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구강 편평세포암종에서 p53 단백과 Cyclin D1발현에 대한 면역조직화학적 연구
김종엽,김경욱,이재훈,김창진,Kim, Jong-Yub,Kim, Kyung-Wook,Lee, Jae-Hoon,Kim, Chang-Jin 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.2
Oral cancer is a common neoplasm in humans and etiologic mechanism is not well known, so treatment and evaluation of oral cancer is difficult problem. Traditional TNM classification between prognosis of tumors and classification of histopathologic differentiation has problem like lack of objectivity through operators. In molecular biology, cancer is developed by alteration of activation of oncogene and/or inactivation of tumor suppressor gene. The p53 gene, one of the tumor suppresor genes, is believed to play an important role through mutation and overexpression in the progression of human cancers. The p53 mutation is most frequent genetic disorder in humans. The Cyclin D1 has tumor suppresion activity by regulation of cell cycle. The Cyclin D1 regulate activity of Rb tumor suppresor gene by stimulation of CDK4 The purpose of this study was to observe the expression of p53 protein and Cyclin D1 in oral squamous cell carcinoma, and to get expectation of the malignancy and prognosis of oral squamous cell carcinoma. Using the 15 cases of squamous cell carcinoma and the microscopic H&E and immunohistochemical stain. We divided it into 3 groups according to the stain extent, clinical stage and histologic differentiation. The results were as follows1.In the features of immunohistochemical stain of 15 cases of squamous cell carcinoma, positive reaction of p53 was identified in 8 cases (53.3%) and positive reaction of cyclin D1 was identified in 3 cases (20%). Both positive reaction of p53 protein and Cyclin D1 was show in only one case. 2.8 of p53 positive cases were linked in 87.5% of the end stage tumor, 62.5% of neck node involvement, 87.5% of poorly and moderately histopathplogic differentiation. 3. All 3 of Cyclin D1 positive cases were linked in the end stage tumor, neck node involvement, poorly and moderately histopathologic differentiation. From above results, expression of p53 protein was identified in 53.3% of 15 cases and these results mean oral squamous cell carcinoma was drived by mutation of p53 protein. Especially, highly positive reaction of p53 protein and Cyclin D1 was identified in cases that involvement of neck lymph node and the end stage tumors and it means that the evaluation of p53 protein and Cyclin D1 was useful for evaluation of malignant tumor as specific tumor marker.
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심미가 중요시되는 임플란트 치료시 타이타늄 링크 - 캐드캠 지르코니아 지대주 사용의 임상적 고려
김종엽(Jong-Yub Kim) 대한치과의사협회 2016 대한치과의사협회지 Vol.54 No.2
Currently increasing use of implants, especially in anterior implant esthetics has become a major concern for both the patient and dentist. In the case of thin biotype if the thickness of the gingival soft tissue is less than 2mm, human eye can detect differences of colors depends on underlying materials. The zirconia abutment can be use not only for better esthetics but also for the hygienic because it is less attractive for the plaque deposition when it compare to the metals. Zirconia itself has many advantages as a biomaterial but also has frequent mechanical problems when it use for abutment of internal connection implant. For prevention or reduction of mechanical failures, use of titanium-link with zirconia super-structure which part that connects directly into the implant can be a good alternative. In this literature, I would like to review the clinical considerations of use of titanium link - CAD/CAM zirconia abutment for dental implant in esthetically important areas.
ScienceON
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