Wnt7b is Upregulated in Macrophages during Thymic Regeneration and Negatively Regulated by RANKL

김종갑,김성민,김봉선,김재봉,윤식,배수경,Kim, Jong-Gab,Kim, Sung-Min,Kim, Bong-Seon,Kim, Jae-Bong,Yoon, Sik,Bae, Soo-Kyung Korean Society of Life Science 2007 생명과학회지 Vol.17 No.7

성체흰쥐의 경우 항암제인 싸이클로포스파마이드 (CY)처리로 퇴축된 가슴샘은 2주 후에 정상조직으로 재생된다. 가슴샘 발생과정에서 이미 알려진 Wnt신호전달의 중요성과는 달리 성체의 가슴샘 재생과정에서 그 역할에 관해서는 알려진 바 전혀 없다. 본 연구의 목적은 발생중인 가슴샘 상피세포에서 발현이 증가된다고 이미 알려져 있는 Wnt7b가 성체의 가슴샘재생과정에서 어떤 발현 양상을 보이는지를 조사하는 것이다. Wnt7b는 가슴샘의 급성 퇴축 이후 3일째 되는 시기에 mRNA와 단백질의 양이 급격히 증가 하였으며, 이중 면역 염색 형광법을 통해 큰포식 세포와 위치적 분포가 일치함을 확인하였다. 또한, Wnt7b유전자의 발현 조절 기전을 밝히기 위해 Wnt7b의 Reporter Vector를 제작하여 Luciferase assay를 이용하여 상위의 신호를 분석하였고, 그 결과 Wnt7b는 RANKL에 의해 그 발현이 감소된다는 사실을 처음으로 밝혔다. 따라서, 본 연구 결과들을 통해 Wnt 7b는 가슴샘의 급성 퇴축 초기 과정에서 나타나는 손상된 세포를 처리하는 큰포식 세포의 기능 조절에 관여할 것으로 생각된다. Thymus can regenerate to its normal mass within 14 days after acute involution induced by cyclophosphamide (CY) in adult rat. Despite the established role of Wnt pathways in the process of thymus development, they have not yet been associated with the regeneration of adult thymus. The purpose of this study was to investigate whether Wnt7b, which is expressed in developing thymic epithelial cells rather than in thymocytes, is modulated during thymic regeneration in adult rat. Here, we show that Wnt7b expression was up-regulated in the regenerating thymus. Cells immunolabeled for the Wnt7b were identified as macrophages. Furthermore, Wnt7b gene expression was decreased by the treatment of receptor activator of NF-kappaB ligand (RANKL). Taken together, our results demonstrate that Wnt7b gene expression was increased in macrophages during thymic regeneration and negatively regulated by RANKL.

일반논문 : 타자의 발견? 타자의 발명? -비숍과 크리스테바의 여행기-

김종갑 ( Jong Gab Kim ) 국제비교한국학회 2012 비교한국학 Comparative Korean Studies Vol.20 No.1

이 글의 목적은 여행기에 나타난 토착민 타자의 재현과 담론적 위상을 살펴보는 데 있다. 16세기 발견의 시대 이후로 유럽의 탐험가나 여행가들은 당시 아직 알려지지 않았던 전인미답의 공간을 찾아서 지구의 방방곡곡을 탐험하고 여행하였다. 그들의 발길이 닿기 전까지 유럽인들에게 알려지지 않았던 대륙이나 섬의 원주민이 토착민이다. 당시 여행기의 독자들은 그와 같이 ``발견된`` 토착민 타자의 모습과 문화를 지켜보면서 당시 유럽의 문명화되고 개화된 정도를 판단할 수 있었다. 토착민은 유럽인이 자신의 얼굴을 비쳐주는 거울로서 유럽인의 자기정체성에 필수적인 존재였다. 그런데 20세기 세계화와 지구촌의 시대로 접어들면서 토착민들은 지구에서 자취를 감추게 되었다. 이것은 식민주의에서 탈식민주의로 이행을 의미하는 것이다. 필자가 이 글에서 주장하려는 내용은 다음과 같다. 여행기의 원래 목적이었던 원주민의 발견과 소개가 불필요해진 세계화의 시대에도 여행기에 대한 수요가 줄어들지 않는다는 사실을 어떻게 설명할 수 있을 것인가? 그것은 발견과 발명의 구분을 통해서 설명할 수 있다. 더 이상 발견할 토착민이 사라진 현실에서 살아남기 위해 여행기 작가들은 이제 토착민을 상상하고 발명하기 시작했다는 것이다. 이자벨라 버드 비숍과 크리스테바의 여행기를 대조 분석하면서 필자는 이 점을 증명하게 될 것이다. This paper concerns the discursive function of the aboriginal other in the travel narrative. The aboriginal people are defined as indigenous inhabitants of places discovered by European explorers. The existence of aboriginal and primitive others completely unknown to Europeans gave rise to a vogue of travel writings. Mungo Park`s and Henry Stanley`s travel writings, for example, excited and then satisfied European curiosity about the other. Not only that, the knowledge that these others were not civilized gave them a sense of self-confidence and assurance as civilized people. But the age of discovery came to an end in the early 20th century, for every nook and cranny of non-Western realm was thoroughly investigated and documented and the life of the inhabitants was already well-known to the West. It followed the absence of the absolute other, the existence of which was the raison d`etre of travel writing. Along with such a changed status of the other the character and nature of travel writing began to undergo a transformation. Their narrative became more literary and less documentary, and as a result the other is now invented rather than discovered. Here the question is: "What is the ideological function of the invented aboriginal other in this age of post-colonialism or postmodernism?" In order to answer this question I compare two travel writings in terms of their rhetorical strategy in representing the other: one is Isabella Bird Bishop`s Korea and Her Neighbours, and the other, Julia Kristeva`s Des Chinoises, written in 1898 and 1974 respectively. The thesis I argue that Kristeva`s other is a hyperreal other, absolute other in excess, since magnified and exaggerated by her guilty conscience as a European intellectual. But her invention of the absolute other is far from innocent. Behind such a gesture lies an ideological strategy of discursive justification. Now she can represent the voice of the other in the name of its absolute otherness, which remained silent until her arrival.

