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기능성 팽만감 환자에서 복부 컴퓨터단층촬영으로 측정한 위장관 가스와 지방량
이홍섭 ( Hong Sub Lee ),김재근 ( Jai Keun Kim ),선주성 ( Joo Sung Sun ),이광재 ( Kwang Jae Lee ) 대한소화기학회 2018 대한소화기학회지 Vol.71 No.6
Background/Aims: The aim of this study was to assess whether increased intestinal gas or fat content in the abdominal cavity is related to abdominal bloating, using three-dimensional abdominal computed tomography scan. Methods: Twenty-nine healthy individuals without abdominal bloating and organic disease (15 women; mean age, 49 years; range of age, 23-73 years) and 30 patients with chronic recurrent abdominal bloating-diagnosed with functional bloating (10 women; mean age, 53 years; range of age, 35-75 years) - participated in this study. The mean values of measured parameters were compared using independent sample t-test. Results: The mean volume of total colon gas in bloated patients was similar to that in control subjects. The distribution of intra-abdominal gas was also similar between the two groups. However, the amount of gas in the transverse colon tended to be significantly higher in patients with bloating than in controls (p=0.06). Body mass index was similar between the two groups (23.4±3.2 kg/m<sup>2</sup> and 22.3±3.1 kg/m<sup>2</sup>, respectively). Moreover, no significant differences with respect to circumferential area, subcutaneous fat, visceral fat area, and total fat area were found between the two groups. Conclusions: Bloating might not just be the result of gastrointestinal gas or intra-abdominal fat. Other contributing factors, such as localized abnormality in gas distribution and visceral hypersensitivity, may be involved. (Korean J Gastroenterol 2018;71:324-331)
합병증이 병발된 난치성 염증성 장질환에서 Infliximab의 치료 효과
이기명 ( Ki Myung Lee ),김종수 ( Jong Soo Kim ),신도현 ( Do Hyun Shin ),정재연 ( Jae Youn Cheong ),유병무 ( Byung Moo Yoo ),김재근 ( Jai Keun Kim ),이광재 ( Kwang Jae Lee ),함기백 ( Ki Baik Hahm ),김진홍 ( Jin Hong Kim ),조성원 ( 대한소화기학회 2004 대한소화기학회지 Vol.44 No.5
Background/Aims: Many studies on infliximab have confirmed its efficacy in the remission induction and even maintenance in refractory and fistulizing Crohn`s disease. We report the treatment efficacy of infliximab in Crohn`s disease and ulcerative colitis
MELAS 증후군과 미토콘드리아 근육병에서의 Tc-99m ECD 뇌 단일 광전자방출 전산화단층촬영 소견 - 자기공명영상과의 비교
유영훈(Young Hoon Ryu),이종두(Jong Doo Lee),윤평호(Pyeong Ho Yoon),김재근(Jai Keun Kim),박상준(Sang Joon Park),전태주(Tae Joo Jeon),남지은(Ji Eun Nam),윤춘식(Choon Sik Yoon) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.6
N/A Purpose: We evaluated brain perfusion SPECT findings of MELAS syndrome and mitochondrial myopathy in correlation with MR imaging in search of specific imaging features. Materials and Methods: Subjects were five patients (four females and one male; age range, 1 to 25 year) who presented with repeated stroke-like episodes, seizures or developmental delay or asymptomatic but had elevated lactic acid in CSF and serum. Conventional non-contrast MR imaging and Tc-99m-ethyl cysteinate dimer (ECD) brain perfusion SPECT were performed and imaging features were analyzed. Results: MRI demonstrated increased T2 signal intensities in the affected areas of gray and white matters mainly in the parietal (4/5) and occipital lobes (4/5) and in the basal ganglia (1/5), which were not restricted to a specific vascular territory. SPECT demonstrated decreased perfusion in the corresponding regions of MRI lesions. In addition, there were perfusion defects in parietal (1 patient), temporal (2), and frontal (1) lobes and basal ganglia (1) and thalami (2). In a patient with mitochondrial myopathy who had normal MRI, decreased perfusion was noted in left parietal area and bilateral thalami. Conclusion: Tc-99m ECD SPECT imaging in patients with MELAS syndrome and mitochondrial myopathy showed hypoperfusion of parieto-occipital cortex, basal ganglia, thalamus and temporal cortex, which were not restricted to a specific vascular territory. There were no specific imaging features on SPECT. The significance of abnormal perfusion on SPECT without corresponding MR abnormalities needs to be evaluated further in larger number of patients.
