탈륨 재주사영상법에서 휴식기재분포영상의 의의

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),정명호(Myung Ho Jeong),강정채(Jung Chaee Kang),송호천(Ho Chun Song) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Apparent washout of T1-201 may occur between redistribution and reinjection images. To examine the frequency of it, we prospectively compared 4-hour redistribution and reinjection images in 63 consequent patients. Al1 patients underwent pharmacological stress test using 0.56 mg/kg dipyridamole. Immediately after the 4-hour redistribution images, 1mCi T1-201 was injected at rest, and images were reacquired 10 minutes after reinjection. The stress, redistribution, and reinjection images were then analyzed semiquantitatively (0=no uptake, l=faint uptake, 2=mildly diminished uptake, 3=normal uptake). Of the 100 abnormal myocardial regions on the stress images, 54 showed either complete or partial reversibility on 4-hour redistribution images. After reinjection 11(21, 2%) of these regions demonstrated apparent T1-201 washout due to low differential uptake of the tracer, Such lesions would appear irreversible if redistribution imaging is not performed before reinjection. Thus 4-hour redistribution imaging should be performed for assessment of myocardial ischemia and viability.

비소세포 폐암의 국소화 및 방사선치료 판정에 있어 Tc-99m MIBI SPECT 의 유용성

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),송호천(Ho Chun Song),남택근(Taek Keung Nam),안정자(Sung Ja Ahn),정웅기(Woong Ki Chung),나병식(Byung Sik Nah) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.2

N/A Tc-99m MIBI, a lipophilic cation, was reported as a useful agent for localization of lung cancer. The effect of radiation therapy on the uptake of Tc-99m MIBI in lung cancer, however, was not well evaluated. The aim of the present study was to elucidate the usefulness of Tc-99m MIBI SPECT in the localization and the assessment. of radiotherapy in non-small cell lung cancer, Tvrenty patients(19 males and 1 female, mean age 59, 16 squamous cell ca and 4 adenocal were studied with Tc-99m MIRI SPECT before radiation therapy. Eleven patients(10 males and 1 female, mean age 59, 8 squamous cell ca and 3 adenoca) were repeated the study 1 month after the completion of radiation therapy(mean dose 6453cGy). All patients showed positive uptakes of Tc-99m MIBI in their tumors. One patient showed a hot uptake in atelectatic area. There was no difference of Tc-99m MIBI uptakes between squamous cell ca and adenoca either on planar or tomographic images. Tc-99m MIBI uptake ratios of squarnous cell ca and adenoca were 1.50 +- 0.16 and 1.45 +- 0.15 on planar images, and 2.73 +- 0.46 and 2.54 +-0.37 on tomographic irnages, respectively. The concordance between radivlogical change(chest x-ray and CT) and change of Tc-99m MIBI uptakes was 9/11 (81.8%). In conclusion, Tc-99m MIRI SPECT was useful in the localization of tumor and the assessment of radiation therapy in non-small cell lung cancer.

갑상선암 환자에서 방사성옥소 ( 131I ) 치료로 인한 림프구의 자매염색분체교환 ( SCE ) 빈도 증가

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),최근희(Keun Hee Choi),김광윤(Kwang Yoon Kim),윤정한(Jung Han Yoon),제갈영종(Young Jong Jae Gal),김재민(Jae Min Kim) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1

N/A To evaluate the genotoxic effect of 131I, lymphocytes from 9 patients who underwent large dose (150 mCi) 131I therapy after total thyroidectomy were studied for sister chromatid exchanges (SCE) before and after their first radioiodine treatments. Frequency of SCE (FSCE) was counted in chromosomes of 30 lymphocytes in each patients, and was expressed as numbers of SCE per cell. Numbers of leukocytes were also observed during 131I therapy. Pretreatment FSCE (4.2±0.7) was not different from the control (3.8±0.4, p=0.17). However, the frequency was significantly elevated after 131I administration (at the second day, 7.9±0.8, p〈0.001) and was diminished but still significantly elevated after a week (at 9th day, 6.4±0.6, p〈0.001). While counts of leukocytes in the peripheral blood showed no change(p〉0.05). In conclusion, chromatids of human lymphocytes were significantly damaged after 131I treatment without any bone marrow supression. And the repair of SCE was not complete within one week.