입장의 결핍과 논문의 과잉 : 논문 쓰기의 문제

김종갑(Jong-Gab Kim) 신영어영문학회 2006 신영어영문학 Vol.34 No.-

Korea is an absence of writers’ position in relation to their discourse. This paper argues that such an absence contributes to the economy of discursive production, resulting in a quantitative explosion of academic papers at the expense of their quality. Such a tendency is accelerated by the absence of readers. As Derrida among many others has asserted, writing in itself is essentially discursive, running wild with no transcendental signified fixing their meandering. Only when the signifier is geared to (the community of) readers, it is anchored to its signified: meaning is social. It follows that scholarly writings in the absence of their readers can be asocial and anarchical, endlessly reproducing themselves in total freedom without constraint. The readers force the writer to take a specific position in regard to his discourse, thus limiting his discursive freedom and his wayward movements. Only then writing becomes his writing, and is given into a system of two-way communication where every argument is expected to find its opponent and defend its position. Such a process of a writer defending his position makes his discourse more systematic and more theoretically conscious, eventually contributing to the maturity of Korean scholars.

고전적 몸과 근대적 몸 -「큐피드와 프시케」와 「미녀와 야수」를 중심으로

김종갑 ( Jong Gab Kim ) 한국비교문학회 2008 比較文學 Vol.44 No.-

Critics and Misreading as Effect without Cause

Jong-Gab Kim(김종갑) 건국대학교 인문학연구원 1996 통일인문학 Vol.28 No.-

랑시에르의 감각의 분할과 말의 몸

김종갑 ( Jong Gab Kim ) 한국비교문학회 2012 比較文學 Vol.58 No.-

특성화고등학교 적합형 컨벤션 교육품질 구성요인 개발 연구

김종갑(Kim, Jong-Gab),오정학(Oh, Jeong-Hak),김철원(Kim, Chul-Won) 한국관광레저학회 2015 관광레저연구 Vol.27 No.3

중국어 관광통역안내사의 장래성 인식집단 간 직무만족 차이 연구

김종갑(Kim Jong-Gab) 한국관광레저학회 2011 관광레저연구 Vol.23 No.3

번역의 가능성과 불가능성: 폴 드만 -『독서의 알레고리』-

김종갑 ( Jong Gab Kim ) 영미문학연구회 2010 안과 밖 Vol.0 No.29

교통약자의 이동성 역량강화와 경찰의 역할

김종갑 ( Jong Gab Kim ) 한국시큐리티융합경영학회 2013 한국융합과학회지 Vol.2 No.1

Pupose: This study aimed to identify potential problems that mobility handicapped people may face and their causes and to present policy proposals on how to solve those problems with focus on travel convenience and pedestrian environments. Set out below is a summary of the proposals. Those fall into three categories. Conclusion: First, rights to access public transport should be protected as constitutional rights as well as basic civil rights. In this respect, governmental support is necessary to secure sufficient man power and technical expertise within this interdisciplinary field. Second, in the context of effectively managing the existing mobility facilities and building more facilities, it is recommended that a range of policy measures be taken including developing vehicles with special functions, increasing the general service level, adopting more low floor buses, improving pedestrian environments, increasing the mandatory number of call taxis for the disabled to be possessed by each call taxi firm, and designating special areas for pedestrian traffic on the basis of a selection process in which political intentions and financial conditions of local governments, the ethical maturity level of citizens, and other elements are reflected. Third, in consideration of the aged andchildren, the size of traffic signs, markings, and signals should be scaled up. Policy measures should be taken to lessen accidents such as right angle collisions at interactions by broadening pedestrian roads and creating more rotaries. In addition, the following specific policy measures should be considered: development of training programs for elderly drivers, required registration of vehicles carrying school or pre-school children, provision of incentives to completers of training programs for drivers, and required installation of a black box in every car.