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Effects of Impressic Acid from Acanthopanax koreanum on NF-κB and PPARγ Activities
김정아,김영호,양서영,송석빈 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
Impressic acid, 3α,11α-dihydroxylup-20(29)-en-28-oic acid, is a lupane-type triterpenoid isolated from Acanthopanax koreanum, which has been used as a Korean folk medicine for rheumatism, hepatitis, diabetes, and inflammatory disorders. Recently, it was reported that impressic acid has inhibitory effects on the LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells and on the nuclear factor of activated T-cells transcription factor activity. Thus, to investigate whether impressic acid has effects on the inhibition of nuclear factor kappa B (NF-κB) and activation of peroxisome proliferator-activated receptor gamma (PPARγ), luciferase reporter assays were used. The effects on the expression of NF-κB and PPARγ target genes were also examined by reverse transcription-polymerase chain reaction. In this study, impressic acid was found to inhibit tumor necrosis factor (TNF)-α induced NF-κB activity and to up-regulate transcriptional activity of PPARγ.
김정아,김행곤,Kim, Jeong-A,Kim, Haeng-Gon 한국정보처리학회 1999 정보처리논문지 Vol.6 No.4
소프트웨어 재사용에서 코드 재사용은 다른 개발자에 의해 작성된 재사용 코드의 이해와 검색의 어려움 등 한계점을 갖는다. 코드 재사용 한계를 극복하기 위해서는 코딩 단계 이전의 설계 단계나 분석 단계의 산물을 재사용 할 수 있어야 한다. 본 연구에서는 객체 모델링 단계에서 이전의 경험을 재사용할 수 있는 환경을 제공하기 위해 질의와 컴포넌트에 대한 analogy를 판단하여 라이브러리의 모델과 패턴을 재사용 할 수 있는 방법을 제안하였다. Analogy 매칭 기법은 설계 패턴의 검색, 이해 그리고 조합 등에 적용되며 본 논문에서 연구된 내용은 다음과 같다. 1. 재사용 라이브러리로부터 유사 컴포넌트 검색 및 추출을 위한 analogical 매칭 함수 제안 2. analogical 매칭을 위해 라이브러리 내에 저장될 재사용 컴포넌트 표현 및 정의 3. 특정 도메인에 대한 의미적 정보의 라이브러리 설계 4. 사용자를 위한 analogical 매칭 에이전트 구축 Code reuse in software reuse has several limitations such as difficulties of understanding and retrieval of the reuse code written by other developers. To overcome these problems, it should be possible to reuse the analysis/design information than source code itself. In this paper, we present analogical matching techniques for the reuse of object models and patterns. We have suggested the design patterns as reusable components and the representation techniques to store them. The contents of the paper is as follows.1. analogical matching functions to retrieve analogous components from reusable libraries. 2. the representation of reusable components to be stored in the library in order to support the analogical matching. 3. the design library with more semantic informations about domains. 4. the analogical matching agent with a user-friendly interface that can retrieve the analogous components from the library based on analogical matching techniques.
간호대학생의 도덕 판단력과 간호윤리 가치관에 관한 연구
김정아,정재임,차영자 경북전문대학교 2007 慶北專門大學 論文集 Vol.25 No.-
The purpose of this study was to investigate the level of the moral judgement and nursing ethical values of nursing students. The subjects were 271 nursing students. The Data were collected through self-reported questionnaires in Oct, 2006. We questionnaired the subjects using Nurse's ethical values questionnaires developed by Lee(1990) and Korean version of Defining Issues Test(DIT). The collected data were analyzed using frequency, percentage, mean, standard deviation, t-test, ANOVA, Sheffer test and Cronbach's α coefficients. The results were as follows; 1. The subjects gave 41.38 points on P Scores, which indicates that rely on the ethical principle when they make moral judgement, and 20.03 points on D Scores, which indicates the overall level of moral judgement. 2. In analyzing the factors that influenced the Moral Judgement Index P and D, it was revealed that nursing student's moral judgement D score were significantly higher at the freshman group. 3. The level of nursing ethical values of nursing students was 3.59±.40 of 5 scores. This meant that the ethical values of nursing students were in the direction of a deontological position. The level of nursing ethical values in the co-working relationship was 4.37±.52, patient relationship 3.83±.53 and task relationship 3.27±.52. The level of nursing ethical values in the human life was lowest(3.25±.65). 4. Factors to related to the nursing ethical values of nursing students were grade, living together with parents, the education standard of mother, financial conditions and the standard for ethical values. 5. The correlation between the moral judgement D score and nursing ethical values of nursing students was analyzed to have positive correlation with statistical significance(r=.299, p=.000).