생쥐골수세포 미소핵검사에 의한 치료용량 방사성옥소 ( 131I ) 의 유전독성 평가

김지열(Ji Yeul Kim),범희승(Hee Seung Bom) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1

N/A Background: Radioiodine(131I), a major component of nuclear fallout and a valuable therapeutic agent for thyrotoxicosis and thyroid cancer, has been regarded as a mutagen or a carcinogen without any convincing evidence. To evaluate the genotoxicity of radioiodine(131I) we performed a micronuclei test mice bone marrow. Materials and methods: Mice (ICR strain, 25∼30 g) were divided to 4 groups: control, group 1 (0.17 mCi/kg, usual therapeutic dose for thyrotoxicosis), group 2 (1.67 mCi/kg, usual therapeutic dose for thyroid cancer), and group 3 (16.67 mCi/kg, usual accumulated dose causing bone marrow suppression). 131I was administered intraperitoneally. Ten mice of each group were sacrificed at days 1 and 3. Bone marrow were smeared and stained with May-Grunwald Giemsa method. One thousand polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) were counted under the light microscope, and the number of micronucleated PCEs were recorded. Results: The frequency of micronuclei in PCE (and NCE in parenthesis) in the control group was 0.25±0.07 (0.23±0.07)% in day 1 and 0.24±0.07 (0.21±0.07)% in day 3. Those in group 1 was 0.27±0.1 (0.23±0.09)% in day 1 and. 0.28±0.07 (0.25±0.06)% in day 3. Micronuclei was noted in 0.29±0.08 (0.26±0.09)% in day 1 and 0.31±0.05 (0.29±0.06)% in day 3 in group 2, and in 0.32±0.06 (0.25±0.09)% in day 1 and 0.33±0.08 (0.3±0.06)% in day 3 in group 3. There was no difference in the frequency of micronuclei between each groups (p〉0.05) Conclusion: Radioiodine (131I) did not cause any genotoxicity in mice bone marrow even at the large dose (16.67 mCi/kg).

골신티그라피에 의한 Hydroxyapatite 안구삽입물로의 섬유혈관증식 평가

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),송호천(Ho Chun Song),정상기(Sang Ki Jeong),박영걸(Young Kul Park) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Thirteen patients received a coralline hydroxyapatite sphere as a buried integrated ocular implant after enucleation surgery. The implant was modified by multiple drillings, 1 mm in diameter, to the center of the sphere to allow more rapid host tissue ingrowth. Tc-99m-MDP planar and tomographic bone scintigraphies were performed at various intervals after implantation (from 100 to 742 days after operation) to assess vascularization of the implant. All patients showed hot uptakes in the implants. These patients underwent a secondary drilling for the final motility peg application. The confirmation of vascular ingrowth was done by inspection of bleeding at the time of bleeding at the time of drilling from the center of the implant. Bleeding from the drilled implant was noted in all patients. In conclusion, hot uptake in the implanted ocular hydroxyapatite implant accurately reflect vascular ingrowth into the implant.

가족 발생적인 갑상선이상의 방사성면역 측정법에 의한 TSH 평가

김지열(Ji Yeul Kim) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.1

N/A The occurrence of thyroid disorders is connected with iodine deficiency, defective synthesis or releasing of thyroid hormone and endemicity. Genetic factors are known as a single gene defects, interaction of multiple genes with environmental factors, as well as chromosomal aberrations. Diofnosis thyroid disorders is enforced by I-131 uptake test, thyroid scanning with I-131 or Tc- 99m and serum radioimmunoassays of T3, T4, free T4 and TSH. They were largely classified as hypothyroidism, hyperthyroidism, simple goiter and normal. The pedigree of 58 families was drawn by propositus, and then the correlation between thyroid disorders and TSH levels was analyzed. The results are as follows: 1) The offsprings and their mothers of 15 families were hypothyroidism, THS level was 5 folds for offsprings and 4 folds for mothers in comparison with control group. 2) 13 families were hyperthyroidism in siblings but their mothers were normal in thyroid function, TSH level of the siblings was lower than control group. 3) Though the offsprings and their mothers of 10 families were similar to TSH level of control group, they are all simple goiter, familial thyroid disorders, in other thyroid function test. The familial thyroid disorders suggested that these transmitted from mothers to offsprings with X-linked dominant or autosomal dominant inheritance.

심근 관류스캔 중 정상 부하영상 소견을 보인 환자에서 휴식기 영상의 필요성에 대한 평가

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),민정준(Jung Jun Min),송호천(Ho Chun Song) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4

N/A Tc-99m myocardial perfusion agents such as Tc-99m sestamibi or Tc-99m tetrofosmin has advantages over T1-201 for myocardial perfusion scan such as low attenuation and easy availability. However, Tc-99m agents do not redistribute so they need to be given 2 times, namely after stress and at rest. To evaluate whether rest image is needed in patients showing normal stress images, 43 patients who underwent both myocardial perfusion scan and coronary angiography and showed normal stress images were evaluated. Findings of rest images of them were evaluated whether they change the diagnosis or treatment plans. Among 43 patients who showed normal stress myocardial perfusion imaging, 31 (72.1%) showed no additional informations. However, among 5 patients with vasospastic angina 4(80%) showed abnormal rest images in spite of normal stress images. So, when vasospastic angina is suspected clinically, rest image could be helpful identifying patients with coronary vasospasm. In conclusion, rest myocardial perfusion images were not helpful in 72.1 % of patients with angina when stress images were normal. In only exception was those with vasospastic angina.

