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백내장 수술 후 생긴 낭포황반부종에서의 유리체강내 트리암시놀론 주입술 일차치료 효과
김주연,김정목,유영주,김철구,조성원,이태곤.Joo Yeon Kim. MD. Joung Mok Kim. MD. Young Ju Lew. MD. PhD. Chul Gu Kim. MD. Sung Won Cho. MD. PhD. Tae Gon Lee. MD 대한안과학회 2012 대한안과학회지 Vol.53 No.3
Purpose: To report the clinical manifestations of intravitreal triamcinolone injection as a primary treatment method for patients with cystoid macular edema after cataract surgery. Methods: The present retrospective study was comprised of patients diagnosed with cystoid macular edema after cataract surgery performed between March 2006 and March 2008. To treat the edema, intravitreal triamcinolone injection was administered. Best corrected visual acuity (BCVA) and central macular thickness were measured, and complications as well as efficacy of the treatment were evaluated. Results: Twelve eyes were selected for the present study with a mean patient age of 67.3 years. The average period between cataract surgery and diagnosis of cystoid macular edema was 7.6 weeks. All 12 eyes received an intravitreal triamcinolone injection, and the patients were followed up for an average of 6.7 months. BCVA (log MAR) was changed from 0.29 ± 0.12 to 0.11 ± 0.09, showing statistically significant improvement (p = 0.000). The OCT showed that the average CMT was statistically decreased from 390.58 ± 94.98 μm to 165.17 ± 39.95 μm (p = 0.001). No complications were reported after the procedure, and vision and edema improved after one month in all 12 eyes. Conclusions: After performing intravitreal triamcinolone injection as a primary treatment method for cystoid macular edema which developed after cataract surgery, rapid recovery and improvement of vision and macular thickness were confirmed in all 12 eyes. J Korean Ophthalmol Soc 2012;53(3):428-433
<sup>99m</sup>Tc-DMSA 검사에서 상대 신섭취율 산출 시 양면상 촬영의 유용성에 대한 고찰
김주연,이한울,권오준,김정열,박민수,조석원,강천구,김재삼,Kim, Joo-Yeon,Lee, Han-Wool,Kwon, O-Jun,Kim, Jung-Yul,Park, Min-Soo,Cho, Seok-Won,Kang, Chun-Goo,Kim, Jae-Sam 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.1
$^{99m}Tc-DMSA$ 신장 신티그라피는 피질에 주로 섭취되어 신실질을 영상화하고 좌우 신장 및 배후방사능에 관심영역을 설정함으로써 상대 신섭취율을 평가할 수 있는 검사로, 진단 및 치료 후 경과관찰에 이용되고 있다. 본 논문에서는 후면상과 양면상 촬영 시 그리고 신장의 깊이를 적용한 경우의 상대 신섭취율 변화를 비교하여 상관관계를 알아보고자 한다. 실험은 신장 팬텀 및 조직등가물질을 이용하여 신장의 깊이에 차이를 주며 깊이 당 각 5번씩 총 25번을 진행하였다. 임상연구는 2014년 2월부터 10월까지 본원에 내원하여 $^{99m}Tc-DMSA$ 검사를 시행한 36명의 성인 환자를 대상으로 하였다. 장비는 감마카메라 INFINIA를 사용하였으며 GE사의 Xeleris Ver. 2.1220을 이용하여 신장 및 배후 방사능 모두 자동으로 관심영역을 설정하였다. 또한 환자별 신장 깊이의 차이를 고려하여 측면상을 촬영한 후 실제 신장 깊이를 측정하였다. 후면상에서의 산술평균값과 양면상에서의 기하학적 평균값 그리고 후면상에 신장 깊이를 적용해준 상대 신섭취율을 비교해보고 유의한 차이가 있는지 살펴보았다. 팬텀 실험 결과 좌, 우 신장 깊이의 차이가 1 cm 미만인 경우에는 양면상을 촬영했을 때와 후면상에 실제 깊이를 적용해준 경우 유의한 차이를 보이지 않았으나(P>0.05), 1 cm를 초과한 경우에는 유의한 차이를 보였다(P<0.05). 임상 연구에서는 후면상만을 촬영해준 경우와 후면상에 신장 깊이를 적용해준 경우의 상관관계(r=0.988)에 비해 양면상을 촬영해준 경우와 후면상에 신장의 깊이를 적용하여 보정해준 경우가 더 높은 상관관계(r=0.999)를 나타냈다. 본 연구에서는 양면상과 후면상을 촬영했을 때의 상대 신섭취율 차이를 확인할 수 있었다. 