간문맥 혈전이 동반된 진행성 간세포암에서 간동맥내 항암제 주입요법
정재연 ( Jae Youn Cheong ),이기명 ( Kee Myung Lee ),조성원 ( Sung Won Cho ),원제환 ( Jae Han Won ),김재근 ( Jai Keun Kim ),왕희정 ( Hee Jung Wang ),함기백 ( Ki Baik Hahm ),김진홍 ( Jin Hong Kim ) 대한내과학회 2004 대한내과학회지 Vol.67 No.1
목적: 간문맥 혈전이 동반된 간세포암은 예후가 매우 불량한 것으로 알려져 있다. 경간동맥 화학색전술은 진행성 간세포암의 치료로 널리 행해지고 있으나 일부 환자에서는 치료 후 간부전이 문제시 된다. 본 연구는 간문맥 혈전이 동반된 진행성 간세포암에서 보존적 치료 및 전신적 항암 요법과 비교하여 간동맥내 5-fluorouracil (FU), cisplatin 주입요법의 치료 효과를 알아보고, 생존에 영향을 미치는 예후인자를 알아보고자 하였다. 방법: 199 Background: Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis has a poor prognosis and has little hope for meaningful therapy. Transarterial chemoembolization has been performed as a treatment for advanced HCC, but some patients die from
4 cm 이하의 단일결절 간세포암종에서 고주파열치료와 경동맥화학색전술의 효과 비교
양민재 ( Min Jae Yang ),안소연 ( So Yun An ),문은준 ( Eun Joon Moon ),이민석 ( Min Suk Lee ),황주안 ( Joo An Hwang ),정재연 ( Jae Youn Cheong ),원제환 ( Je Hwan Won ),김재근 ( Jai Keun Kim ),왕희정 ( Hee Jung Wang ),조성원 ( Sung 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4
Carcinoma, Hepatocellular, Radiofrequency ablation, Chemoembolization, Therapeutic, 간세포암종, 고주파열치료, 경동맥화학 색전술 Background/Aims: Radiofrequency ablation (RFA) is an established curative therapeutic modality for unresectable hepatocellular carcinoma (HCC), and transarterial chemoembolization (TACE) has been used as a palliative treatment for inoperable HCC. It is still unknown whether RFA and TACE are equally effective for improving the survival of patients with unresectable HCC that is amenable to either treatment. The aim of this retrospective study was to compare the clinical impacts of two treatments, and analyze the prognostic factors for recurrence and survival. Methods: Ninety-three patients with a single HCC smaller than 4 cm who showed complete responses (complete ablation or complete lipiodol tagging) after treatment with RFA (n=43) or TACE (n=50) between January 2002 and February 2009 were investigated. Univariate and multivariate analyses were performed for 13 potential prognostic factors using the Cox proportional-hazards model. Results: The time-to-recurrence rates at 1, 2, and 3 years after treatment were 32.9%, 44.3%, and 55.4%, respectively, for the RFA group, and 42%, 68.3%, 71.7% for the TACE group. The probability of survival at 1, 2, and 3 years was 97.7%, 77.4%, and 63.1%, respectively, for the RFA group, and 95.9%, 76.1%, and 60.2% for the TACE group. The time-to-recurrence and overall survival rates did not differ significantly between the two treatment groups. A multivariate Cox proportional-hazards model revealed that a tumor size larger than 3 cm and lower serum albumin levels were independent risk factors for recurrence, and that being male, being seropositive for hepatitis B surface antigen, and having a higher serum albumin level were independent favorable prognostic factors for survival. Conclusions: TACE and RFA exhibited similar therapeutic effects in terms of recurrence and survival for patients with a single HCC smaller than 4 cm, if they could exhibited complete responses. (Korean J Hepatol 2009;15:474-485)