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위십이지장질환에서 Helicobacter Pylori 의 DNA Variation 에 관한 연구
노임환(Im Hwan Roe),김창인(Chang In Kim),하동렬(Dong Ryul Ha),진영주(Young Joo Jin),송일한(Il Han Song),임창영(Chang Young Lim),김정원(Jung Won Kim),김정택(Jung Taik Kim),이종화(Jong Hwa Kim),염정선(Jung Sun Yeom) 대한내과학회 1997 대한내과학회지 Vol.53 No.4
N/A Background: The evidence for H. pylori as a gastrointestnal pathogen is now very strong, if not overwhelming. Among the pathogenic factors of H. pylori, flagella and urease are considered to be major factors causing the gastrododenal disease. We observed the gene diversity of H. pylori using the PCR-amplified 1.4Kb fla A gene and 0.9Kb ure B gene and examined the relationship between the gene pattern and the gastroduodenal disease. Method: Fifty-one cases of isolated strains were cultured at the Helicobacter-selective blood agar plates. To compare the gene diversity among the isolates of gastroduodenal disease genotypes was analyzed by PCR-based RFLP. 1.4Kb fla A gene and 0.9Kb ure B genes from isolates were amplified by PCR and digested with Hae 3 restriction enzymes to observe the restriction fragment length polymophysm. Protein patterns were also compared to examine the antigenic variations. Total cell proteins, and octyl-glucose extracts from isolates were analyzed by SDS-PAGE gel electrophoresis. Results: 41 cases (80.4%) of H. pylori were isolated in the 51 cases of gastroduodenal diseases. We could classify theses isolates 3 types of PCR-RFLP in the fla A gene, 900+500bp, 500+500+400bp, 600+800bp, and 9 types in the ure B gene. PCR-RFLP in the fla A gene and ure B gene of the isolates was different from the standard strain of Australia and the genetic diversity was not related to the types of the gastroduodenal disease. We demonstrated variations in the protein pattern and antigenic profiles among the isolates by SDS-PAGE analysis. These data also did not show any relationship between protein pattern and types of gastroduodenal diseases. Conclusion: Tese studies showed many different gene diversity in the flagella and urease gene without any relationship with the types of gastoduodenal disease. And variable protein pattern were noted among the strains of H. pylori. Further studies to demonstrate the pathgenecity of H. pylori should be continued even if there was no relationship between the genomic diversity of the flagella or urease and the types of gastroduodenal disease.
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이정택 ( Jung Taik Lee ),김방출 ( Bang Chool Kim ) 한국체육사학회 2014 체육사학회지 Vol.19 No.2
본 연구는 10년간 지속된 평창 동계올림픽 유치 과정을 미국 언론의 시선을 통해 알아봄으로써 동계올림픽 유치가 우리나라의 체육사에 주는 사회문화적 및 역사적 맥락을 알아보고자 하였다. 본 연구의 목적을 달성하기 위해 미국의 3대 주요 신문인 뉴욕타임즈, 워싱턴 포스트, 월스트리트저널의 평창 동계올림픽 유치 과정에 대한 기사 2010년, 2014년, 2018년으로 나누어 살펴보았으며 그 결과는 다음과 같다. 2010년 동계올림픽 유치 과정에 대한 미국 언론의 시선은 밴쿠버의 동계올림픽 유치 가능성 확대, 미국의 하계올림픽 유치에 대한 우려, 평창 동계올림픽 유치 실패 이유로 나타나고 있었다. 2014년 동계올림픽 유치 과정에 대한 미국 언론의 시선은 동계올림픽 유치를 위한 투자 확대, 동계올림픽 유치에 대한 러시아의 열망, 러시아의 동계올림픽 유치 성공 요인으로 나타나고 있었다. 2018년 동계올림픽 유치 과정에 대한 미국 언론의 시선은 평창 동계올림픽 유치 과정에서 나타나는 윤리적 문제, 평창 동계올림픽 유치의 높은 가능성, 평창 동계올림픽 유치 성공 이유로 나타나고 있었다. The purpose of this study is to examine the sociocultural and historical implications of hosting Pyeongchang Winter Olympics on Korean physical education history. This study analyses the perspectives of the American press on the 10 year process of bids for Pyeongchang Winter Olympics. Articles about bids for Pyeongchang Winter Olympics from the three major American press (The New York Times, The Washington Post, The Wall Street Journal) were divided into three parts for the analysis: 2010, 2014 and 2018. The findings showed that the main themes for 2010 Winter Olympics were the high possibility of hosting Winter Olympics in Vancouver, concerns in U.S. about bids for Summer Olympics, and the reason why Pyeongchang failed. In 2014, it was apparent that the main themes were expanding investment on hosting Winter Olympics, Russia``s desire to host Winter Olympics, and the success factors for hosting Winter Olympics in Russia. For the 2018 Winter Olympics, the American press centered towards emersion of ethical matters in the process of bids in Pyeongchang, high possibility of hosting Winter Olympics in Pyeongchang and the reasons for Pyeongchang``s successful bidding.