마우스에서 경구투여한 방사성스트론튬의 제거에 대한 경구투여 카이토산과 알긴산의 효과

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),최근희(Keun Hee Choi),김희경(Hee Kyung Kim),김광윤(Kwang Yoon Kim) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1

N/A Radiostrontium is one of fallouts. It can be absorbed through intestine and causing radiation injury to bones. The purpose of this study is to evaluate the inhibitory effect of 10% chitosan (water soluble and insoluble) and 10% alginate (water soluble and insoluble) on radiostrontium adsorption. Water soluble and insoluble chitosans and alginates were given to 10 NIH male mice in each group for 7 days. At the 7th day, 74 MBq of 85Sr were given through orogastric tube. Chitosans and alginates were given for additional 7 days. During the 7 days, radioactivities of feces were counted daily. Finally animals were sacrificed, and radioactivities of bones were counted. Feca1 excretion was significantly higher in chitosan and alginate group as compared to control from the lst day (p〈0.01). Water soluble chitosan group showed highest fecal excretion. Bony retention was significantly lower in the treated group than the control (p〈0.01). There was no difference among treated groups. In conclusion, both water soluble and insoluble chitosans and alginates were effective agents on lowering orally ingested radiostrontium (85Sr)

디피리다몰 심근관류 SPECT 를 이용한 관동맥질환 진단에 있어 남녀간의 진단율 비교

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),민정준(Jung Jun Min),송호천(Ho Cheon Song),정환정(Hwan Jeong Jeong) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2

N/A Purpose: Myocardial SPECT is an effective test for detecting coronary artery disease in the general population. But the diagnostic accuracy between sexes is not defined. The purpose of this study is to compare the diagnostic accuracy between males and females. Materials and Methods: One hundred and seventy seven male and 98 female patients who underwent myocardial SPECT within 1 month of coronary angiography were studied. Myocardial SPECTs were considered abnormal if fixed or reversible perfusion defects were detected. Stenosis severity of ≥ 50% luminal diameter reduction of any artery defined coronary artery disease (CAD). Results: Overall sensitivity for detection of CAD was 98% in men and 97% in women (p=not significant). However, specificities, accuracies, and positive predictive values (PPV) in men and women were 49% vs 31% (p〈0.05), 81% vs 57% (p〈0.01), 78% vs 48% (P〈0.01), respectively Diagnostic accuracies for detection of right coronary artery disease were not different in both sexes, however, accuracies for detection of left anterior descending artery disease and left circumflex artery disease were significantly lower in female (p〈0.05). Conclusion: A significant difference of diagnostic accuracy between sexes, especially in LAD and LCx disease, was noted. Artifacts from breast attenuation might be a cause for the lower diagnostic accuracy in female.

각종 소화기암에서 교질성 방사성 린 (燐) 을 이용한 전이성 간암의 방사선 내부치료 - 제1보 : 대장 - 직장암에서 교질성 린을 이용한 간전이의 예방 -

김지열(Ji Yeul Kim),범희승(Hee Seung Bom),최원(Won Choi),김영진(Young Jin Kim) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A Metastases to the liver presents a common clinical problem in the management of patients with colo-rectal cancer, and are responsible for a high degree of morbidity and mortality associated with this malignancy. Unfortunately, attempts at preventing the development of liver metastases in high risk patients has so far been unsuccessful. Ongoing studies of adjuvant chemotherapy have not yet illustrated a significant increase in survival in patients receiving such therapy. The purpose of the study is to investigate the value of adjuvant radiotherapy given in the form of colloidal chromic phosphate P-32 suspension administered via portal vein after radical resection of the primary cancer, in preventing the growth of occult metastases in the liver. Twenty one patients (10 patients of treated group with 11 controls) were followed 18 months after operation. There was no significant change in the CBC and liver functions after administration of P-32 labeled colloidal chromic phosphate. The number of patients who showed local metastases at 18 months were 2 in the treated group and 3 in the control group. While liver metastases occurred in one patient at 6 months and in three at 12 months in the control group, there was no development of liver metastases by 12 months in the treated group. At 18 month follow-up CT scan one patient in the treated group showed a single nodule in the liver. In conclusion liver metastasis rate was lower in the patients who received colloidal P-32 chromic phosphate via portal vein after radical resection of the primary cole-rectal cancer