합성페놀성 산화방지제의 티아민 분해능

한명규(Myung-Kyu Han),김준환(Jun-Whan Kim),신효선(Hyo-Sun Shin) 한국식품과학회 1990 한국식품과학회지 Vol.22 No.4

생육모의 연구에 의한 한반도에서의 기후변화에 따른 벼 생산성 및 적응기술 평가

이충근 ( Chung Kuen Lee ),김준환 ( Jun Whan Kim ),손지영 ( Ji Young Shon ),양운호 ( Woon Ho Yang ),윤영환 ( Young Hwan Yoon ),최경진 ( Kyung Jin Choi ),김광수 ( Kwang Soo Kim ) 한국농림기상학회 2012 한국농림기상학회지 Vol.14 No.4

Air temperature in Korea has increased by 1.5oC over the last 100 years, which is nearly twice the global average rate during the same period. Moreover, it is projected that such change in temperature will continue in the 21st century. The objective of this study was to evaluate the potential impacts of future climate change on the rice production and adaptation methods in Korea. Climate data for the baseline (1971~2000) and the three future climate (2011~2040, 2041~2070, and 2071~2100) at fifty six sites in South Korea under IPCC SRES A1B scenario were used as the input to the rice crop model ORYZA2000. Six experimental schemes were carried out to evaluate the combined effects of climatic warming, CO2 fertilization, and cropping season on rice production. We found that the average production in 2071~2100 would decrease by 23%, 27%, and 29% for early, middle, and middle-late rice maturing type, respectively, when cropping seasons were fixed. In contrast, predicted yield reduction was ~0%, 6%, and 7%, for early, middle, and middle-late rice maturing type, respectively, when cropping seasons were changed. Analysis of variation suggested that climatic warming, CO2 fertilization, cropping season, and rice maturing type contributed 60, 10, 12, and 2% of rice yield, respectively. In addition, regression analysis suggested 14~46 and 53~86% of variations in rice yield were explained by grain number and filled grain ratio, respectively, when cropping season was fixed. On the other hand, 46~78 and 22~53% of variations were explained respectively with changing cropping season. It was projected that sterility caused by high temperature would have no effect on rice yield. As a result, rice yield reduction in the future climate in Korea would resulted from low filled grain ratio due to high growing temperature during grain-filling period because the CO2 fertilization was insufficient to negate the negative effect of climatic warming. However, adjusting cropping seasons to future climate change may alleviate the rice production reduction by minimizing negative effect of climatic warming without altering positive effect of CO2 fertilization, which improves weather condition during the grain-filling period.

대장암에서 Cdx2 단백발현의 의의

백종해 ( Jong Hae Pack ),김태동 ( Tae Dong Kim ),오현아 ( Heun Ah Oh ),이은주 ( Eun Joo Lee ),김준환 ( Jun Whan Kim ),장병익 ( Byung Ik Jang ),김태년 ( Tae Nyeun Kim ),정문관 ( Moon Kwan Jung ),배영경 ( Young Kyung Bae ) 대한소화기학회 2005 대한소화기학회지 Vol.46 No.3