후면상만 촬영한 경우에도 깊이를 보정해줬을 때와 비교하여 상관관계가 있음을 알 수 있었으나 오차를 줄이기 위해서는 양면상을 촬영해주는 방법을 권고한다. Purpose $^{99m}Tc-DMSA$ renal scintigraphy serves as location, size and shape of kidney, so it has been used for diagnosis and passage observation after the operation or treatment. There are 3 methods of calculating the relative renal uptake ratio such as geometric mean of the counts from the anterior and posterior views, arithmetical mean from the only posterior view and posterior view which applied the renal depths. In this study, we seek to correlation between the change of total relative uptake ratio according to different inspection methods of obtaining the renal count rate. Materials and Methods The phantom experiments proceeded 5 times depending on each renal depth with the kidney phantom and tissue equivalent materials. In the clinical research, we investigated 36 adult patients who had visited our hospital from february to october, 2014 and received $^{99m}Tc-DMSA$ renal scan. The equipment was used as a gamma camera named INFINIA (General Electric Healthcare, milwaukee, USA) and we drew the region of interests through semiautomatic method by using Xeleris Ver. 2.1220 of GE. In addition, we obtained the lateral view of kidney to measure the renal depth of each patient. Then the results were compared with 3 methods of calculating relative renal uptake ratio. Results The phantom studies show when the difference between the left ant right kidney depth were less than 1 cm, there were no statistically significant difference among values calculated through anterior and posterior views and only posterior view (P>0.05), while the excess of 1cm, the results showed a statistically significant change in the value (P<0.05). In case of clinical research, the correlation between total relative uptake ratio by obtaining both sides of image and posterior view applied the kidney depth (r=0.999) was higher than by obtaining only posterior view and applying the kidney depth to one side image (r=0.988). Conclusion This study has found that, the difference of calculating total relative uptake ratio compared with obtaining anterior and posterior views and only posterior view. In order to reduce the error, we recommend the method of obtaining anterior and posterior views and is considered to be useful, particularly the patients have similar uptake ratio of left and right kidney and difficulties of measurements of kidney depth.
테라비트급 나노 스케일 SONOS 플래시 메모리 제작 및 소자 특성 평가
김주연,김문경,김병철,김정우,서광열,Kim, Joo-Yeon,Kim, Moon-Kyung,Kim, Byung-Cheul,Kim, Jung-Woo,Seo, Kwang-Yell 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.12
To implement tera bit level non-volatile memories of low power and fast operation, proving statistical reproductivity and satisfying reliabilities at the nano-scale are a key challenge. We fabricate the charge trapping nano scaled SONOS unit memories and 64 bit flash arrays and evaluate reliability and performance of them. In case of the dielectric stack thickness of 4.5 /9.3 /6.5 nm with the channel width and length of 34 nm and 31nm respectively, the device has about 3.5 V threshold voltage shift with write voltage of $10\;{\mu}s$, 15 V and erase voltage of 10 ms, -15 V. And retention and endurance characteristics are above 10 years and $10^5$ cycle, respectively. The device with LDD(Lightly Doped Drain) process shows reduction of short channel effect and GIDL(Gate Induced Drain Leakage) current. Moreover we investigate three different types of flash memory arrays.