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백서에서의 폐쇄성 황달에 대한 Ursodeoxycholic Acid의 치료효과
노임환(Im Whan Roh),김정택(Jung Taik Kim),박효순(Hyo Soon Park),명나혜(Na Hye Myeong) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
N/A Background/Aims: Cholestasis and bile duct proliferation are considered to be initiated by the changes in bile composition and/or increasing intraluminal pressure. Especially toxic hydrophobic bile acids such as lithocholic acid, chendodeoxycholic acid(CDCA), and cholic acid cause the damage on the bile duct and hepatocyte and finally bile duct proliferation and cholestasis. It is not clear whether bile per se has an initiating mechanism in bile duct proliferation and if a modification in the bile composition can reduce bile duct proliferation and cholestasis. The aim of this study was to investigate the effect of Ursodeoxycholic acid(UDCA) treatment on both cholestatic markers and bile duct proliferation following bile duct ligation. Methods: After bile duct ligation, male Sprague-Dawley rats weighing 220+ 30 gm were divided into 3 groups and 2 groups among thern were treated for 30 days with either UDCA(10 mg/kg, N=15) or UDCA and CDCA(each 5 mg/kg, N=15). Animals were sacrificed at day 30. Results: The serum activity of alkaline phosphatase, and r-glutamyltransferase(rGTP) was significantly lower(p0.01) in the UDCA-treated rats. Serum GOT, total bilirubin, bile acids were lower(pC0.001) in the UDCA-treated rats compared to both of UDCA and CDCA treated and control group. Histologic examination showed that the number of ductular cells in the portal area was significantly(p0.001), reduced in UDCA-treated compared to UDCA and CDCA treated and contro] groups. The replication activity, assessed as Proliferating Cell Nuclear Antigen(PCNA)-positive cells, was also significantly lower in UDCA treated rats. Lobular bile ductules were decreased about three fold in the UDCA treated group than the other 2 groups. Conversely serum activity of GOT, alkaline phosphatase, rGTP, total bilinbin, chole- sterol was not different between the UDCA and CDCA treated and control rats except significant lower(p0.01) serum bile acid in the UDCA and CDCA treated rats. Conclusion: These data indicate that UDCA treatment significantly reduce the replicative activity and this effect is asso- ciated with both an improvement in serum levels of cholestatic markers and histologic findings. Although the mechanism of choleretic effect followig UDCA administration is still hypothetical, UDCA may reduce the level of irritating bile salts such as chenodeoxycholic acid ancl lithocholic acid and increase periductular bile acid recirculation. Therefore, longterm UDCA treatment support the beneficial effect in cholestatic disease. (Korean J Gastroenterol 1996; 28:402 - 408)
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췌장암에서의 Transforming Growth Factor (TGF)β1, TGFβ Receptor Ⅱ, p53 단백질 및 K-ras 돌연변이 유전자의 임상적 의의
김구상(Ku Sang Kim),채영수(Young Su Chae),김정택(Jung Taik Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4
Purpose: Many cancers, including pancreatic cancer, harbor defects in TGFβ signaling and are resistant to TGFβ mediated growth inhibition. In addition, the expression of the p53 gene and mutations in K-ras might play an important role in the multistep carcinogenesis of pancreatic cancer. This study examined the expression level of TGFβ1, TGFβ receptorⅡ (TβRⅡ), p53 protein and K-ras mutation in pancreatic cancer, along with their role and clinical significance. Methods: The overexpression of TGFβ1, TβRⅡ and p53 protein was evaluated using an immunohistochemical assay. The K-ras mutation was analyzed by PCR-RFLP in the surgical resected pancreatic tissue from 26 pancreatic ductal adenocarcinomas and 5 normal pancreases. Results: Immunohistochemical analysis of TGFβ1 and Tβ RⅡ revealed positive immunostaining in 73.1% and 76.9% of the tumors, respectively, which were significantly higher than the normal pancreas (P=0.008). The p53 protein was positive in none of the 5 normal ducts and 16 out of 26 (61.5%) pancreatic carcinoma specimens. The K-ras mutation was positive in none of the 5 normal ducts, and in 20 of the 26 pancreatic carcinoma specimens (76.9%). The presence of TGFβ1 and TβRⅡ in the cancer samples was significantly associated with node metastasis, advanced tumor stage (P<0.01), and a short survival time (P<0.05). The p53-positive pancreatic cancers showed a significantly lower survival rate than those with p53-negative tumors (P<0.05). There was no correlation between K-ras mutations and the survival rates. Conclusion: The detection of K-ras mutations and TGFβ1, TβRⅡ and p53 protein overexpression can predict the prognosis of pancreatic carcinoma patients.
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노임환(Im Hwan Roe),김정택(Jung Taik Kim),배순기(Soon Ki Bae) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: Defective esophageal peristalsis has been recognized as a feature of reflux esophagitis for many years, even if the esophagea1 manometry is of little value in the diagnosis of reflux esophagitis. The aim of the study is to evaluate the esophageal peristaltic function in patients wii;I severe endoscopic esophagitis(acid reflux esophagitis, corrosive esophagitis, alkaline reflux esophagitis), and to observe the change of peristaltic function after the improvement of the esophagitis, Methods: The conventional manometry was performed in 27 patients with endoscopi- cally high grade esophagitis(13 acid reflux esophagitis, 4 corrosive esophagitis, 10 alkaline reflux esopbagitis), before and after treating esophageal inflammation. Peristaltic dysfuction was the occurrence of either failed primary peristalsis or very low amplitude of peristaltic waves in the distal esophagus. The types of failed primary peristalsis included no generation of peristalsis, simultaneous contractions and retrograde peristalsis. Results: Significant differences were found in the motility variables, especially lower esophageal sphincter pressure(LESP), peristaltic amplitude, and primary peristaltic activities in 13 patients with the reflux esophagitis and 3 of 4 patients with the corrosive esopagitis after healing. Also we observed that manometric findings in 5 cases with the severe alkaline reflux esophagitis with no treatment improvement revealed aperistalsis or very small peristaltic amplitude similar to the initial manometric results. Conclusions: These results indicate that the peristaltic dysfunction is directly related to the severity of the esophagtis and that the peristaltic dysfunction is reversible after improvement of the esophageal inflammation. The severe mucosal inflammation is an important determinant causing the esophageal peristaltic dysfunction. (Korean J Gastroenterol 1995;27:283 - 291)
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