목적: Cdx2는 최근에 알려진 유전자로 intestine-specific transcription factor를 암호화하고 인체에서는 소장과 대장의 상피 세포에서 특이적으로 발현되며 장상피세포의 성장과 분화에 중요한 역할을 한다. 원발 대장암에서 Cdx2 단백발현 이상이 보고되었고, 종양억제 유전자로 작용할 것이라는 연구 결과가 있다. 이에 저자는 침윤 대장암 조직에서 Cdx2 단백발현 정도를 측정하여 한국인 대장암에서 Cdx2 단백발현 소실의 빈도를 알아보고, Cdx2 단백발현 유무와 대장암의 임상병리 특징과의 관련성을 분석함으로써, Cdx2 발현정도가 대장암 발생 및 종양의 표현형 결정에 어떤 영향을 미치는지 알아보고자 하였다. 대상 및 방법: 영남대학교 의과대학 부속병원에서 대장암으로 수술한 환자 420명의 종양 조직 및 유방암, 정상 대장, 간, 위, 폐, 신장, 난소 조직을 대조군으로 하여 면역조직화학염색을 이용하여 Cdx2 단백 발현을 조사하였다. 결과: 환자의 90.5% (380/420)에서 Cdx2 단백발현이 관찰되었으며, 이 중 83% (349/420)는 강양성, 7.5% (31/420)는 약양성이었다. 대조군으로 사용한 145개 유방암 조직 모두에서 Cdx2 단백발현은 관찰되지 않았으며, 정상 간, 신장, 폐, 난소 조직도 모두 Cdx2 면역조직화학 염색에 음성이었다. 정상 위 점막에서는 장형화생을 동반한 부위에 국한되어 Cdx2 발현이 관찰되었다. 종양 인접 부위에 존재하거나 대조군으로 사용한 정상 대장 점막조직에서는 100%에서 Cdx2 단백발현이 관찰되었다. 임상병리 특징과 Cdx2 단백발현과의 관계는 종양의 침윤이 깊을수록(p<0.05), 림프절 전이가 있는 경우(p<0.001), 원격전이가 있는 경우 그리고 조직분화도가 낮을수록(p<0.001) Cdx2 단백발현이 의미 있게 감소하였다. 결론: 종양의 악성도와 Cdx2 단백발현 소실과는 밀접한 관련성이 있으며, 따라서 Cdx2가 대장 및 직장암의 예후인자로 유용한 역할을 할 수 있을 것이다. 또한 Cdx2 단백은 장세포 기원의 암종에 매우 특이한 표지자로서, 전이 암종의 원발 장기 규명에 이용할 수 있을 것으로 생각한다. Background/Aims: The caudal-related homeobox transcription factor, Cdx2, plays an important role in proliferation and differentiation of intestinal epithelial cells. Its expression is confined to normal and neoplastic intestinal epithelium. We evaluated Cdx2 expression in advanced colorectal cancers to determine the correlation between Cdx2 expression and clinicopathologic characteristics. Methods: Four hundreds twenty consecutive colorectal cancers were included in the study. Cdx2 expression was investigated by immunohistochemistry using tissue microarrays constructed from surgically resected specimens. 145 invasive breast cancers, normal tissues from gastric mucosa, liver, lung, kidney and ovary were used as control. Nuclear staining was considered to be positive and the result was divided into 3 categories. Results: In the colorectal cancers, Cdx2 was expressed in 380 of 420 (90.5%) cases, and 349 of 380 (83%) cases showed strong and diffuse staining and 31 of 420 (7.5%) cases showed weakly positive staining. Forty patients (9.5%) of colorectal cancer were negative for Cdx2. All of the invasive breast cancers and all non-neoplastic control tissues except the regions of intestinal metaplasia in gastric mucosa, which showed strong Cdx2 expression, were negative for Cdx2. Loss of Cdx2 expression was observed more frequently in cases with deeper invasion (p<0.05), lymph node metastasis (p<0.05), poor histologic differentiation (p<0.001), and distant metastasis (p<0.05). Conclusions: Cdx2 could be a highly sensitive marker to detect metastasis from intestine and might be useful as a novel prognostic marker in colorectal cancers. (Korean J Gastroenterol 2005;46:204-210)

한류의 선순환적 확장을 위한 한국어의 역할에 대한 연구

이서구(Lee Seo Koo),전병찬(Jeon Byung Chan),이성근(Yi Seong Keun),김준환(Kim Jun Whan),김종근(Kim Jong Kun) 한국소비문화학회 2016 소비문화연구 Vol.19 No.3

