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김진현,김은혜,김윤희,Kim, Jin-Hyun,Kim, Eun-Hye,Kim, Yoon-Hee 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.1
Objectives : This paper recommends a global budget based payment system for reimbursing oriental medical services in the national health insurance. Methods : We analyzed previous research outcomes related to oriental medical services and payment system We reviewed the experiences of other countries' global budget system in terms of their strength and weakness. In addition, we developed a reimbursement method for oriental medical services based on global budget. Results : Our reviews focused on global budget system of Germany, the Netherlands, the United Kingdom, Canada, France, and Taiwan. The estimation of global budget in the national health insurance was described in two scenarios. First scenario was to allocate oriental medical services in scale after signing a contract for global budget. In this case, 4.16% of the national health insurance expenditure was allocated for the oriental medical services. Second scenario was to estimate the global budget in a historical context. As a result, the first scenario in total budget was higher than the second, and we proposed a retrospective adjustment method for the gap between the budget and the actual expenditure Conclusions : The payment system for oriental medical services is recommended to shift from fee-for-service to global budget.
김진현,김철,김상균,장현철,한정민,예상준,송미영,Kim, Jin-Hyun,Kim, Chul,Kim, Sang-Kyun,Jang, Hyun-Chul,Han, Jeong-Min,Yea, Sang-Jun,Song, Mi-Young 대한예방한의학회 2009 대한예방한의학회지 Vol.13 No.3
Objectives : In this study, we survey papers about the combined therapy of oriental medicine and western medicine in oriental medicine viewpoint. Methods : First, we collected research papers on combined treatment, and we found 70 papers in the two internet sites, 'OASIS' and 'KISTI', using the keywords 'combined treatment', 'collaborated diagnosis', 'oriental-western medicine', and 'western-oriental medicine'. Then we analyzed them according to year, oriental-western medicine, diseases, research methods and subjects. Results & Conclusions : Researches for combined therapy had some problems as follows : First, studies have been made only for limited diseases like cancer, infection, stroke, etc. Second, methods of research are also limited. Some methods such as in vivo, in vitro and case-report are used repeatedly. Third, only the positive aspects of the combined therapy are proposed. We don't find the side effects of the combined therapy at all. To solve these problems, more objective and balanced studies such as RCT for various diseases should be performed.
김진현,김태영,주명종,남기대 ( Jin Hyun Kim,Tae Young Kim,Myung Jong Ju,Ki Dae Nam ) 한국공업화학회 1996 공업화학 Vol.7 No.3
Sodium N-lauroyl-N-methyl taurate의 cmc에 대한 온도효과를 검토하였다. cmc값들은 처음 20℃∼40℃의 온도 범위에서는 감소하다가 더욱 온도가 증가되면 다시 증가하는 경향이었다. cmc에 대한 온도의 의존성으로부터 여러가지 열역학적 파라미터들(ΔH_m, ΔG_m, ΔS_m)을 산출하였다. Sodium N-lauroyl-N-methyl taurate의 cmc에 대한 여러 전해질들의 첨가효과를 또한 검토하였고, 소수성결합 형성에너지 및 미셀의 해리도를 log cmc와 log conc.의 곡선으로부터 산출하였다. ΔH_m값들은 온도가 증가함에 따라 감소하였고, 40℃∼50℃의 온도범위에서 부호가 양에서 음으로 변하였다. ΔG_m값들은 전해질 농도 및 온도가 증가할수록 감소하였다. The effect of temperature on the cmc of sodium N-lauroyl-N-methyl taurate was examined. The cmc values were found to be decreased initially but increased further with the increase of temperature. From the temperature dependence of cmc, various thermodynamic properties were calculated. The effects of various electrolytes on the cmc of sodium N-lauroyl-N-methyl-taurate were also examined. The free energy of hydrophobic bond formation and the degree of dissociation of the micelles were calculated from log cmc vs. log counter ion concentration plots. The ΔH_m values were decreased with increasing the temperature and changed their signs from plus to minus at 40℃∼50℃. The ΔG_m values were decreased with the increase of electrolyte concentration and temperature.
맵리듀스 프레임웍 상에서 맵리듀스 함수 호출을 최적화하는 순차 패턴 마이닝 기법
김진현,심규석,Kim, Jin-Hyun,Shim, Kyu-Seok 한국정보처리학회 2011 정보처리학회논문지D Vol.18 No.2
시퀀스(sequence) 데이터가 주어졌을 때 그 중에서 빈번(frequent)한 순차 패턴을 찾는 순차 패턴 마이닝(sequential pattern mining)은 여러 어플리케이션(application)에 사용되는 중요한 데이터마이닝 문제이다. 순차 패턴 마이닝은 웹 접속 패턴, 고객 구매 패턴, 특정 질병의 DNA 시퀀스를 찾는 등 광범위한 분야에서 사용된다. 본 논문에서는 맵리듀스(MapReduce) 프레임웍 상에서 맵리듀스 함수 호출을 최적화하는 순차 패턴 마이닝 알고리즘을 개발하였다. 이 알고리즘은 여러 대의 기계에 데이터들을 분산시켜 병렬적으로 빈번한 순차 패턴을 찾는다. 실험적으로 다양한 데이터를 이용하여 파라미터 값을 변화시켜가며 제안된 알고리즘의 성능을 종합적으로 확인하였다. 그리고 실험 결과를 통해 제안된 알고리즘은 기계 수에 대해 선형적인 속도 개선을 보인다는 것을 확인하였다. Sequential pattern mining that determines frequent patterns appearing in a given set of sequences is an important data mining problem with broad applications. For example, sequential pattern mining can find the web access patterns, customer's purchase patterns and DNA sequences related with specific disease. In this paper, we develop the sequential pattern mining algorithms using MapReduce framework. Our algorithms distribute input data to several machines and find frequent sequential patterns in parallel. With synthetic data sets, we did a comprehensive performance study with varying various parameters. Our experimental results show that linear speed up can be achieved through our algorithms with increasing the number of used machines.
Purification of homoharringtonine and removal of residual solvents by spray drying
김진현,Byung-Sik Kim 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.1
Homohamingtonine was purified from Cephalotaxus koreanaadsorbent treatment, low-pressure chromatography, and high performance liquid chromatography (HPLC). A crudeextract was obtained by methanol extraction of biomass, followed by liquid-liquid extraction using chloroform. Thewaxy compounds were efficiently removed by adsorbent (active clay P-1) treatment. The extract was purified to greaterthan 52% with an 86.4% step yield by silica gel low-pressure chromatography. High performance liquid chromatog-raphy steps, which were composed of an HPLC step with silica column and an HPLC step with ODS column, wereapplied to give 98% purity with high yield. Amorphousby dissolving homoharringtonine in methylene chloride/methanol (98/2, v/v), followed by spray drying. Residual sol-vents, methylene chloride and methanol, could be reduced to 250 ppm and 1,160 ppm by spray drying and successivedrying in a vacuum oven.