혈액질환에 속발하는 이차성 위암

김지훈,지성배,허훈,진형민,김욱,김동욱,이종욱,민우성,김춘추,전해명,Kim, Ji-Hoon,Jee, Sung-Bae,Huh, Hoon,Chin, Hyung-Min,Kim, Wook,Kim, Dong-Wook,Lee, Jong-Wook,Min, Woo-Sung,Kim, Choon-Choo,Jeon, Hae-Myung 대한위암학회 2007 대한위암학회지 Vol.7 No.4

Purpose: Patients with hematologic diseases such as chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL) are known to have an increased chance of acquiring a secondary neoplasm. Stomach cancer is one of the most common malignant diseases in Korea, and we investigated whether the incidence of secondary stomach cancer in patients with a hematologic disease increases, in order to determine if a more intensive screening program for detecting secondary gastric cancer was required. We also investigated the safety of performing a gastrectomy in hematologic disease patients. Materials and Methods: From 1992 to 2006, the medical records of 8376 patients diagnosed with one of the six common hematologic diseases were reviewed. Results: Nine secondary stomach cancers were found among the 8376 patients during the 15-year observation period. No surgical-related complications occurred, and there was no recurrence of stomach cancer if detected early. Conclusion: It seems that a more intensive screening program for detecting secondary gastric cancer in hematologic disease patients is not required, and surgery is not risky in these patients. 목적: 만성 골수성 백혈병이나 말성 림프구성 백혈병에서 이차성 암의 위험은 증가하는 것으로 알려져 있다. 백혈병을 비롯한 혈액질환을 가진 환자에서 우리나라에서 가장 흔한 암 가운데 하나인 위암의 위험이 증가하는지 조사하여 혈액질환 환자를 대상으로 위암에 대한 보다 적극적인 검진이 필요한지 알아보고자 하였다. 또한 응고장애나 면역저하와 같은 수술에 관련된 위험인자가 있을 수 있는 혈액질환 환자에서 위암 수술이 안전하게 이루어질 수 있는지에 대해 조사하고자 하였다. 대상 및 방법: 지난 15년가 성모병원에서 백혈병 및 다발성 골수종, 재생불량성 빈혈로 진단받은 8,376명의 환자를 대상으로 의무기록을 후향적으로 조사하였다. 결과: 총 9예의 이차성 위암이 확인되었다. 감염이나 출혈등 수술관련 합병증은 발생하지 않았으며, 조기에 발견된 경우 재발도 관찰되지 않았다. 결론: 위암의 빈도가 일반인에 비해 크게 증가하지 않아 혈액질환 환자에서 이차성 위암의 감시를 위한 집중적인 프로그램이 따로 도입되어야 할 필요성은 없는 것으로 생각되며, 혈액질환 환자의 위암 수술에 있어 합병증도 크게 증가하지는 않는 것으로 생각된다.

김제시 간척지역 천부 지하수내 철 환원작용 특성에 대한 고찰

김지훈,정태진,류종식,김락현,Kim, Ji-Hoon,Cheong, Tae-Jin,Ryu, Jong-Sik,Kim, Rak-Hyeon 대한자원환경지질학회 2013 자원환경지질 Vol.46 No.1

간척지를 포함하고 있는 연구지역에서 육지에서 해안지역으로 근접할수록 측정된 지하수의 산화환원 전위 (Eh)와 용존 산소량 (DO)은 낮게 관찰되었다 (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l). 이는 연구지역 지하수의 산화환경이 육지에서 해안가로 근접할수록 호기성 환경에서 아혐기성/혐기성 환경으로 변화한다는 것을 의미한다. 또한 지하수 수질 분석 결과에 의하면 철이온 (Fe)이 지하수에 많이 포함되어 있으며 (> 20 mg/l), 대부분의 2가 철로 존재한다. 이러한 연구지역 해안가 지하수들의 특징들은 지하수들이 철의 환원작용 (Fe reduction)이 일어날 수 있는 혐기성 환경에 위치하고 있음을 지시해준다. 철 환원작용이 일어나기 위해서는 3가 철의 공급원이 필요한데, 관측정 퇴적물의 철이온 추출실험에 의하면 연구지역의 퇴적물은 철 환원작용에 필요한 3가 철이온에 대한 충분한 공급원 역할을 할 수 있다. 따라서 분석한 지하수 및 퇴적물의 결과들을 종합해석하면, 연구지역에서 일어나는 철 환원작용은 갯벌의 간척활동과 많은 관련을 가지고 있는 것으로 추정된다. The study area is located on the western coastal region of Korea, partly had been reclaimed lands. Groundwaters of the coastal area show lower Eh and DO values (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l), and higher Fe concentrations (> 20 mg/l) than those of the inner land (< 0.3 mg/l), indicating that the redox condition of groundwater changes from oxic into suboxic/anoxic conditions as it flows from the inland toward the coastal area. In addition, Fe speciation of groundwater from the coastal area demonstrates that the most dissolved Fe exist as $Fe^{2+}$, reflecting that groundwater is under the anoxic condition to sufficiently occur Fe reduction. According to the result of Fe extraction with the sediment samples from three wells (A, B, C), the sediments provide enough $Fe^{3+}$ to occur the Fe reduction in the groundwater. Integrated all results of the groundwater and sediment, we infer that the Fe reduction to occur in groundwater is associated with the reclamation processes of the study area.