본 연구는 한국어 학습이 한류 확산에 미치는 매개효과와 조절효과를 분석하였다. 본 연구의 구체적인 목적은 첫째, 한류에 대한 선호도가 한국어 학습에 미치는 영향을 검증하였다. 둘째, 한국어 학습이 한류에 대한 충성도에 미치는 영향을 분석하였다. 마지막으로, 한류 확산모형에서 한국어 학습의 조절효과를 분석하였다. 연구가설에는 포함되어 있지 않지만, 추가적으로 한국어 학습이 한국의 국가 이미지, 국민 이미지, 한국상품 선호, 그리고 한국 방문의도 등 전반적인 한국 선호에 미치는 영향을 분석하였다. 36개국 804명의 외국인을 대상으로 분석한 결과는 다음과 같다. 먼저 K-pop, 그리고 영화 등에 대한 한류 선호도가 한국어 학습 니즈를 증가시키는 것으로 나타났다. 둘째, 한국어 학습이 한류 충성도에 미치는 영향을 분석한 결과 한국어 학습자는 게임을 제외한 나머지 한류 콘텐츠를 더욱 지속하고자 하는 것으로 나타났다. 또한 한국어 학습은 한국 상품 선호도, 한국 국가 이미지, 국민 이미지, 한국 방문의도 등 모든 차원에서 긍정적인 유의한 영향을 미치는 것으로 나타났다. 마지막으로 한국어 학습의 조절효과를 분석한 결과 한류의 확장과 한국과 관련된 다양한 차원들(한국 상품 선호도, 한국 국가 이미지, 국민 이미지, 한국 방문의도)의 관계에 유의미한 조절효과가 있는 것으로 나타났다. 이와 같은 분석을 통해 본 연구는 한류 확산을 증가시킬 수 있는 요인으로 한국어의 전략적, 문화적 도구로써의 역할을 정립하였다. This Study analyzes mediating and moderating effect of Korean learning on the diffusion of Hallyu. More specifically, the authors verify the effect of Hallyu preference on learning Korean. They also analyze the effect of Korean learning on diversification of Hallyu experience, and analyze the effect of Korean learning on preference of Korea consisted of various dimension such as country image, Korean people image, preference for Korean products, and visiting intention. Finally, they examine the moderating effect of Korean learning on the diffusion of Hallyu. The data is collected from 804 foreigners from 36 countries. The analysis of relationship between present Hallyu preference and Korean learning revealed that the intention to learn Korean is significantly increased by preference for K-pop, Korean movies, and games only except Korean dramas. The result also showed that the more foreigners have learned Korean, the more they have experienced various Hallyu contents. The effect of Korean learning on the diffusion of Hallyu is verified by analyzing the relationship between Korean learning and Hallyu loyalty. The result showed that foreigners who have learned Korean want to experience Hallyu contents such as K-pop, Korean dramas, Korean movies except games more than non Korean learners. The result also showed that Korean learning has significant effect on dimensions of preference for Korea which consisted of national image, Korean people image, preference for Korean products, and visiting intention. Lastly, Korean learning moderated the relationship of Hallyu loyalty and four dimensions of preference for Korea. The relationship between Hallyu loyalty and national image of Korea is more positively accelerated by Korean learning. Korean learning also reinforced each relationship between Hallyu loyalty and other three dimensions of preference for Korea. As a result, this study identified the role of Korean language as a strategic and cultural tool to accelerate the diffusion of Hallyu.

연구보문 : 인도네시아의 농업투자환경

양원하 ( Won Ha Yang ),안종웅 ( Jong Woong Ahn ),곽창길 ( Chang Kil Kwak ),한희석 ( Hee Seog Han ),이충근 ( Chung Kuen Lee ),손지영 ( Ji Young Shon ),김준환 ( Jun Whan Kim ),김연규 ( Yuon Gyu Kim ) 한국국제농업개발학회 2011 韓國國際農業開發學會誌 Vol.23 No.1

Indonesia is a home to the majority of populations. With its tropical climate, Indonesia has abundant natural resources and plants and animals biodiversity. The Agricultural sector, which accounts for 13-15% of the gross domestic product (GDP) of the country, has recently increased. Meanwhile, the number of farmers is half of the total households. Agricultural productivity has generally recorded low levels. Indonesia`s agricultural production has steadily increased since 1980. Despite the East Asian financial crisis in the late 1990s, agricultural production in 2000 recovered to the level of previous years. From 2003 to 2005, the production of cereals, bulbous plant, vegetables, sugar and meat in Indonesia were 47.24, 22.4, 14.7, 2.3, and 2.2 million tons, respectively. The supplies of cereals, bulbous plant, vegetables, sugar, and meat recorded 38.3, 12.0, 1.5, 3.6 and 2.3 million tons respectively. These records show that cereal is relatively sufficient while vegetables and bulbous plants are leading export products and sugar and milk are major imported items. Promising investment sectors in Indonesian agriculture include agro-industrial cereal farming and food processing, farm development, irrigation and water conservation technologies, agricultural science and technology and human resources development. If we consider investment in the Indonesian agricultural sector, we shall review Indonesia`s investment conditions, as well as relevant laws and practices in advance by analyzing strengths and weaknesses in the agriculture.