김주연,최재황,Kim, Joo Yeon,Choi, Jae Hwang 한국도서관정보학회 2014 한국도서관정보학회지 Vol.45 No.2
국가기록원은 소장기록물의 저작권을 보호하기 위하여 현재 '소장기록물 저작권 운영지침'과 '열람실 운영규정'을 마련하여 운영 중이다. 그러나 국가기록원 '소장기록물 저작권 운영지침'과 '열람실 운영규정'은 저작권법의 준용 또는 국가기록원 내부의 저작권 관리 원칙만을 규정하고 있을 뿐 소장기록물에 대한 기록물 유형별 저작권 문제는 제시하지 못하고 있다. 이미 수집된 소장기록물의 이용 활성화를 위해서는 기록의 각 유형별 저작물의 판단 기준이나 원칙을 제시하여, 이용자들이 쉽게 저작권 문제에 접근할 수 있도록 별도의 상세한 세부지침이 마련되어야 하며, 향후 소장기록물 수집을 위해서도 저작재산권이나 저작인격권에 대한 세부사항을 규정할 필요가 있다. 본 연구는 이를 위한 사전분석이다. 향후 소장기록물과 관련된 저작권 측면의 활발한 논의와 운영 방안이 모색되어야 할 것이다. The National Archives of Korea(NAK) has arranged and operated 'Guidelines on Operating Copyright for Archives' and 'Regulations on Operating Reference Room' to protect the copyright for archives. However, the Guidelines and the Regulations only provide application to the Copyright Act and principles on internal managing copyright without presenting copyright issues for each type of archives. Therefore, additional detailed guidelines have to be arranged for the users to access to copyright issues easily by presenting them the standards of judgement or principles on copyright issues for each type of the archives to facilitate the use of archives collected already. We also need to define the details on Copyright Act and Moral Rights Act to collect archives. This study is an prior analysis for that purpose. Lively discussion and way of operation in an aspect of the copyright in relation to private records should be sought in the future.
포도막염에 의한 이차개방각녹내장에서 마이토마이신 섬유주절제술과 아메드밸브삽입술의 임상성적
김주연,심형섭,김황기,손용호.Joo Yeon Kim. MD. Hyoung Sub Shim. MD. Hwang Ki Kim. MD. Yong Ho Sohn. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.4
Purpose: To assess and compare the clinical outcomes of primary trabeculectomy with mitomycin C and Ahmed valve implantation for secondary open-angle glaucoma following uveitis. Methods: This study was conducted retrospectively on 30 eyes of 25 patients with open-angle glaucoma secondary to uveitis that had undergone trabeculectomy with mitomycin C and 33 eyes of 24 patients that had undergone Ahmed valve implantation. The clinical outcome indicators used in this study were intraocular pressure (IOP), number of anti-glaucoma agents, surgical success rate and occurrence of complications. Results: Mean IOP and surgical success rate in patients who had undergone trabeculectomy with mitomycin C after a 12 month postoperative period were 14.0±8.2 mmHg and 76.7%, respectively, while those of patients with Ahmed valve implantation were 13.2±7.7 mmHg and 81.8%. The data did not show clinical significance. There was greater risk of surgical failure in patients at a younger age and/or with diabetes mellitus in cases of having gone through trabeculectomy with mitomycin C. Conclusions: Both trabeculectomy with mitomycon C and Ahmed valve implantation can be considered as primary surgical treatments for patients with open-angle glaucoma secondary to uveitis. However, trabeculectomy with mitomycin C should only be applied to a limited extent in patients that are young and/or have diabetes mellitus. J Korean Ophthalmol Soc 2010;51(4):575-580
전해도금법으로 증착한 Cu-Sn 합금막의 배선특성에 관한 연구
김주연,배규식,Kim, Ju-Yeon,Bae, Gyu-Sik 한국재료학회 2002 한국재료학회지 Vol.12 No.3
Sn was selected as an alloying element of Cu. The Cu-Sn thin layers were deposited on the Si substrates by the electroplating method and their properties were studied. By rapidly thermal annealing(RTA) up to 40$0^{\circ}C$ after electroplating, sheet resistance decreased and adhesion strength increased, but that trend was reversed at the 50$0^{\circ}C$ RTA. Cu-Sn particles grew dense and the surface was uniform up to 40$0^{\circ}C$, but at 50$0^{\circ}C$, empty area was introduced and the surface became rough owing to oxidation and particle coarsening and agglomeration. Deposited layer contained significant amount of Si, while pure Cu-Sn layer with the composition ratio of 90:10 was present only on the top surface. However, no significant change in the Cu composition within alloy layers occured by the RTA regardless of its temperature. This indicates that the Cu diffusion into the Si was suppressed by the presence of Sn.
