, leading to an eventual regeneration of the disc using the minimally invasive surgical procedure and organ culture. In preliminary study, disc cells were seeded into the scaffolds and cellular responses were assessed by MTT assay and scanning electron microscopy (SEM). Based on these results, we could know that tissue engineered scaffolds might provide favorable environments for the regeneration of tissues. Organ culture was performed in fresh porcine spinal motion segments with endplates on both sides. These spinal motion segments were classified into three groups: control (Intact), injured NP (Defect), and inserting tissue engineered scaffolds (Insert). The specimens were cultivated for 7 days, subsequently structural stability, cell proliferation and morphological changes were evaluated by the relaxation time, quantity of DNA, GAG and histological examination. In these results, inserting group showed higher relaxation time, reduced decrement of DNA contents, and accumulated GAG amount. Consequently, the tissue engineered scaffolds used in this study seen to be a promising base scaffolds for regenerative intervertebral disc due to its capacity to absorb external dynamic loading and the possible ideal environment provided for disc cell growing.
중추신경계 수막종과 신경초종의 압착도말 세포학적 소견 및 감별진단
김영주,전미영,양영일,김찬환,윤혜경,강신광,Kim, Young-Ju,Jeon, Mi-Yeong,Yang, Young-Il,Kim, Chan-Hwan,Yoon, Hae-Kyoung,Khang, Shin-Kwang 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2
This study was peformed in order to evaluate the usefulness of the crush cytologic features and differential diagnosis between meningiomas and schwannomas in the central nervous system. Deeply seated and unusually located meningiomas and schwannomas with equivocal or erroneous frozen section diagnosis can be correctly diagnosed cytologically in crush preparations. Twenty-four meningiomas and nine schwannomas were studied by frozen section and crush preparation technique. These tumors displayed distinctive cytologic features. in meningiomas, the tumor tissue fragments were easy to crush, and the tumor cells were arranged in small clusters, flat sheets, papilla-like, whorling pattern or singly. Individual tumor cells displayed round or oval nuclei with finely granular chromatin pattern and inconspicuous small nucleoli. Occasionally psammoma bodies, nuclear pseudoinclusion or nuclear grooves were found. In schwannomas, tissue fragments were hard in consistency and difficult to crush. The crushed tissue presented as thick, irregular fragments with shard borders. The cells showed ill-defined cytoplasm and round, oval, cigar-shaped or curved nuclei. It is important to emphasize that the smear pattern under low-power view and cytologic features are helpful in discriminating between these two tumors.
한양천 ( Yang Chun Han ),강명주 ( Myoung Joo Kang ),박정하 ( Jeong Ha Park ),이원석 ( Won Sik Lee ),손창학 ( Chang Hak Sohn ),김찬환 ( Chan Hwan Kim ),주영돈 ( Young Don Joo ) 대한내과학회 2006 대한내과학회지 Vol.71 No.6
위장관에 발생하는 T세포 악성림프종은 발생 빈도가 낮고, 특히 식도에 발생하는 원발성 T세포 악성림프종은 극히 드문 것으로 보고되고 있다. 저자들은 60세 남자로 수 주 간의 연하곤란을 주소로 내원하여 상부위장관 내시경 검사 및 방사선학적 검사상 T세포 악성림프종으로 진단받은 후 복합항암요법을 통해 성공적으로 치료된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Gastrointestinal tract (GIT) lymphomas usually originate from B-lymphocytes but rarely from T-lymphocytes. The stomach is the most common site for extranodal GIT lymphoma but the esophagus is a rare site. In addition, a primary esophageal T-cell lymphoma is an uncommon disorder. We encountered a case of a primary esophageal T-cell lymphoma in a 11 60-year-old man, who had swallowing difficulties and multiple ulcers in the upper and lower esophageal mucosa on gastroscopy. Immunohistochemical staining for the biopsy material from the multiple esophageal ulcers tested positive for LCA and CD45RO (pan T-cell marker) and negative for cytokeratin and CD20 reactivity, respectively. No other abnormal lesions were observed on a computed tomography scan of the neck, chest, abdomen and pelvis. After six cycles of combination chemotherapy with cyclophosphamide, adriamycin, vincristin, prednisolone, etoposide and gemcitabine, the multiple esophageal ulcers had completely disappeared suggesting a complete clinical response. We report this case with a review of the relevant literature(Korean J Med 71:694-698. 2006)
노은지 ( Eun Ji No ),허진원 ( Jin Won Hur ),이성순 ( Sung Soon Lee ),이영민 ( Young Min Lee ),이혁표 ( Hyuk Pyo Lee ),김주인 ( Joo In Kim ),염호기 ( Ho Kee Yum ),최수전 ( Soo Jeon Choi ),최석진 ( Suk Jin Choi ),김찬환 ( Chan Hwan 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.1
Alpha-fetoprotein(AFP) is a plasma protein produced in the fetal liver, yolk sac and gastrointestinal tract. The plasma level of AFP decreases markedly 1 year after birth. The AFP level is usually increased in hepatocellular carcinoma and yolk sac tumor but is rare in a primary lung cancer. We report a case of primary adenocarcinoma of lung producing high levels of AFP. (Tuberc Respir Dis 2006; 61: 70-73)
이영민(Young Min Lee),오경석(Kyung Seok Oh),조길현(Kil Hyeon Cho),장현정(Hyeon Jung Jang),이상혁(Sang Hyuk Lee),설상영(Sang Yong Seol),정정명(Jung Myung Chung),최하진(Ha Jin Choi),김찬환(Chan Hwan Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives: Gastric dysplasia is defined as a lesion characterized by cellular atypia, abnormal differentiation and disorganized architecture without showing malignant nature in histology. Even though it was known as a precursor of gastric cancer, there were few studies in clinical and biological aspect in practice. Because the early detection of gastric cancer is very important, we have evaluated the risk of gastric carcinoma following the gastric dysplasia in prevention of gastric cancer. Methods: The authors evaluated the clinical and histological findings of 27 cases of gastric dysplasia for at least 3-12 months among 38 cases of gastric dysplasia and which confirmed from January 1992 to June 1994. Results: The sex distribution of 38 cases with gastric dysplasia was that men were 29 cases and women were 9 cases. The Highest incidence was above 6th decades(30cases) in age. Twenty seven cases of gastric dysplasia could be followed prospectively. Each histologic findings were as follow, mild dysplasia 12 cases, moderate dysplasia 7 cases and severe dysplasia 8 cases respectively. The endoscopic findings showed erosion 6 cases(16%), flat lesion 8 cases(21%), ulcer 10 cases(26%), polypoid lesion 14 cases(37%) respectively, The evolution of dysplasia was regression 4 cases, persistence 4 cases, progression 3 cases, cancer 1 case(9%) in mild dysplasia and regression 2 cases, persistence 2 cases, progression 1 case, cancer 2 cases(29%) in moderate dysplasia. In eight severe dysplasia, 1 case of regression, 3 cases of persistence and 4 cases of cancer(50%) were developed. Polypectomy was performed in 12 cases and 1 case was regressed from severe dysplasia after mucosal resection. In 27 cases of gastric epithelial dysplasia, gastric cancers were developed in 7 cases(26%) and early gastric cancers were 4 cases(57%) among them and the most common lesion was ulcer(5 cases). Conclusion: Gastric dysplasia should be strictly followed up with repeated endoscopic examination as well as treated the adequate endoscopic procedure for the prevention of progression or the risk of developing cancer.