인접전류패턴을 사용한 변형된 방향 대수적 영상복원법

김지훈,김찬용,김경연,최봉열,Kim, Ji Hoon,Kim, Chan Yong,Kim, Kyung Youn,Choi, Bong Yeol 대한전자공학회 2012 전자공학회논문지 Vol.50 No.8

전기 임피던스 단층촬영법(electrical impedance tomography, EIT)에서 관심 대상물 내부 영상을 복원하는 방법 중 하나인 방향 대수적 영상복원법(directional algebraic reconstruction technique, DART)은 삼각함수형태로 설계된 전류패턴을 외부 전극에 인가하고 이로부터 얻어지는 전압과의 상관관계를 이용하여 영상복원 알고리즘의 입력인 각 전극사이의 저항을 유도하게 된다. 이때, 저항유도 시간이 발생하고 이는 DART 알고리즘을 실시간 영상복원에 적용하는데 장애가 되고 있다. 이 논문에서는 저항유도 시간의 문제를 해결하기 위하여 기존에 사용하던 삼각함수형태의 전류패턴대신 인접전류패턴을 사용한 변형된 방향 대수적 영상복원법(modified directional algebraic reconstruction technique, mDART)을 제안한다. 제안한 방법은 주입한 전류와 측정된 전압으로부터 저항을 유도하지 않고 측정전압을 바로 복원 알고리즘의 입력으로 사용하기 때문에 DART의 영상복원시간의 대부분을 차지하는 저항유도 시간을 없앨 수 있을 뿐만 아니라 인접전류패턴을 사용하여 복원영상의 질도 향상시킬 수 있다. 이 논문의 타당성을 입증하기 위하여 모의실험을 수행하였으며 제안한 방법은 기존 방법보다 복원시간의 개선뿐만 아니라 영상오차 관점에서도 성능이 개선됨을 확인하였다. The directional algebraic reconstruction technique (DART) using the trigonometric current pattern is one of the image reconstruction algorithms in electrical impedance tomography (EIT). This method needs to compute resistances between electrode pairs as using relation between the injected currents and measured voltages for the reconstruction of the inner image. The delay time is incurred in this process. Therefore this paper proposes modified directional algebraic reconstruction technique (mDART) using the adjacent current pattern instead of the trigonometric current pattern to solve the delay time for initial resistance values. The proposed method uses measured voltages instead of computed resistances in the reconstruction algorithm. Hence this method can eliminate the delay time because it does not use the resistances. In conclusion, the proposed method improves image quality and image reconstruction time by using the adjacent current pattern. To prove performance of the proposed method, we carried on computer simulation of various cases.

부유형 해양 광생물반응기를 이용한 자외선과 초기 미세조류 접종 농도와의 상관관계 규명

김지훈,박한울,정성균,김수권,김희윤,박용성,홍한마루,이철균,Kim, Z-Hun,Park, Hanwool,Jung, Seong-Gyun,Kim, Su-Kwon,Kim, Hee-Yun,Park, Yong Sung,Hong, Han Ma Roo,Lee, Choul-Gyun 한국해양바이오학회 2015 한국해양바이오학회지 Vol.7 No.2

The purpose of this study was to investigate a relationship between ultraviolet radiation and initial cell density (ICD) of microalgae using a floating marine photobioreactor (PBR). To examine the effect of ultraviolet (UV) radiation in sunlight on biomass productivity as a function of ICD, 0.5-L floating PBRs covered with or without UV cut-off film were placed in an outdoor rectangular tank containing 200 L of water. At the lower ICDs, 0.01 and 0.05 g/L, biomass productivities in the PBRs without UV cut-off film decreased by $278{\pm}21%$ and $222{\pm}3%$ compared with those with the film, respectively. In contrast, the presence of UV cut-off film did not have a significant effect on biomass productivities at the higher ICDs, 0.25 and 1.25 g/L. When the differences in biomass productivity made by the UV cut-off film were plotted against the sum of cell projection area per light receiving area of the PBR, the results revealed that the inhibitory effect of UV on biomass productivity can be negligible when the sum of cell projection area is equal to the light receiving area of the PBR. These results show that photoinhibition caused by UV radiation could be eliminated via operating the PBR with a proper ICD.