ELMo 임베딩 기반 문장 중요도를 고려한 중심 문장 추출방법
김은희(Eun Hee Kim),임명진(Myung Jin Lim),신주현(Ju Hyun Shin) 한국스마트미디어학회 2021 스마트미디어저널 Vol.10 No.1
본 연구는 뉴스 기사에서 기사문을 구성하는 문장별 중요도를 고려하여 요약문을 추출하는 방법에 관한 것으로 문장 중요도에 영향을 주는 특성으로 중심 문장(Topic Sentence)일 확률, 기사 제목 및 다른 문장과의 유사도, 문장 위치에 따른 가중치를 추출하여 문장 중요도를 계산하는 방법을 제안한다. 이때, 중심 문장(Topic Sentence)은 일반 문장과는 구별되는 특징을 가질 것이라는 가설을 세우고, 딥러닝 기반 분류 모델을 학습시켜 입력 문장에 대한 중심 문장 확률값을 구한다. 또한 사전학습된 ELMo 언어 모델을 활용하여 문맥 정보를 반영한 문장 벡터값을 기준으로 문장간 유사도를 계산하여 문장 특성으로 추출한다. LSTM 및 BERT 모델의 중심 문장 분류성능은 정확도 93%, 재현율 96.22%, 정밀도 89.5%로 높은 분석 결과가 나왔으며, 이렇게 추출된 문장 특성을 결합하여 문장별 중요도를 계산한 결과, 기존 TextRank 알고리즘과 비교하여 중심 문장 추출 성능이 10% 정도 개선된 것을 확인할 수 있었다. This study is about a method of extracting a summary from a news article in consideration of the importance of each sentence constituting the article. We propose a method of calculating sentence importance by extracting the probabilities of topic sentence, similarity with article title and other sentences, and sentence position as characteristics that affect sentence importance. At this time, a hypothesis is established that the Topic Sentence will have a characteristic distinct from the general sentence, and a deep learning-based classification model is trained to obtain a topic sentence probability value for the input sentence. Also, using the pre-learned ELMo language model, the similarity between sentences is calculated based on the sentence vector value reflecting the context information and extracted as sentence characteristics. The topic sentence classification performance of the LSTM and BERT models was 93% accurate, 96.22% recall, and 89.5% precision, resulting in high analysis results. As a result of calculating the importance of each sentence by combining the extracted sentence characteristics, it was confirmed that the performance of extracting the topic sentence was improved by about 10% compared to the existing TextRank algorithm.
김주연,주현수,반주연,송경식,성연희,Kim, Joo-Youn,Ju, Hyun-Soo,Ban, Ju-Yeon,Song, Kyung-Sik,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2008 한국약용작물학회지 Vol.16 No.6
Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), has pharmacological effects such as anti-inflammatory, antiallergic, analgesic and antioxidant activities. We investigated a methanol extract of Moutan cortex for neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to $10\;{\mu}M\;A{\beta}$ (25-35) for 24 h induced neuronal apoptotic death. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced neuronal cell death at 30 and $50\;{\mu}g/m{\ell}$, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) which were measured by fluorescent dyes. Moutan cortex also inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$ (25-35), which was measured by HPLC. These results suggest that Moutan cortex prevents $A{\beta}$ (25-35)-induced neuronal cell damage by interfering with the increase of $[Ca^{2+}]_i$, and then inhibiting glutamate release and ROS generation. Moutan cortex may have a therapeutic role in preventing the progression of Alzheimer's disease.
김주연,Kim, Ju-Yeon 대한출판문화협회 1997 출판저널 Vol.216 No.-
바라건데 언젠가는 18세기부터 오늘에 이르는 독일비평사 한권쯤 내 손으로 썼으면 한다. 이들을 읽을 때마다 그들의 예감과 통찰력에 나 자신 부끄러움을 느끼면서 언젠가 이들 수준에 이를 것인지 아득한 동경에 빠진다.