소아 궤양성 대장염의 수술적 치료 성적

김지훈,김현영,정성은,박귀원,김우기,Kim, Ji-Hoon,Kim, Hyun-Young,Jung, Sung-Eun,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 2005 소아외과 Vol.11 No.2

Ulcerative colitis, an inflammatory bowel disease, is primarily managed medically with a combination of 5-ASA and steroids. However, this chronic disease requires surgical management if symptoms persist or complications develop despite medical management. The clinical course, indications and outcome of surgical management of 21 patients under the age of 15 who were endoscopically diagnosed with ulcerative colitis at the Seoul National University Children's Hospital between January, 1988 and January, 2003 were reviewed. Mean follow up period was 3 years and 10 months. The mean age was 10.3 years old. All patients received medical management after diagnosis and 8 patients (38 %) eventually required surgical management. Of 13 patients who received medical management only, 7 patients (53 %) showed remission, 4 patients are still on medical management, and 2 patients expired due to congenital immune deficiency and hepatic failure as a result of sclerosing cholangitis. In 8 patients who received surgical management, the indications for operation were, 1 patient sigmoid colon perforation and 7 patients intractability despite medical management. The perforated case had a segmental colon resection and the other 7 patients underwent total colectomy with ileal pouch-anal anastomosis. One patient expired postoperatively due to pneumonia and sepsis. and 1 is still on medical management because of mild persistent hematochezia after surgery. Six other operated patients are doing well without medical therapy. Pediatric ulcerative colitis patients can be surgically managed if the patient is intractable to medical management or if complications such as perforation are present. Total colectomy & ileal pouch-anal anastomosis is thought to be the adequate surgical method.

Bidirectional Laser Triggering in Highly-resistive Vanadium-dioxide Thin Films by Using a 966-nm Pump Laser Diode

김지훈,Bong-Jun Kim,유봉안,강현욱,남승윤,오정환,이용욱 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.2

By incorporating a 966-nm pump laser diode, we realized bidirectional laser triggering in a twoterminal planar device based on a highly-resistive vanadium-dioxide (VO2) thin film grown by using the pulsed laser deposition method. Bidirectional laser triggering of up to 10 mA was achieved by directly illuminating the VO2 film with a focused infrared laser beam, and the transient responses of the laser-triggered currents were analyzed. A switching contrast between the off-state and the on-state currents was measured as 3571, and the rising and the falling times were measured as 40 and 20 ms, respectively, when laser pulses with a pulse width of 100 ms excited the VO2-based device.

일방향 CFRP적층판의 모드II 동적 층간파괴인성 평가

김지훈,정태훈,이현,양인영,조규재,심재기,Kim, Ji-Hoon,Jeong, Tae-Hoon,Lee, Hyun,Yang, In-Young,Cho, Gyu-Jae,Sim, Jae-Ki 한국안전학회 2000 한국안전학회지 Vol.15 No.4

In this paper, an investigation was performed on the ModeII dynamic interlaminar fracture toughness of unidirectional CFRP laminates. The stacking sequences used in this experiment are two kinds of [$0_20$] and [$0_{10}F_20_{10}$]. In the experiments, Split Hopkinson's Bar test was applied to dynamic and notched flexure test. The Mode II fracture toughness of each unidirectional CFRP was estimated by the analyzed deflection of the specimen and J-Integral with the measured impulsive load and reactions at the supported points. As an experimental results, the specimen [$0_{10}F_20_{10}$] appears greater than that of [$0_20$] for the J-integral and displacement velocity at a measuring point within the range of experiment.

The Interplay between Star Formation and AGN Activities : A Case Study of LQSONG

김지훈,임명신,김도형,Kim, Ji Hoon,Im, Myungshin,Kim, Dohyeong 한국천문학회 2012 天文學會報 Vol.37 No.2

One of the most intriguing questions regarding black hole (BH)-galaxy co-evolution picture is how the BH accretion, or active galactic nucleus (AGN) activity is linked to star formation (SF) activity. While it is suggested that AGN luminosity of quasars correlates with SF luminosity, it is still unclear how AGN activity is connected to SF activity based on host galaxy properties. Utilizing AKARI's unique slit-less spectroscopic capability and wavelength coverage, we probed star formation activity of several types of AGNs by measuring the PAH 3.3 ${\mu}m$ emission. First, we detected the PAH 3.3 ${\mu}m$ emission from seven out of 27 Seyfert type-1 galaxies at z~0.36. While these galaxies deviate significantly from the local Mbh-${\sigma}$ relation meaning their black holes proceed the host galaxies in terms of evolution, they appear to follow the correlation between nuclear SF and AGN activities of local Seyfert type-1 galaxies. This implies that SF and AGN activities are directly connected at the nuclear region for these Seyfert type-1 AGNs. We also obtained 2-5 ${\mu}m$ spectra for subsamples of Quasar Spectroscopic Observation in Near-infrared Grism (QSONG) which consists of reverberation-mapped AGNs and PG-QSOs. We detected the PAH 3.3 ${\mu}m$ emission from 16 out of 31 reverberation-mapped AGNs and 10 out of 49 PG-QSOs and measured their line strengths. We present the correlations between SF and AGN activities and discuss if there is any dependency of the correlations on properties of host galaxies, such as morphology, or the presence of radio jets.

후포분지 홀로세 퇴적물의 유기물에 대한 지화학 분석 결과 및 의미

김지훈,박명호,공기수,한현철,정태진,최지영,김진호,강무희,이치원,오재호,Kim, Ji-Hoon,Park, Myong-Ho,Kong, Gee-Soo,Han, Hyun-Chul,Cheong, Tae-Jin,Choi, Ji-Young,Kim, Jin-Ho,Kang, Moo-Hee,Lee, Chi-Won,Oh, Jae-Ho 대한자원환경지질학회 2010 자원환경지질 Vol.43 No.1

Geochemical approaches on the two recovered piston cores were performed to understand the characteristics of organic matters and the influence of the sea level variation of the East Sea in the Hupo Basin since the Holocene. The analyzing results on organic components (TOC and TN), and isotopic compositions of organic matters showed the variation to core locations and sampling depths. In core 08HZP-01, their values were gradually changed with depth from 4 mbsf to seafloor. However, rapid variation was observed at the boundary of 4.71 mbsf (meter below seafloor) in core 08HZP-03. Based on TOC/TN, $\delta^{13}C_{org}$ and $\delta^{15}N_{org}$, the origin of organic matters in the Hupo Basin can be divided into three groups; 1) predominant marine algae, 2) $C_3$ land plant, and 3) mixture of $C_3$ land plant and marine/freshwater algae. It is likely that the vertical and spatial variations of organic and isotopic compositions reflect the shifts in sedimentary environment (including sediment transportation) by ocean currents and sea-level changes and others during the Holocene period. 동해안의 후포분지에서 채취한 두 개의 피스톤 코어를 이용하여 후포분지에서의 홀로세 퇴적물 내 유기물의 특징 및 동해 해수면 변화와의 관계를 규명하고자 지화학적 접근을 시도하였다. 채취한 시료에 대한 유기물 성분 분석(TOC와 TN)과 유기물 동위원소($\delta^{13}C_{org}$와 $\delta^{15}N_{org}$) 분석 결과들은 코어와 시료 채취 심도에 따라 분석값들이 특징적으로 변화한다. 코어 08HZP-01에서는 4 mbsf(meter below seafloor)에서 코어 표면까지 비교적 채취 심도가 상부로 갈수록 지화학 분석값들이 점이적으로 증가하지만, 코어 08HZP-03에서는 4.71 mbsf를 기준으로 상부와 하부에서 급격한 지화학 분석값들의 변화가 발생한다. 유기물의 TOC/TN과 $\delta^{13}C_{org}$와 $\delta^{15}N_{org}$의 값을 종합적으로 고려하였을 때, 후포분지의 유기물은 해양 조류 기원이 우세한 집단, $C_3$ 육성 식물 기원이 우세한 집단, 해성/육성 조류와 $C_3$ 육성 식물의 혼합기원이 우세한 집단으로 구분할 수 있다. 이러한 퇴적물 내 유기물의 심도에 따른 특성 및 기원 변화는 주로 홀로세 동해 해류와 해수면 등의 변화에 따른 퇴적환경 변화 (퇴적물 이동 포함)에 기인한 것으로 보인다.

올 한해도 이슈였던 사료와 질병, 그 복잡한 상관관계

김지훈,Kim, Ji-Hun 한국단미사료협회 2005 피드저널 Vol.3 No.12